Published in Nature on January 21, 2007
Cellular and molecular mechanisms of pain. Cell (2009) 9.36
TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A (2007) 5.27
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2007) 4.10
Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature (2010) 4.04
TRPA1 acts as a cold sensor in vitro and in vivo. Proc Natl Acad Sci U S A (2009) 3.46
A gain-of-function mutation in TRPA1 causes familial episodic pain syndrome. Neuron (2010) 3.31
Transient receptor potential A1 is a sensory receptor for multiple products of oxidative stress. J Neurosci (2008) 3.30
The Concise Guide to PHARMACOLOGY 2013/14: ion channels. Br J Pharmacol (2013) 3.03
A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol Pain (2007) 2.91
Transient receptor potential channels: targeting pain at the source. Nat Rev Drug Discov (2009) 2.88
International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel family. Pharmacol Rev (2010) 2.66
Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J Clin Invest (2007) 2.66
TRPA1 is a major oxidant sensor in murine airway sensory neurons. J Clin Invest (2008) 2.55
Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) (2008) 2.51
Structure of the TRPA1 ion channel suggests regulatory mechanisms. Nature (2015) 2.47
Molecular basis of infrared detection by snakes. Nature (2010) 2.40
Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception. Nature (2010) 2.35
HC-030031, a TRPA1 selective antagonist, attenuates inflammatory- and neuropathy-induced mechanical hypersensitivity. Mol Pain (2008) 2.32
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
Transient receptor potential TRPA1 channel desensitization in sensory neurons is agonist dependent and regulated by TRPV1-directed internalization. J Physiol (2007) 2.26
A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel. Cell (2013) 2.25
From chills to chilis: mechanisms for thermosensation and chemesthesis via thermoTRPs. Curr Opin Neurobiol (2007) 2.08
TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo. Pain (2010) 2.06
The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions. J Biol Chem (2008) 2.03
Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery. Chem Rev (2013) 2.02
Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases. FASEB J (2008) 1.93
Nociceptive signals induce trafficking of TRPA1 to the plasma membrane. Neuron (2009) 1.93
Probing protein structure by amino acid-specific covalent labeling and mass spectrometry. Mass Spectrom Rev (2009) 1.86
Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction. J Biol Chem (2007) 1.78
General anesthetics activate a nociceptive ion channel to enhance pain and inflammation. Proc Natl Acad Sci U S A (2008) 1.78
Nociceptors: the sensors of the pain pathway. J Clin Invest (2010) 1.72
A single N-terminal cysteine in TRPV1 determines activation by pungent compounds from onion and garlic. Nat Neurosci (2008) 1.71
Zinc activates damage-sensing TRPA1 ion channels. Nat Chem Biol (2009) 1.71
A primer on ankyrin repeat function in TRP channels and beyond. Mol Biosyst (2008) 1.70
TRPA1 contributes to cold hypersensitivity. J Neurosci (2010) 1.68
Relative contributions of TRPA1 and TRPV1 channels in the activation of vagal bronchopulmonary C-fibres by the endogenous autacoid 4-oxononenal. J Physiol (2008) 1.66
Exploiting quorum sensing to confuse bacterial pathogens. Microbiol Mol Biol Rev (2013) 1.64
The transient receptor potential channel TRPA1: from gene to pathophysiology. Pflugers Arch (2012) 1.63
Contribution of TRPV1-TRPA1 interaction to the single channel properties of the TRPA1 channel. J Biol Chem (2010) 1.63
Transduction of redox signaling by electrophile-protein reactions. Sci Signal (2009) 1.62
Advances in Bioconjugation. Curr Org Chem (2010) 1.60
Homologous and heterologous desensitization of capsaicin and mustard oil responses utilize different cellular pathways in nociceptors. Pain (2007) 1.60
Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1. Proc Natl Acad Sci U S A (2008) 1.59
The role of transient receptor potential cation channels in Ca2+ signaling. Cold Spring Harb Perspect Biol (2010) 1.56
Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli. Proc Natl Acad Sci U S A (2011) 1.56
Thermosensory and nonthermosensory isoforms of Drosophila melanogaster TRPA1 reveal heat-sensor domains of a thermoTRP Channel. Cell Rep (2012) 1.56
