Published in Annu Rev Biochem on January 01, 2005
The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev (2006) 6.80
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol (2007) 6.20
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51
Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol (2005) 2.98
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol (2009) 2.82
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A (2009) 2.68
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry (2006) 2.01
Identification of intracellular carriers for the endocannabinoid anandamide. Proc Natl Acad Sci U S A (2009) 1.77
Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol (2008) 1.75
Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem (2006) 1.71
Chemical probes of endocannabinoid metabolism. Pharmacol Rev (2013) 1.68
Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. Proc Natl Acad Sci U S A (2009) 1.64
Is lipid signaling through cannabinoid 2 receptors part of a protective system? Prog Lipid Res (2011) 1.60
Modulating the endocannabinoid system in human health and disease--successes and failures. FEBS J (2013) 1.59
Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways. Chem Rev (2011) 1.56
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J Pharmacol Exp Ther (2011) 1.52
A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci (2011) 1.50
Enhancement of endocannabinoid signaling with JZL184, an inhibitor of the 2-arachidonoylglycerol hydrolyzing enzyme monoacylglycerol lipase, produces anxiolytic effects under conditions of high environmental aversiveness in rats. Pharmacol Res (2011) 1.48
Unconventional serine proteases: variations on the catalytic Ser/His/Asp triad configuration. Protein Sci (2008) 1.44
Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A (2008) 1.41
Endocannabinoid signaling in microglial cells. Neuropharmacology (2008) 1.36
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol (2007) 1.34
Drug design for neuropathic pain regulation from traditional Chinese medicine. Sci Rep (2013) 1.30
The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. BMC Biochem (2009) 1.28
Endocannabinoids in liver disease. Hepatology (2011) 1.27
Strategies for discovering and derisking covalent, irreversible enzyme inhibitors. Future Med Chem (2010) 1.27
Lipidomic analysis of endocannabinoid metabolism in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 1.23
Endocannabinoids and the control of energy homeostasis. J Biol Chem (2008) 1.22
Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders. Expert Opin Drug Discov (2009) 1.22
Binding and inactivation mechanism of a humanized fatty acid amide hydrolase by alpha-ketoheterocycle inhibitors revealed from cocrystal structures. J Am Chem Soc (2009) 1.18
Lipoxygenase-mediated oxidation of polyunsaturated N-acylethanolamines in Arabidopsis. J Biol Chem (2011) 1.18
Identification of N-acylphosphatidylserine molecules in eukaryotic cells. Biochemistry (2007) 1.17
N-arachidonyl maleimide potentiates the pharmacological and biochemical effects of the endocannabinoid 2-arachidonylglycerol through inhibition of monoacylglycerol lipase. J Pharmacol Exp Ther (2008) 1.17
The discovery and development of inhibitors of fatty acid amide hydrolase (FAAH). Bioorg Med Chem Lett (2011) 1.16
Ethanolamide oxylipins of linolenic acid can negatively regulate Arabidopsis seedling development. Plant Cell (2013) 1.12
Manipulation of Arabidopsis fatty acid amide hydrolase expression modifies plant growth and sensitivity to N-acylethanolamines. Proc Natl Acad Sci U S A (2006) 1.10
Crystal structure of fatty acid amide hydrolase bound to the carbamate inhibitor URB597: discovery of a deacylating water molecule and insight into enzyme inactivation. J Mol Biol (2010) 1.09
Endocannabinoid influence in drug reinforcement, dependence and addiction-related behaviors. Pharmacol Ther (2011) 1.08
Endocannabinoids in the retina: from marijuana to neuroprotection. Prog Retin Eye Res (2008) 1.08
Proinflammatory stimuli control N-acylphosphatidylethanolamine-specific phospholipase D expression in macrophages. Mol Pharmacol (2011) 1.07
Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacol Res (2012) 1.06
