Published in Mol Cell Biol on July 01, 2002
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining. Biochem J (2009) 3.89
Alternative end-joining is suppressed by the canonical NHEJ component Xrcc4-ligase IV during chromosomal translocation formation. Nat Struct Mol Biol (2010) 2.65
Eukaryotic DNA ligases: structural and functional insights. Annu Rev Biochem (2008) 2.44
Polymerase mu is a DNA-directed DNA/RNA polymerase. Mol Cell Biol (2003) 2.26
The X family portrait: structural insights into biological functions of X family polymerases. DNA Repair (Amst) (2007) 1.98
XRCC4:DNA ligase IV can ligate incompatible DNA ends and can ligate across gaps. EMBO J (2007) 1.80
Autophosphorylation-dependent remodeling of the DNA-dependent protein kinase catalytic subunit regulates ligation of DNA ends. Nucleic Acids Res (2004) 1.77
The role of mechanistic factors in promoting chromosomal translocations found in lymphoid and other cancers. Adv Immunol (2010) 1.77
End-joining repair of double-strand breaks in Drosophila melanogaster is largely DNA ligase IV independent. Genetics (2004) 1.68
DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining. Nucleic Acids Res (2004) 1.67
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Rejoining of DNA double-strand breaks as a function of overhang length. Mol Cell Biol (2005) 1.52
Impact of DNA ligase IV on the fidelity of end joining in human cells. Nucleic Acids Res (2003) 1.52
Role of human Pso4 in mammalian DNA repair and association with terminal deoxynucleotidyl transferase. Proc Natl Acad Sci U S A (2003) 1.47
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Processing of DNA for nonhomologous end-joining by cell-free extract. EMBO J (2005) 1.38
Lack of sugar discrimination by human Pol mu requires a single glycine residue. Nucleic Acids Res (2003) 1.38
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DNA-PK: a dynamic enzyme in a versatile DSB repair pathway. DNA Repair (Amst) (2014) 1.31
A specific loop in human DNA polymerase mu allows switching between creative and DNA-instructed synthesis. Nucleic Acids Res (2006) 1.30
Involvement of DNA polymerase mu in the repair of a specific subset of DNA double-strand breaks in mammalian cells. Nucleic Acids Res (2007) 1.27
End-bridging is required for pol mu to efficiently promote repair of noncomplementary ends by nonhomologous end joining. Nucleic Acids Res (2008) 1.24
The involvement of DNA-damage and -repair defects in neurological dysfunction. Am J Hum Genet (2008) 1.17
A genomics-based screen for yeast mutants with an altered recombination/end-joining repair ratio. Genetics (2002) 1.14
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XRCC4 and XLF form long helical protein filaments suitable for DNA end protection and alignment to facilitate DNA double strand break repair. Biochem Cell Biol (2013) 1.09
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Overexpression of human DNA polymerase mu (Pol mu) in a Burkitt's lymphoma cell line affects the somatic hypermutation rate. Nucleic Acids Res (2004) 1.07
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Limited terminal transferase in human DNA polymerase mu defines the required balance between accuracy and efficiency in NHEJ. Proc Natl Acad Sci U S A (2009) 1.05
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. Biochemistry (2008) 1.04
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Inhibition of double-strand break non-homologous end-joining by cisplatin adducts in human cell extracts. Nucleic Acids Res (2005) 0.98
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Editing of misaligned 3'-termini by an intrinsic 3'-5' exonuclease activity residing in the PHP domain of a family X DNA polymerase. Nucleic Acids Res (2008) 0.95
Base damage immediately upstream from double-strand break ends is a more severe impediment to nonhomologous end joining than blocked 3'-termini. Radiat Res (2011) 0.94
A role for DNA polymerase mu in the emerging DJH rearrangements of the postgastrulation mouse embryo. Mol Cell Biol (2008) 0.93
Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair. PLoS Genet (2009) 0.93
Conferring a template-dependent polymerase activity to terminal deoxynucleotidyltransferase by mutations in the Loop1 region. Nucleic Acids Res (2009) 0.93
Multiple functions of DNA polymerases. CRC Crit Rev Plant Sci (2007) 0.92
