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1
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Liver-specific deletion of the NADPH-cytochrome P450 reductase gene: impact on plasma cholesterol homeostasis and the function and regulation of microsomal cytochrome P450 and heme oxygenase.
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J Biol Chem
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2003
|
1.88
|
|
2
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Determination of the role of target tissue metabolism in lung carcinogenesis using conditional cytochrome P450 reductase-null mice.
|
Cancer Res
|
2007
|
1.44
|
|
3
|
Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling.
|
Nat Neurosci
|
2010
|
1.30
|
|
4
|
In vivo mechanisms of tissue-selective drug toxicity: effects of liver-specific knockout of the NADPH-cytochrome P450 reductase gene on acetaminophen toxicity in kidney, lung, and nasal mucosa.
|
Mol Pharmacol
|
2004
|
1.30
|
|
5
|
Regulation of the cytochrome P450 2A genes.
|
Toxicol Appl Pharmacol
|
2004
|
1.29
|
|
6
|
Role of CYP2A5 in the clearance of nicotine and cotinine: insights from studies on a Cyp2a5-null mouse model.
|
J Pharmacol Exp Ther
|
2009
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1.29
|
|
7
|
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
|
J Biol Chem
|
2005
|
1.24
|
|
8
|
CYP2A13: variable expression and role in human lung microsomal metabolic activation of the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
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J Pharmacol Exp Ther
|
2007
|
1.22
|
|
9
|
Transgenic mice with a hypomorphic NADPH-cytochrome P450 reductase gene: effects on development, reproduction, and microsomal cytochrome P450.
|
J Pharmacol Exp Ther
|
2004
|
1.19
|
|
10
|
Mycobacterium tuberculosis Rv3586 (DacA) is a diadenylate cyclase that converts ATP or ADP into c-di-AMP.
|
PLoS One
|
2012
|
1.17
|
|
11
|
Comparative metabolism of the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol by rat cytochrome P450 2A3 and human cytochrome P450 2A13.
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Drug Metab Dispos
|
2003
|
1.14
|
|
12
|
Metabolism of nicotine and cotinine by human cytochrome P450 2A13.
|
Drug Metab Dispos
|
2004
|
1.13
|
|
13
|
An intestinal epithelium-specific cytochrome P450 (P450) reductase-knockout mouse model: direct evidence for a role of intestinal p450s in first-pass clearance of oral nifedipine.
|
Drug Metab Dispos
|
2008
|
1.13
|
|
14
|
Quantitative distribution of mRNAs encoding the 19 human UDP-glucuronosyltransferase enzymes in 26 adult and 3 fetal tissues.
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Xenobiotica
|
2011
|
1.10
|
|
15
|
Conditional knockout of the mouse NADPH-cytochrome p450 reductase gene.
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Genesis
|
2003
|
1.09
|
|
16
|
Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.
|
Chem Res Toxicol
|
2005
|
1.04
|
|
17
|
Generation and characterization of a Cyp2f2-null mouse and studies on the role of CYP2F2 in naphthalene-induced toxicity in the lung and nasal olfactory mucosa.
|
J Pharmacol Exp Ther
|
2011
|
1.03
|
|
18
|
Expression of cytochrome p450 and other biotransformation genes in fetal and adult human nasal mucosa.
|
Drug Metab Dispos
|
2005
|
1.02
|
|
19
|
Identification of critical amino acid residues of human CYP2A13 for the metabolic activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.
|
Drug Metab Dispos
|
2004
|
1.02
|
|
20
|
Prenatal polycyclic aromatic hydrocarbon exposure leads to behavioral deficits and downregulation of receptor tyrosine kinase, MET.
|
Toxicol Sci
|
2010
|
1.00
|
|
21
|
Genetic polymorphisms of the human CYP2A13 gene: identification of single-nucleotide polymorphisms and functional characterization of an Arg257Cys variant.
|
J Pharmacol Exp Ther
|
2002
|
1.00
|
|
22
|
Effects of 8-methoxypsoralen on cytochrome P450 2A13.
