Published in Eur J Immunol on April 01, 2010
DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy. Dev Cell (2011) 2.17
Human β-D-3 Exacerbates MDA5 but Suppresses TLR3 Responses to the Viral Molecular Pattern Mimic Polyinosinic:Polycytidylic Acid. PLoS Genet (2015) 1.38
Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur J Immunol (2011) 1.27
Antiviral mechanisms of human defensins. J Mol Biol (2013) 1.22
A worldwide analysis of beta-defensin copy number variation suggests recent selection of a high-expressing DEFB103 gene copy in East Asia. Hum Mutat (2011) 1.21
Antimicrobial peptides and gut microbiota in homeostasis and pathology. EMBO Mol Med (2013) 1.17
Facioscapulohumeral dystrophy: the path to consensus on pathophysiology. Skelet Muscle (2014) 1.16
Determination of beta-defensin genomic copy number in different populations: a comparison of three methods. PLoS One (2011) 1.12
DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle. Hum Mol Genet (2014) 1.06
Antimicrobial peptides and their potential application in inflammation and sepsis. Crit Care (2012) 1.02
Beta-defensins: what are they really doing in the oral cavity? Oral Dis (2011) 0.99
Defensins: antifungal lessons from eukaryotes. Front Microbiol (2014) 0.99
The immunology of host defence peptides: beyond antimicrobial activity. Nat Rev Immunol (2016) 0.94
The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation. Skin Pharmacol Physiol (2012) 0.93
β-Defensins activate human mast cells via Mas-related gene X2. J Immunol (2013) 0.90
Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract. PLoS One (2013) 0.90
Facioscapulohumeral muscular dystrophy: consequences of chromatin relaxation. Curr Opin Neurol (2012) 0.88
The yin and yang of human Beta-defensins in health and disease. Front Immunol (2012) 0.88
Understanding the roles of gingival beta-defensins. J Oral Microbiol (2012) 0.86
Epithelial antimicrobial peptides: guardian of the oral cavity. Int J Pept (2014) 0.85
High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One (2012) 0.83
Defensin DEFB103 bidirectionally regulates chemokine and cytokine responses to a pro-inflammatory stimulus. Sci Rep (2013) 0.83
The novel human β-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss. J Biol Chem (2013) 0.82
Antimicrobial peptides and wound healing: biological and therapeutic considerations. Exp Dermatol (2016) 0.80
Immune-directed support of rich microbial communities in the gut has ancient roots. Dev Comp Immunol (2014) 0.80
Human beta-defensin 3 induces maturation of human langerhans cell-like dendritic cells: an antimicrobial peptide that functions as an endogenous adjuvant. J Invest Dermatol (2012) 0.80
Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections. Pathog Glob Health (2016) 0.80
Human β-defensin 2 induces extracellular accumulation of adenosine in Escherichia coli. Antimicrob Agents Chemother (2013) 0.78
Modulation of host defense peptide-mediated human mast cell activation by LPS. Innate Immun (2015) 0.78
Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity. Int J Nanomedicine (2015) 0.77
Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways. J Leukoc Biol (2015) 0.76
Overexpression of Porcine Beta-Defensin 2 Enhances Resistance to Actinobacillus pleuropneumoniae Infection in Pigs. Infect Immun (2015) 0.76
The role of antimicrobial peptides in chronic inflammatory skin diseases. Postepy Dermatol Alergol (2016) 0.76
The Role of Antimicrobial Peptides in Influenza Virus Infection and Their Potential as Antiviral and Immunomodulatory Therapy. Pharmaceuticals (Basel) (2016) 0.75
Cytotoxicity of HBD3 for dendritic cells, normal human epidermal keratinocytes, hTERT keratinocytes, and primary oral gingival epithelial keratinocytes in cell culture conditions. Toxicol Lett (2015) 0.75
Structure-Dependent Immune Modulatory Activity of Protegrin-1 Analogs. Antibiotics (Basel) (2014) 0.75
Human β-Defensin 3 Reduces TNF-α-Induced Inflammation and Monocyte Adhesion in Human Umbilical Vein Endothelial Cells. Mediators Inflamm (2017) 0.75
Potassium is a key signal in host-microbiome dysbiosis in periodontitis. PLoS Pathog (2017) 0.75
Human β-defensin 3 increases the TLR9-dependent response to bacterial DNA. Eur J Immunol (2017) 0.75
The θ-defensin retrocyclin 101 inhibits TLR4- and TLR2-dependent signaling and protects mice against influenza infection. J Leukoc Biol (2017) 0.75
Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol (2001) 25.63
Psoriasis is associated with increased beta-defensin genomic copy number. Nat Genet (2007) 8.07
Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science (1999) 7.86
Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem (2000) 6.19
A chromosome 8 gene-cluster polymorphism with low human beta-defensin 2 gene copy number predisposes to Crohn disease of the colon. Am J Hum Genet (2006) 5.10
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet (2000) 4.57
Interleukin 10 protects mice from lethal endotoxemia. J Exp Med (1993) 4.46
Molecular and evolutionary history of melanism in North American gray wolves. Science (2009) 3.87
Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function. Cell (1993) 3.84
A -defensin mutation causes black coat color in domestic dogs. Science (2007) 3.47
AMPed up immunity: how antimicrobial peptides have multiple roles in immune defense. Trends Immunol (2009) 3.40
Extensive normal copy number variation of a beta-defensin antimicrobial-gene cluster. Am J Hum Genet (2003) 3.27
The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol (2002) 2.57
Human beta-defensin 4: a novel inducible peptide with a specific salt-sensitive spectrum of antimicrobial activity. FASEB J (2001) 2.52
Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res (2001) 2.45
Modulation of the TLR-mediated inflammatory response by the endogenous human host defense peptide LL-37. J Immunol (2006) 2.32
Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci U S A (2003) 2.32
Human -defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2. Proc Natl Acad Sci U S A (2007) 2.10
Discovery of new human beta-defensins using a genomics-based approach. Gene (2001) 2.08
Targeting melanocortin receptors as a novel strategy to control inflammation. Pharmacol Rev (2004) 2.08
Cathelicidin antimicrobial peptides block dendritic cell TLR4 activation and allergic contact sensitization. J Immunol (2007) 1.42
Duplication and selection in the evolution of primate beta-defensin genes. Genome Biol (2003) 1.37
Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3. J Biol Chem (2008) 1.28
Putting on the brakes: cyclic AMP as a multipronged controller of macrophage function. Sci Signal (2009) 1.27
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins. J Immunol (2009) 1.21
Melanocortin 3 receptors control crystal-induced inflammation. FASEB J (2006) 1.08
The novel beta-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo. FASEB J (2006) 1.07
Diminishment of alpha-MSH anti-inflammatory activity in MC1r siRNA-transfected RAW264.7 macrophages. J Leukoc Biol (2008) 1.06
The complexity of selection at the major primate beta-defensin locus. BMC Evol Biol (2005) 1.02
Differential mRNA expression of antimicrobial peptides and proteins in atopic dermatitis as compared to psoriasis vulgaris and healthy skin. Int Arch Allergy Immunol (2008) 0.99
Structure-function relationship of the human antimicrobial peptide LL-37 and LL-37 fragments in the modulation of TLR responses. Biol Chem (2009) 0.92
Mouse genomic variation and its effect on phenotypes and gene regulation. Nature (2011) 10.66
Resolution of inflammation: state of the art, definitions and terms. FASEB J (2007) 5.12
Inflammatory resolution: new opportunities for drug discovery. Nat Rev Drug Discov (2004) 5.08
Role of the immune system in chronic pain. Nat Rev Neurosci (2005) 4.10
Dominant role of the niche in melanocyte stem-cell fate determination. Nature (2002) 4.05
Cyclin-dependent kinase inhibitors enhance the resolution of inflammation by promoting inflammatory cell apoptosis. Nat Med (2006) 3.79
Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability. Cell (2002) 3.72
The VPAC(2) receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell (2002) 3.29
Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature (2009) 3.27
A randomized controlled trial of peripheral blood mononuclear cell depletion in experimental human lung inflammation. Am J Respir Crit Care Med (2013) 2.71
Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development. Cell (2012) 2.62
The human antimicrobial peptide LL-37 is a multifunctional modulator of innate immune responses. J Immunol (2002) 2.57
