Published in Int J Mol Med on July 01, 2005
Emodin suppresses lipopolysaccharide-induced pro-inflammatory responses and NF-κB activation by disrupting lipid rafts in CD14-negative endothelial cells. Br J Pharmacol (2010) 1.08
Topical anti-inflammatory activity of Polygonum cuspidatum extract in the TPA model of mouse ear inflammation. J Inflamm (Lond) (2008) 1.07
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling. BMC Genomics (2010) 0.91
A Review of the Pharmacological Effects of the Dried Root of Polygonum cuspidatum (Hu Zhang) and Its Constituents. Evid Based Complement Alternat Med (2013) 0.89
Emodin enhances alveolar epithelial barrier function in rats with experimental acute pancreatitis. World J Gastroenterol (2010) 0.84
Anti-inflammatory activity of a novel family of aryl ureas compounds in an endotoxin-induced airway epithelial cell injury model. PLoS One (2012) 0.83
Emodin Inhibits Homocysteine-Induced C-Reactive Protein Generation in Vascular Smooth Muscle Cells by Regulating PPARγ Expression and ROS-ERK1/2/p38 Signal Pathway. PLoS One (2015) 0.83
Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. Exp Biol Med (Maywood) (2014) 0.83
Therapeutic effect of emodin on collagen-induced arthritis in mice. Inflammation (2013) 0.82
Effect of reactive oxygen species generation in rabbit corneal epithelial cells on inflammatory and apoptotic signaling pathways in the presence of high osmotic pressure. PLoS One (2013) 0.81
The anthraquinone derivative Emodin ameliorates neurobehavioral deficits of a rodent model for schizophrenia. J Neural Transm (Vienna) (2008) 0.80
Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB. J Cancer (2016) 0.78
Emodin elicits cytotoxicity in human lung adenocarcinoma A549 cells through inducing apoptosis. Inflammopharmacology (2013) 0.78
Emodin reverses gemcitabine resistance in pancreatic cancer cells via the mitochondrial apoptosis pathway in vitro. Int J Oncol (2011) 0.78
Protective effects of emodin combined with danshensu on experimental severe acute pancreatitis. Inflamm Res (2009) 0.77
Emodin potentiates the antiproliferative effect of interferon α/β by activation of JAK/STAT pathway signaling through inhibition of the 26S proteasome. Oncotarget (2016) 0.77
Enhancement of ICAM-1 via the JAK2/STAT3 signaling pathway in a rat model of severe acute pancreatitis-associated lung injury. Exp Ther Med (2016) 0.75
INHIBITORY EFFECT OF EMODIN ON RAW 264.7 ACTIVATED WITH DOUBLE STRANDED RNA ANALOGUE POLY I:C. Afr J Tradit Complement Altern Med (2017) 0.75
Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science (2009) 21.24
Regulation of cellular metabolism by protein lysine acetylation. Science (2010) 10.55
Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes. Genes Dev (2008) 7.09
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
The complete genome sequence of the Arabidopsis and tomato pathogen Pseudomonas syringae pv. tomato DC3000. Proc Natl Acad Sci U S A (2003) 5.62
Functional profiling of a human cytomegalovirus genome. Proc Natl Acad Sci U S A (2003) 5.21
Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation. Cancer Cell (2009) 4.47
Accurate whole-genome sequencing and haplotyping from 10 to 20 human cells. Nature (2012) 3.74
Interaction of the Cas6 riboendonuclease with CRISPR RNAs: recognition and cleavage. Structure (2011) 3.58
Single-layer MoS2 phototransistors. ACS Nano (2011) 3.43
A universal method to produce low-work function electrodes for organic electronics. Science (2012) 3.33
The PDGF family: four gene products form five dimeric isoforms. Cytokine Growth Factor Rev (2004) 3.29
The TIGR rice genome annotation resource: annotating the rice genome and creating resources for plant biologists. Nucleic Acids Res (2003) 3.12
Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma. N Engl J Med (2015) 3.00
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care (2012) 2.84
Mechanism of activity-dependent downregulation of the neuron-specific K-Cl cotransporter KCC2. J Neurosci (2004) 2.76
Cutaneous dirt-adherent disease with single apparent transverse leukonychia on the fingernails. Arch Dermatol (2009) 2.65
Upregulation of Nox4 by hypertrophic stimuli promotes apoptosis and mitochondrial dysfunction in cardiac myocytes. Circ Res (2010) 2.65
Macroporous nanowire nanoelectronic scaffolds for synthetic tissues. Nat Mater (2012) 2.57
Modeling desertification change in Minqin County, China. Environ Monit Assess (2005) 2.56
