Published in Circ Res on June 16, 2005
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest (2009) 2.41
Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest (2011) 2.09
Angiopoietin 2 is a partial agonist/antagonist of Tie2 signaling in the endothelium. Mol Cell Biol (2009) 2.09
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun (2012) 1.78
Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J (2008) 1.72
COMP-angiopoietin-1 promotes wound healing through enhanced angiogenesis, lymphangiogenesis, and blood flow in a diabetic mouse model. Proc Natl Acad Sci U S A (2006) 1.42
Excessive cardiac insulin signaling exacerbates systolic dysfunction induced by pressure overload in rodents. J Clin Invest (2010) 1.34
VE-PTP controls blood vessel development by balancing Tie-2 activity. J Cell Biol (2009) 1.32
Angiopoietin-2: development of inhibitors for cancer therapy. Curr Oncol Rep (2009) 1.29
Pericyte requirement for anti-leak action of angiopoietin-1 and vascular remodeling in sustained inflammation. Am J Pathol (2011) 1.08
Angiopoietin-1 protects heart against ischemia/reperfusion injury through VE-cadherin dephosphorylation and myocardiac integrin-β1/ERK/caspase-9 phosphorylation cascade. Mol Med (2011) 1.05
Hematopoietic stem and progenitor cells regulate the regeneration of their niche by secreting Angiopoietin-1. Elife (2015) 1.00
COMP-angiopoietin-1 enhances skeletal muscle blood flow and insulin sensitivity in mice. Am J Physiol Endocrinol Metab (2009) 0.96
Nitric oxide regulates Angiopoietin1/Tie2 expression after stroke. Neurosci Lett (2006) 0.96
Additive effect of AAV-mediated angiopoietin-1 and VEGF expression on the therapy of infarcted heart. Int J Cardiol (2008) 0.94
Intracavernous delivery of a designed angiopoietin-1 variant rescues erectile function by enhancing endothelial regeneration in the streptozotocin-induced diabetic mouse. Diabetes (2011) 0.92
VEGFR and type-V RTK activation and signaling. Cold Spring Harb Perspect Biol (2013) 0.91
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation. J Clin Invest (2016) 0.82
Tie1 controls angiopoietin function in vascular remodeling and inflammation. J Clin Invest (2016) 0.81
COMP-angiopoietin-1 promotes cavernous angiogenesis in a type 2 diabetic rat model. J Korean Med Sci (2013) 0.80
QHREDGS enhances tube formation, metabolism and survival of endothelial cells in collagen-chitosan hydrogels. PLoS One (2013) 0.80
COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway. Exp Neurobiol (2015) 0.79
Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis. Circ Res (2015) 0.78
Mesenchymal stem cells modified with angiopoietin-1 gene promote wound healing. Stem Cell Res Ther (2013) 0.77
Measurement of angiogenic phenotype by use of two-dimensional mesenteric angiogenesis assay. Methods Mol Biol (2009) 0.77
Cartilage oligometric matrix protein-angiopoietin-1 promotes revascularization through increased survivin expression in dermal endothelial cells of skin grafts in mice. Am J Pathol (2007) 0.77
Tubular Overexpression of Angiopoietin-1 Attenuates Renal Fibrosis. PLoS One (2016) 0.76
A Designed Angiopoietin-1 Variant, Dimeric CMP-Ang1 Activates Tie2 and Stimulates Angiogenesis and Vascular Stabilization in N-glycan Dependent Manner. Sci Rep (2015) 0.76
Designed angiopoietin-1 variant, COMP-angiopoietin-1, rescues erectile function through healthy cavernous angiogenesis in a hypercholesterolemic mouse. Sci Rep (2015) 0.76
Cartilage Oligomeric Matrix Protein Angiopoeitin-1 Provides Benefits During Nerve Regeneration In Vivo and In Vitro. Ann Biomed Eng (2015) 0.75
Effect of cartilage oligomeric matrix protein angiopoietin-1 on peripheral nerves in db/db diabetic mice. Curr Ther Res Clin Exp (2008) 0.75
Angiopoietin and vascular remodeling: the data at face value. Circ Res (2006) 0.75
Angiopoietin-Tie signalling in the cardiovascular and lymphatic systems. Clin Sci (Lond) (2017) 0.75
Cartilage oligomeric matrix protein enhances the vascularization of acellular nerves. Neural Regen Res (2016) 0.75
COMP-angiopoietin1 potentiates the effects of bone morphogenic protein-2 on ischemic necrosis of the femoral head in rats. PLoS One (2014) 0.75
Angiopoietin-1 deficiency increases tumor metastasis in mice. BMC Cancer (2017) 0.75
The gut microbiota as an environmental factor that regulates fat storage. Proc Natl Acad Sci U S A (2004) 26.56
