Published in Pharmacol Ther on July 01, 2005
Physiological roles for ecto-5'-nucleotidase (CD73). Purinergic Signal (2006) 2.98
Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL. Nat Med (2013) 2.67
Gemcitabine and cytosine arabinoside cytotoxicity: association with lymphoblastoid cell expression. Cancer Res (2008) 2.58
Pharmacological considerations for tenofovir and emtricitabine to prevent HIV infection. J Antimicrob Chemother (2010) 2.41
Structural insight into the mechanism of substrate specificity and catalytic activity of an HD-domain phosphohydrolase: the 5'-deoxyribonucleotidase YfbR from Escherichia coli. J Mol Biol (2008) 2.19
Cellular function and molecular structure of ecto-nucleotidases. Purinergic Signal (2012) 2.13
Basal release of ATP: an autocrine-paracrine mechanism for cell regulation. Sci Signal (2010) 1.91
Ecto-nucleoside triphosphate diphosphohydrolase 1 (E-NTPDase1/CD39) regulates neutrophil chemotaxis by hydrolyzing released ATP to adenosine. J Biol Chem (2008) 1.31
Metastasis-related plasma membrane proteins of human breast cancer cells identified by comparative quantitative mass spectrometry. Mol Cell Proteomics (2009) 1.21
The purinergic neurotransmitter revisited: a single substance or multiple players? Pharmacol Ther (2014) 1.06
Ecto-5'-nucleotidase: Structure function relationships. Purinergic Signal (2006) 1.05
Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver. Am J Physiol Gastrointest Liver Physiol (2011) 1.05
Recombinant ecto-5'-nucleotidase (CD73) has long lasting antinociceptive effects that are dependent on adenosine A1 receptor activation. Mol Pain (2010) 1.04
The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer (2016) 1.00
Polymeric nanogel formulations of nucleoside analogs. Expert Opin Drug Deliv (2007) 0.98
Nucleotide degradation and ribose salvage in yeast. Mol Syst Biol (2013) 0.98
Genetic factors influencing cytarabine therapy. Pharmacogenomics (2009) 0.97
The clinically relevant pharmacogenomic changes in acute myelogenous leukemia. Pharmacogenomics (2012) 0.94
Effects of hormonal contraception on antiretroviral drug metabolism, pharmacokinetics and pharmacodynamics. Am J Reprod Immunol (2014) 0.93
Activated hepatic stellate cells upregulate transcription of ecto-5'-nucleotidase/CD73 via specific SP1 and SMAD promoter elements. Am J Physiol Gastrointest Liver Physiol (2012) 0.92
Suppression of 5'-nucleotidase enzymes promotes AMP-activated protein kinase (AMPK) phosphorylation and metabolism in human and mouse skeletal muscle. J Biol Chem (2011) 0.91
Effect of tenofovir on nucleotidases and cytokines in HIV-1 target cells. PLoS One (2013) 0.89
Zidovudine and Lamivudine for HIV Infection. Clin Med Rev Ther (2010) 0.89
Sex hormones regulate tenofovir-diphosphate in female reproductive tract cells in culture. PLoS One (2014) 0.88
Boosting regulatory T cell function by CD4 stimulation enters the clinic. Front Immunol (2012) 0.87
Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics. Pharmacogenet Genomics (2009) 0.87
Chronic hypoxia impairs extracellular nucleotide metabolism and barrier function in pulmonary artery vasa vasorum endothelial cells. Angiogenesis (2011) 0.87
Structural insights into the inhibition of cytosolic 5'-nucleotidase II (cN-II) by ribonucleoside 5'-monophosphate analogues. PLoS Comput Biol (2011) 0.86
Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging. Cancer Metab (2013) 0.86
The human NAD metabolome: Functions, metabolism and compartmentalization. Crit Rev Biochem Mol Biol (2015) 0.86
Estradiol regulation of nucleotidases in female reproductive tract epithelial cells and fibroblasts. PLoS One (2013) 0.86
Discovery of predictive biomarkers for litter size in boar spermatozoa. Mol Cell Proteomics (2015) 0.86
An emerging role for adenosine and its receptors in bone homeostasis. Front Endocrinol (Lausanne) (2012) 0.85
Crystal structures of the novel cytosolic 5'-nucleotidase IIIB explain its preference for m7GMP. PLoS One (2014) 0.84
Rolofylline, an adenosine A1 receptor antagonist, inhibits osteoclast differentiation as an inverse agonist. Br J Pharmacol (2013) 0.84