Cyclic AMP promotes growth and secretion in human polycystic kidney epithelial cells. Kidney Int (2004) 2.55
Structure and function of archaeal box C/D sRNP core proteins. Nat Struct Biol (2003) 2.55
A redox-dependent pathway for regulating class II HDACs and cardiac hypertrophy. Cell (2008) 2.47
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes. Nat Immunol (2002) 2.46
Pharmacological inhibition of AMP-activated protein kinase provides neuroprotection in stroke. J Biol Chem (2005) 2.44
Gene RB cloned from Solanum bulbocastanum confers broad spectrum resistance to potato late blight. Proc Natl Acad Sci U S A (2003) 2.43
Reference values for continuous glucose monitoring in Chinese subjects. Diabetes Care (2009) 2.41
BDNF-induced TrkB activation down-regulates the K+-Cl- cotransporter KCC2 and impairs neuronal Cl- extrusion. J Cell Biol (2002) 2.40
Efficient formulation of the stochastic simulation algorithm for chemically reacting systems. J Chem Phys (2004) 2.36
A new class of Solvent-in-Salt electrolyte for high-energy rechargeable metallic lithium batteries. Nat Commun (2013) 2.33
The extracellular matrix protein mindin is a pattern-recognition molecule for microbial pathogens. Nat Immunol (2003) 2.26
MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells. Arterioscler Thromb Vasc Biol (2010) 2.23
Slc26a11, a chloride transporter, localizes with the vacuolar H(+)-ATPase of A-intercalated cells of the kidney. Kidney Int (2011) 2.21
A protocol for isolation and culture of mesenchymal stem cells from mouse compact bone. Nat Protoc (2010) 2.20
Disruption of tumor neovasculature by microbubble enhanced ultrasound: a potential new physical therapy of anti-angiogenesis. Ultrasound Med Biol (2011) 2.18
The quality of reporting of randomized controlled trials of traditional Chinese medicine: a survey of 13 randomly selected journals from mainland China. Clin Ther (2007) 2.08
Molecular basis of box C/D RNA-protein interactions; cocrystal structure of archaeal L7Ae and a box C/D RNA. Structure (2004) 2.08
Visual word processing and experiential origins of functional selectivity in human extrastriate cortex. Proc Natl Acad Sci U S A (2007) 2.06
Oncogenic ERBB3 mutations in human cancers. Cancer Cell (2013) 2.06
Woltjer-Taylor state without Taylor's conjecture: plasma relaxation at all wavelengths. Phys Rev Lett (2012) 1.98
Structure of the Cmr2 subunit of the CRISPR-Cas RNA silencing complex. Structure (2012) 1.97
Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat Med (2013) 1.93
Molecular and cytological analyses of large tracks of centromeric DNA reveal the structure and evolutionary dynamics of maize centromeres. Genetics (2003) 1.92
Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J Clin Invest (2005) 1.90
Distinctive patterns of gene expression in premalignant gastric mucosa and gastric cancer. Cancer Res (2003) 1.88
Health risks of limited-contact water recreation. Environ Health Perspect (2011) 1.86
Bis(2-dimethylamino-1,10-phenanthroline-κN,N')bis-(thio-cyanato-κN)nickel(II) methanol disolvate. Acta Crystallogr Sect E Struct Rep Online (2008) 1.86
Chromosome 7p11.2 (EGFR) variation influences glioma risk. Hum Mol Genet (2011) 1.83
Serum tumor markers for detection of hepatocellular carcinoma. World J Gastroenterol (2006) 1.82
DNA interstrand crosslink repair in mammalian cells: step by step. Crit Rev Biochem Mol Biol (2010) 1.82
Structure of an RNA silencing complex of the CRISPR-Cas immune system. Mol Cell (2013) 1.82
Using peripheral blood mononuclear cells to determine a gene expression profile of acute ischemic stroke: a pilot investigation. Circulation (2005) 1.79
Tissue plasminogen activator is a potent activator of PDGF-CC. EMBO J (2004) 1.79
Spatial variability of shallow groundwater level, electrical conductivity and nitrate concentration, and risk assessment of nitrate contamination in North China Plain. Environ Int (2005) 1.78
Crystal structure of a Cbf5-Nop10-Gar1 complex and implications in RNA-guided pseudouridylation and dyskeratosis congenita. Mol Cell (2006) 1.77
Central role of IL-6 receptor signal-transducing chain gp130 in activation of L-selectin adhesion by fever-range thermal stress. Immunity (2004) 1.76
ZIP8, member of the solute-carrier-39 (SLC39) metal-transporter family: characterization of transporter properties. Mol Pharmacol (2006) 1.76
Longitudinal association of vitamin B-6, folate, and vitamin B-12 with depressive symptoms among older adults over time. Am J Clin Nutr (2010) 1.74
