Published in Nucleic Acids Res on July 13, 2005
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Mutations in FAM111B cause hereditary fibrosing poikiloderma with tendon contracture, myopathy, and pulmonary fibrosis. Am J Hum Genet (2013) 1.70
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A potential role of heat shock proteins and nicotinamide N-methyl transferase in predicting response to radiation in bladder cancer. Int J Cancer (2002) 1.20
Improvement of chemotherapy efficacy by inactivation of a DNA-repair pathway. Lancet Oncol (2003) 1.12
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Targeting human 8-oxoguanine DNA glycosylase (hOGG1) to mitochondria enhances cisplatin cytotoxicity in hepatoma cells. Carcinogenesis (2007) 1.04
A new phenotype of brain iron accumulation with dystonia, optic atrophy, and peripheral neuropathy. Mov Disord (2012) 1.01
Large-scale transcriptional profiling and functional assays reveal important roles for Rho-GTPase signalling and SCL during haematopoietic differentiation of human embryonic stem cells. Hum Mol Genet (2011) 0.99
A novel DNA damage recognition protein in Schizosaccharomyces pombe. Nucleic Acids Res (2006) 0.98
Evidence for widespread reticulate evolution within human duplicons. Am J Hum Genet (2005) 0.98
Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4. Mol Ther (2004) 0.94
Dual repair modulation reverses Temozolomide resistance in vitro. Mol Cancer Ther (2004) 0.94
Late-onset sacsinopathy diagnosed by exome sequencing and comparative genomic hybridization. J Neurogenet (2013) 0.93
Allelic expression analysis of the osteoarthritis susceptibility locus that maps to MICAL3. BMC Med Genet (2012) 0.92
Reciprocal relationship between O6-methylguanine-DNA methyltransferase P140K expression level and chemoprotection of hematopoietic stem cells. Cancer Res (2008) 0.92
Effect of O6-(4-bromothenyl)guanine on different temozolomide schedules in a human melanoma xenograft model. Int J Cancer (2002) 0.90
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DNA alkylation and repair in the large bowel: animal and human studies. J Nutr (2002) 0.90
Atl1 regulates choice between global genome and transcription-coupled repair of O(6)-alkylguanines. Mol Cell (2012) 0.90
Torin1-mediated TOR kinase inhibition reduces Wee1 levels and advances mitotic commitment in fission yeast and HeLa cells. J Cell Sci (2014) 0.89
Alkyltransferase-like protein (Atl1) distinguishes alkylated guanines for DNA repair using cation-π interactions. Proc Natl Acad Sci U S A (2012) 0.89
Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria. Am J Pathol (2011) 0.89
Lentivirus-mediated expression of mutant MGMTP140K protects human CD34+ cells against the combined toxicity of O6-benzylguanine and 1,3-bis(2-chloroethyl)-nitrosourea or temozolomide. Hum Gene Ther (2004) 0.88
Convenient and efficient syntheses of oligodeoxyribonucleotides containing O(6)-(carboxymethyl)guanine and O(6)-(4-oxo-4-(3-pyridyl)butyl)guanine. Nucleosides Nucleotides Nucleic Acids (2012) 0.87
Gene expression for enzymes and transporters involved in regulating adenosine and inosine levels in rat forebrain neurons, astrocytes and C6 glioma cells. J Neurosci Res (2006) 0.87
Elevated N3-methylpurine-DNA glycosylase DNA repair activity is associated with lung cancer. Mutat Res (2012) 0.86
Tumor O(6)-methylguanine-DNA methyltransferase inactivation by oral lomeguatrib. Clin Cancer Res (2010) 0.85
Reduced MGMT activity in human colorectal adenomas is associated with K-ras GC->AT transition mutations in a population exposed to methylating agents. Carcinogenesis (2004) 0.85
Clinical and functional characterisation of the combined respiratory chain defect in two sisters due to autosomal recessive mutations in MTFMT. Mitochondrion (2013) 0.85
Identification of a neuronal transcription factor network involved in medulloblastoma development. Acta Neuropathol Commun (2013) 0.85
Finding genes that influence quantitative traits with tree-based clustering. BMC Proc (2011) 0.84