Enzyme kinetics of the mitochondrial deoxyribonucleoside salvage pathway are not sufficient to support rapid mtDNA replication. PLoS Comput Biol (2011) 0.84
Fibroblasts from patients with Diamond-Blackfan anaemia show abnormal expression of genes involved in protein synthesis, amino acid metabolism and cancer. BMC Genomics (2009) 0.83
Modulators of nucleoside metabolism in the therapy of brain diseases. Curr Top Med Chem (2011) 0.83
Gemcitabine metabolic pathway genetic polymorphisms and response in patients with non-small cell lung cancer. Pharmacogenet Genomics (2012) 0.83
Cytosolic 5'-Nucleotidase 1A As a Target of Circulating Autoantibodies in Autoimmune Diseases. Arthritis Care Res (Hoboken) (2016) 0.82
Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108. J Biol Chem (2010) 0.81
Identification of Drosophila and human 7-methyl GMP-specific nucleotidases. J Biol Chem (2012) 0.81
Generation, Release, and Uptake of the NAD Precursor Nicotinic Acid Riboside by Human Cells. J Biol Chem (2015) 0.80
Contribution of non-endothelium-dependent substances to exercise hyperaemia: are they O(2) dependent? J Physiol (2012) 0.80
Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila. FEBS J (2014) 0.79
Effect of HIV-1 infection and sex on the cellular pharmacology of the antiretroviral drugs zidovudine and lamivudine. Antimicrob Agents Chemother (2012) 0.79
Microsporidia: Why Make Nucleotides if You Can Steal Them? PLoS Pathog (2016) 0.79
Effects of tenofovir on cytokines and nucleotidases in HIV-1 target cells and the mucosal tissue environment in the female reproductive tract. Antimicrob Agents Chemother (2014) 0.78
The role of sex hormones and the tissue environment in immune protection against HIV in the female reproductive tract. Am J Reprod Immunol (2014) 0.77
Multi-lineage differentiation of human umbilical cord Wharton's Jelly Mesenchymal Stromal Cells mediates changes in the expression profile of stemness markers. PLoS One (2015) 0.76
Resistance revealed in acute lymphoblastic leukemia. Nat Med (2013) 0.76
Heart mitochondrial TTP synthesis and the compartmentalization of TMP. J Biol Chem (2014) 0.76
Hepatitis C virus non-structural protein 3 interacts with cytosolic 5'(3')-deoxyribonucleotidase and partially inhibits its activity. PLoS One (2013) 0.76
Thymidine phosphorylase influences [(18)F]fluorothymidine uptake in cancer cells and patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging (2014) 0.75
Pharmacogenetic characterization of naturally occurring germline NT5C1A variants to chemotherapeutic nucleoside analogs. Pharmacogenet Genomics (2016) 0.75
Invited Lectures : Overviews Purinergic signalling: past, present and future. Purinergic Signal (2006) 0.75
Identification, Heterologous Expression, and Functional Characterization of Bacillus subtilis YutF, a HAD Superfamily 5'-Nucleotidase with Broad Substrate Specificity. PLoS One (2016) 0.75
Development and evaluation of a standardized ELISA for the determination of autoantibodies against cN-1A (Mup44, NT5C1A) in sporadic inclusion body myositis. Auto Immun Highlights (2016) 0.75
Pyrimidine Salvage Enzymes Are Essential for De Novo Biosynthesis of Deoxypyrimidine Nucleotides in Trypanosoma brucei. PLoS Pathog (2016) 0.75
Ribose Supplementation Alone or with Elevated Creatine Does Not Preserve High Energy Nucleotides or Cardiac Function in the Failing Mouse Heart. PLoS One (2013) 0.75
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol (2002) 2.88
Association of DNA polymerase mu (pol mu) with Ku and ligase IV: role for pol mu in end-joining double-strand break repair. Mol Cell Biol (2002) 2.25
Phase 1 trial of the proteasome inhibitor bortezomib and pegylated liposomal doxorubicin in patients with advanced hematologic malignancies. Blood (2004) 1.62
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A (2003) 1.47
Mammalian 5'-nucleotidases. J Biol Chem (2003) 1.42
On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Hum Mol Genet (2004) 1.24
Regulation of the interaction of inosine monophosphate dehydrogenase with mycophenolic Acid by GTP. J Biol Chem (2005) 1.21