Hydrazidase, a novel amidase signature enzyme that hydrolyzes acylhydrazides. J Bacteriol (2015) 1.06
N-Acylethanolamine metabolism interacts with abscisic acid signaling in Arabidopsis thaliana seedlings. Plant Cell (2007) 1.05
The fatty acid amide hydrolase 385 A/A (P129T) variant: haplotype analysis of an ancient missense mutation and validation of risk for drug addiction. Hum Genet (2006) 1.05
Endocannabinoid tone versus constitutive activity of cannabinoid receptors. Br J Pharmacol (2011) 1.05
Formation of B and T cell subsets require the cannabinoid receptor CB2. Immunogenetics (2006) 1.05
Oxidation of the endogenous cannabinoid arachidonoyl ethanolamide by the cytochrome P450 monooxygenases: physiological and pharmacological implications. Pharmacol Rev (2010) 1.05
Fatty acid amide hydrolase shapes NKT cell responses by influencing the serum transport of lipid antigen in mice. J Clin Invest (2010) 1.04
Critical enzymes involved in endocannabinoid metabolism. Protein Pept Lett (2007) 1.04
Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH). Bioorg Med Chem Lett (2009) 1.03
The role of endocannabinoids system in fatty liver disease and therapeutic potentials. Saudi J Gastroenterol (2013) 1.02
Lipid profiling reveals tissue-specific differences for ethanolamide lipids in mice lacking fatty acid amide hydrolase. Lipids (2010) 1.00
11CO2 fixation: a renaissance in PET radiochemistry. Chem Commun (Camb) (2013) 1.00
The endocannabinoid system: an overview. Front Behav Neurosci (2012) 0.99
Intrathecal cannabilactone CB(2)R agonist, AM1710, controls pathological pain and restores basal cytokine levels. Pain (2012) 0.99
Architecture of cannabinoid signaling in mouse retina. J Comp Neurol (2010) 0.99
Lipid droplets are novel sites of N-acylethanolamine inactivation by fatty acid amide hydrolase-2. J Biol Chem (2009) 0.98
Synthesis and quantitative structure-activity relationship of fatty acid amide hydrolase inhibitors: modulation at the N-portion of biphenyl-3-yl alkylcarbamates. J Med Chem (2008) 0.97
Synthesis and structure-activity relationships of N-(2-oxo-3-oxetanyl)amides as N-acylethanolamine-hydrolyzing acid amidase inhibitors. J Med Chem (2010) 0.97
Primary fatty acid amide metabolism: conversion of fatty acids and an ethanolamine in N18TG2 and SCP cells. J Lipid Res (2011) 0.95
Endocannabinoid-mediated synaptic plasticity and addiction-related behavior. Neuropharmacology (2011) 0.94
Type-1 cannabinoid receptors colocalize with caveolin-1 in neuronal cells. Neuropharmacology (2007) 0.94
Radiosynthesis and evaluation of [¹¹C-carbonyl]-labeled carbamates as fatty acid amide hydrolase radiotracers for positron emission tomography. J Med Chem (2012) 0.93
Lack of effect of chronic pre-treatment with the FAAH inhibitor URB597 on inflammatory pain behaviour: evidence for plastic changes in the endocannabinoid system. Br J Pharmacol (2012) 0.93
Aspects of endocannabinoid signaling in periimplantation biology. Mol Cell Endocrinol (2008) 0.93
X-ray crystallographic analysis of alpha-ketoheterocycle inhibitors bound to a humanized variant of fatty acid amide hydrolase. J Med Chem (2010) 0.93
Structure-property relationships of a class of carbamate-based fatty acid amide hydrolase (FAAH) inhibitors: chemical and biological stability. ChemMedChem (2009) 0.93
More aroused, less fatigued: fatty acid amide hydrolase gene polymorphisms influence acute response to amphetamine. Neuropsychopharmacology (2009) 0.92
Measuring endocannabinoid hydrolysis: refining our tools and understanding. AAPS J (2009) 0.92
Antiaversive effects of cannabinoids: is the periaqueductal gray involved? Neural Plast (2008) 0.91
Development of highly sensitive fluorescent assays for fatty acid amide hydrolase. Anal Biochem (2006) 0.91
The synthesis and in vivo evaluation of [18F]PF-9811: a novel PET ligand for imaging brain fatty acid amide hydrolase (FAAH). Nucl Med Biol (2012) 0.91
Mutations in Arabidopsis fatty acid amide hydrolase reveal that catalytic activity influences growth but not sensitivity to abscisic acid or pathogens. J Biol Chem (2009) 0.90
Discovery and molecular basis of potent noncovalent inhibitors of fatty acid amide hydrolase (FAAH). Proc Natl Acad Sci U S A (2011) 0.89
