Published in Neurobiol Aging on June 23, 2005
ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain. Neurobiol Aging (2007) 1.24
Dissociation of neuropathologic findings and cognition: case report of an apolipoprotein E epsilon2/epsilon2 genotype. Arch Neurol (2007) 1.22
Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. J Neurosci Methods (2011) 1.00
Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer's disease. Acta Neuropathol (2011) 0.96
Hsp90 chaperone inhibitor 17-AAG attenuates Aβ-induced synaptic toxicity and memory impairment. J Neurosci (2014) 0.95
Apolipoprotein E and cholesterol in aging and disease in the brain. Future Lipidol (2008) 0.94
Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. Acta Neuropathol (2011) 0.90
Cerebrospinal fluid biomarkers of Alzheimer's disease in healthy elderly. Front Biosci (Landmark Ed) (2013) 0.89
APOE ε4, Alzheimer's disease pathology, cerebrovascular disease, and cognitive change over the years prior to death. Psychol Aging (2013) 0.87
DHA-PC and PSD-95 decrease after loss of synaptophysin and before neuronal loss in patients with Alzheimer's disease. Sci Rep (2014) 0.87
Is synaptic loss a unique hallmark of Alzheimer's disease? Biochem Pharmacol (2014) 0.87
Possible Alzheimer's disease in an apolipoprotein E2 homozygote. J Alzheimers Dis (2009) 0.80
Synaptic protein α1-takusan mitigates amyloid-β-induced synaptic loss via interaction with tau and postsynaptic density-95 at postsynaptic sites. J Neurosci (2013) 0.79
Synaptic protein levels altered in vascular dementia. Neuropathol Appl Neurobiol (2015) 0.78
Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability. Alzheimers Dement (2016) 0.78
APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations. Ann Neurol (2016) 0.77
Synaptophysin depletion and intraneuronal Aβ in organotypic hippocampal slice cultures from huAPP transgenic mice. Mol Neurodegener (2016) 0.76
Protective effects of APOE e2 against disease progression in subcortical vascular mild cognitive impairment patients: A three-year longitudinal study. Sci Rep (2017) 0.75
Probable early-onset Alzheimer's disease in an apolipoprotein E2 homozygote. Dement Geriatr Cogn Disord (2010) 0.75
In Vivo Characterization of ARN14140, a Memantine/Galantamine-Based Multi-Target Compound for Alzheimer's Disease. Sci Rep (2016) 0.75
Identification of the Role of miR-142-5p in Alzheimer's Disease by Comparative Bioinformatics and Cellular Analysis. Front Mol Neurosci (2017) 0.75
Sevoflurane Acts on Ubiquitination-Proteasome Pathway to Reduce Postsynaptic Density 95 Protein Levels in Young Mice. Anesthesiology (2017) 0.75
Effect of APOE Genotype on Synaptic Proteins in Earlier Adult Life. J Alzheimers Dis (2017) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet (2008) 25.83
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
A life course approach to chronic disease epidemiology: conceptual models, empirical challenges and interdisciplinary perspectives. Int J Epidemiol (2002) 15.31
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet (2010) 7.94
Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet (2008) 7.31
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis. Lancet (2012) 4.87
Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. Lancet (2012) 4.63
The accuracy of diagnosis of parkinsonian syndromes in a specialist movement disorder service. Brain (2002) 4.16
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. Diabetes (2008) 3.76
Variations in the G6PC2/ABCB11 genomic region are associated with fasting glucose levels. J Clin Invest (2008) 3.51
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet (2012) 3.21
Equity in access to total joint replacement of the hip and knee in England: cross sectional study. BMJ (2010) 3.16
The effect of rural-to-urban migration on obesity and diabetes in India: a cross-sectional study. PLoS Med (2010) 3.16
90-day mortality after 409,096 total hip replacements for osteoarthritis, from the National Joint Registry for England and Wales: a retrospective analysis. Lancet (2013) 3.00
Comparison of the associations of body mass index and measures of central adiposity and fat mass with coronary heart disease, diabetes, and all-cause mortality: a study using data from 4 UK cohorts. Am J Clin Nutr (2010) 2.82
Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control (2008) 2.68
A common haplotype of the glucokinase gene alters fasting glucose and birth weight: association in six studies and population-genetics analyses. Am J Hum Genet (2006) 2.44