TRPA1-mediated responses in trigeminal sensory neurons: interaction between TRPA1 and TRPV1. Eur J Neurosci (2009) 1.53
Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors. EMBO Mol Med (2011) 1.50
The TRPA1 channel in migraine mechanism and treatment. Br J Pharmacol (2014) 1.50
TRPA1 agonists evoke coughing in guinea pig and human volunteers. Am J Respir Crit Care Med (2009) 1.49
TRPA1 underlies a sensing mechanism for O2. Nat Chem Biol (2011) 1.47
Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci (2009) 1.44
Roles of transient receptor potential channels in pain. Brain Res Rev (2008) 1.44
The thermo-TRP ion channel family: properties and therapeutic implications. Br J Pharmacol (2012) 1.39
Protein targets of reactive metabolites of thiobenzamide in rat liver in vivo. Chem Res Toxicol (2008) 1.37
TRPV1 is activated by both acidic and basic pH. J Neurosci (2009) 1.37
TRPA1: A gatekeeper for inflammation. Annu Rev Physiol (2012) 1.36
Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists. Mol Pain (2007) 1.34
Ozone activates airway nerves via the selective stimulation of TRPA1 ion channels. J Physiol (2009) 1.34
Nitrooleic acid, an endogenous product of nitrative stress, activates nociceptive sensory nerves via the direct activation of TRPA1. Mol Pharmacol (2009) 1.33
Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. Proc Natl Acad Sci U S A (2009) 1.33
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain (2008) 1.33
Irritating channels: the case of TRPA1. J Physiol (2010) 1.32
Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc Natl Acad Sci U S A (2008) 1.31
Modulation of the transient receptor potential channel TRPA1 by phosphatidylinositol 4,5-biphosphate manipulators. Pflugers Arch (2008) 1.31
TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins. Nat Commun (2014) 1.30
TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice. PLoS One (2009) 1.30
Broccoli consumption interacts with GSTM1 to perturb oncogenic signalling pathways in the prostate. PLoS One (2008) 1.30
TRP channels entering the structural era. J Physiol (2008) 1.28
Intracellular alkalization causes pain sensation through activation of TRPA1 in mice. J Clin Invest (2008) 1.27
Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. Neuron (2014) 1.27
TRPV1: on the road to pain relief. Curr Mol Pharmacol (2008) 1.26
Oxidative challenges sensitize the capsaicin receptor by covalent cysteine modification. Proc Natl Acad Sci U S A (2009) 1.25
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacol Ther (2011) 1.24
A TRPA1-dependent mechanism for the pungent sensation of weak acids. J Gen Physiol (2011) 1.19
Sensory detection and responses to toxic gases: mechanisms, health effects, and countermeasures. Proc Am Thorac Soc (2010) 1.18
Clioquinol and pyrithione activate TRPA1 by increasing intracellular Zn2+. Proc Natl Acad Sci U S A (2009) 1.18
Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopy. J Biol Chem (2011) 1.17
Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium (2009) 1.16
H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO-TRPA1-CGRP signalling pathway. Nat Commun (2014) 1.16
Activation of TRPA1 channels by fenamate nonsteroidal anti-inflammatory drugs. Pflugers Arch (2009) 1.16
Endogenous production of H2S in the gastrointestinal tract: still in search of a physiologic function. Antioxid Redox Signal (2010) 1.15
Canonical transient receptor potential 6 (TRPC6), a redox-regulated cation channel. J Biol Chem (2010) 1.15
Transient receptor potential ankyrin 1 mediates toluene diisocyanate-evoked respiratory irritation. Am J Respir Cell Mol Biol (2008) 1.14
TRPA1 receptors mediate environmental irritant-induced meningeal vasodilatation. Pain (2010) 1.12
Agonist-induced changes in Ca(2+) permeation through the nociceptor cation channel TRPA1. Biophys J (2010) 1.12
Burning cold: involvement of TRPA1 in noxious cold sensation. J Gen Physiol (2009) 1.11
TRPA1 contributes to specific mechanically activated currents and sensory neuron mechanical hypersensitivity. J Physiol (2011) 1.11
Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol (2009) 1.09
Molecular and cellular limits to somatosensory specificity. Mol Pain (2008) 1.09
Function and regulation of TRP family channels in C. elegans. Pflugers Arch (2009) 1.09
Photochemical activation of TRPA1 channels in neurons and animals. Nat Chem Biol (2013) 1.09
Direct modification of the proinflammatory cytokine macrophage migration inhibitory factor by dietary isothiocyanates. J Biol Chem (2009) 1.08
Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain. Proc Natl Acad Sci U S A (2014) 1.07
UV light phototransduction activates transient receptor potential A1 ion channels in human melanocytes. Proc Natl Acad Sci U S A (2013) 1.06
Vagal afferent nerves with the properties of nociceptors. Auton Neurosci (2009) 1.06
Kinetics and mechanism of protein tyrosine phosphatase 1B inactivation by acrolein. Chem Res Toxicol (2007) 1.06
Properties and therapeutic potential of transient receptor potential channels with putative roles in adversity: focus on TRPC5, TRPM2 and TRPA1. Curr Drug Targets (2011) 1.06
Converting cold into pain. Exp Brain Res (2009) 1.06
Comprehensive RNA-Seq expression analysis of sensory ganglia with a focus on ion channels and GPCRs in Trigeminal ganglia. PLoS One (2013) 1.06
Large-scale analysis of the human and mouse transcriptomes. Proc Natl Acad Sci U S A (2002) 25.47
Coordinated transcription of key pathways in the mouse by the circadian clock. Cell (2002) 14.07
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell (2003) 10.94
A TRP channel that senses cold stimuli and menthol. Cell (2002) 8.66
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron (2004) 8.17
Adding new chemistries to the genetic code. Annu Rev Biochem (2010) 6.32
Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science (2010) 6.29
A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chem Biol (2007) 6.20
Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. Proc Natl Acad Sci U S A (2002) 6.00
Profiling enzyme activities in vivo using click chemistry methods. Chem Biol (2004) 5.97
Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites. Proc Natl Acad Sci U S A (2009) 5.86
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science (2010) 5.50
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell (2010) 5.47
Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects. Nat Chem Biol (2008) 5.32
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
TRPM8 is required for cold sensation in mice. Neuron (2007) 5.25
Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition. J Am Chem Soc (2003) 4.92
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc Natl Acad Sci U S A (2008) 4.80
An expanded eukaryotic genetic code. Science (2003) 4.66
Trp ion channels and temperature sensation. Annu Rev Neurosci (2006) 4.35
Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature (2010) 4.04
The Drosophila ortholog of vertebrate TRPA1 regulates thermotaxis. Genes Dev (2005) 3.89
A heat-sensitive TRP channel expressed in keratinocytes. Science (2002) 3.85
Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK. Proc Natl Acad Sci U S A (2006) 3.83
Addition of a photocrosslinking amino acid to the genetic code of Escherichiacoli. Proc Natl Acad Sci U S A (2002) 3.77
Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell (2008) 3.64
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science (2005) 3.63
Identification of protein pheromones that promote aggressive behaviour. Nature (2007) 3.55
Piezo proteins are pore-forming subunits of mechanically activated channels. Nature (2012) 3.54
The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin. Curr Biol (2005) 3.53
Enzymatic pathways that regulate endocannabinoid signaling in the nervous system. Chem Rev (2008) 3.51
Overcoming mutation-based resistance to antiandrogens with rational drug design. Elife (2013) 3.49
Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation. Science (2011) 3.48
Genetic incorporation of unnatural amino acids into proteins in mammalian cells. Nat Methods (2007) 3.45
Expanding the genetic code. Annu Rev Biophys Biomol Struct (2006) 3.36
Structure and function of fatty acid amide hydrolase. Annu Rev Biochem (2005) 3.33
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nat Chem Biol (2008) 3.23
A stem cell-based approach to cartilage repair. Science (2012) 3.22
An enhanced system for unnatural amino acid mutagenesis in E. coli. J Mol Biol (2009) 3.20
Discovering potent and selective reversible inhibitors of enzymes in complex proteomes. Nat Biotechnol (2003) 3.17
The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations. Proc Natl Acad Sci U S A (2008) 3.13
Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods (2009) 3.13
Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system. Nat Neurosci (2010) 3.11
