PubRank

S J Heales

Author PubWeight™ 45.07‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Hum Mol Genet 2005 4.12
2 Nitric oxide-mediated inhibition of the mitochondrial respiratory chain in cultured astrocytes. J Neurochem 1994 1.67
3 Effect of peroxynitrite on the mitochondrial respiratory chain: differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 1995 1.66
4 Adaptation of the nitrate reductase and Griess reaction methods for the measurement of serum nitrate plus nitrite levels. Ann Clin Biochem 1997 1.63
5 Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol 2001 1.40
6 Nitric oxide produced by activated astrocytes rapidly and reversibly inhibits cellular respiration. Neurosci Lett 1995 1.34
7 Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases. J Neurochem 1997 1.33
8 Cerebrospinal fluid concentrations of pterins and metabolites of serotonin and dopamine in a pediatric reference population. Pediatr Res 1993 1.22
9 Nitric oxide-mediated mitochondrial damage: a potential neuroprotective role for glutathione. Free Radic Biol Med 1996 1.14
10 Interrelationships between astrocyte function, oxidative stress and antioxidant status within the central nervous system. Prog Neurobiol 1997 1.07
11 Evidence for increased nitric oxide production in multiple sclerosis. J Neurol Neurosurg Psychiatry 1995 1.03
12 Peroxynitrite and brain mitochondria: evidence for increased proton leak. J Neurochem 1998 1.02
13 Age dependent changes in the cerebrospinal fluid concentration of nitrite and nitrate. Ann Clin Biochem 1996 0.99
14 Tetrahydrobiopterin deficiency and brain nitric oxide synthase in the hph1 mouse. J Inherit Metab Dis 1995 0.97
15 Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene. Hum Mol Genet 1996 0.97
16 The potential role of nitric oxide in multiple sclerosis. Mult Scler 1998 0.96
17 The assumption that nitric oxide inhibits mitochondrial ATP synthesis is correct. FEBS Lett 1999 0.96
18 Neurochemical effects following peripheral administration of tetrahydropterin derivatives to the hph-1 mouse. J Neurochem 1996 0.95
19 Glutamate neurotoxicity is associated with nitric oxide-mediated mitochondrial dysfunction and glutathione depletion. Brain Res 1998 0.93
20 Effects of 1-methyl-4-phenylpyridinium on isolated rat brain mitochondria: evidence for a primary involvement of energy depletion. J Neurochem 1994 0.89
21 Activation of neuronal nitric-oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor. J Biol Chem 1999 0.87
22 Postnatal development of the complexes of the electron transport chain in isolated rat brain mitochondria. Dev Neurosci 1994 0.87
23 Mitochondrial respiratory chain defects are not accompanied by an increase in the activities of lactate dehydrogenase or manganese superoxide dismutase in paediatric skeletal muscle biopsies. J Inherit Metab Dis 1999 0.87
24 Tetrahydrobiopterin regulates cyclic GMP-dependent electrogenic Cl- secretion in mouse ileum in vitro. J Physiol 1997 0.87
25 Elevated cerebrospinal fluid and serum nitrate and nitrite levels in patients with central nervous system complications of HIV-1 infection: a correlation with blood-brain-barrier dysfunction. J Neurol Sci 1998 0.87
26 Development of pharmacological strategies for mitochondrial disorders. Br J Pharmacol 2014 0.87
27 Glutathione protects astrocytes from peroxynitrite-mediated mitochondrial damage: implications for neuronal/astrocytic trafficking and neurodegeneration. Dev Neurosci 1996 0.86
28 Raised serum nitrate and nitrite levels in patients with multiple sclerosis. J Neurol Sci 1997 0.85
29 Stimulation of the brain NO/cyclic GMP pathway by peripheral administration of tetrahydrobiopterin in the hph-1 mouse. J Neurochem 1999 0.84
