Published in J Biol Chem on December 26, 2001
Fluorescence lifetime measurements and biological imaging. Chem Rev (2010) 3.99
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2006) 2.45
Retinopathy in mice induced by disrupted all-trans-retinal clearance. J Biol Chem (2008) 2.35
The bisretinoids of retinal pigment epithelium. Prog Retin Eye Res (2011) 2.02
Involvement of all-trans-retinal in acute light-induced retinopathy of mice. J Biol Chem (2009) 2.01
The retinal pigment epithelium in health and disease. Curr Mol Med (2010) 1.87
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophthalmol Vis Sci (2011) 1.78
The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A (2007) 1.78
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
Interpretations of fundus autofluorescence from studies of the bisretinoids of the retina. Invest Ophthalmol Vis Sci (2010) 1.75
Quantitative fundus autofluorescence in mice: correlation with HPLC quantitation of RPE lipofuscin and measurement of retina outer nuclear layer thickness. Invest Ophthalmol Vis Sci (2013) 1.73
Phospholipid meets all-trans-retinal: the making of RPE bisretinoids. J Lipid Res (2009) 1.69
The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration. Biochim Biophys Acta (2009) 1.66
ATP-binding cassette transporter ABCA4: molecular properties and role in vision and macular degeneration. J Bioenerg Biomembr (2007) 1.54
Functional roles of bestrophins in ocular epithelia. Prog Retin Eye Res (2009) 1.52
Phagocyte cell migration is mediated by phospholipases PLD1 and PLD2. Blood (2006) 1.44
How much blue light should an IOL transmit? Br J Ophthalmol (2003) 1.41
Interaction of A2E with model membranes. Implications to the pathogenesis of age-related macular degeneration. J Gen Physiol (2002) 1.36
Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J Biol Chem (2009) 1.33
Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Invest Ophthalmol Vis Sci (2009) 1.32
Chemistry of the retinoid (visual) cycle. Chem Rev (2013) 1.28
G1961E mutant allele in the Stargardt disease gene ABCA4 causes bull's eye maculopathy. Exp Eye Res (2009) 1.26
Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal. J Biol Chem (2012) 1.18
New insights into retinoid metabolism and cycling within the retina. Prog Retin Eye Res (2012) 1.16
Centrifugal expansion of fundus autofluorescence patterns in Stargardt disease over time. Arch Ophthalmol (2011) 1.08
Possible influences of lutein and zeaxanthin on the developing retina. Clin Ophthalmol (2007) 1.07
Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway. Biochemistry (2007) 1.07
Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin. Exp Eye Res (2009) 1.05
Effective delivery of large genes to the retina by dual AAV vectors. EMBO Mol Med (2013) 1.04
Fundus autofluorescence and the bisretinoids of retina. Photochem Photobiol Sci (2010) 1.04
Mass spectrometry provides accurate and sensitive quantitation of A2E. Photochem Photobiol Sci (2010) 1.02
Therapy for macular degeneration: insights from acne. Proc Natl Acad Sci U S A (2003) 1.01
The specific binding of retinoic acid to RPE65 and approaches to the treatment of macular degeneration. Proc Natl Acad Sci U S A (2004) 1.01
Defective lipid transport and biosynthesis in recessive and dominant Stargardt macular degeneration. Prog Lipid Res (2010) 0.99
[Comparison of parameters of time-resolved autofluorescence between healthy subjects and patients suffering from early AMD]. Ophthalmologe (2009) 0.97
Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity. Vision Res (2009) 0.96
ATP-binding cassette transporter ABCA4 and chemical isomerization protect photoreceptor cells from the toxic accumulation of excess 11-cis-retinal. Proc Natl Acad Sci U S A (2014) 0.96
A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine. Invest Ophthalmol Vis Sci (2011) 0.95
Genetics and molecular pathology of Stargardt-like macular degeneration. Prog Retin Eye Res (2010) 0.95
Recovery of rod photoresponses in ABCR-deficient mice. Invest Ophthalmol Vis Sci (2008) 0.94
Experimental approaches to the study of A2E, a bisretinoid lipofuscin chromophore of retinal pigment epithelium. Methods Mol Biol (2010) 0.92
Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. J Biol Chem (2009) 0.92
Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols. Mol Vis (2011) 0.90
Fundus autofluorescence findings in a mouse model of retinal detachment. Invest Ophthalmol Vis Sci (2012) 0.90