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Rapid vascular regrowth in tumors after reversal of VEGF inhibition. J Clin Invest (2006) 6.12
VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol (2005) 5.56
Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system. Nat Rev Mol Cell Biol (2009) 5.55
Relationship between nucleosome positioning and DNA methylation. Nature (2010) 5.27
Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors. Am J Pathol (2002) 5.04
A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol (2006) 4.55
Activation of rac and cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells. Mol Cell Biol (2002) 4.50
Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol (2004) 4.47
Loss of autophagy diminishes pancreatic beta cell mass and function with resultant hyperglycemia. Cell Metab (2008) 4.33
Functionally specialized junctions between endothelial cells of lymphatic vessels. J Exp Med (2007) 4.10
Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. J Clin Invest (2005) 4.09
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation (2007) 3.77
Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung. Nat Med (2004) 3.64
Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis. J Clin Invest (2004) 3.53
Cellular abnormalities of blood vessels as targets in cancer. Curr Opin Genet Dev (2005) 3.38
Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Am J Physiol Heart Circ Physiol (2005) 3.28
Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms. EMBO J (2006) 2.98
Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity. Genes Dev (2008) 2.91
Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol (2008) 2.85
Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol (2005) 2.80
Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov (2012) 2.57
Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine. Nat Med (2012) 2.51
Significance of blood vessel leakiness in cancer. Cancer Res (2002) 2.43
Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors. Am J Pathol (2003) 2.37
The sphingolipid transporter spns2 functions in migration of zebrafish myocardial precursors. Science (2008) 2.35
Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1. Nat Cell Biol (2008) 2.35
Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol (2005) 2.34
Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med (2009) 2.34
Critical role of CD11b+ macrophages and VEGF in inflammatory lymphangiogenesis, antigen clearance, and inflammation resolution. Blood (2009) 2.30
Robotic vs laparoscopic resection of rectal cancer: short-term outcomes of a case-control study. Dis Colon Rectum (2011) 2.28
Angiogenic role of LYVE-1-positive macrophages in adipose tissue. Circ Res (2007) 2.22
Adipose vascular endothelial growth factor regulates metabolic homeostasis through angiogenesis. Cell Metab (2013) 2.21
Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab (2009) 2.13
GSA-SNP: a general approach for gene set analysis of polymorphisms. Nucleic Acids Res (2010) 2.09
SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling. Nature (2002) 2.08
Angiopoietin-2 functions as an autocrine protective factor in stressed endothelial cells. Proc Natl Acad Sci U S A (2006) 2.03
A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein. J Biol Chem (2004) 1.96
Metformin prevents progression of heart failure in dogs: role of AMP-activated protein kinase. Circulation (2009) 1.95
VEGF and c-Met blockade amplify angiogenesis inhibition in pancreatic islet cancer. Cancer Res (2011) 1.92
Regulatory roles for APJ, a seven-transmembrane receptor related to angiotensin-type 1 receptor in blood pressure in vivo. J Biol Chem (2004) 1.91
Complementary actions of inhibitors of angiopoietin-2 and VEGF on tumor angiogenesis and growth. Cancer Res (2010) 1.90
A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling. Nat Genet (2004) 1.87
Contrasting actions of selective inhibitors of angiopoietin-1 and angiopoietin-2 on the normalization of tumor blood vessels. Am J Pathol (2009) 1.87
Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation (2003) 1.86
Adenovirus serotype 5 fiber shaft influences in vivo gene transfer in mice. Hum Gene Ther (2003) 1.85
COMP-Ang1: a designed angiopoietin-1 variant with nonleaky angiogenic activity. Proc Natl Acad Sci U S A (2004) 1.85
Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102. Cancer Res (2007) 1.83
Controlling escape from angiogenesis inhibitors. Nat Rev Cancer (2012) 1.81
CHO cells in biotechnology for production of recombinant proteins: current state and further potential. Appl Microbiol Biotechnol (2011) 1.79
In situ force mapping of mammary gland transformation. Integr Biol (Camb) (2011) 1.78
Decreased number and impaired angiogenic function of endothelial progenitor cells in patients with chronic renal failure. Arterioscler Thromb Vasc Biol (2004) 1.78
Phosphorylation of VE-cadherin is modulated by haemodynamic forces and contributes to the regulation of vascular permeability in vivo. Nat Commun (2012) 1.78
TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice. J Clin Invest (2009) 1.76
Cell type-specific regulation of RhoA activity during cytokinesis. J Biol Chem (2004) 1.76
Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation. Blood (2005) 1.75
T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity (2011) 1.75
COMP-angiopoietin-1 ameliorates renal fibrosis in a unilateral ureteral obstruction model. J Am Soc Nephrol (2006) 1.74
Interaction between Tie receptors modulates angiogenic activity of angiopoietin2 in endothelial progenitor cells. Cardiovasc Res (2006) 1.72
Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis. EMBO J (2008) 1.72
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol (2010) 1.72
Prolonged targeting of ischemic/reperfused myocardium by liposomal adenosine augments cardioprotection in rats. J Am Coll Cardiol (2009) 1.71
Maturation of TonEBP expression in developing rat kidney. Am J Physiol Renal Physiol (2004) 1.70
Iron administration before stem cell harvest enables MR imaging tracking after transplantation. Radiology (2013) 1.70
The E1784K mutation in SCN5A is associated with mixed clinical phenotype of type 3 long QT syndrome. J Clin Invest (2008) 1.69
Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition. J Exp Med (2012) 1.65
Ischemia-reperfusion injury activates innate immunity in rat kidneys. Transplantation (2005) 1.64
Markers for microscopic imaging of lymphangiogenesis and angiogenesis. Ann N Y Acad Sci (2008) 1.62
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J Clin Invest (2007) 1.61
Conditional ablation of LYVE-1+ cells unveils defensive roles of lymphatic vessels in intestine and lymph nodes. Blood (2013) 1.60
Immunocytochemical localization of pendrin in intercalated cell subtypes in rat and mouse kidney. Am J Physiol Renal Physiol (2002) 1.59
MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion. Mol Biol Cell (2005) 1.59
EphB ligand, ephrinB2, suppresses the VEGF- and angiopoietin 1-induced Ras/mitogen-activated protein kinase pathway in venous endothelial cells. FASEB J (2002) 1.58
Inhibition of phosphatidylinositol 3-kinase enhances mitogenic actions of insulin in endothelial cells. J Biol Chem (2001) 1.58
The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis. BMB Rep (2008) 1.57
Multiple angiopoietin recombinant proteins activate the Tie1 receptor tyrosine kinase and promote its interaction with Tie2. J Cell Biol (2005) 1.57
A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis. J Biol Chem (2004) 1.56
Inhibition of cytolytic T lymphocyte proliferation by autologous CD4+/CD25+ regulatory T cells in a colorectal carcinoma patient is mediated by transforming growth factor-beta. Cancer Res (2002) 1.54
The sphingosine-1-phosphate transporter Spns2 expressed on endothelial cells regulates lymphocyte trafficking in mice. J Clin Invest (2012) 1.54
Bone marrow-derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice. J Clin Invest (2007) 1.52
Positive correlation between the dysregulation of transforming growth factor-β1 and aneurysmal pathological changes in patients with Marfan syndrome. Circ J (2012) 1.52
Stereotactic body radiation therapy for inoperable hepatocellular carcinoma as a local salvage treatment after incomplete transarterial chemoembolization. Cancer (2012) 1.52
Reduced VEGF production, angiogenesis, and vascular regrowth contribute to the antitumor properties of dual mTORC1/mTORC2 inhibitors. Cancer Res (2011) 1.51
Analysis of expert consultation referrals to the Korean Society of Anesthesiologists (KSA): a comparison of procedural sedation and general anesthesia. J Anesth (2012) 1.51