Published in Nat Rev Neurosci on August 01, 2005
Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry (2009) 8.74
Astrocytes: biology and pathology. Acta Neuropathol (2009) 8.43
Mammalian nicotinic acetylcholine receptors: from structure to function. Physiol Rev (2009) 5.64
Diffusion in brain extracellular space. Physiol Rev (2008) 5.34
Long-term potentiation depends on release of D-serine from astrocytes. Nature (2010) 4.36
Uniquely hominid features of adult human astrocytes. J Neurosci (2009) 3.49
Vesicular release of glutamate from unmyelinated axons in white matter. Nat Neurosci (2007) 3.39
Integrated brain circuits: astrocytic networks modulate neuronal activity and behavior. Annu Rev Physiol (2010) 3.38
Cellular scaling rules for rodent brains. Proc Natl Acad Sci U S A (2006) 2.87
Astrovirus encephalitis in boy with X-linked agammaglobulinemia. Emerg Infect Dis (2010) 2.69
Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol (2012) 2.49
Engaging neuroscience to advance translational research in brain barrier biology. Nat Rev Neurosci (2011) 2.40
Psychoneuroimmunology meets neuropsychopharmacology: translational implications of the impact of inflammation on behavior. Neuropsychopharmacology (2011) 2.31
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat Neurosci (2010) 2.30
Gliogenesis and glial pathology in depression. CNS Neurol Disord Drug Targets (2007) 2.26
Astrocyte calcium waves: what they are and what they do. Glia (2006) 2.17
Immune system to brain signaling: neuropsychopharmacological implications. Pharmacol Ther (2011) 2.12
Reactive gliosis and the multicellular response to CNS damage and disease. Neuron (2014) 2.08
Artifact versus reality--how astrocytes contribute to synaptic events. Glia (2012) 2.02
Plasticity of astrocytic coverage and glutamate transporter expression in adult mouse cortex. PLoS Biol (2006) 2.00
Gliotransmitters travel in time and space. Neuron (2014) 1.99
The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. Mol Cell (2010) 1.97
Selective dysfunction of hippocampal CA1 astrocytes contributes to delayed neuronal damage after transient forebrain ischemia. J Neurosci (2007) 1.93
Astrocytes in the epileptic brain. Neuron (2008) 1.86
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission. J Neurosci (2013) 1.82
Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia (2011) 1.78
mGluR5 stimulates gliotransmission in the nucleus accumbens. Proc Natl Acad Sci U S A (2007) 1.77
Locus coeruleus alpha-adrenergic-mediated activation of cortical astrocytes in vivo. Cereb Cortex (2008) 1.76
Endogenous nonneuronal modulators of synaptic transmission control cortical slow oscillations in vivo. Proc Natl Acad Sci U S A (2009) 1.76
Successive neuron loss in the thalamus and cortex in a mouse model of infantile neuronal ceroid lipofuscinosis. Neurobiol Dis (2006) 1.69
Gliotransmission: Exocytotic release from astrocytes. Brain Res Rev (2009) 1.68
The hemo-neural hypothesis: on the role of blood flow in information processing. J Neurophysiol (2007) 1.65
Molecular evolution of adeno-associated virus for enhanced glial gene delivery. Mol Ther (2009) 1.57
Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus. J Neurochem (2007) 1.57
Deletion of astroglial Dicer causes non-cell-autonomous neuronal dysfunction and degeneration. J Neurosci (2011) 1.52
Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol (2011) 1.50
Target cell-specific modulation of neuronal activity by astrocytes. Proc Natl Acad Sci U S A (2006) 1.49
Astrocytes and ischemic injury. Stroke (2008) 1.49
RNAi screen in mouse astrocytes identifies phosphatases that regulate NF-kappaB signaling. Mol Cell (2006) 1.47
Astrocytes in Alzheimer's disease. Neurotherapeutics (2010) 1.47