Regional distribution and effects of postmortal delay on endocannabinoid content of the human brain. Neuroscience (2008) 0.88
Modulation of the endocannabinoid system: vulnerability factor and new treatment target for stimulant addiction. Front Psychiatry (2013) 0.88
Temporal changes in mouse brain fatty acid amide hydrolase activity. Neuroscience (2009) 0.87
Genetic loss of Faah compromises male fertility in mice. Biol Reprod (2008) 0.87
Reversible competitive α-ketoheterocycle inhibitors of fatty acid amide hydrolase containing additional conformational constraints in the acyl side chain: orally active, long-acting analgesics. J Med Chem (2011) 0.87
Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase. Proc Natl Acad Sci U S A (2013) 0.87
Prostamide F(2) α receptor antagonism combined with inhibition of FAAH may block the pro-inflammatory mediators formed following selective FAAH inhibition. Br J Pharmacol (2014) 0.86
Generation of N-acylphosphatidylethanolamine by members of the phospholipase A/acyltransferase (PLA/AT) family. J Biol Chem (2012) 0.86
High levels of γ-glutamyl hydrolase (GGH) are associated with poor prognosis and unfavorable clinical outcomes in invasive breast cancer. BMC Cancer (2013) 0.86
Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.86
Association of polymorphisms of the cannabinoid receptor (CNR1) and fatty acid amide hydrolase (FAAH) genes with heroin addiction: impact of long repeats of CNR1. Pharmacogenomics J (2009) 0.86
Endocannabinoids stimulate human melanogenesis via type-1 cannabinoid receptor. J Biol Chem (2012) 0.85
Anandamide and NADA bi-directionally modulate presynaptic Ca2+ levels and transmitter release in the hippocampus. Br J Pharmacol (2007) 0.85
N-acylethanolamine (NAE) inhibits growth in Arabidopsis thaliana seedlings via ABI3-dependent and -independent pathways. Plant Signal Behav (2011) 0.85
Differences in the endocannabinoid system of sperm from fertile and infertile men. PLoS One (2012) 0.85
Evaluation of interactions between cannabinoid compounds and diazepam in electroshock-induced seizure model in mice. J Neural Transm (Vienna) (2008) 0.84
Fluoride-mediated capture of a noncovalent bound state of a reversible covalent enzyme inhibitor: X-ray crystallographic analysis of an exceptionally potent α-ketoheterocycle inhibitor of fatty acid amide hydrolase. J Am Chem Soc (2011) 0.84
Rational design of fatty acid amide hydrolase inhibitors that act by covalently bonding to two active site residues. J Am Chem Soc (2013) 0.84
Genetic factors modulating the response to stimulant drugs in humans. Curr Top Behav Neurosci (2012) 0.84
α-Ketoheterocycle-based Inhibitors of Fatty Acid Amide Hydrolase (FAAH). ACS Chem Neurosci (2011) 0.83
Overexpression of Fatty Acid Amide Hydrolase Induces Early Flowering in Arabidopsis thaliana. Front Plant Sci (2012) 0.83
The endocannabinoid system and spermatogenesis. Front Endocrinol (Lausanne) (2013) 0.83
Energetic metabolism and human sperm motility: impact of CB₁ receptor activation. Endocrinology (2010) 0.83
Modulation of the endocannabinoid system in viable and non-viable first trimester pregnancies by pregnancy-related hormones. Reprod Biol Endocrinol (2011) 0.83
Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase. ACS Med Chem Lett (2013) 0.83
Organophosphate-sensitive lipases modulate brain lysophospholipids, ether lipids and endocannabinoids. Chem Biol Interact (2008) 0.83
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature (2007) 7.12
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol (2007) 6.20
Profiling enzyme activities in vivo using click chemistry methods. Chem Biol (2004) 5.97
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell (2010) 5.47
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. J Am Chem Soc (2003) 4.92
Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature (2010) 4.04
Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell (2008) 3.64
Identification of protein pheromones that promote aggressive behaviour. Nature (2007) 3.55
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (2011) 3.48