ACCO: ASCO core curriculum outline. J Clin Oncol (2005) 1.20
Role of estrogen receptor in the regulation of ecto-5'-nucleotidase and adenosine in breast cancer. Clin Cancer Res (2004) 1.17
Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma. Melanoma Res (2006) 1.13
The evidence for two opposite, ATP-generating and ATP-consuming, extracellular pathways on endothelial and lymphoid cells. Biochem J (2002) 1.02
Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin. Cancer Res (2009) 1.00
Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA. Proc Natl Acad Sci U S A (2013) 1.00
Sequential azacitidine plus lenalidomide combination for elderly patients with untreated acute myeloid leukemia. Haematologica (2012) 0.99
Inhibition of nucleoside transport by protein kinase inhibitors. J Pharmacol Exp Ther (2003) 0.96
Induction of apoptosis in IL-3-dependent hematopoietic cell lines by guanine nucleotide depletion. Blood (2003) 0.95
Targeted disruption of the inosine 5'-monophosphate dehydrogenase type I gene in mice. Mol Cell Biol (2003) 0.93
Inhibition of nucleoside transport by p38 MAPK inhibitors. J Biol Chem (2002) 0.92
Synthesis of 2'-deoxy-2'-[18F]fluoro-9-β-D-arabinofuranosylguanine: a novel agent for imaging T-cell activation with PET. Mol Imaging Biol (2011) 0.92
Impact of TET2 mutations on mRNA expression and clinical outcomes in MDS patients treated with DNA methyltransferase inhibitors. Hematol Oncol (2010) 0.91
Synergy between imatinib and mycophenolic acid in inducing apoptosis in cell lines expressing Bcr-Abl. Blood (2004) 0.88
Age and genetics: how do prognostic factors at diagnosis explain disparities in acute myeloid leukemia? Am J Clin Oncol (2015) 0.88
Lipid rafts remodeling in estrogen receptor-negative breast cancer is reversed by histone deacetylase inhibitor. Mol Cancer Ther (2006) 0.88
Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinase. Cancer Res (2002) 0.86
Determinants of sensitivity of human T-cell leukemia CCRF-CEM cells to immucillin-H. Leuk Res (2008) 0.85
The effect of an intense mentoring program on junior investigators' preparation for a patient-oriented clinical research career. Acad Med (2015) 0.85
Molecular characterization of recombinant mouse adenosine kinase and evaluation as a target for protein phosphorylation. Eur J Biochem (2004) 0.84
Tenascin C interacts with ecto-5'-nucleotidase (eN) and regulates adenosine generation in cancer cells. Biochim Biophys Acta (2007) 0.84
A77 1726 induces differentiation of human myeloid leukemia K562 cells by depletion of intracellular CTP pools. Mol Pharmacol (2002) 0.84
Clinical course of thrombocytopenia in patients treated with imatinib mesylate for accelerated phase chronic myelogenous leukemia. Am J Hematol (2002) 0.82
Effects of the IMP-dehydrogenase inhibitor, Tiazofurin, in bcr-abl positive acute myelogenous leukemia. Part I. In vivo studies. Leuk Res (2004) 0.82
Enforced expression of cytosolic 5'-nucleotidase I confers resistance to nucleoside analogues in vitro but systemic chemotherapy toxicity precludes in vivo selection. Cancer Chemother Pharmacol (2005) 0.81
Reduced rRNA expression and increased rDNA promoter methylation in CD34+ cells of patients with myelodysplastic syndromes. Blood (2012) 0.80
Cyclosporin A and FK506 decrease adenosine kinase activity and adenosine uptake in T-lymphocytes. J Lab Clin Med (2002) 0.80
Effect of lysophosphatidic acid acyltransferase-beta inhibition in acute leukemia. Leuk Res (2006) 0.79
Guanine nucleotide depletion mediates translocation of nucleolar proteins, including RNA helicase A (DHX-9). Nucleosides Nucleotides Nucleic Acids (2008) 0.79
Regulation of equilibrative nucleoside uptake by protein kinase inhibitors. Nucleosides Nucleotides Nucleic Acids (2004) 0.78
Cyclopentenyl cytosine induces senescence in breast cancer cells through the nucleolar stress response and activation of p53. Mol Pharmacol (2011) 0.78
Regulation of ribosomal gene expression in cancer. J Cell Physiol (2015) 0.78
Reactive oxygen species regulate nucleostemin oligomerization and protein degradation. J Biol Chem (2011) 0.77