Published in Nat Rev Mol Cell Biol on June 01, 2005
Role of autophagy in cancer. Nat Rev Cancer (2007) 10.88
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ (2008) 10.45
Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78
Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis. Genes Dev (2007) 6.35
A critical role for the autophagy gene Atg5 in T cell survival and proliferation. J Exp Med (2006) 6.01
Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog (2007) 4.73
Growth arrest and autophagy are required for salivary gland cell degradation in Drosophila. Cell (2007) 4.55
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis. Oncogene (2008) 3.63
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat Cell Biol (2010) 2.78
The regulation of autophagy - unanswered questions. J Cell Sci (2011) 2.73
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015. Cell Death Differ (2014) 2.66
Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation. Nat Cell Biol (2010) 2.37
Autophagy is a renoprotective mechanism during in vitro hypoxia and in vivo ischemia-reperfusion injury. Am J Pathol (2010) 2.24
Apoptotic and non-apoptotic programmed cardiomyocyte death in ventricular remodelling. Cardiovasc Res (2008) 2.22
Autophagy, not apoptosis, is essential for midgut cell death in Drosophila. Curr Biol (2009) 2.20
Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal (2011) 2.04
Role and regulation of autophagy in cancer. Biochim Biophys Acta (2009) 2.00
Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: From tuberous sclerosis to common acquired epilepsies. Epilepsia (2009) 1.98
Autophagy in proximal tubules protects against acute kidney injury. Kidney Int (2012) 1.98
Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J Biol Chem (2008) 1.93
Caspase cleavage of Atg4D stimulates GABARAP-L1 processing and triggers mitochondrial targeting and apoptosis. J Cell Sci (2009) 1.92
Uba1 functions in Atg7- and Atg3-independent autophagy. Nat Cell Biol (2013) 1.91
Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy. PLoS One (2009) 1.88
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem (2008) 1.84
Functions of autophagy in normal and diseased liver. Autophagy (2013) 1.81
Molecular determinants of caste differentiation in the highly eusocial honeybee Apis mellifera. BMC Dev Biol (2007) 1.79
The cell biology of autophagy in metazoans: a developing story. Development (2008) 1.76
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem (2011) 1.74
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila. PLoS Genet (2007) 1.66
Autophagic degradation of the BCR-ABL oncoprotein and generation of antileukemic responses by arsenic trioxide. Blood (2012) 1.66
The epidermal growth factor receptor antibody cetuximab induces autophagy in cancer cells by downregulating HIF-1alpha and Bcl-2 and activating the beclin 1/hVps34 complex. Cancer Res (2010) 1.54
Mitochondrial electron transport chain complex III is required for antimycin A to inhibit autophagy. Chem Biol (2011) 1.50
Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function. Mol Cell Biol (2006) 1.48
Overexpression of Atg5 in mice activates autophagy and extends lifespan. Nat Commun (2013) 1.46
Eating on the fly: function and regulation of autophagy during cell growth, survival and death in Drosophila. Autophagy (2008) 1.45
Extracellular matrix regulation of autophagy. Curr Opin Cell Biol (2008) 1.44
Beclin-1 expression is a predictor of clinical outcome in patients with esophageal squamous cell carcinoma and correlated to hypoxia-inducible factor (HIF)-1alpha expression. Pathol Oncol Res (2009) 1.43
Regulation of autophagy in mammals and its interplay with apoptosis. Cell Mol Life Sci (2010) 1.40
Role of autophagy in breast cancer. Autophagy (2007) 1.39
Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice. Pharmacol Res Perspect (2016) 1.39
Cladosporol A triggers apoptosis sensitivity by ROS-mediated autophagic flux in human breast cancer cells. BMC Cell Biol (2017) 1.38
DNA damage and autophagy. Mutat Res (2011) 1.34
Autophagy and cartilage homeostasis mechanisms in joint health, aging and OA. Nat Rev Rheumatol (2011) 1.34
Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res (2008) 1.34
Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity. J Virol (2011) 1.34
LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol (2010) 1.32
Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy. J Clin Invest (2012) 1.29
Reactive nitrogen species regulate autophagy through ATM-AMPK-TSC2-mediated suppression of mTORC1. Proc Natl Acad Sci U S A (2013) 1.29
Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal (2009) 1.28
Inhibition of integrin-mediated crosstalk with epidermal growth factor receptor/Erk or Src signaling pathways in autophagic prostate epithelial cells induces caspase-independent death. Mol Biol Cell (2007) 1.28
Autophagy interplay with apoptosis and cell cycle regulation in the growth inhibiting effect of resveratrol in glioma cells. PLoS One (2011) 1.27