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nat Biotechnol (2003) 3.17
Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods (2009) 3.13
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci (2010) 3.11
Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry (2004) 3.10
A streamlined platform for high-content functional proteomics of primary human specimens. Nat Methods (2005) 3.00
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther (2004) 2.99
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol (2006) 2.98
Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol (2005) 2.98
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain (2004) 2.94
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nat Neurosci (2008) 2.87
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol (2009) 2.82
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A (2009) 2.68
Mechanism-based profiling of enzyme families. Chem Rev (2006) 2.66
The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest (2004) 2.52
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A (2002) 2.52
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (2002) 2.50
Characterization of monoacylglycerol lipase inhibition reveals differences in central and peripheral endocannabinoid metabolism. Chem Biol (2009) 2.48
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37
Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nat Chem Biol (2006) 2.25
Disparate proteome reactivity profiles of carbon electrophiles. Nat Chem Biol (2008) 2.25
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype. Nat Biotechnol (2002) 2.17
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A (2010) 2.16
A tandem orthogonal proteolysis strategy for high-content chemical proteomics. J Am Chem Soc (2005) 2.14
A functional proteomic strategy to discover inhibitors for uncharacterized hydrolases. J Am Chem Soc (2007) 2.13
Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. J Biol Chem (2010) 2.10
Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. J Biol Chem (2006) 2.09
The expanding role of mass spectrometry in metabolite profiling and characterization. Chembiochem (2005) 2.04
Activity-based probes for proteomic profiling of histone deacetylase complexes. Proc Natl Acad Sci U S A (2007) 2.03
Pharmacological activity of fatty acid amides is regulated, but not mediated, by fatty acid amide hydrolase in vivo. J Pharmacol Exp Ther (2002) 2.01
Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry (2006) 2.01
Global profiling of dynamic protein palmitoylation. Nat Methods (2011) 1.99
Activity-based probes for the proteomic profiling of metalloproteases. Proc Natl Acad Sci U S A (2004) 1.98
A potent and selective inhibitor of KIAA1363/AADACL1 that impairs prostate cancer pathogenesis. Chem Biol (2011) 1.97
Carcinoma and stromal enzyme activity profiles associated with breast tumor growth in vivo. Proc Natl Acad Sci U S A (2004) 1.96
Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry (2007) 1.90
The metabolic serine hydrolases and their functions in mammalian physiology and disease. Chem Rev (2011) 1.89
Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem (2005) 1.88
Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes. Nat Protoc (2007) 1.87
Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol (2005) 1.86
Fatty acid amide hydrolase deficiency limits early pregnancy events. J Clin Invest (2006) 1.86
Activity-based protein profiling for biochemical pathway discovery in cancer. Nat Rev Cancer (2010) 1.84
Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes. Nat Biotechnol (2009) 1.84
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol (2012) 1.79
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol (2005) 1.76
Activation of the endocannabinoid system by organophosphorus nerve agents. Nat Chem Biol (2008) 1.75
Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol (2011) 1.74
Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling. J Pharmacol Exp Ther (2009) 1.74
A missense mutation in human fatty acid amide hydrolase associated with problem drug use. Proc Natl Acad Sci U S A (2002) 1.74
Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine. J Biol Chem (2006) 1.71
Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. J Med Chem (2005) 1.71
Activity-based protein profiling for the functional annotation of enzymes. Nat Methods (2007) 1.70
Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. J Biol Chem (2003) 1.70
Circuitry for associative plasticity in the amygdala involves endocannabinoid signaling. J Neurosci (2004) 1.70
Chemical probes of endocannabinoid metabolism. Pharmacol Rev (2013) 1.68
Reduced cellular expression and activity of the P129T mutant of human fatty acid amide hydrolase: evidence for a link between defects in the endocannabinoid system and problem drug use. Hum Mol Genet (2004) 1.68
Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors. Nat Chem Biol (2011) 1.66
A second fatty acid amide hydrolase with variable distribution among placental mammals. J Biol Chem (2006) 1.63
Maternal PPAR gamma protects nursing neonates by suppressing the production of inflammatory milk. Genes Dev (2007) 1.62
Chemical strategies for activity-based proteomics. Chembiochem (2004) 1.62
Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. J Biol Chem (2008) 1.60
Proteome-wide mapping of cholesterol-interacting proteins in mammalian cells. Nat Methods (2013) 1.59
Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. J Am Chem Soc (2007) 1.56
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling. Bioorg Med Chem Lett (2008) 1.54
Evaluation of fatty acid amide hydrolase inhibition in murine models of emotionality. Psychopharmacology (Berl) (2007) 1.53
The postmortal accumulation of brain N-arachidonylethanolamine (anandamide) is dependent upon fatty acid amide hydrolase activity. J Lipid Res (2004) 1.52
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors. Proc Natl Acad Sci U S A (2011) 1.52
Mechanistic and pharmacological characterization of PF-04457845: a highly potent and selective fatty acid amide hydrolase inhibitor that reduces inflammatory and noninflammatory pain. J Pharmacol Exp Ther (2011) 1.52
DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. Nat Chem Biol (2012) 1.51
A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry (2006) 1.51
Protein-reactive natural products. Angew Chem Int Ed Engl (2005) 1.47
NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol (2013) 1.46
Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. Mol Pharmacol (2009) 1.46
Chemical proteomics with sulfonyl fluoride probes reveals selective labeling of functional tyrosines in glutathione transferases. Chem Biol (2013) 1.44
Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem (2007) 1.44
Increased seizure susceptibility and proconvulsant activity of anandamide in mice lacking fatty acid amide hydrolase. J Neurosci (2003) 1.43
The development and application of methods for activity-based protein profiling. Curr Opin Chem Biol (2004) 1.42
Determining target engagement in living systems. Nat Chem Biol (2013) 1.41
Structure-guided inhibitor design for human FAAH by interspecies active site conversion. Proc Natl Acad Sci U S A (2008) 1.41
The pharmacological landscape and therapeutic potential of serine hydrolases. Nat Rev Drug Discov (2012) 1.39
The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. J Am Chem Soc (2006) 1.36
Synergy between enzyme inhibitors of fatty acid amide hydrolase and cyclooxygenase in visceral nociception. J Pharmacol Exp Ther (2008) 1.35
Assignment of protein function in the postgenomic era. Nat Chem Biol (2005) 1.34
Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase. Am J Physiol Heart Circ Physiol (2007) 1.34
Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay. Pharmacol Biochem Behav (2010) 1.33
Alterations of endocannabinoid signaling, synaptic plasticity, learning, and memory in monoacylglycerol lipase knock-out mice. J Neurosci (2011) 1.32
Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task. Neuropsychopharmacology (2006) 1.32
Functional lysine modification by an intrinsically reactive primary glycolytic metabolite. Science (2013) 1.31
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells. Mol Pharmacol (2008) 1.31
Inhibitors of endocannabinoid-metabolizing enzymes reduce precipitated withdrawal responses in THC-dependent mice. AAPS J (2009) 1.31