Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3.

PubWeight™: 1.27‹?› | Rank: Top 10%

🔗 View Article (PMID 15970596)

Published in J Biol Chem on June 21, 2005

Authors

Hongjie Yuan1, Kevin Erreger, Shashank M Dravid, Stephen F Traynelis

Author Affiliations

1: Department of Pharmacology, Emory University School of Medicine, Rollins Research Center, Atlanta, Georgia 30322-3090, USA.

Articles citing this

Glutamate receptor ion channels: structure, regulation, and function. Pharmacol Rev (2010) 11.25

Mechanism of differential control of NMDA receptor activity by NR2 subunits. Nature (2009) 2.64

Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci (2009) 2.19

Mechanistic Insight into NMDA Receptor Dysregulation by Rare Variants in the GluN2A and GluN2B Agonist Binding Domains. Am J Hum Genet (2016) 1.54

Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J Physiol (2007) 1.34

Functional analysis of a de novo GRIN2A missense mutation associated with early-onset epileptic encephalopathy. Nat Commun (2014) 1.29

Specific sites within the ligand-binding domain and ion channel linkers modulate NMDA receptor gating. J Neurosci (2010) 1.28

Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol (2011) 1.17

Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating. J Gen Physiol (2007) 1.16

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening. J Gen Physiol (2011) 1.05

Potentiation of Glycine-Gated NR1/NR3A NMDA Receptors Relieves Ca-Dependent Outward Rectification. Front Mol Neurosci (2010) 0.97

Interactions among positions in the third and fourth membrane-associated domains at the intersubunit interface of the N-methyl-D-aspartate receptor forming sites of alcohol action. J Biol Chem (2012) 0.96

Recent insights into the mode of action of memantine and ketamine. Curr Opin Pharmacol (2014) 0.94

Probing the activation sequence of NMDA receptors with lurcher mutations. J Gen Physiol (2012) 0.93

An NMDA receptor gating mechanism developed from MD simulations reveals molecular details underlying subunit-specific contributions. Biophys J (2013) 0.92

Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action. Br J Pharmacol (2007) 0.91

Ethanol inhibition of constitutively open N-methyl-D-aspartate receptors. J Pharmacol Exp Ther (2011) 0.90

GRIN2D Recurrent De Novo Dominant Mutation Causes a Severe Epileptic Encephalopathy Treatable with NMDA Receptor Channel Blockers. Am J Hum Genet (2016) 0.85

The effect of noise on CaMKII activation in a dendritic spine during LTP induction. J Neurophysiol (2010) 0.85

Different sites of alcohol action in the NMDA receptor GluN2A and GluN2B subunits. Neuropharmacology (2015) 0.83

Molecular Mechanism of Disease-Associated Mutations in the Pre-M1 Helix of NMDA Receptors and Potential Rescue Pharmacology. PLoS Genet (2017) 0.83

Key binding interactions for memantine in the NMDA receptor. ACS Chem Neurosci (2012) 0.82

A novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating. Mol Pharmacol (2013) 0.81

A de novo loss-of-function GRIN2A mutation associated with childhood focal epilepsy and acquired epileptic aphasia. PLoS One (2017) 0.79

The Hydrophobic Effect Contributes to the Closed State of a Simplified Ion Channel through a Conserved Hydrophobic Patch at the Pore-Helix Crossing. Front Pharmacol (2015) 0.78

Probing Intersubunit Interfaces in AMPA-subtype Ionotropic Glutamate Receptors. Sci Rep (2016) 0.78

Extracellular proton-modulated pore-blocking effect of the anticonvulsant felbamate on NMDA channels. Biophys J (2007) 0.77

Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. Br J Pharmacol (2010) 0.76

The differential contribution of GluN1 and GluN2 to the gating operation of the NMDA receptor channel. Pflugers Arch (2014) 0.76

Intersubunit interactions at putative sites of ethanol action in the M3 and M4 domains of the NMDA receptor GluN1 and GluN2B subunits. Br J Pharmacol (2016) 0.75

Functional Evaluation of a De Novo GRIN2A Mutation Identified in a Patient with Profound Global Developmental Delay and Refractory Epilepsy. Mol Pharmacol (2017) 0.75

Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. Nat Neurosci (2017) 0.75

Articles by these authors

Structural basis for partial agonist action at ionotropic glutamate receptors. Nat Neurosci (2003) 4.55

Subunit-specific gating controls rat NR1/NR2A and NR1/NR2B NMDA channel kinetics and synaptic signalling profiles. J Physiol (2005) 2.90

Activation of NR1/NR2B NMDA receptors. Nat Neurosci (2003) 2.47

Mechanism of Ca2+/calmodulin-dependent kinase II regulation of AMPA receptor gating. Nat Neurosci (2011) 2.31

Glutamate receptor gating. Crit Rev Neurobiol (2004) 2.31

Control of NMDA receptor function by the NR2 subunit amino-terminal domain. J Neurosci (2009) 2.19

Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol Pharmacol (2003) 1.91

Astrocytic control of synaptic NMDA receptors. J Physiol (2007) 1.85

Modulation of the dimer interface at ionotropic glutamate-like receptor delta2 by D-serine and extracellular calcium. J Neurosci (2009) 1.63

Activation of recombinant NR1/NR2C NMDA receptors. J Physiol (2008) 1.57

Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-D-aspartate glutamate receptors. Mol Pharmacol (2007) 1.56

Adenosine A(2A) receptor mediates microglial process retraction. Nat Neurosci (2009) 1.56

Common signaling pathways link activation of murine PAR-1, LPA, and S1P receptors to proliferation of astrocytes. Mol Pharmacol (2003) 1.55

Control of assembly and function of glutamate receptors by the amino-terminal domain. Mol Pharmacol (2010) 1.54

P2Y1 receptor signaling is controlled by interaction with the PDZ scaffold NHERF-2. Proc Natl Acad Sci U S A (2005) 1.48

The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia. Proc Natl Acad Sci U S A (2003) 1.40

A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors. Nat Commun (2010) 1.38

Syntaxin 1A interaction with the dopamine transporter promotes amphetamine-induced dopamine efflux. Mol Pharmacol (2008) 1.38

Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc Natl Acad Sci U S A (2007) 1.36

Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes. Exp Neurol (2004) 1.36

Subunit-specific mechanisms and proton sensitivity of NMDA receptor channel block. J Physiol (2007) 1.34

Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. J Neurosci (2005) 1.33

New advances in NMDA receptor pharmacology. Trends Pharmacol Sci (2011) 1.32

Structural aspects of AMPA receptor activation, desensitization and deactivation. Curr Opin Neurobiol (2007) 1.30

Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun (2011) 1.26

Modulation of glycine potency in rat recombinant NMDA receptors containing chimeric NR2A/2D subunits expressed in Xenopus laevis oocytes. J Physiol (2007) 1.24

Subunit-selective allosteric inhibition of glycine binding to NMDA receptors. J Neurosci (2012) 1.22

Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. J Neurosci (2009) 1.22

Protons trap NR1/NR2B NMDA receptors in a nonconducting state. J Neurosci (2005) 1.21

Activation of protease-activated receptor-1 triggers astrogliosis after brain injury. J Neurosci (2005) 1.21

Quinazolin-4-one derivatives: A novel class of noncompetitive NR2C/D subunit-selective N-methyl-D-aspartate receptor antagonists. J Med Chem (2010) 1.20

Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling. Mol Pharmacol (2005) 1.20

Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. J Neurosci (2010) 1.19

Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors. J Neurosci (2010) 1.18

Allosteric interaction between zinc and glutamate binding domains on NR2A causes desensitization of NMDA receptors. J Physiol (2005) 1.18

Structural and mechanistic determinants of a novel site for noncompetitive inhibition of GluN2D-containing NMDA receptors. J Neurosci (2011) 1.18

Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators. Mol Pharmacol (2011) 1.17

Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors. Mol Pharmacol (2013) 1.15

Caffeine-mediated inhibition of calcium release channel inositol 1,4,5-trisphosphate receptor subtype 3 blocks glioblastoma invasion and extends survival. Cancer Res (2010) 1.14

Zinc inhibition of rat NR1/NR2A N-methyl-D-aspartate receptors. J Physiol (2007) 1.09

Plasmin potentiates synaptic N-methyl-D-aspartate receptor function in hippocampal neurons through activation of protease-activated receptor-1. J Biol Chem (2008) 1.09

Allosteric regulation and spatial distribution of kainate receptors bound to ancillary proteins. J Physiol (2003) 1.09

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood. Brain (2014) 1.08

GluN1 splice variant control of GluN1/GluN2D NMDA receptors. J Physiol (2012) 1.04

PAR-1 deficiency protects against neuronal damage and neurologic deficits after unilateral cerebral hypoxia/ischemia. J Cereb Blood Flow Metab (2004) 1.02

Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. Proc Natl Acad Sci U S A (2005) 1.02

Behavioral analysis of NR2C knockout mouse reveals deficit in acquisition of conditioned fear and working memory. Neurobiol Learn Mem (2011) 1.01

The PDZ scaffold NHERF-2 interacts with mGluR5 and regulates receptor activity. J Biol Chem (2006) 1.00

The serine protease plasmin cleaves the amino-terminal domain of the NR2A subunit to relieve zinc inhibition of the N-methyl-D-aspartate receptors. J Biol Chem (2009) 0.99

Sodium channel activation augments NMDA receptor function and promotes neurite outgrowth in immature cerebrocortical neurons. J Neurosci (2009) 0.97

Protease-activated receptor 1-dependent neuronal damage involves NMDA receptor function. Exp Neurol (2009) 0.97

Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. Protein Sci (2005) 0.96

PAR1 and PAR2 couple to overlapping and distinct sets of G proteins and linked signaling pathways to differentially regulate cell physiology. Mol Pharmacol (2010) 0.96

Molecular pharmacology of human NMDA receptors. Neurochem Int (2011) 0.96

Deletion of glutamate delta-1 receptor in mouse leads to aberrant emotional and social behaviors. PLoS One (2012) 0.95

Differential regulation of microglial motility by ATP/ADP and adenosine. Parkinsonism Relat Disord (2009) 0.94

Learning and memory deficits in mice lacking protease activated receptor-1. Neurobiol Learn Mem (2007) 0.93

S-nitrosylation of AMPA receptor GluA1 regulates phosphorylation, single-channel conductance, and endocytosis. Proc Natl Acad Sci U S A (2012) 0.93

Missense dopamine transporter mutations associate with adult parkinsonism and ADHD. J Clin Invest (2014) 0.92

Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Mol Pharmacol (2012) 0.92

Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus. Mol Brain (2011) 0.92

Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. J Pharmacol Exp Ther (2010) 0.92

A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2. A mutagenic, kinetic, and crystallographic study. J Biol Chem (2005) 0.92

Norepinephrine modulates the motility of resting and activated microglia via different adrenergic receptors. J Biol Chem (2013) 0.92

Systemic inflammation regulates microglial responses to tissue damage in vivo. Glia (2014) 0.90

Protease-activated receptor 1 (PAR1) coupling to G(q/11) but not to G(i/o) or G(12/13) is mediated by discrete amino acids within the receptor second intracellular loop. Cell Signal (2012) 0.89

Contribution of the M1 transmembrane helix and pre-M1 region to positive allosteric modulation and gating of N-methyl-D-aspartate receptors. Mol Pharmacol (2013) 0.89

N-Hydroxypyrazolyl glycine derivatives as selective N-methyl-D-aspartic acid receptor ligands. J Med Chem (2008) 0.88

Novel NMDA receptor modulators: an update. Expert Opin Ther Pat (2012) 0.87

Effect of ifenprodil on GluN1/GluN2B N-methyl-D-aspartate receptor gating. Mol Pharmacol (2012) 0.86

Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorg Med Chem (2009) 0.86

Protease activated receptor 1-induced glutamate release in cultured astrocytes is mediated by Bestrophin-1 channel but not by vesicular exocytosis. Mol Brain (2012) 0.86

Synthesis and structure activity relationship of tetrahydroisoquinoline-based potentiators of GluN2C and GluN2D containing N-methyl-D-aspartate receptors. J Med Chem (2013) 0.86

Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery. Clin Neurosurg (2005) 0.85

Exacerbation of dopaminergic terminal damage in a mouse model of Parkinson's disease by the G-protein-coupled receptor protease-activated receptor 1. Mol Pharmacol (2007) 0.85

PKC phosphorylates GluA1-Ser831 to enhance AMPA receptor conductance. Channels (Austin) (2012) 0.84

Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat. Eur J Neurosci (2013) 0.83

Design, synthesis, and structure-activity relationship of a novel series of GluN2C-selective potentiators. J Med Chem (2014) 0.83

Crystal structure and pharmacological characterization of a novel N-methyl-D-aspartate (NMDA) receptor antagonist at the GluN1 glycine binding site. J Biol Chem (2013) 0.83

NMDA receptor modulators: an updated patent review (2013-2014). Expert Opin Ther Pat (2014) 0.82

Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Mol Brain (2008) 0.82

Regulation of GluA1 α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor function by protein kinase C at serine-818 and threonine-840. Mol Pharmacol (2014) 0.81

The genetics of neuropsychiatric diseases: looking in and beyond the exome. Annu Rev Neurosci (2015) 0.81

Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. J Med Chem (2008) 0.81

Structure-activity relationships and pharmacophore model of a noncompetitive pyrazoline containing class of GluN2C/GluN2D selective antagonists. J Med Chem (2013) 0.81

Modal gating of GluN1/GluN2D NMDA receptors. Neuropharmacology (2013) 0.81

Channel-mediated astrocytic glutamate modulates hippocampal synaptic plasticity by activating postsynaptic NMDA receptors. Mol Brain (2015) 0.79

Mutations in the transmembrane domain M3 generate spontaneously open orphan glutamate δ1 receptor. Brain Res (2011) 0.79

Deletion of glutamate delta-1 receptor in mouse leads to enhanced working memory and deficit in fear conditioning. PLoS One (2013) 0.79

L-type calcium channel activity in osteoblast cells is regulated by the actin cytoskeleton independent of protein trafficking. J Bone Miner Metab (2011) 0.79

Glutamate receptors: variation in structure-function coupling. Trends Pharmacol Sci (2006) 0.78

Neuroscience: an intrusive chaperone. Nature (2005) 0.78

How glutamate receptor subunits mix and match: details uncovered. Neuron (2011) 0.77