Published in Ageing Res Rev on August 01, 2005
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Positive lysosomal modulation as a unique strategy to treat age-related protein accumulation diseases. Rejuvenation Res (2012) 0.86
Mechanism of ceroid formation in atherosclerotic plaque: in situ studies using a combination of Raman and fluorescence spectroscopy. J Biomed Opt (2011) 0.80
Medical bioremediation of age-related diseases. Microb Cell Fact (2009) 0.76
You don't need a weatherman: famines, evolution, and intervention into aging. Age (Dordr) (2006) 0.75
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
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Autophagy regulates lipid metabolism. Nature (2009) 13.33
Human gut microbiota in obesity and after gastric bypass. Proc Natl Acad Sci U S A (2009) 8.25
Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study. J Neuropathol Exp Neurol (2005) 6.16
Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell (2010) 5.09
Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. J Cell Biol (2005) 4.91
Methods for monitoring autophagy from yeast to human. Autophagy (2007) 4.89
Autophagy gone awry in neurodegenerative diseases. Nat Neurosci (2010) 4.72
Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease. J Neurosci (2008) 4.63
Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function. Nat Med (2008) 4.44
In search of an "autophagomometer". Autophagy (2009) 4.31
Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease. Nat Neurosci (2010) 4.22
Autophagy regulates adipose mass and differentiation in mice. J Clin Invest (2009) 3.95
HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. EMBO J (2010) 3.90
Consequences of the selective blockage of chaperone-mediated autophagy. Proc Natl Acad Sci U S A (2006) 3.87
Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration. Neuron (2006) 3.51
Microautophagy of cytosolic proteins by late endosomes. Dev Cell (2011) 3.51
Autophagy and its possible roles in nervous system diseases, damage and repair. Autophagy (2005) 3.27
Activation of chaperone-mediated autophagy during oxidative stress. Mol Biol Cell (2004) 3.26
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy. J Clin Invest (2008) 3.23
Autophagy and neurodegeneration: when the cleaning crew goes on strike. Lancet Neurol (2007) 3.18
Negligible particle-specific antibacterial activity of silver nanoparticles. Nano Lett (2012) 3.18
Chaperone-mediated autophagy in aging and disease. Curr Top Dev Biol (2006) 3.10
Autophagy in the cellular energetic balance. Cell Metab (2011) 3.06
Coronavirus replication complex formation utilizes components of cellular autophagy. J Biol Chem (2003) 2.96
Nanomaterials in the environment: behavior, fate, bioavailability, and effects. Environ Toxicol Chem (2008) 2.88
Elevated globotriaosylsphingosine is a hallmark of Fabry disease. Proc Natl Acad Sci U S A (2008) 2.87
Oxidative stress and autophagy. Antioxid Redox Signal (2006) 2.79
Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits. Brain (2011) 2.76
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet (2009) 2.69
DNA microarray detection of nitrifying bacterial 16S rRNA in wastewater treatment plant samples. Water Res (2005) 2.66
Gut microbiota and its possible relationship with obesity. Mayo Clin Proc (2008) 2.63
Pancreatic islet production of vascular endothelial growth factor--a is essential for islet vascularization, revascularization, and function. Diabetes (2006) 2.53
Natural history of Fabry renal disease: influence of alpha-galactosidase A activity and genetic mutations on clinical course. Medicine (Baltimore) (2002) 2.51
Altered dynamics of the lysosomal receptor for chaperone-mediated autophagy with age. J Cell Sci (2007) 2.51
Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions. Water Res (2006) 2.48
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2006) 2.45
Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. J Clin Invest (2008) 2.40
Lysosome membrane lipid microdomains: novel regulators of chaperone-mediated autophagy. EMBO J (2006) 2.39
Altered lipid content inhibits autophagic vesicular fusion. FASEB J (2010) 2.35
Autophagy is disrupted in a knock-in mouse model of juvenile neuronal ceroid lipofuscinosis. J Biol Chem (2006) 2.34
The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane. Mol Cell Biol (2008) 2.33
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy. Hum Mol Genet (2010) 2.25
Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. Water Res (2008) 2.23