Ethnicity, socio-economic position and gender--do they affect reported health-care seeking behaviour? Soc Sci Med (2003) 2.43
An analysis of prospective risk factors for aortic stiffness in men: 20-year follow-up from the Caerphilly prospective study. Hypertension (2010) 2.40
Does psychological distress predict the risk of ischemic stroke and transient ischemic attack? The Caerphilly Study. Stroke (2002) 2.30
Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biol Psychiatry (2005) 2.27
Sociodemographic patterning of non-communicable disease risk factors in rural India: a cross sectional study. BMJ (2010) 2.21
Association between birth weight and blood pressure is robust, amplifies with age, and may be underestimated. Hypertension (2006) 2.14
Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials. Int J Geriatr Psychiatry (2004) 2.09
The influence of absolute cardiovascular risk, patient utilities, and costs on the decision to treat hypertension: a Markov decision analysis. J Hypertens (2003) 2.09
45-day mortality after 467,779 knee replacements for osteoarthritis from the National Joint Registry for England and Wales: an observational study. Lancet (2014) 2.00
Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force. Alzheimers Dement (2013) 1.98
SITAR--a useful instrument for growth curve analysis. Int J Epidemiol (2010) 1.92
Which hemostatic markers add to the predictive value of conventional risk factors for coronary heart disease and ischemic stroke? The Caerphilly Study. Circulation (2005) 1.89
Cortisol, testosterone, and coronary heart disease: prospective evidence from the Caerphilly study. Circulation (2005) 1.84
Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet (2011) 1.82
Mothers' anxiety during pregnancy is associated with asthma in their children. J Allergy Clin Immunol (2009) 1.82
Systematic review: accuracy of anti-citrullinated Peptide antibodies for diagnosing rheumatoid arthritis. Ann Intern Med (2010) 1.78
Investigating Black-White differences in prostate cancer prognosis: A systematic review and meta-analysis. Int J Cancer (2008) 1.73
Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study. Am J Clin Nutr (2007) 1.73
A genome-wide association search for type 2 diabetes genes in African Americans. PLoS One (2012) 1.72
Life course trajectories of systolic blood pressure using longitudinal data from eight UK cohorts. PLoS Med (2011) 1.71
Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity. Hypertension (2008) 1.64
Is relative leg length a biomarker of childhood nutrition? Long-term follow-up of the Hyderabad Nutrition Trial. Int J Epidemiol (2011) 1.61
Rural MBBS degree in India. Lancet (2010) 1.55
Predicting the time of conversion to MCI in the elderly: role of verbal expression and learning. Neurology (2009) 1.54
The risk of prostate cancer amongst South Asian men in southern England: the PROCESS cohort study. BJU Int (2008) 1.53
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals. Am J Hum Genet (2007) 1.52
Association between pre- and perinatal exposures and Tourette syndrome or chronic tic disorder in the ALSPAC cohort. Br J Psychiatry (2013) 1.51
Clinical relevance of the neurotrophins and their receptors. Clin Sci (Lond) (2006) 1.48
Age and gender differences in physical capability levels from mid-life onwards: the harmonisation and meta-analysis of data from eight UK cohort studies. PLoS One (2011) 1.45
The effectiveness and reliability of peer-marking in first-year medical students. Med Educ (2006) 1.39
Genetic regulation of birth weight and fasting glucose by a common polymorphism in the islet cell promoter of the glucokinase gene. Diabetes (2005) 1.38
alpha- and beta-secretase: profound changes in Alzheimer's disease. Biochem Biophys Res Commun (2002) 1.37
Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain. Pain (2010) 1.37
Multiple sclerosis risk sharing scheme: two year results of clinical cohort study with historical comparator. BMJ (2009) 1.37
Resting functional connectivity reveals residual functional activity in Alzheimer's disease. Biol Psychiatry (2013) 1.33
Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. PLoS One (2013) 1.32
Structural MRI changes detectable up to ten years before clinical Alzheimer's disease. Neurobiol Aging (2011) 1.32