Exome sequencing analysis identifies compound heterozygous mutation in ABCA4 in a Chinese family with Stargardt disease. PLoS One (2014) 0.88
Accumulation of A2-E in mitochondrial membranes of cultured RPE cells. Graefes Arch Clin Exp Ophthalmol (2006) 0.88
Rapid formation of all-trans retinol after bleaching in frog and mouse rod photoreceptor outer segments. Photochem Photobiol Sci (2010) 0.88
Fundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration. J Clin Med (2014) 0.85
Enzymatic degradation of A2E, a retinal pigment epithelial lipofuscin bisretinoid. J Am Chem Soc (2011) 0.85
Improved dual AAV vectors with reduced expression of truncated proteins are safe and effective in the retina of a mouse model of Stargardt disease. Hum Mol Genet (2015) 0.82
Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration. Proc Natl Acad Sci U S A (2016) 0.82
Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light. J Biol Chem (2013) 0.82
Synthesis of antioxidants for prevention of age-related macular degeneration. J Nat Prod (2013) 0.81
Design, synthesis, and evaluation of nonretinoid retinol binding protein 4 antagonists for the potential treatment of atrophic age-related macular degeneration and Stargardt disease. J Med Chem (2014) 0.80
Calcium overload is associated with lipofuscin formation in human retinal pigment epithelial cells fed with photoreceptor outer segments. Eye (Lond) (2011) 0.80
Fundus autofluorescence and photoreceptor cell rosettes in mouse models. Invest Ophthalmol Vis Sci (2014) 0.80
Immunochemical recognition of A2E, a pigment in the lipofuscin of retinal pigment epithelial cells. Proc Natl Acad Sci U S A (2007) 0.79
Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice. Photochem Photobiol (2012) 0.79
Pharmacological inhibition of lipofuscin accumulation in the retina as a therapeutic strategy for dry AMD treatment. Drug Discov Today Ther Strateg (2013) 0.79
Morphological and physiological retinal degeneration induced by intravenous delivery of vitamin A dimers in rabbits. Dis Model Mech (2014) 0.79
Bicyclic [3.3.0]-Octahydrocyclopenta[c]pyrrolo Antagonists of Retinol Binding Protein 4: Potential Treatment of Atrophic Age-Related Macular Degeneration and Stargardt Disease. J Med Chem (2015) 0.78
Clinical applications of fundus autofluorescence in retinal disease. Int J Retina Vitreous (2016) 0.78
Formation of lipofuscin-like material in the RPE Cell by different components of rod outer segments. Exp Eye Res (2013) 0.78
High resolution MALDI imaging mass spectrometry of retinal tissue lipids. J Am Soc Mass Spectrom (2014) 0.77
Vitamin A dimers trigger the protracted death of retinal pigment epithelium cells. Cell Death Dis (2014) 0.77
Comparison of photosensitizing effect of lipofuscin granules from retinal pigment epithelium of human donor eyes and their fluorophore A2E. Dokl Biochem Biophys (2006) 0.77
Light filtering in a retinal pigment epithelial cell culture model. Optom Vis Sci (2011) 0.76
PBN (Phenyl-N-Tert-Butylnitrone)-Derivatives Are Effective in Slowing the Visual Cycle and Rhodopsin Regeneration and in Protecting the Retina from Light-Induced Damage. PLoS One (2015) 0.76
Identification of a novel lipofuscin pigment (iisoA2E) in retina and its effects in the retinal pigment epithelial cells. J Biol Chem (2013) 0.76
Effects of organic solvents on two retinal pigment epithelial lipofuscin fluorophores, A2E and all-trans-retinal dimer. J Zhejiang Univ Sci B (2014) 0.75
Receptor tyrosine kinase MERTK is not required for transfer of bis-retinoids to the retinal pigmented epithelium. J Biol Chem (2016) 0.75
Lipofuscin-associated photo-oxidative stress during fundus autofluorescence imaging. PLoS One (2017) 0.75
Norbixin Protects Retinal Pigmented Epithelium Cells and Photoreceptors against A2E-Mediated Phototoxicity In Vitro and In Vivo. PLoS One (2016) 0.75
All-trans retinal levels and formation of lipofuscin precursors after bleaching in rod photoreceptors from wild type and Abca4(-/-) mice. Exp Eye Res (2017) 0.75
Vitamin A-aldehyde adducts: AMD risk and targeted therapeutics. Proc Natl Acad Sci U S A (2016) 0.75
Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium. Photochem Photobiol Sci (2015) 0.75
Ultra-widefield fundus autofluorescence in age-related macular degeneration. PLoS One (2017) 0.75
Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2. Mol Cell (2006) 7.33
Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium. Proc Natl Acad Sci U S A (2006) 2.45
Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE. Invest Ophthalmol Vis Sci (2002) 2.41
Serotype-dependent packaging of large genes in adeno-associated viral vectors results in effective gene delivery in mice. J Clin Invest (2008) 2.40
Assaying double-strand break repair pathway choice in mammalian cells using a targeted endonuclease or the RAG recombinase. Methods Enzymol (2006) 2.21
A2E, a byproduct of the visual cycle. Vision Res (2003) 2.05
A blue-blocking intraocular lens should be used in cataract surgery. Arch Ophthalmol (2005) 1.97
Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement. Angew Chem Int Ed Engl (2002) 1.95
A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation. J Biol Chem (2003) 1.83
Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E. Proc Natl Acad Sci U S A (2004) 1.80
The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model. Proc Natl Acad Sci U S A (2007) 1.78
SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci (2007) 1.77
Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate. Proc Natl Acad Sci U S A (2005) 1.75
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia. Nat Genet (2013) 1.71
The susceptibility of the retina to photochemical damage from visible light. Prog Retin Eye Res (2011) 1.67
Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem (2005) 1.65
Small molecule RPE65 antagonists limit the visual cycle and prevent lipofuscin formation. Biochemistry (2006) 1.63
Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populations. Am J Med Genet A (2006) 1.54
Retinal pigment epithelium lipofuscin proteomics. Mol Cell Proteomics (2008) 1.50
Complement activation by bisretinoid constituents of RPE lipofuscin. Invest Ophthalmol Vis Sci (2008) 1.47
Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration. Proc Natl Acad Sci U S A (2010) 1.40
Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease. J Biol Chem (2009) 1.33
Iron chelation protects the retinal pigment epithelial cell line ARPE-19 against cell death triggered by diverse stimuli. Invest Ophthalmol Vis Sci (2009) 1.32
Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells. Exp Eye Res (2005) 1.31
Structural analysis and dynamics of retinal chromophore in dark and meta I states of rhodopsin from 2H NMR of aligned membranes. J Mol Biol (2007) 1.31
A2-rhodopsin: a new fluorophore isolated from photoreceptor outer segments. Org Biomol Chem (2003) 1.31
Quantitative fundus autofluorescence in recessive Stargardt disease. Invest Ophthalmol Vis Sci (2014) 1.27
Photooxidation of A2-PE, a photoreceptor outer segment fluorophore, and protection by lutein and zeaxanthin. Exp Eye Res (2005) 1.26
Association of type 1 diabetes with two Loci on 12q13 and 16p13 and the influence coexisting thyroid autoimmunity in Japanese. J Clin Endocrinol Metab (2008) 1.24
Subtyping of avian influenza viruses H1 to H15 on the basis of hemagglutinin genes by PCR assay and molecular determination of pathogenic potential. J Clin Microbiol (2008) 1.24
The Fanconi anemia group A protein modulates homologous repair of DNA double-strand breaks in mammalian cells. Carcinogenesis (2005) 1.21
Hypoglycemia and hyperglycemia due to insulin antibodies against therapeutic human insulin: treatment with double filtration plasmapheresis and prednisolone. Am J Med Sci (2005) 1.21
A method of drusen measurement based on the geometry of fundus reflectance. Biomed Eng Online (2003) 1.19
Confronting the challenges of natural product-based antifungal discovery. Chem Biol (2011) 1.19
Photoreceptor cell degeneration in Abcr (-/-) mice. Adv Exp Med Biol (2010) 1.18
DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle (2009) 1.18
The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in Japan. J Clin Endocrinol Metab (2005) 1.17
A cleavable affinity biotinylating agent reveals a retinoid binding role for RPE65. Biochemistry (2003) 1.12
Quantitative fundus autofluorescence in healthy eyes. Invest Ophthalmol Vis Sci (2013) 1.11
Deuterium NMR structure of retinal in the ground state of rhodopsin. Biochemistry (2004) 1.10
Comparison of near-infrared and short-wavelength autofluorescence in retinitis pigmentosa. Invest Ophthalmol Vis Sci (2013) 1.09
Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway. Biochemistry (2007) 1.07