30 Inhibition of tetrahydrobiopterin synthesis reduces in vivo nitric oxide production in experimental endotoxic shock. Biochem Biophys Res Commun 1996 0.84
31 Astrocyte-derived nitric oxide causes both reversible and irreversible damage to the neuronal mitochondrial respiratory chain. J Neurochem 2000 0.83
32 Depletion of brain glutathione results in a decrease of glutathione reductase activity; an enzyme susceptible to oxidative damage. Brain Res 1996 0.83
33 Catalase deficiency, diabetes, and mitochondrial function. Lancet 2001 0.83
34 Intravenous L-carnitine and acetyl-L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency and isovaleric acidemia. Pediatr Res 1994 0.83
35 Impairment of the nitric oxide/cyclic GMP pathway in cerebellar slices prepared from the hph-1 mouse. Brain Res 1996 0.82
36 Effect of treatment with glycine and L-carnitine in medium-chain acyl-coenzyme A dehydrogenase deficiency. J Pediatr 1993 0.82
37 Evaluation of the efficacy of potential therapeutic agents at protecting against nitric oxide synthase-mediated mitochondrial damage in activated astrocytes. Brain Res Brain Res Protoc 1997 0.81
38 Potential mechanisms for nitric oxide-mediated impairment of brain mitochondrial energy metabolism. Biochem Soc Trans 1997 0.79
39 Pretreatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase. J Neurochem 1997 0.79
40 Pretreatment of astrocytes with interferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage. J Neurochem 1998 0.79
41 Astrocyte nitric oxide causes neuronal mitochondrial damage, but antioxidant release limits neuronal cell death. Ann N Y Acad Sci 1999 0.78
42 Decreased endothelial cell glutathione and increased sensitivity to oxidative stress in an in vitro blood-brain barrier model system. Brain Res 1998 0.78
43 Increased inducible nitric oxide synthase protein but limited nitric oxide formation occurs in astrocytes of the hph-1 (tetrahydrobiopterin deficient) mouse. Brain Res 1998 0.76
44 Increased urinary nitric oxide metabolites in patients with multiple sclerosis correlates with early and relapsing disease. Mult Scler 1999 0.76
45 Comparison of mitochondrial respiratory chain enzyme activities in rodent astrocytes and neurones and a human astrocytoma cell line. Neurosci Lett 1998 0.76
46 Nitric oxide and antioxidant status in glucose and oxygen deprived neonatal and adult rat brain synaptosomes. Neurochem Res 1996 0.75
47 Paroxysmal dystonic choreoathetosis: clinical features and investigation of pathophysiology in a large family. Mov Disord 2000 0.75
48 Astrocytic mitochondrial respiratory chain complex I activity and cellular GSH status. Biochem Soc Trans 1998 0.75
49 Peroxynitrite causes proton leak in brain mitochondria. Biochem Soc Trans 1998 0.75
50 Peroxynitrite anion stimulates arginine release from cultured rat astrocytes. J Neurochem 1999 0.75
51 Astrocytic mitochondrial respiratory chain damage: effect on cellular ATP levels. Biochem Soc Trans 1998 0.75
52 Tetrahydrobiopterin and quinonoid dihydrobiopterin concentrations in CSF from patients with dihydropteridine reductase deficiency. J Inherit Metab Dis 1993 0.75
53 The determination of methaemoglobin levels by first derivative spectroscopy. Clin Chim Acta 1985 0.75
54 Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin. FEBS Lett 1997 0.75
55 The investigation of inborn errors in vivo using stable isotopes. Eur J Pediatr 1994 0.75
56 Stimulation of glyceraldehyde-3-phosphate dehydrogenase by oxyhemoglobin. Biochem Soc Trans 1998 0.75
57 Effect of astrocytic nitric oxide production on neuronal mitochondrial activity. Biochem Soc Trans 1997 0.75
58 The diagnosis of carnitine palmitoyltransferase II deficiency is now possible in small skeletal muscle biopsies. J Inherit Metab Dis 2000 0.75