In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. J Neurosci (2013) 1.47
Functions of astrocytes and their potential as therapeutic targets. Neurotherapeutics (2010) 1.44
Receptor-mediated glutamate release from volume sensitive channels in astrocytes. Proc Natl Acad Sci U S A (2005) 1.44
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity. Proc Natl Acad Sci U S A (2007) 1.42
Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route. ASN Neuro (2012) 1.40
Adenosine signaling and function in glial cells. Cell Death Differ (2009) 1.39
A glycogen phosphorylase inhibitor selectively enhances local rates of glucose utilization in brain during sensory stimulation of conscious rats: implications for glycogen turnover. J Neurochem (2007) 1.37
Transplanted astrocytes derived from BMP- or CNTF-treated glial-restricted precursors have opposite effects on recovery and allodynia after spinal cord injury. J Biol (2008) 1.36
Modulation of brain hemichannels and gap junction channels by pro-inflammatory agents and their possible role in neurodegeneration. Antioxid Redox Signal (2009) 1.34
OXPHOS mutations and neurodegeneration. EMBO J (2012) 1.33
Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. PLoS One (2008) 1.32
Tumor necrosis factor alpha mediates lipopolysaccharide-induced microglial toxicity to developing oligodendrocytes when astrocytes are present. J Neurosci (2008) 1.32
Astrocyte Ca²⁺ signalling: an unexpected complexity. Nat Rev Neurosci (2014) 1.27
Overexpression of inducible heat shock protein 70 and its mutants in astrocytes is associated with maintenance of mitochondrial physiology during glucose deprivation stress. Cell Stress Chaperones (2006) 1.27
Astrocyte pathology in major depressive disorder: insights from human postmortem brain tissue. Curr Drug Targets (2013) 1.26
P2X1 and P2X5 subunits form the functional P2X receptor in mouse cortical astrocytes. J Neurosci (2008) 1.23
Bestrophin-1 encodes for the Ca2+-activated anion channel in hippocampal astrocytes. J Neurosci (2009) 1.22
Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (System xc-) to normal and pathological glutamatergic signaling. Pharmacol Rev (2012) 1.21
Photothrombosis ischemia stimulates a sustained astrocytic Ca2+ signaling in vivo. Glia (2009) 1.20
Gene expression in temporal lobe epilepsy is consistent with increased release of glutamate by astrocytes. Mol Med (2007) 1.19
Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons. Proc Natl Acad Sci U S A (2014) 1.18
Mitochondrial calcium signaling mediates rhythmic extracellular ATP accumulation in suprachiasmatic nucleus astrocytes. J Neurosci (2011) 1.18
Glial connexins and gap junctions in CNS inflammation and disease. J Neurochem (2008) 1.17
Mass spectrometric and computational analysis of cytokine-induced alterations in the astrocyte secretome. Proteomics (2009) 1.17
Neuronal chemokines: versatile messengers in central nervous system cell interaction. Mol Neurobiol (2007) 1.15
Exocytosis of ATP from astrocytes modulates phasic and tonic inhibition in the neocortex. PLoS Biol (2014) 1.15
Coincident generation of pyramidal neurons and protoplasmic astrocytes in neocortical columns. J Neurosci (2012) 1.14
Crosstalk between spinal astrocytes and neurons in nerve injury-induced neuropathic pain. PLoS One (2009) 1.14
Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxid Redox Signal (2009) 1.14
Astrocytes as regulators of synaptic function: a quest for the Ca2+ master key. Neuroscientist (2011) 1.13
Regulation of cerebral vasculature in normal and ischemic brain. Neuropharmacology (2008) 1.12
Kynurenic acid leads, dopamine follows: a new case of volume transmission in the brain? J Neural Transm (Vienna) (2006) 1.12
Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Proc Natl Acad Sci U S A (2011) 1.12