Tolerance for 8-oxoguanine but not thymine glycol in alignment-based gap filling of partially complementary double-strand break ends by DNA polymerase lambda in human nuclear extracts. Nucleic Acids Res (2008) 0.92
Anti-apoptotic protein BCL2 down-regulates DNA end joining in cancer cells. J Biol Chem (2010) 0.92
Terminal deoxynucleotidyl transferase requires KU80 and XRCC4 to promote N-addition at non-V(D)J chromosomal breaks in non-lymphoid cells. Nucleic Acids Res (2012) 0.91
A comparison of BRCT domains involved in nonhomologous end-joining: introducing the solution structure of the BRCT domain of polymerase lambda. DNA Repair (Amst) (2008) 0.91
Coordination of DNA-PK activation and nuclease processing of DNA termini in NHEJ. Antioxid Redox Signal (2010) 0.90
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Characterization of SpPol4, a unique X-family DNA polymerase in Schizosaccharomyces pombe. Nucleic Acids Res (2005) 0.90
Modeling DNA polymerase μ motions: subtle transitions before chemistry. Biophys J (2010) 0.89
Biological and therapeutic relevance of nonreplicative DNA polymerases to cancer. Antioxid Redox Signal (2012) 0.89
DNA-binding determinants promoting NHEJ by human Polμ. Nucleic Acids Res (2012) 0.89
DNA ligase IV as a new molecular target for temozolomide. Biochem Biophys Res Commun (2009) 0.89
Translesion DNA synthesis-assisted non-homologous end-joining of complex double-strand breaks prevents loss of DNA sequences in mammalian cells. Nucleic Acids Res (2009) 0.87
Solution structure of polymerase mu's BRCT Domain reveals an element essential for its role in nonhomologous end joining. Biochemistry (2007) 0.87
Nonhomologous DNA end joining in cell-free extracts. J Nucleic Acids (2010) 0.86
Essential factors for incompatible DNA end joining at chromosomal DNA double strand breaks in vivo. PLoS One (2011) 0.86
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Endoplasmic reticulum stress is involved in the response of human laryngeal carcinoma cells to Carboplatin but is absent in Carboplatin-resistant cells. PLoS One (2013) 0.83
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XLF deficiency results in reduced N-nucleotide addition during V(D)J recombination. Blood (2016) 0.81
The minimal Bacillus subtilis nonhomologous end joining repair machinery. PLoS One (2013) 0.81
Proofreading activity of DNA polymerase Pol2 mediates 3'-end processing during nonhomologous end joining in yeast. PLoS Genet (2008) 0.81
"Gate-keeper" residues and active-site rearrangements in DNA polymerase μ help discriminate non-cognate nucleotides. PLoS Comput Biol (2013) 0.81
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Characterization of terminal deoxynucleotidyl transferase and polymerase mu in zebrafish. Immunogenetics (2007) 0.79
DNA expansions generated by human Polμ on iterative sequences. Nucleic Acids Res (2012) 0.78
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Yeast pol4 promotes tel1-regulated chromosomal translocations. PLoS Genet (2013) 0.77
Integration of DNA damage and repair with murine double-minute 2 (Mdm2) in tumorigenesis. Int J Mol Sci (2012) 0.76
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Understanding and re-engineering nucleoprotein machines to cure human disease. Nanomedicine (Lond) (2008) 0.75
Role of the yeast DNA repair protein Nej1 in end processing during the repair of DNA double strand breaks by non-homologous end joining. DNA Repair (Amst) (2015) 0.75
Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight. PLoS One (2013) 0.75
Increased neuronal death and disturbed axonal growth in the Polμ-deficient mouse embryonic retina. Sci Rep (2016) 0.75
DNA stabilization at the Bacillus subtilis PolX core--a binding model to coordinate polymerase, AP-endonuclease and 3'-5' exonuclease activities. Nucleic Acids Res (2012) 0.75
Phaeocystis globosa Virus DNA Polymerase X: a "Swiss Army knife", Multifunctional DNA polymerase-lyase-ligase for Base Excision Repair. Sci Rep (2017) 0.75
Structural accommodation of ribonucleotide incorporation by the DNA repair enzyme polymerase Mu. Nucleic Acids Res (2017) 0.75
Strand specific RNA-sequencing and membrane lipid profiling reveals growth phase-dependent cold stress response mechanisms in Listeria monocytogenes. PLoS One (2017) 0.75
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