Association of body mass index measured in childhood, adolescence, and young adulthood with risk of ischemic heart disease and stroke: findings from 3 historical cohort studies. Am J Clin Nutr (2006) 1.30
A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations. Diabetes (2002) 1.29
Childhood socioeconomic position and objectively measured physical capability levels in adulthood: a systematic review and meta-analysis. PLoS One (2011) 1.28
The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One (2008) 1.28
Traditional finals and OSCEs in predicting consultant and self-reported clinical skills of PRHOs: a pilot study. Med Educ (2003) 1.27
Environmental equity, air quality, socioeconomic status, and respiratory health: a linkage analysis of routine data from the Health Survey for England. J Epidemiol Community Health (2005) 1.26
Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease? Lancet Neurol (2007) 1.26
Targeting nerve growth factor in pain: what is the therapeutic potential? BioDrugs (2008) 1.26
How likely are older people to take up different falls prevention activities? Prev Med (2008) 1.24
Timing of puberty determines serum insulin-like growth factor-I in late adulthood. J Clin Endocrinol Metab (2006) 1.23
Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS). J Epidemiol Community Health (2011) 1.23
Survival in multiple system atrophy. Mov Disord (2008) 1.23
The etiopathogenesis of Parkinson disease and suggestions for future research. Part I. J Neuropathol Exp Neurol (2007) 1.21
Biological activity of nerve growth factor precursor is dependent upon relative levels of its receptors. J Biol Chem (2009) 1.21
The motor phenotype of Parkinson's disease in relation to age at onset. Mov Disord (2011) 1.20
How common are complications of Parkinson's disease? J Neurol (2002) 1.19
Brain-derived neurotrophic factor drives the changes in excitatory synaptic transmission in the rat superficial dorsal horn that follow sciatic nerve injury. J Physiol (2009) 1.19
Population prevalence of Tourette syndrome: a systematic review and meta-analysis. Mov Disord (2014) 1.16
Prevalence of Tourette syndrome and chronic tics in the population-based Avon longitudinal study of parents and children cohort. J Am Acad Child Adolesc Psychiatry (2011) 1.15
Systematic review and UK-based study of PARK2 (parkin), PINK1, PARK7 (DJ-1) and LRRK2 in early-onset Parkinson's disease. Mov Disord (2012) 1.14
Accuracy of clinical diagnosis of progressive supranuclear palsy. Mov Disord (2004) 1.14
Insulin resistance and depressive symptoms in middle aged men: findings from the Caerphilly prospective cohort study. BMJ (2005) 1.14
Associations of anti-hypertensive treatments with Alzheimer's disease, vascular dementia, and other dementias. J Alzheimers Dis (2011) 1.13
Gender and age inequity in the provision of coronary revascularisation in England in the 1990s: is it getting better? Soc Sci Med (2004) 1.12
Productive herpes simplex virus in brain of elderly normal subjects and Alzheimer's disease patients. J Med Virol (2005) 1.12
Haplotypes extending across ACE are associated with Alzheimer's disease. Hum Mol Genet (2003) 1.11
Auditory threshold, phonologic demand, and incident dementia. Neurology (2012) 1.11
Prenatal maternal mood is associated with altered diurnal cortisol in adolescence. Psychoneuroendocrinology (2013) 1.10
ACTN3 genotype, athletic status, and life course physical capability: meta-analysis of the published literature and findings from nine studies. Hum Mutat (2011) 1.10
Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis. J Urol (2005) 1.10
Real epidemiologists don't do ecological studies? Int J Epidemiol (2005) 1.10
Risk and presenting features of prostate cancer amongst African-Caribbean, South Asian and European men in North-east London. BJU Int (2006) 1.09
Life course trajectories of alcohol consumption in the United Kingdom using longitudinal data from nine cohort studies. BMC Med (2015) 1.08
Cytomegalovirus is present in a very high proportion of brains from vascular dementia patients. Neurobiol Dis (2002) 1.07
Associations of growth trajectories in infancy and early childhood with later childhood outcomes. Am J Clin Nutr (2011) 1.07
Geographical variation in the provision of elective primary hip and knee replacement: the role of socio-demographic, hospital and distance variables. J Public Health (Oxf) (2009) 1.07
The associations of interleukin-6 (IL-6) and downstream inflammatory markers with risk of cardiovascular disease: the Caerphilly Study. Atherosclerosis (2009) 1.07