Glutamate and ATP signalling in white matter pathology. J Anat (2011) 1.11
Astrocytic control of synaptic transmission and plasticity: a target for drugs of abuse? Neuropharmacology (2008) 1.11
Glial regulation of neuronal function: from synapse to systems physiology. J Neuroendocrinol (2012) 1.11
Identification of novel glial genes by single-cell transcriptional profiling of Bergmann glial cells from mouse cerebellum. PLoS One (2010) 1.10
Amygdala transcriptome and cellular mechanisms underlying stress-enhanced fear learning in a rat model of posttraumatic stress disorder. Neuropsychopharmacology (2010) 1.10
The blood-brain barrier: an engineering perspective. Front Neuroeng (2013) 1.09
Purinergic transmission in the central nervous system. Pflugers Arch (2006) 1.09
Astrocytic modulation of blood brain barrier: perspectives on Parkinson's disease. Front Cell Neurosci (2014) 1.07
ATP-mediated glucosensing by hypothalamic tanycytes. J Physiol (2011) 1.06
Thrombospondins as key regulators of synaptogenesis in the central nervous system. Matrix Biol (2012) 1.06
Calcium Signaling and Gliotransmission in Normal vs. Reactive Astrocytes. Front Pharmacol (2012) 1.06
The increased activity of TRPV4 channel in the astrocytes of the adult rat hippocampus after cerebral hypoxia/ischemia. PLoS One (2012) 1.06
Fluorescent-protein stabilization and high-resolution imaging of cleared, intact mouse brains. PLoS One (2015) 1.05
Fast subplasma membrane Ca2+ transients control exo-endocytosis of synaptic-like microvesicles in astrocytes. J Neurosci (2008) 1.04
Reactive astrogliosis causes the development of spontaneous seizures. J Neurosci (2015) 1.04
Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia. Glia (2013) 1.04
Astrocytic calcium signaling: mechanism and implications for functional brain imaging. Methods Mol Biol (2009) 1.04
Proteinase-activated receptors in the nucleus of the solitary tract: evidence for glial-neural interactions in autonomic control of the stomach. J Neurosci (2009) 1.04
The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes. Proc Natl Acad Sci U S A (2009) 1.03
Sustained neuronal activity generated by glial plasticity. J Neurosci (2011) 1.03
Three-dimensional confocal morphometry - a new approach for studying dynamic changes in cell morphology in brain slices. J Anat (2007) 1.03
Nonlinear gap junctions enable long-distance propagation of pulsating calcium waves in astrocyte networks. PLoS Comput Biol (2010) 1.02
Insulin promotes glycogen storage and cell proliferation in primary human astrocytes. PLoS One (2011) 1.02
Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. J Biol Chem (2009) 1.02
Pathophysiogenesis of mesial temporal lobe epilepsy: is prevention of damage antiepileptogenic? Curr Med Chem (2014) 1.02
CX(3)CR1 deficiency alters hippocampal-dependent plasticity phenomena blunting the effects of enriched environment. Front Cell Neurosci (2011) 1.02
Astrocytes and epilepsy. Neurotherapeutics (2010) 1.02
Shedding microvesicles: artefacts no more. Trends Cell Biol (2009) 8.84
The small chemical vacuolin-1 inhibits Ca(2+)-dependent lysosomal exocytosis but not cell resealing. EMBO Rep (2004) 1.82
Distribution and signaling of TREM2/DAP12, the receptor system mutated in human polycystic lipomembraneous osteodysplasia with sclerosing leukoencephalopathy dementia. Eur J Neurosci (2004) 1.71
Macropinocytosis: regulated coordination of endocytic and exocytic membrane traffic events. J Cell Sci (2006) 1.64
Regulated exocytosis: a novel, widely expressed system. Nat Cell Biol (2002) 1.61
The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. J Neurochem (2009) 1.38
Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J Neurosci (2005) 1.35
