Published in Mol Cell Biol on September 01, 2002
A Rac switch regulates random versus directionally persistent cell migration. J Cell Biol (2005) 4.40
Activity of Rho-family GTPases during cell division as visualized with FRET-based probes. J Cell Biol (2003) 3.85
Localized zones of Rho and Rac activities drive initiation and expansion of epithelial cell-cell adhesion. J Cell Biol (2007) 3.76
Collective chemotaxis requires contact-dependent cell polarity. Dev Cell (2010) 2.95
Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling. J Cell Biol (2010) 2.65
RhoA and RhoC have distinct roles in migration and invasion by acting through different targets. J Cell Biol (2011) 2.59
Localized RhoA activation as a requirement for the induction of membrane ruffling. Mol Biol Cell (2005) 2.58
Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix. J Cell Biol (2006) 2.58
Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. J Cell Biol (2007) 2.33
Cadherin Switch during EMT in Neural Crest Cells Leads to Contact Inhibition of Locomotion via Repolarization of Forces. Dev Cell (2015) 2.29
Development of an optimized backbone of FRET biosensors for kinases and GTPases. Mol Biol Cell (2011) 2.28
Vinculin regulates the recruitment and release of core focal adhesion proteins in a force-dependent manner. Curr Biol (2013) 2.20
Rho protein crosstalk: another social network? Trends Cell Biol (2011) 2.19
A Rac-cGMP signaling pathway. Cell (2007) 2.16
The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src. Mol Cell Biol (2006) 2.11
Regulation of rice NADPH oxidase by binding of Rac GTPase to its N-terminal extension. Plant Cell (2007) 2.11
A role for Rho GTPases and cell-cell adhesion in single-cell motility in vivo. Nat Cell Biol (2009) 2.05
Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion. J Cell Biol (2004) 2.02
Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors. Proc Natl Acad Sci U S A (2008) 1.97
Activity-dependent synaptogenesis: regulation by a CaM-kinase kinase/CaM-kinase I/betaPIX signaling complex. Neuron (2008) 1.94
Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chem Rev (2011) 1.88
Coactivation of Rac1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor. Mol Biol Cell (2003) 1.72
Oncogene-like induction of cellular invasion from centrosome amplification. Nature (2014) 1.72
The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis. J Cell Biol (2010) 1.70
SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility. Mol Cell (2011) 1.70
Haemodynamics-driven developmental pruning of brain vasculature in zebrafish. PLoS Biol (2012) 1.65
DOCK8 is a Cdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood (2012) 1.63
Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase. EMBO Rep (2005) 1.62
Feedback regulation through myosin II confers robustness on RhoA signalling at E-cadherin junctions. Nat Cell Biol (2015) 1.62
Dynamics of the Rho-family small GTPases in actin regulation and motility. Cell Adh Migr (2011) 1.60
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Immediate-early signaling induced by E-cadherin engagement and adhesion. J Biol Chem (2007) 1.54
Complement fragment C3a controls mutual cell attraction during collective cell migration. Dev Cell (2011) 1.54
Loss of Par3 promotes breast cancer metastasis by compromising cell-cell cohesion. Nat Cell Biol (2012) 1.53
Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors. Nat Protoc (2009) 1.53
Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells. Mol Biol Cell (2005) 1.48
p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J Cell Biol (2008) 1.41
Activated ezrin promotes cell migration through recruitment of the GEF Dbl to lipid rafts and preferential downstream activation of Cdc42. Mol Biol Cell (2007) 1.36
Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKCalpha in a Rac1 activation pathway. J Cell Biol (2009) 1.36
Myosin IIA/IIB restrict adhesive and protrusive signaling to generate front-back polarity in migrating cells. J Cell Biol (2011) 1.36
ZO-1- and ZO-2-dependent integration of myosin-2 to epithelial zonula adherens. Mol Biol Cell (2008) 1.36
The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration. J Cell Biol (2005) 1.33
A photocleavable rapamycin conjugate for spatiotemporal control of small GTPase activity. J Am Chem Soc (2010) 1.29
An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells. J Cell Biol (2007) 1.25
Force-induced cell polarisation is linked to RhoA-driven microtubule-independent focal-adhesion sliding. J Cell Sci (2009) 1.21
Coordinating cytoskeletal tracks to polarize cellular movements. J Cell Biol (2004) 1.20
Yersinia pseudotuberculosis spatially controls activation and misregulation of host cell Rac1. PLoS Pathog (2005) 1.20
Rapid activation of Rac GTPase in living cells by force is independent of Src. PLoS One (2009) 1.20
Activation of Cdc42 by trans interactions of the cell adhesion molecules nectins through c-Src and Cdc42-GEF FRG. J Cell Biol (2004) 1.20
The tumor suppressor DAPK inhibits cell motility by blocking the integrin-mediated polarity pathway. J Cell Biol (2006) 1.19
Rab11 regulates cell-cell communication during collective cell movements. Nat Cell Biol (2013) 1.19
Imaging protein activity in live embryos using fluorescence resonance energy transfer biosensors. Nat Protoc (2011) 1.16
Rapid global fitting of large fluorescence lifetime imaging microscopy datasets. PLoS One (2013) 1.16