|
Carcinogenesis
|
2004
|
1.00
|
|
23
|
Mechanisms of olfactory toxicity of the herbicide 2,6-dichlorobenzonitrile: essential roles of CYP2A5 and target-tissue metabolic activation.
|
Toxicol Appl Pharmacol
|
2010
|
1.00
|
|
24
|
Development of oxidative stress by cytochrome P450 induction in rodents is selective for barbiturates and related to loss of pyridine nucleotide-dependent protective systems.
|
J Biol Chem
|
2008
|
0.99
|
|
25
|
A mouse model with liver-specific deletion and global suppression of the NADPH-cytochrome P450 reductase gene: characterization and utility for in vivo studies of cyclophosphamide disposition.
|
J Pharmacol Exp Ther
|
2007
|
0.99
|
|
26
|
Identification of cytochrome P450 oxidoreductase gene variants that are significantly associated with the interindividual variations in warfarin maintenance dose.
|
Drug Metab Dispos
|
2011
|
0.97
|
|
27
|
Human UDP-glucuronosyltransferase UGT2A2: cDNA construction, expression, and functional characterization in comparison with UGT2A1 and UGT2A3.
|
Pharmacogenet Genomics
|
2009
|
0.97
|
|
28
|
Role of small intestinal cytochromes p450 in the bioavailability of oral nifedipine.
|
Drug Metab Dispos
|
2007
|
0.97
|
|
29
|
Characterization of CYP2A13*2, a variant cytochrome P450 allele previously found to be associated with decreased incidences of lung adenocarcinoma in smokers.
|
Drug Metab Dispos
|
2008
|
0.94
|
|
30
|
Mechanism of chloroform-induced renal toxicity: non-involvement of hepatic cytochrome P450-dependent metabolism.
|
Toxicol Appl Pharmacol
|
2007
|
0.93
|
|
31
|
Development of a real-time polymerase chain reaction-based method for the measurement of relative allelic expression and identification of CYP2A13 alleles with decreased expression in human lung.
|
J Pharmacol Exp Ther
|
2004
|
0.93
|
|
32
|
Characterization and quantitative analysis of DNA adducts formed from lower chlorinated PCB-derived quinones.
|
Chem Res Toxicol
|
2004
|
0.93
|
|
33
|
Immunoblot analysis and immunohistochemical characterization of CYP2A expression in human olfactory mucosa.
|
Biochem Pharmacol
|
2003
|
0.92
|
|
34
|
Generation and characterization of a novel Cyp2a(4/5)bgs-null mouse model.
|
Drug Metab Dispos
|
2012
|
0.92
|
|
35
|
Transcriptional regulation of human CYP2A13 expression in the respiratory tract by CCAAT/enhancer binding protein and epigenetic modulation.
|
Mol Pharmacol
|
2006
|
0.92
|
|
36
|
Identification of Val117 and Arg372 as critical amino acid residues for the activity difference between human CYP2A6 and CYP2A13 in coumarin 7-hydroxylation.
|
Arch Biochem Biophys
|
2004
|
0.91
|
|
37
|
Deletion of the NADPH-cytochrome P450 reductase gene in cardiomyocytes does not protect mice against doxorubicin-mediated acute cardiac toxicity.
|
Drug Metab Dispos
|
2008
|
0.91
|
|
38
|
The pneumotoxin 3-methylindole is a substrate and a mechanism-based inactivator of CYP2A13, a human cytochrome P450 enzyme preferentially expressed in the respiratory tract.
|
Drug Metab Dispos
|
2009
|
0.91
|
|
39
|
Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.
|
Pharmacogenet Genomics
|
2009
|
0.91
|
|
40
|
Disruption of P450-mediated vitamin E hydroxylase activities alters vitamin E status in tocopherol supplemented mice and reveals extra-hepatic vitamin E metabolism.
|
J Lipid Res
|
2012
|
0.90
|
|
41
|
Role of CYP2A5 in the bioactivation of the lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mice.