P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nat Commun (2011) 2.18
Aberrant inflammation and resistance to glucocorticoids in annexin 1-/- mouse. FASEB J (2002) 2.13
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains. Genome Biol (2013) 2.04
Resolution of inflammation: an integrated view. EMBO Mol Med (2013) 2.01
Impact of LL-37 on anti-infective immunity. J Leukoc Biol (2004) 2.01
Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia. Thorax (2009) 1.87
Monocytes control second-phase neutrophil emigration in established lipopolysaccharide-induced murine lung injury. Am J Respir Crit Care Med (2012) 1.82
A re-evaluation of the role of host defence peptides in mammalian immunity. Curr Protein Pept Sci (2005) 1.78
Cardiac malformations and midline skeletal defects in mice lacking filamin A. Hum Mol Genet (2006) 1.74
Modulation of phagocytosis of apoptotic neutrophils by supernatant from dexamethasone-treated macrophages and annexin-derived peptide Ac(2-26). J Immunol (2005) 1.68
Immunomodulatory activities of small host defense peptides. Antimicrob Agents Chemother (2005) 1.67
Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions. Arterioscler Thromb Vasc Biol (2012) 1.67
Human and mouse mutations in WDR35 cause short-rib polydactyly syndromes due to abnormal ciliogenesis. Am J Hum Genet (2011) 1.66
Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury. J Immunol (2011) 1.63
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood (2005) 1.62
Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood (2008) 1.61
Leukocyte antiadhesive actions of annexin 1: ALXR- and FPR-related anti-inflammatory mechanisms. Blood (2003) 1.60
Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest (2012) 1.57
Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development. J Invest Dermatol (2012) 1.56
Annexin I regulates SKCO-15 cell invasion by signaling through formyl peptide receptors. J Biol Chem (2006) 1.55
Cutting edge: Humanized nano-proresolving medicines mimic inflammation-resolution and enhance wound healing. J Immunol (2011) 1.52
Spatial and temporal profiles for anti-inflammatory gene expression in leukocytes during a resolving model of peritonitis. J Immunol (2006) 1.52
The role of the purinergic P2X7 receptor in inflammation. J Inflamm (Lond) (2007) 1.50
Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A (2013) 1.49
Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol (2005) 1.43
β-Defensins: multifunctional modulators of infection, inflammation and more? J Innate Immun (2012) 1.42
The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc Natl Acad Sci U S A (2004) 1.41
The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes. J Immunol (2004) 1.41
Novel ENU-induced eye mutations in the mouse: models for human eye disease. Hum Mol Genet (2002) 1.41
Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37. PLoS One (2011) 1.39
The link module from human TSG-6 inhibits neutrophil migration in a hyaluronan- and inter-alpha -inhibitor-independent manner. J Biol Chem (2002) 1.39
Modulation of inflammation and response to dexamethasone by Annexin 1 in antigen-induced arthritis. Arthritis Rheum (2004) 1.39
Duplication and selection in the evolution of primate beta-defensin genes. Genome Biol (2003) 1.37
NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice. Proc Natl Acad Sci U S A (2002) 1.36
Dominant mutations of Col4a1 result in basement membrane defects which lead to anterior segment dysgenesis and glomerulopathy. Hum Mol Genet (2005) 1.33
Genotype-phenotype correlation of mouse pde6b mutations. Invest Ophthalmol Vis Sci (2005) 1.31
Thrombospondin-1 mimetic peptide inhibitors of angiogenesis and tumor growth: design, synthesis, and optimization of pharmacokinetics and biological activities. J Med Chem (2005) 1.31
A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. FASEB J (2003) 1.30
Glucocorticoids induce protein S-dependent phagocytosis of apoptotic neutrophils by human macrophages. J Immunol (2009) 1.30
Signatures of diversifying selection in European pig breeds. PLoS Genet (2013) 1.30
Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists. Pharmacol Ther (2010) 1.29
Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression. Dev Cell (2011) 1.29
Analysis and separation of residues important for the chemoattractant and antimicrobial activities of beta-defensin 3. J Biol Chem (2008) 1.28