Solid-state 2H NMR structure of retinal in metarhodopsin I. J Am Chem Soc (2006) 1.07
Photographic patterns in macular images: representation by a mathematical model. J Biomed Opt (2004) 1.06
Anthocyanins protect against A2E photooxidation and membrane permeabilization in retinal pigment epithelial cells. Photochem Photobiol (2005) 1.05
Autofluorescence characteristics of normal foveas and reconstruction of foveal autofluorescence from limited data subsets. Invest Ophthalmol Vis Sci (2005) 1.05
Elovl4 5-bp deletion knock-in mouse model for Stargardt-like macular degeneration demonstrates accumulation of ELOVL4 and lipofuscin. Exp Eye Res (2009) 1.05
Use of reverse transcriptase PCR to subtype N1 to N9 neuraminidase genes of avian influenza viruses. J Clin Microbiol (2009) 1.02
A2E, a fluorophore of RPE lipofuscin, can destabilize membrane. Adv Exp Med Biol (2006) 1.02
Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments. Chirality (2004) 1.00
Lutein and zeaxanthin supplementation reduces photooxidative damage and modulates the expression of inflammation-related genes in retinal pigment epithelial cells. Free Radic Biol Med (2012) 1.00
SYBR green-based real-time reverse transcription-PCR for typing and subtyping of all hemagglutinin and neuraminidase genes of avian influenza viruses and comparison to standard serological subtyping tests. J Clin Microbiol (2011) 0.99
Rdh12 activity and effects on retinoid processing in the murine retina. J Biol Chem (2009) 0.99
The proteasome: a target of oxidative damage in cultured human retina pigment epithelial cells. Invest Ophthalmol Vis Sci (2008) 0.99
Broadening the spectrum of β-lactam antibiotics through inhibition of signal peptidase type I. Antimicrob Agents Chemother (2012) 0.98
Isolation of ginkgolides A, B, C, J and bilobalide from G. biloba extracts. Phytochemistry (2004) 0.98
Quantitative fundus autofluorescence and optical coherence tomography in best vitelliform macular dystrophy. Invest Ophthalmol Vis Sci (2014) 0.97
Indirect antioxidant protection against photooxidative processes initiated in retinal pigment epithelial cells by a lipofuscin pigment. Rejuvenation Res (2006) 0.97
A novel source of methylglyoxal and glyoxal in retina: implications for age-related macular degeneration. PLoS One (2012) 0.97
Absolute stereochemistry of allylic alcohols, amines, and other ene moieties: a microscale cross metathesis/exciton chirality protocol. J Am Chem Soc (2003) 0.96
Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity. Vision Res (2009) 0.96
Inherited bone marrow failure syndromes in 2012. Int J Hematol (2012) 0.96
Mechanisms involved in A2E oxidation. Exp Eye Res (2008) 0.96
Chemistry and biology of terpene trilactones from Ginkgo biloba. Angew Chem Int Ed Engl (2004) 0.95
Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors. J Biol Chem (2003) 0.95
A novel bisretinoid of retina is an adduct on glycerophosphoethanolamine. Invest Ophthalmol Vis Sci (2011) 0.95
Type 1 diabetes and interferon therapy: a nationwide survey in Japan. Diabetes Care (2011) 0.95
Metabolic improvement of male prisoners with type 2 diabetes in Fukushima Prison, Japan. Diabetes Res Clin Pract (2007) 0.95
Toward an understanding of bisretinoid autofluorescence bleaching and recovery. Invest Ophthalmol Vis Sci (2012) 0.95
Fundus autofluorescence imaging in a patient with rapidly developing scotoma. Retin Cases Brief Rep (2012) 0.95
Bilateral iliopsoas hematomas under sedation: a complication of postoperative therapy after coronary artery bypass grafting. Acta Med Okayama (2010) 0.94
Solution and biologically relevant conformations of enantiomeric 11-cis-locked cyclopropyl retinals. J Am Chem Soc (2002) 0.93
Association of HLA-DQ genotype in autoantibody-negative and rapid-onset type 1 diabetes. Diabetes Care (2002) 0.93
Melanoregulin (MREG) modulates lysosome function in pigment epithelial cells. J Biol Chem (2009) 0.92
Increased cone sensitivity to ABCA4 deficiency provides insight into macular vision loss in Stargardt's dystrophy. Biochim Biophys Acta (2011) 0.91
Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetes. J Clin Endocrinol Metab (2007) 0.91
Preparation of alkyl-modified silicon nanosheets by hydrosilylation of layered polysilane (Si6H6). J Am Chem Soc (2012) 0.90
Photo-products of retinal pigment epithelial bisretinoids react with cellular thiols. Mol Vis (2011) 0.90