|
J Pharmacol Exp Ther
|
2012
|
0.90
|
|
42
|
Potential biological functions of cytochrome P450 reductase-dependent enzymes in small intestine: novel link to expression of major histocompatibility complex class II genes.
|
J Biol Chem
|
2012
|
0.90
|
|
43
|
Generation and characterization of a CYP2A13/2B6/2F1-transgenic mouse model.
|
Drug Metab Dispos
|
2012
|
0.90
|
|
44
|
The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5.
|
Drug Metab Dispos
|
2011
|
0.89
|
|
45
|
Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic.
|
Pain
|
2011
|
0.89
|
|
46
|
Targeted disruption of the olfactory mucosa-specific Cyp2g1 gene: impact on acetaminophen toxicity in the lateral nasal gland, and tissue-selective effects on Cyp2a5 expression.
|
J Pharmacol Exp Ther
|
2003
|
0.89
|
|
47
|
NADPH-cytochrome P450 oxidoreductase: roles in physiology, pharmacology, and toxicology.
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Drug Metab Dispos
|
2012
|
0.88
|
|
48
|
Regulation of cytochrome P450 gene expression in the olfactory mucosa.
|
Chem Biol Interact
|
2004
|
0.88
|
|
49
|
A novel defensive mechanism against acetaminophen toxicity in the mouse lateral nasal gland: role of CYP2A5-mediated regulation of testosterone homeostasis and salivary androgen-binding protein expression.
|
Mol Pharmacol
|
2011
|
0.88
|
|
50
|
A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
|
Carcinogenesis
|
2011
|
0.87
|
|
51
|
High abundance of testosterone and salivary androgen-binding protein in the lateral nasal gland of male mice.
|
J Steroid Biochem Mol Biol
|
2009
|
0.87
|
|
52
|
Role of CYP2A13 in the bioactivation and lung tumorigenicity of the tobacco-specific lung procarcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: in vivo studies using a CYP2A13-humanized mouse model.
|
Carcinogenesis
|
2013
|
0.87
|
|
53
|
Inhibition by allyl sulfides and phenethyl isothiocyanate of methyl-n-pentylnitrosamine depentylation by rat esophageal microsomes, human and rat CYP2E1, and Rat CYP2A3.
|
Nutr Cancer
|
2004
|
0.86
|
|
54
|
Generation of a mouse model with a reversible hypomorphic cytochrome P450 reductase gene: utility for tissue-specific rescue of the reductase expression, and insights from a resultant mouse model with global suppression of P450 reductase expression in extrahepatic tissues.
|
J Pharmacol Exp Ther
|
2010
|
0.86
|
|
55
|
Impact of nicotine metabolism on nicotine's pharmacological effects and behavioral responses: insights from a Cyp2a(4/5)bgs-null mouse.
|
J Pharmacol Exp Ther
|
2013
|
0.85
|
|
56
|
Transcriptional regulation of rat CYP2A3 by nuclear factor 1: identification of a novel NFI-A isoform, and evidence for tissue-selective interaction of NFI with the CYP2A3 promoter in vivo.
|
J Biol Chem
|
2004
|
0.85
|
|
57
|
Mechanisms of permanent loss of olfactory receptor neurons induced by the herbicide 2,6-dichlorobenzonitrile: effects on stem cells and noninvolvement of acute induction of the inflammatory cytokine IL-6.
|
Toxicol Appl Pharmacol
|
2013
|
0.85
|
|
58
|
Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.
|
Drug Metab Dispos
|
2012
|
0.84
|
|
59
|
Analysis of testosterone and dihydrotestosterone in mouse tissues by liquid chromatography-electrospray ionization-tandem mass spectrometry.
|
Anal Biochem
|
2010
|
0.83
|
|
60
|
Mechanisms of differential expression of the CYP2A13 7520C and 7520G alleles in human lung: allelic expression analysis for CYP2A13 heterogeneous nuclear RNA, and evidence for the involvement of multiple cis-regulatory single nucleotide polymorphisms.
|
Pharmacogenet Genomics
|
2009
|
0.83
|
|
61
|
Potent mutagenicity of 3-methylindole requires pulmonary cytochrome P450-mediated bioactivation: a comparison to the prototype cigarette smoke mutagens B(a)P and NNK.
|
Chem Res Toxicol
|
2010
|
0.82
|
|
62
|
Single nucleotide polymorphisms of the human cyp2a13 gene: evidence for a null allele.