Human β-defensin 3 affects the activity of pro-inflammatory pathways associated with MyD88 and TRIF. Eur J Immunol (2011) 1.27
Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation. Am J Pathol (2005) 1.27
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. Proc Natl Acad Sci U S A (2004) 1.26
Regulation of pigmentation in zebrafish melanophores. Pigment Cell Res (2006) 1.25
The human cationic host defense peptide LL-37 mediates contrasting effects on apoptotic pathways in different primary cells of the innate immune system. J Leukoc Biol (2006) 1.25
Interaction and cellular localization of the human host defense peptide LL-37 with lung epithelial cells. Infect Immun (2005) 1.24
FPR2/ALX receptor expression and internalization are critical for lipoxin A4 and annexin-derived peptide-stimulated phagocytosis. FASEB J (2010) 1.23
Activation of the annexin 1 counter-regulatory circuit affords protection in the mouse brain microcirculation. FASEB J (2007) 1.22
Dying and necrotic neutrophils are anti-inflammatory secondary to the release of alpha-defensins. J Immunol (2009) 1.21
Bone marrow-derived SP cells can contribute to the respiratory tract of mice in vivo. J Cell Sci (2005) 1.21
Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol (2003) 1.21
A novel biological activity for galectin-1: inhibition of leukocyte-endothelial cell interactions in experimental inflammation. Am J Pathol (2003) 1.20
RNA:DNA hybrids are a novel molecular pattern sensed by TLR9. EMBO J (2014) 1.19
Annexin A1 regulates intestinal mucosal injury, inflammation, and repair. J Immunol (2008) 1.18
Mutation spectrum in RAB3GAP1, RAB3GAP2, and RAB18 and genotype-phenotype correlations in warburg micro syndrome and Martsolf syndrome. Hum Mutat (2013) 1.17
Melanocortin receptor signaling in RAW264.7 macrophage cell line. Peptides (2005) 1.16
Wa5 is a novel ENU-induced antimorphic allele of the epidermal growth factor receptor. Mamm Genome (2004) 1.16
Signal sequence conservation and mature peptide divergence within subgroups of the murine beta-defensin gene family. Mol Biol Evol (2003) 1.16
Presence of visual head tracking differentiates normal sighted from retinal degenerate mice. Neurosci Lett (2002) 1.15
Innate responses of B cells. Eur J Immunol (2007) 1.15
Activation of melanocortin type 3 receptor as a molecular mechanism for adrenocorticotropic hormone efficacy in gouty arthritis. Arthritis Rheum (2002) 1.15
Novel insights into the inhibitory effects of Galectin-1 on neutrophil recruitment under flow. J Leukoc Biol (2008) 1.14
A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. Proc Natl Acad Sci U S A (2011) 1.14
Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest (2015) 1.13
Inhibitory control of endothelial galectin-1 on in vitro and in vivo lymphocyte trafficking. FASEB J (2007) 1.12
The role and regulation of 11beta-hydroxysteroid dehydrogenase type 1 in the inflammatory response. Mol Cell Endocrinol (2008) 1.12
Ligand-specific glucocorticoid receptor activation in human platelets. Blood (2005) 1.12
Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling. J Pediatr (2004) 1.12
Ligation of the adhesion-GPCR EMR2 regulates human neutrophil function. FASEB J (2007) 1.11
Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity. J Biol Chem (2004) 1.10
Annexin-1 modulates T-cell activation and differentiation. Blood (2006) 1.10
Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3. J Biol Chem (2007) 1.10
Melanocortin 3 receptors control crystal-induced inflammation. FASEB J (2006) 1.08
An overview of the effects of annexin 1 on cells involved in the inflammatory process. Mem Inst Oswaldo Cruz (2005) 1.08
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development. J Cell Sci (2008) 1.08
Neural crest progenitors of the melanocyte lineage: coat colour patterns revisited. Development (2002) 1.08
Genomic anatomy of the Tyrp1 (brown) deletion complex. Proc Natl Acad Sci U S A (2006) 1.07
Differential persistence among genomovars of the Burkholderia cepacia complex in a murine model of pulmonary infection. Infect Immun (2002) 1.07
The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol (2012) 1.07
Animal models of cystic fibrosis. J Cyst Fibros (2004) 1.06
Interleukin 17 sustains rather than induces inflammation. Biochem Pharmacol (2008) 1.06