Dense-core granules: a specific hallmark of the neuronal/neurosecretory cell phenotype. J Cell Sci (2004) 1.22
Regulated exocytosis: new organelles for non-secretory purposes. Nat Rev Mol Cell Biol (2005) 1.22
Enlargeosome traffic: exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both. Traffic (2007) 1.19
{alpha}-synuclein and its A30P mutant affect actin cytoskeletal structure and dynamics. Mol Biol Cell (2009) 1.11
Cell surface dynamics - how Rho GTPases orchestrate the interplay between the plasma membrane and the cortical cytoskeleton. J Cell Sci (2012) 1.02
Differential Expression of Markers and Activities in a Group of PC12 Nerve Cell Clones. Eur J Neurosci (1992) 1.01
REST: an oncogene or a tumor suppressor? Trends Cell Biol (2013) 0.98
Expression of the neurosecretory process in PC12 cells is governed by REST. J Neurochem (2008) 0.97
Enlargeosome, an exocytic vesicle resistant to nonionic detergents, undergoes endocytosis via a nonacidic route. Mol Biol Cell (2004) 0.96
Neurosecretion competence. A comprehensive gene expression program identified in PC12 cells. J Biol Chem (2002) 0.96
Annexin2 coating the surface of enlargeosomes is needed for their regulated exocytosis. EMBO J (2006) 0.94
BACE1 expression and activity: relevance in Alzheimer's disease. Neurodegener Dis (2007) 0.94
The regulated exocytosis of enlargeosomes is mediated by a SNARE machinery that includes VAMP4. J Cell Sci (2008) 0.93
Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome. J Cell Sci (2009) 0.92
The regulation of synaptic function by alpha-synuclein. Commun Integr Biol (2010) 0.91
A signaling loop of REST, TSC2 and β-catenin governs proliferation and function of PC12 neural cells. J Cell Sci (2011) 0.90
Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes. Glia (2011) 0.89
REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability. EMBO J (2013) 0.88
REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes. J Cell Biol (2011) 0.88
Ectosomes. Curr Biol (2011) 0.88
The rest repression of the neurosecretory phenotype is negatively modulated by BHC80, a protein of the BRAF/HDAC complex. J Neurosci (2009) 0.83
A new form of neurite outgrowth sustained by the exocytosis of enlargeosomes expressed under the control of REST. Traffic (2010) 0.81
In PC12 cells, expression of neurosecretion and neurite outgrowth are governed by the transcription repressor REST/NRSF. Cell Mol Neurobiol (2010) 0.80
L1CAM and its cell-surface mutants: new mechanisms and effects relevant to the physiology and pathology of neural cells. J Neurochem (2012) 0.80
Expression of dense-core vesicles and of their exocytosis are governed by the repressive transcription factor NRSF/REST. Ann N Y Acad Sci (2009) 0.79
Non-secretory exocytoses in the brain. J Physiol Paris (2006) 0.79
Dual REST-dependence of L1CAM: from gene expression to alternative splicing governed by Nova2 in neural cells. J Neurochem (2012) 0.79
The Ca2+-dependent exocytosis of enlargeosomes is greatly reinforced by genistein via a non-tyrosine kinase-dependent mechanism. FEBS Lett (2007) 0.78
Fusion has found its calcium sensor. Nat Cell Biol (2004) 0.78
Translocation of signalling proteins to the plasma membrane revealed by a new bioluminescent procedure. BMC Cell Biol (2011) 0.78
Outgrowth of neurites is a dual process. Commun Integr Biol (2010) 0.78
NGF signaling in PC12 cells: the cooperation of p75(NTR) with TrkA is needed for the activation of both mTORC2 and the PI3K signalling cascade. Biol Open (2013) 0.78
Expression and function of the dense-core vesicle membranes are governed by the transcription repressor REST. FEBS Lett (2013) 0.77
Interactions between nitric oxide and sphingolipids and the potential consequences in physiology and pathology. Trends Pharmacol Sci (2003) 0.77