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Drug Metab Dispos
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2003
|
0.82
|
|
63
|
Transcriptional suppression of CYP2A13 expression by lipopolysaccharide in cultured human lung cells and the lungs of a CYP2A13-humanized mouse model.
|
Toxicol Sci
|
2013
|
0.82
|
|
64
|
Defining a relationship between dietary fatty acids and the cytochrome P450 system in a mouse model of fatty liver disease.
|
Physiol Genomics
|
2010
|
0.81
|
|
65
|
Role of hepatic and intestinal p450 enzymes in the metabolic activation of the colon carcinogen azoxymethane in mice.
|
Chem Res Toxicol
|
2014
|
0.80
|
|
66
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Generation and characterization of a transgenic mouse model with hepatic expression of human CYP2A6.
|
Biochem Biophys Res Commun
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2005
|
0.80
|
|
67
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Bioactivation of the nasal toxicant 2,6-dichlorobenzonitrile: an assessment of metabolic activity in human nasal mucosa and identification of indicators of exposure and potential toxicity.
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Chem Res Toxicol
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2013
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0.79
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68
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Role of mammary epithelial and stromal P450 enzymes in the clearance and metabolic activation of 7,12-dimethylbenz(a)anthracene in mice.
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Toxicol Lett
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2012
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0.79
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|
69
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The role of cytochrome P450-dependent metabolism in the regulation of mouse hepatic growth hormone signaling components and target genes by 3-methylcholanthrene.
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Drug Metab Dispos
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2012
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0.79
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70
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Expression of the rat CYP2A3 gene in transgenic mice.
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Drug Metab Dispos
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2002
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0.79
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71
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A novel monoclonal antibody of human stem cell factor inhibits umbilical cord blood stem cell ex vivo expansion.
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J Hematol Oncol
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2012
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0.79
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72
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Dietary regulation of mouse intestinal P450 expression and drug metabolism.
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Drug Metab Dispos
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2012
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0.78
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73
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A critical role of Fas-associated protein with death domain phosphorylation in intracellular reactive oxygen species homeostasis and aging.
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Antioxid Redox Signal
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2014
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0.77
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|
74
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Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice.
|
PLoS One
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2013
|
0.77
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75
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Possible genotoxic modes of action for naphthalene.
|
Regul Toxicol Pharmacol
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2007
|
0.77
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76
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Regulation of intestinal cytochrome P450 expression by hepatic cytochrome P450: possible involvement of fibroblast growth factor 15 and impact on systemic drug exposure.
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Mol Pharmacol
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2013
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0.76
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77
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Essential role of the cytochrome P450 enzyme CYP2A5 in olfactory mucosal toxicity of naphthalene.
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Drug Metab Dispos
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2013
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0.76
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|
78
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Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes.
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Chem Res Toxicol
|
2013
|
0.75
|
|
79
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The role of renal proximal tubule P450 enzymes in chloroform-induced nephrotoxicity: utility of renal specific P450 reductase knockout mouse models.
|
Toxicol Appl Pharmacol
|
2013
|
0.75
|
|
80
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Downregulation of mouse hepatic CYP3A protein by 3-methylcholanthrene does not require cytochrome P450-dependent metabolism.
|
Drug Metab Dispos
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2013
|
0.75
|
|
81
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Suppression of cytochrome P450 reductase expression promotes astrocytosis in subventricular zone of adult mice.
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Neurosci Lett
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2013
|
0.75
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