Assignment of endogenous substrates to enzymes by global metabolite profiling. Biochemistry (2004) 3.10
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (2011) 3.07
Opposite thermosensor in fruitfly and mouse. Nature (2003) 3.04
An ion channel essential for sensing chemical damage. J Neurosci (2007) 3.03
A streamlined platform for high-content functional proteomics of primary human specimens. Nat Methods (2005) 3.00
Reversible inhibitors of fatty acid amide hydrolase that promote analgesia: evidence for an unprecedented combination of potency and selectivity. J Pharmacol Exp Ther (2004) 2.99
An enzyme that regulates ether lipid signaling pathways in cancer annotated by multidimensional profiling. Chem Biol (2006) 2.98
Mechanism of carbamate inactivation of FAAH: implications for the design of covalent inhibitors and in vivo functional probes for enzymes. Chem Biol (2005) 2.98
Mice lacking fatty acid amide hydrolase exhibit a cannabinoid receptor-mediated phenotypic hypoalgesia. Pain (2004) 2.94
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Addition of p-azido-L-phenylalanine to the genetic code of Escherichia coli. J Am Chem Soc (2002) 2.88
Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum. Nat Neurosci (2008) 2.87
Addition of the keto functional group to the genetic code of Escherichia coli. Proc Natl Acad Sci U S A (2002) 2.84
High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol. Nat Neurosci (2006) 2.83
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chem Biol (2009) 2.82
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4. Proc Natl Acad Sci U S A (2009) 2.80
Expanding the genetic code. Angew Chem Int Ed Engl (2004) 2.78
Genomically recoded organisms expand biological functions. Science (2013) 2.73
The role of Drosophila Piezo in mechanical nociception. Nature (2012) 2.72
Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo. Proc Natl Acad Sci U S A (2009) 2.68
Mechanism-based profiling of enzyme families. Chem Rev (2006) 2.66
GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. J Biol Chem (2006) 2.65
Self-renewal of embryonic stem cells by a small molecule. Proc Natl Acad Sci U S A (2006) 2.65
The endogenous cannabinoid system protects against colonic inflammation. J Clin Invest (2004) 2.52
Enzyme activity profiles of the secreted and membrane proteome that depict cancer cell invasiveness. Proc Natl Acad Sci U S A (2002) 2.52
An efficient rapid system for profiling the cellular activities of molecular libraries. Proc Natl Acad Sci U S A (2006) 2.51
Structural adaptations in a membrane enzyme that terminates endocannabinoid signaling. Science (2002) 2.50
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc Natl Acad Sci U S A (2013) 2.49
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Genome-scale functional profiling of the mammalian AP-1 signaling pathway. Proc Natl Acad Sci U S A (2003) 2.45
A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta. Proc Natl Acad Sci U S A (2008) 2.39
A chemical toolkit for proteins--an expanded genetic code. Nat Rev Mol Cell Biol (2006) 2.39
The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. Nat Neurosci (2010) 2.37
Recombinant expression of selectively sulfated proteins in Escherichia coli. Nat Biotechnol (2006) 2.31
Genome-wide functional analysis of human cell-cycle regulators. Proc Natl Acad Sci U S A (2006) 2.31
A novel automated platform for quantifying the extent of skeletal tumour involvement in prostate cancer patients using the Bone Scan Index. Eur Urol (2012) 2.27
Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels. J Neurosci (2008) 2.26
Proteomic profiling of metalloprotease activities with cocktails of active-site probes. Nat Chem Biol (2006) 2.25
Disparate proteome reactivity profiles of carbon electrophiles. Nat Chem Biol (2008) 2.25
Efficient incorporation of unnatural amino acids into proteins in Escherichia coli. Nat Methods (2006) 2.24
Caenorhabditis elegans TRPA-1 functions in mechanosensation. Nat Neurosci (2007) 2.19
Oxysterols direct immune cell migration via EBI2. Nature (2011) 2.19
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
Proteomic profiling of mechanistically distinct enzyme classes using a common chemotype. Nat Biotechnol (2002) 2.17
More than cool: promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci (2006) 2.17
Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A (2010) 2.16
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