Association between lung cancer risk and single nucleotide polymorphisms in the first intron and codon 178 of the DNA repair gene, O6-alkylguanine-DNA alkyltransferase. Int J Cancer (2008) 0.84
The nitrosated bile acid DNA lesion O6-carboxymethylguanine is a substrate for the human DNA repair protein O6-methylguanine-DNA methyltransferase. Nucleic Acids Res (2013) 0.83
Bladder tumor contains higher N7-methylguanine levels in DNA than adjacent normal bladder epithelium. Cancer Epidemiol Biomarkers Prev (2006) 0.83
Associations between tissue-specific DNA alkylation, DNA repair and cell proliferation in the colon and colon tumour yield in mice treated with 1,2-dimethylhydrazine. Carcinogenesis (2003) 0.83
Repair and removal of azoxymethane-induced O6-methylguanine in rat colon by O6-methylguanine DNA methyltransferase and apoptosis. Mutat Res (2013) 0.83
The P140K mutant of human O(6)-methylguanine-DNA-methyltransferase (MGMT) confers resistance in vitro and in vivo to temozolomide in combination with the novel MGMT inactivator O(6)-(4-bromothenyl)guanine. J Gene Med (2006) 0.82
Folate deficiency alters hepatic and colon MGMT and OGG-1 DNA repair protein expression in rats but has no effect on genome-wide DNA methylation. Cancer Prev Res (Phila) (2010) 0.81
Heterogeneity of O(6)-alkylguanine-DNA alkyltransferase activity in colorectal cancer: implications for treatment. Oncology (2002) 0.81
Sensitization of a human ovarian cancer cell line to temozolomide by simultaneous attenuation of the Bcl-2 antiapoptotic protein and DNA repair by O6-alkylguanine-DNA alkyltransferase. Mol Cancer Ther (2004) 0.80
Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer (2003) 0.79
NDUFS8-related Complex I Deficiency Extends Phenotype from "PEO Plus" to Leigh Syndrome. JIMD Rep (2012) 0.78
Synthesis of oligodeoxyribonucleotides containing a conformationally-locked anti analogue of O6-methyl-2'-deoxyguanosine and their recognition by MGMT and Atl1. Chem Commun (Camb) (2012) 0.78
Endogenous retrovirus-K and nervous system diseases. Curr Neurol Neurosci Rep (2014) 0.77
Lung cancer risk and variation in MGMT activity and sequence. DNA Repair (Amst) (2007) 0.77
Design and use of scorpions fluorescent signaling molecules. Methods Mol Biol (2008) 0.77
Dual agent chemoprotection by retroviral co-expression of either MDR1 or MRP1 with the P140K mutant of O6-methylguanine-DNA-methyl transferase. J Gene Med (2006) 0.77
GSTM1 copy number and lung cancer risk. Mutat Res (2009) 0.77
Smoking is associated with a decrease of O6-alkylguanine-DNA alkyltransferase activity in bronchial epithelial cells. Int J Cancer (2006) 0.77
Predicting the myelotoxicity of chemotherapy: the use of pretreatment O6-methylguanine-DNA methyltransferase determination in peripheral blood mononuclear cells. Melanoma Res (2011) 0.76
Bayesian inference supports a location and neighbour-dependent model of DNA methylation propagation at the MGMT gene promoter in lung tumours. J Theor Biol (2013) 0.76
Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations. Nucleic Acids Res (2013) 0.76
Molecular characterization of an adaptive response to alkylating agents in the opportunistic pathogen Aspergillus fumigatus. Nucleic Acids Res (2012) 0.76
Expression of O-Alkylguanine-DNA Alkyltransferase in Normal and Malignant Bladder Tissue of Egyptian Patients. J Nucleic Acids (2010) 0.75
Differential chemosensitivity to antifolate drugs between RAS and BRAF melanoma cells. Mol Cancer (2014) 0.75
No association between N7-methyldeoxyguanosine and 8-oxodeoxyguanosine levels in human lymphocyte DNA. Mutat Res (2006) 0.75
Towards more specific O6-methylguanine-DNA methyltransferase (MGMT) inactivators. Bioorg Med Chem (2011) 0.75
The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. Nucleosides Nucleotides Nucleic Acids (2007) 0.75
The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine. Org Biomol Chem (2006) 0.75
Topographical study of O(6)-alkylguanine DNA alkyltransferase repair activity and N7-methylguanine levels in resected lung tissue. Chem Biol Interact (2013) 0.75