A Trio-Rac1-Pak1 signalling axis drives invadopodia disassembly. Nat Cell Biol (2014) 1.15
Cell migration is regulated by platelet-derived growth factor receptor endocytosis. Mol Cell Biol (2009) 1.15
Cell biology of embryonic migration. Birth Defects Res C Embryo Today (2008) 1.14
RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. J Cell Biol (2013) 1.13
Modulation of Rho guanine exchange factor Lfc activity by protein kinase A-mediated phosphorylation. Mol Cell Biol (2009) 1.12
The potential of optical proteomic technologies to individualize prognosis and guide rational treatment for cancer patients. Target Oncol (2009) 1.10
Live-cell fluorescence microscopy with molecular biosensors: what are we really measuring? Biophys J (2012) 1.08
Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity. Proc Natl Acad Sci U S A (2008) 1.08
Spatial control of Cdc42 signalling by a GM130-RasGRF complex regulates polarity and tumorigenesis. Nat Commun (2014) 1.07
β1 integrins regulate fibroblast chemotaxis through control of N-WASP stability. EMBO J (2011) 1.07
Translocation of CrkL to focal adhesions mediates integrin-induced migration downstream of Src family kinases. Mol Cell Biol (2003) 1.07
Discoidin domain receptor 1 controls linear invadosome formation via a Cdc42-Tuba pathway. J Cell Biol (2014) 1.06
Rapid turnover rate of phosphoinositides at the front of migrating MDCK cells. Mol Biol Cell (2008) 1.06
Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Förster resonance energy transfer. Philos Trans R Soc Lond B Biol Sci (2008) 1.05
Integrating receptor signal inputs that influence small Rho GTPase activation dynamics at the immunological synapse. Mol Cell Biol (2009) 1.05
Deletion of ABCA1 and ABCG1 impairs macrophage migration because of increased Rac1 signaling. Circ Res (2010) 1.05
Upregulation of CCR3 by age-related stresses promotes choroidal endothelial cell migration via VEGF-dependent and -independent signaling. Invest Ophthalmol Vis Sci (2011) 1.05
The novel synaptogenic protein Farp1 links postsynaptic cytoskeletal dynamics and transsynaptic organization. J Cell Biol (2012) 1.05
An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. J Cell Sci (2009) 1.04
Optogenetic reporters: Fluorescent protein-based genetically encoded indicators of signaling and metabolism in the brain. Prog Brain Res (2012) 1.03
Spatiotemporal activation of Rac1 for engulfment of apoptotic cells. Proc Natl Acad Sci U S A (2008) 1.03
Visualizing and quantifying adhesive signals. Curr Opin Cell Biol (2008) 1.02
Reelin signals through apolipoprotein E receptor 2 and Cdc42 to increase growth cone motility and filopodia formation. J Neurosci (2010) 1.02
Quantification of local morphodynamics and local GTPase activity by edge evolution tracking. PLoS Comput Biol (2008) 1.01
Tiam1 interaction with the PAR complex promotes talin-mediated Rac1 activation during polarized cell migration. J Cell Biol (2012) 1.01
Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA. PLoS One (2012) 1.00
RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney cells. Mol Biol Cell (2004) 1.00
Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization. J Biol Chem (2009) 0.99
The role of RPE cell-associated VEGF₁₈₉ in choroidal endothelial cell transmigration across the RPE. Invest Ophthalmol Vis Sci (2011) 0.99
Interplay between chemotaxis and contact inhibition of locomotion determines exploratory cell migration. Nat Commun (2015) 0.98
Rho GTPase isoforms in cell motility: Don't fret, we have FRET. Cell Adh Migr (2014) 0.98
Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42. J Cell Biol (2013) 0.98
Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. J Cell Sci (2013) 0.97
Paxillin-kinase-linker tyrosine phosphorylation regulates directional cell migration. Mol Biol Cell (2009) 0.97
Helicobacter pylori CagA induces AGS cell elongation through a cell retraction defect that is independent of Cdc42, Rac1, and Arp2/3. Infect Immun (2006) 0.95
Quantitative ratiometric imaging of FRET-biosensors in living cells. Methods Cell Biol (2013) 0.95
The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells. J Biol Chem (2015) 0.95
Real-time observation of flow-induced cytoskeletal stress in living cells. Am J Physiol Cell Physiol (2011) 0.94
A novel role of nectins in inhibition of the E-cadherin-induced activation of Rac and formation of cell-cell adherens junctions. Mol Biol Cell (2003) 0.94
Mtss1 promotes cell-cell junction assembly and stability through the small GTPase Rac1. PLoS One (2012) 0.93
ROCK1 and 2 differentially regulate actomyosin organization to drive cell and synaptic polarity. J Cell Biol (2015) 0.93
Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance. EMBO Rep (2012) 0.93
Application of fluorescence resonance energy transfer and magnetic twisting cytometry to quantify mechanochemical signaling activities in a living cell. Sci Signal (2008) 0.92
Human Mena associates with Rac1 small GTPase in glioblastoma cell lines. PLoS One (2009) 0.91
The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues. Cell Rep (2014) 0.91
A novel biased allosteric compound inhibitor of parturition selectively impedes the prostaglandin F2alpha-mediated Rho/ROCK signaling pathway. J Biol Chem (2010) 0.91
Targeting Cx43 and N-cadherin, which are abnormally upregulated in venous leg ulcers, influences migration, adhesion and activation of Rho GTPases. PLoS One (2012) 0.90
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