Chaperone-mediated autophagy: a unique way to enter the lysosome world. Trends Cell Biol (2012) 2.22
Functional interaction between autophagy and ciliogenesis. Nature (2013) 2.21
Chaperone-mediated autophagy is required for tumor growth. Sci Transl Med (2011) 2.21
Dysfunctional high-density lipoprotein in patients on chronic hemodialysis. J Am Coll Cardiol (2012) 2.21
Fabry disease in childhood. J Pediatr (2004) 2.20
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J Cell Biol (2009) 2.16
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy. Mol Biol Cell (2008) 2.14
Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin. J Biol Chem (2001) 2.14
Lysosomal alpha-galactosidase controls the generation of self lipid antigens for natural killer T cells. Immunity (2010) 2.09
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
Molecular identification of the catabolic vinyl chloride reductase from Dehalococcoides sp. strain VS and its environmental distribution. Appl Environ Microbiol (2004) 2.06
Autophagy in hypothalamic AgRP neurons regulates food intake and energy balance. Cell Metab (2011) 2.04
Loss of macroautophagy promotes or prevents fibroblast apoptosis depending on the death stimulus. J Biol Chem (2007) 2.02
Olfactory dysfunction correlates with amyloid-beta burden in an Alzheimer's disease mouse model. J Neurosci (2010) 2.02
A comprehensive glossary of autophagy-related molecules and processes. Autophagy (2010) 2.00
A blue-blocking intraocular lens should be used in cataract surgery. Arch Ophthalmol (2005) 1.97
Inhibitory effect of dietary lipids on chaperone-mediated autophagy. Proc Natl Acad Sci U S A (2012) 1.97
Pathophysiology of chaperone-mediated autophagy. Int J Biochem Cell Biol (2004) 1.97
Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed Engl (2002) 1.95
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Identification of regulators of chaperone-mediated autophagy. Mol Cell (2010) 1.92
Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci (2013) 1.88
Abeta localization in abnormal endosomes: association with earliest Abeta elevations in AD and Down syndrome. Neurobiol Aging (2004) 1.88
Long-term therapy with agalsidase alfa for Fabry disease: safety and effects on renal function in a home infusion setting. Nephrol Dial Transplant (2005) 1.84
The foreseeability of real anti-aging medicine: focusing the debate. Exp Gerontol (2003) 1.84
Protein homeostasis and aging: The importance of exquisite quality control. Ageing Res Rev (2010) 1.84
Lysosomal degradation of alpha-synuclein in vivo. J Biol Chem (2010) 1.82
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease. J Clin Invest (2008) 1.79
Methods to monitor chaperone-mediated autophagy. Methods Enzymol (2009) 1.78
The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A (2007) 1.78
SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci (2007) 1.77
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease. EMBO Mol Med (2012) 1.75
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A (2009) 1.72
Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc Natl Acad Sci U S A (2008) 1.71
Macroautophagy regulates energy metabolism during effector T cell activation. J Immunol (2010) 1.71
Growth of a Dehalococcoides-like microorganism on vinyl chloride and cis-dichloroethene as electron acceptors as determined by competitive PCR. Appl Environ Microbiol (2003) 1.70
Lipophagy: connecting autophagy and lipid metabolism. Int J Cell Biol (2012) 1.69
Neuronal macroautophagy: from development to degeneration. Mol Aspects Med (2006) 1.69
Protein degradation and aging. Exp Gerontol (2005) 1.69
The susceptibility of the retina to photochemical damage from visible light. Prog Retin Eye Res (2011) 1.67
Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem (2005) 1.65
Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. J Neurosci (2008) 1.65
Autophagy and disease: always two sides to a problem. J Pathol (2011) 1.64
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry (2006) 1.63
Rab5-stimulated up-regulation of the endocytic pathway increases intracellular beta-cleaved amyloid precursor protein carboxyl-terminal fragment levels and Abeta production. J Biol Chem (2003) 1.60
App gene dosage modulates endosomal abnormalities of Alzheimer's disease in a segmental trisomy 16 mouse model of down syndrome. J Neurosci (2003) 1.59
Weekly enzyme replacement therapy may slow decline of renal function in patients with Fabry disease who are on long-term biweekly dosing. J Am Soc Nephrol (2007) 1.59