Draft genome of the kiwifruit Actinidia chinensis. Nat Commun (2013) 1.72
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate. Cancer Res (2004) 1.72
RNA recognition and cleavage by a splicing endonuclease. Science (2006) 1.70
Fabrication of single- and multilayer MoS2 film-based field-effect transistors for sensing NO at room temperature. Small (2011) 1.69
Slc39a14 gene encodes ZIP14, a metal/bicarbonate symporter: similarities to the ZIP8 transporter. Mol Pharmacol (2008) 1.69
The complex exogenous RNA spectra in human plasma: an interface with human gut biota? PLoS One (2012) 1.68
Diffusion tensor imaging of Parkinson's disease, atypical parkinsonism, and essential tremor. Mov Disord (2013) 1.68
Ultrasound-guided establishment of hip arthroscopy portals. Arthroscopy (2009) 1.67
Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population. Am J Clin Nutr (2010) 1.67
Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res (2009) 1.65
Prevalence and evolution of drug resistance HIV-1 variants in Henan, China. Cell Res (2005) 1.64
Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J Clin Invest (2002) 1.64
Porous Li4 Ti5 O12 coated with N-doped carbon from ionic liquids for Li-ion batteries. Adv Mater (2011) 1.63
Kaposi's sarcoma-associated herpesvirus lytic origin (ori-Lyt)-dependent DNA replication: identification of the ori-Lyt and association of K8 bZip protein with the origin. J Virol (2003) 1.63
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation. Hum Mol Genet (2005) 1.63
Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteome. Proc Natl Acad Sci U S A (2006) 1.63
Role of Toll-like receptor 2 in the immune response against hepadnaviral infection. J Hepatol (2012) 1.62
Nanog regulates self-renewal of cancer stem cells through the insulin-like growth factor pathway in human hepatocellular carcinoma. Hepatology (2012) 1.61
The TWEAK-Fn14 system is a critical regulator of denervation-induced skeletal muscle atrophy in mice. J Cell Biol (2010) 1.61
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplant (2009) 1.60
Geoclimatic influences on invasive aspergillosis after hematopoietic stem cell transplantation. Clin Infect Dis (2010) 1.58
A new linearized Crank-Nicolson mixed element scheme for the extended Fisher-Kolmogorov equation. ScientificWorldJournal (2013) 1.58
Transcription factor AtMYB103 is required for anther development by regulating tapetum development, callose dissolution and exine formation in Arabidopsis. Plant J (2007) 1.58
SNP-SNP interactions in breast cancer susceptibility. BMC Cancer (2006) 1.56
Revascularization of ischemic tissues by PDGF-CC via effects on endothelial cells and their progenitors. J Clin Invest (2005) 1.55
Global analysis of the transcriptional response of whitefly to tomato yellow leaf curl China virus reveals the relationship of coevolved adaptations. J Virol (2011) 1.54
The long-term efficacy of medical male circumcision against HIV acquisition. AIDS (2013) 1.53
Heritability of the specific cognitive ability of face perception. Curr Biol (2010) 1.52
Diversity in conserved genes in tomato. BMC Genomics (2007) 1.52
Combined effects of docetaxel and angiostatin gene therapy in prostate tumor model. Mol Ther (2003) 1.49
Sequence, annotation, and analysis of synteny between rice chromosome 3 and diverged grass species. Genome Res (2005) 1.48
Kaposi's sarcoma-associated herpesvirus ori-Lyt-dependent DNA replication: cis-acting requirements for replication and ori-Lyt-associated RNA transcription. J Virol (2004) 1.48
An HIV-1 resistance polymorphism in TRIM5α gene among Chinese intravenous drug users. J Acquir Immune Defic Syndr (2011) 1.47
Amyloid beta₁₋₄₂ (Aβ₄₂) up-regulates the expression of sortilin via the p75(NTR)/RhoA signaling pathway. J Neurochem (2013) 1.46
Probing lipid rafts with proximity imaging: actions of proatherogenic stimuli. Am J Physiol Heart Circ Physiol (2005) 1.46
Cardiovascular actions and therapeutic potential of tanshinone IIA. Atherosclerosis (2011) 1.45
Mediation of multiple pathways regulating cell proliferation, migration, and apoptosis in the human malignant glioma cell line U87MG via unphosphorylated STAT1: laboratory investigation. J Neurosurg (2013) 1.44
Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs. PLoS One (2008) 1.44
VANGL2 mutations in human cranial neural-tube defects. N Engl J Med (2010) 1.44
A pilot study of intense pulsed light in the treatment of Riehl's melanosis. Dermatol Surg (2010) 1.42