Published in Eur J Biochem on October 15, 1979
Variations in cross-bridge attachment rate and tension with phosphorylation of myosin in mammalian skinned skeletal muscle fibers. Implications for twitch potentiation in intact muscle. J Gen Physiol (1989) 2.83
A Xenopus oocyte beta subunit: evidence for a role in the assembly/expression of voltage-gated calcium channels that is separate from its role as a regulatory subunit. Proc Natl Acad Sci U S A (1997) 1.88
A synthetic peptide substrate specific for casein kinase II. Proc Natl Acad Sci U S A (1985) 1.79
Identification of calmodulin-dependent protein kinase III and its major Mr 100,000 substrate in mammalian tissues. Proc Natl Acad Sci U S A (1985) 1.58
Function of a calmodulin in postsynaptic densities. II. Presence of a calmodulin-activatable protein kinase activity. J Cell Biol (1981) 1.34
The role of calcium ions in the mechanism of action of alpha-adrenergic agonists in rat liver. Biochem J (1984) 1.28
Isolation and characterization of calmodulin from spinach leaves and in vitro translation mixtures. Proc Natl Acad Sci U S A (1980) 1.25
Interactive properties of calmodulin. Biochem J (1988) 1.19
Calmodulin-microtubule association in cultured mammalian cells. J Cell Biol (1984) 1.06
Regulation of microtubule cold stability by calmodulin-dependent and -independent phosphorylation. Proc Natl Acad Sci U S A (1983) 1.02
Acetylation negatively regulates glycogen phosphorylase by recruiting protein phosphatase 1. Cell Metab (2012) 1.02
Cloning and sequencing of a calcium-binding protein regulated by cyclic AMP in the thyroid. EMBO J (1989) 0.95
Interactions of basic polypeptides and proteins with calmodulin. Biochem J (1980) 0.95
Phosphorylation in isolated Chlamydomonas axonemes: a phosphoprotein may mediate the Ca2+-dependent photophobic response. J Cell Biol (1985) 0.93
Protein kinase activity associated with pancreatic zymogen granules. Biochem J (1985) 0.85
Single molecule analyses of the conformational substates of calmodulin bound to the phosphorylase kinase complex. Protein Sci (2007) 0.80
The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft. Trends Endocrinol Metab (2016) 0.79
I/Lyn mouse phosphorylase kinase deficiency: mutation disrupts expression of the alpha/alpha'-subunit mRNAs. Proc Natl Acad Sci U S A (1989) 0.78
Cyclic AMP-independent casein/glycogen synthase kinases from pig polymorphonuclear leucocytes. Biochem J (1981) 0.78
The quaternary structure of phosphorylase kinase as influenced by low concentrations of urea. Evidence suggesting a structural role for calmodulin. Biochem J (1990) 0.78
Baculovirus-directed expression of the gamma-subunit of phosphorylase kinase: purification and calmodulin dependence. Biochem J (1994) 0.77
Reduced cAMP levels and glycogen phosphorylase activation in isoproterenol perfused SHR myocardium. Basic Res Cardiol (1984) 0.77
Neural regulation of the formation of skeletal muscle phosphorylase kinase holoenzyme in adult and developing rat muscle. Biochem J (1997) 0.76
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature (1996) 26.30
Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J (2000) 22.23
Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J (1996) 16.68
Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Balpha. Curr Biol (1997) 15.32
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem (1995) 14.14
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett (1995) 9.62
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell (1994) 8.52
GSK3 takes centre stage more than 20 years after its discovery. Biochem J (2001) 7.74
Role of translocation in the activation and function of protein kinase B. J Biol Chem (1997) 7.29
The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Arch Gen Psychiatry (1998) 6.34
Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett (1990) 6.20
Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase. FEBS Lett (1996) 6.16
Activation of the MAP kinase pathway by the protein kinase raf. Cell (1992) 5.95
Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1. Science (1998) 5.62
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J (1993) 5.60
The role of protein phosphorylation in neural and hormonal control of cellular activity. Nature (1982) 5.30
Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature (1994) 5.17
Paradoxical activation of Raf by a novel Raf inhibitor. Chem Biol (1999) 4.98
MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J (1992) 4.97
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biol Chem (1999) 4.83
Leptin-specific patterns of gene expression in white adipose tissue. Genes Dev (2000) 4.57
The psychosocial etiology of adolescent drug use: a family interactional approach. Genet Soc Gen Psychol Monogr (1990) 4.49
Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem (1980) 4.43
An electrophoretic study of the low-molecular-weight components of myosin. Biochem J (1970) 4.37
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J (1994) 4.37
Dissection of the protein kinase cascade by which nerve growth factor activates MAP kinases. Nature (1991) 4.35
On target with a new mechanism for the regulation of protein phosphorylation. Trends Biochem Sci (1993) 4.30
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature (1989) 4.27
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells. Curr Biol (2000) 4.24
Mechanism of activation and function of protein kinase B. Curr Opin Genet Dev (1998) 4.22
Structural basis for the recognition of regulatory subunits by the catalytic subunit of protein phosphatase 1. EMBO J (1997) 4.05
A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation. Mol Cell (2001) 4.01
Suppressor T cells. J Immunol (1972) 3.92
Protein phosphatase-1 and protein phosphatase-2A from rabbit skeletal muscle. Methods Enzymol (1988) 3.88
Protein phosphatases come of age. J Biol Chem (1989) 3.77
Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature (1995) 3.77
Long-term followup of polyarteritis nodosa, microscopic polyangiitis, and Churg-Strauss syndrome: analysis of four prospective trials including 278 patients. Arthritis Rheum (2001) 3.67
The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle. Nature (1990) 3.63
A prospective, multicenter, randomized trial comparing steroids and pulse cyclophosphamide versus steroids and oral cyclophosphamide in the treatment of generalized Wegener's granulomatosis. Arthritis Rheum (1997) 3.62
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. EMBO J (1996) 3.51
Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons. Nature (1999) 3.50
Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients. Medicine (Baltimore) (1999) 3.50
MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin. Nature (1992) 3.49
Identification of the NH2-terminal blocking group of calcineurin B as myristic acid. FEBS Lett (1982) 3.42
The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature (1998) 3.41
Association between cigarette smoking and anxiety disorders during adolescence and early adulthood. JAMA (2000) 3.38
Beyond the dopamine receptor: the DARPP-32/protein phosphatase-1 cascade. Neuron (1999) 3.36
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem (1998) 3.29
The search for physiological substrates of MAP and SAP kinases in mammalian cells. Trends Cell Biol (1997) 3.26
The subunit structure of rabbit-skeletal-muscle phosphorylase kinase, and the molecular basis of its activation reactions. Eur J Biochem (1973) 3.12
Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J (1994) 3.11
Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins. Proc Natl Acad Sci U S A (1994) 3.09
Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5. Nature (2001) 3.09
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett (1992) 3.07
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epithelium. Nature (1988) 3.06
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol (1994) 3.06
Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity. Biochemistry (1992) 3.05
Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1. Biochem J (1999) 3.03
Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell (1992) 2.99
FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J (1996) 2.98
Childhood abuse and neglect: specificity of effects on adolescent and young adult depression and suicidality. J Am Acad Child Adolesc Psychiatry (1999) 2.96
Mental health service use in the community and schools: results from the four-community MECA Study. Methods for the Epidemiology of Child and Adolescent Mental Disorders Study. J Am Acad Child Adolesc Psychiatry (1996) 2.94
Two-year results of treatment with depot leuprolide acetate for central precocious puberty. J Pediatr (1992) 2.93
Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation. Immunity (1998) 2.92
One of the protein phosphatase 1 isoenzymes in Drosophila is essential for mitosis. Cell (1990) 2.91
Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiol Rev (1999) 2.89
Identification of the Ca2+-dependent modulator protein as the fourth subunit of rabbit skeletal muscle phosphorylase kinase. FEBS Lett (1978) 2.86
Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture. Proc Natl Acad Sci U S A (1980) 2.84
Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. Proc Natl Acad Sci U S A (1994) 2.84
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathway. FEBS Lett (2001) 2.83
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf. Methods Enzymol (1995) 2.82
Cdc2 H1 kinase is negatively regulated by a type 2A phosphatase in the Xenopus early embryonic cell cycle: evidence from the effects of okadaic acid. EMBO J (1990) 2.81
Discovery of a Ca2+- and calmodulin-dependent protein phosphatase: probable identity with calcineurin (CaM-BP80). FEBS Lett (1982) 2.75
DARPP-32, a dopamine-regulated neuronal phosphoprotein, is a potent inhibitor of protein phosphatase-1. Nature (1984) 2.74
The role of protein phosphorylation in the hormonal control of enzyme activity. Eur J Biochem (1985) 2.74
Conversion of SB 203580-insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem Biol (1998) 2.73
Activation of protein kinase B beta and gamma isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B alpha. Biochem J (1998) 2.73
Childhood maltreatment increases risk for personality disorders during early adulthood. Arch Gen Psychiatry (1999) 2.73
Prognostic factors in polyarteritis nodosa and Churg-Strauss syndrome. A prospective study in 342 patients. Medicine (Baltimore) (1996) 2.72
MAP kinase activator from insulin-stimulated skeletal muscle is a protein threonine/tyrosine kinase. EMBO J (1992) 2.71
Stress-activated protein kinase-2/p38 and a rapamycin-sensitive pathway are required for C2C12 myogenesis. J Biol Chem (1999) 2.70
The Diagnostic Interview Schedule for Children-Revised Version (DISC-R): I. Preparation, field testing, interrater reliability, and acceptability. J Am Acad Child Adolesc Psychiatry (1993) 2.69
Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest (1995) 2.65
Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart. Nature (1976) 2.65
The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor. EMBO J (1996) 2.64
Protein phosphatases: properties and role in cellular regulation. Science (1983) 2.61
Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane. Nature (1991) 2.60
A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta. EMBO J (2001) 2.60
Protein phosphatases: recent progress. Adv Second Messenger Phosphoprotein Res (1991) 2.57
The clinician's illusion. Arch Gen Psychiatry (1984) 2.55
Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing. Nucleic Acids Res (1992) 2.53
Eukaryotic organisms in Proterozoic oceans. Philos Trans R Soc Lond B Biol Sci (2006) 2.52