Autophagy activation and enhanced mitophagy characterize the Purkinje cells of pcd mice prior to neuronal death. Mol Brain (2009) 1.26
Regulation and function of autophagy during cell survival and cell death. Cold Spring Harb Perspect Biol (2012) 1.25
Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells. Cell Cycle (2012) 1.25
Genetic control of programmed cell death during animal development. Annu Rev Genet (2009) 1.24
Autophagy: molecular machinery, regulation, and implications for renal pathophysiology. Am J Physiol Renal Physiol (2009) 1.22
Neuronal apoptosis and autophagy cross talk in aging PS/APP mice, a model of Alzheimer's disease. Am J Pathol (2008) 1.22
Accelerated cell death in Podospora autophagy mutants. Eukaryot Cell (2005) 1.20
Mitochondria and reactive oxygen species. Hypertension (2009) 1.19
Adenoviruses induce autophagy to promote virus replication and oncolysis. Virology (2011) 1.18
Mitochondrial dysfunction and mitophagy activation in blood mononuclear cells of fibromyalgia patients: implications in the pathogenesis of the disease. Arthritis Res Ther (2010) 1.18
Reticulophagy and ribophagy: regulated degradation of protein production factories. Int J Cell Biol (2012) 1.16
Prosurvival Bcl-2 family members affect autophagy only indirectly, by inhibiting Bax and Bak. Proc Natl Acad Sci U S A (2014) 1.14
Down-regulation of inhibitor of apoptosis levels provides competence for steroid-triggered cell death. J Cell Biol (2007) 1.12
Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis. Neurosci Lett (2011) 1.12
Distinct death mechanisms in Drosophila development. Curr Opin Cell Biol (2010) 1.12
ANG II promotes autophagy in podocytes. Am J Physiol Cell Physiol (2010) 1.11
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy. Cell Res (2012) 1.08
Autophagy and neuronal cell death in neurological disorders. Cold Spring Harb Perspect Biol (2012) 1.08
Autophagy functions in programmed cell death. Autophagy (2008) 1.07
Roles of autophagy in cetuximab-mediated cancer therapy against EGFR. Autophagy (2010) 1.07
Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta (2010) 1.07
A functionalized single-walled carbon nanotube-induced autophagic cell death in human lung cells through Akt-TSC2-mTOR signaling. Cell Death Dis (2011) 1.07
Abnormal autophagy, ubiquitination, inflammation and apoptosis are dependent upon lysosomal storage and are useful biomarkers of mucopolysaccharidosis VI. Pathogenetics (2009) 1.06
Autophagy in Drosophila melanogaster. Biochim Biophys Acta (2009) 1.06
Role of autophagy in heart failure associated with aging. Heart Fail Rev (2010) 1.06
FOXO3 induces FOXO1-dependent autophagy by activating the AKT1 signaling pathway. Autophagy (2012) 1.05
Intertwined pathways of programmed cell death in immunity. Immunol Rev (2010) 1.04
The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis (2013) 1.03
Cilengitide induces autophagy-mediated cell death in glioma cells. Neuro Oncol (2011) 1.03
Oridonin up-regulates expression of P21 and induces autophagy and apoptosis in human prostate cancer cells. Int J Biol Sci (2012) 1.02
Rottlerin-induced autophagy leads to the apoptosis in breast cancer stem cells: molecular mechanisms. Mol Cancer (2013) 1.01
Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila. Proc Natl Acad Sci U S A (2009) 1.00
Regulation of Innate Immune Responses by Bovine Herpesvirus 1 and Infected Cell Protein 0 (bICP0). Viruses (2009) 0.99
Does the calcein-AM method assay the total cellular 'labile iron pool' or only a fraction of it? Biochem J (2007) 0.99
Membrane trafficking in neuronal maintenance and degeneration. Cell Mol Life Sci (2012) 0.99
Deficiency of the transcriptional regulator p8 results in increased autophagy and apoptosis, and causes impaired heart function. Mol Biol Cell (2010) 0.99
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease. Curr Alzheimer Res (2015) 0.98
XBP-1u suppresses autophagy by promoting the degradation of FoxO1 in cancer cells. Cell Res (2013) 0.98
Chloroquine promotes apoptosis in melanoma cells by inhibiting BH3 domain-mediated PUMA degradation. J Invest Dermatol (2013) 0.97
Regulatory coordination between two major intracellular homeostatic systems: heat shock response and autophagy. J Biol Chem (2013) 0.96
Ophiopogonin B-induced autophagy in non-small cell lung cancer cells via inhibition of the PI3K/Akt signaling pathway. Oncol Rep (2012) 0.96
Enhanced autophagy from chronic toxicity of iron and mutant A53T α-synuclein: implications for neuronal cell death in Parkinson disease. J Biol Chem (2011) 0.96
YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Br J Pharmacol (2014) 0.95
Downregulation of VRK1 by p53 in response to DNA damage is mediated by the autophagic pathway. PLoS One (2011) 0.95
Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell Cycle (2013) 0.95
High glucose induces autophagy in podocytes. Exp Cell Res (2013) 0.95
The contribution of autophagy to lymphocyte survival and homeostasis. Immunol Rev (2012) 0.95