Published in Mol Pharm on August 01, 2005
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Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities. J Pharmacol Exp Ther (2009) 1.02
Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine. AAPS J (2010) 1.01
Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. J Pharm Biomed Anal (2010) 0.99
Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences. J Agric Food Chem (2012) 0.92
Inhibition of the MRP1-mediated transport of the menadione-glutathione conjugate (thiodione) in HeLa cells as studied by SECM. Proc Natl Acad Sci U S A (2012) 0.81
Triple Recycling Processes Impact Systemic and Local Bioavailability of Orally Administered Flavonoids. AAPS J (2015) 0.79
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Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase. J Biol Chem (2005) 2.68
Prognostic and predictive value of a microRNA signature in stage II colon cancer: a microRNA expression analysis. Lancet Oncol (2013) 2.67
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Absorption and metabolism of flavonoids in the caco-2 cell culture model and a perused rat intestinal model. Drug Metab Dispos (2002) 1.80
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Metabolism of flavonoids via enteric recycling: role of intestinal disposition. J Pharmacol Exp Ther (2003) 1.55
Characterization of polymyxin B-induced nephrotoxicity: implications for dosing regimen design. Antimicrob Agents Chemother (2012) 1.52
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Enteric disposition and recycling of flavonoids and ginkgo flavonoids. J Altern Complement Med (2003) 1.37
Identification of the position of mono-O-glucuronide of flavones and flavonols by analyzing shift in online UV spectrum (lambdamax) generated from an online diode array detector. J Agric Food Chem (2010) 1.33
Structure and concentration changes affect characterization of UGT isoform-specific metabolism of isoflavones. Mol Pharm (2009) 1.32
Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. PLoS One (2008) 1.29
Disposition of flavonoids via enteric recycling: structural effects and lack of correlations between in vitro and in situ metabolic properties. Drug Metab Dispos (2006) 1.28
First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci (2011) 1.27
Pharmacokinetics and renal disposition of polymyxin B in an animal model. Antimicrob Agents Chemother (2012) 1.26
Absorption and metabolism of genistein and its five isoflavone analogs in the human intestinal Caco-2 model. Cancer Chemother Pharmacol (2004) 1.25
Uridine diphosphate glucuronosyltransferase isoform-dependent regiospecificity of glucuronidation of flavonoids. J Agric Food Chem (2011) 1.24
A validated ultra-performance liquid chromatography-tandem mass spectrometry method for the quantification of polymyxin B in mouse serum and epithelial lining fluid: application to pharmacokinetic studies. J Antimicrob Chemother (2013) 1.23
Coupling of conjugating enzymes and efflux transporters: impact on bioavailability and drug interactions. Curr Drug Metab (2005) 1.21
MicroRNA-217 promotes ethanol-induced fat accumulation in hepatocytes by down-regulating SIRT1. J Biol Chem (2012) 1.19
Breast cancer resistance protein (ABCG2) determines distribution of genistein phase II metabolites: reevaluation of the roles of ABCG2 in the disposition of genistein. Drug Metab Dispos (2012) 1.19
Disposition of flavonoids via recycling: comparison of intestinal versus hepatic disposition. Drug Metab Dispos (2005) 1.16
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In vitro assessment and multicenter cohort study of comparative nephrotoxicity rates associated with colistimethate versus polymyxin B therapy. Antimicrob Agents Chemother (2014) 1.14
Commentary: bioavailability of flavonoids and polyphenols: call to arms. Mol Pharm (2007) 1.13
Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes. Mol Pharm (2010) 1.13
Disposition of flavonoids via enteric recycling: enzyme-transporter coupling affects metabolism of biochanin A and formononetin and excretion of their phase II conjugates. J Pharmacol Exp Ther (2004) 1.13
Ovol1 regulates meiotic pachytene progression during spermatogenesis by repressing Id2 expression. Development (2005) 1.12
The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol (2006) 1.11
Bioavailability challenges associated with development of anti-cancer phenolics. Mini Rev Med Chem (2010) 1.10
Nanoporous carbons through direct carbonization of a zeolitic imidazolate framework for supercapacitor electrodes. Chem Commun (Camb) (2012) 1.09
Disposition of flavonoids via enteric recycling: enzyme stability affects characterization of prunetin glucuronidation across species, organs, and UGT isoforms. Mol Pharm (2007) 1.09
Disposition of flavonoids via enteric recycling: determination of the UDP-glucuronosyltransferase isoforms responsible for the metabolism of flavonoids in intact Caco-2 TC7 cells using siRNA. Mol Pharm (2007) 1.09
Temporal interplay between efflux pumps and target mutations in development of antibiotic resistance in Escherichia coli. Antimicrob Agents Chemother (2012) 1.06
In vitro potency of various polymyxin B components. Antimicrob Agents Chemother (2011) 1.05
Species- and disposition model-dependent metabolism of raloxifene in gut and liver: role of UGT1A10. Drug Metab Dispos (2005) 1.05
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Biopharmaceutical and pharmacokinetic characterization of matrine as determined by a sensitive and robust UPLC-MS/MS method. J Pharm Biomed Anal (2009) 1.03
Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother (2013) 1.03
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Disposition of flavonoids via enteric recycling: UDP-glucuronosyltransferase (UGT) 1As deficiency in Gunn rats is compensated by increases in UGT2Bs activities. J Pharmacol Exp Ther (2009) 1.02
Enhancement of oral bioavailability of 20(S)-ginsenoside Rh2 through improved understanding of its absorption and efflux mechanisms. Drug Metab Dispos (2011) 1.01
Anisotropic intrinsic lattice thermal conductivity of phosphorene from first principles. Phys Chem Chem Phys (2015) 1.01
Breast cancer resistance protein (BCRP) and sulfotransferases contribute significantly to the disposition of genistein in mouse intestine. AAPS J (2010) 1.01
Potential beneficial metabolic interactions between tamoxifen and isoflavones via cytochrome P450-mediated pathways in female rat liver microsomes. Pharm Res (2004) 1.01
Disposition mechanisms of raloxifene in the human intestinal Caco-2 model. J Pharmacol Exp Ther (2004) 0.99
Simultaneous determination of genistein and its four phase II metabolites in blood by a sensitive and robust UPLC-MS/MS method: Application to an oral bioavailability study of genistein in mice. J Pharm Biomed Anal (2010) 0.99
Direct synthesis of MOF-derived nanoporous carbon with magnetic Co nanoparticles toward efficient water treatment. Small (2014) 0.99
Facile synthesis of nanoporous carbons with controlled particle sizes by direct carbonization of monodispersed ZIF-8 crystals. Chem Commun (Camb) (2013) 0.98
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Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model. J Pharmacol Exp Ther (2010) 0.97
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Role of SIRT1-FoxO1 signaling in dietary saturated fat-dependent upregulation of liver adiponectin receptor 2 in ethanol-administered mice. Antioxid Redox Signal (2011) 0.97
Use of isoform-specific UGT metabolism to determine and describe rates and profiles of glucuronidation of wogonin and oroxylin A by human liver and intestinal microsomes. Pharm Res (2010) 0.96
Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo). Pharm Res (2008) 0.96
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Interactions among ovarian hormones and time of testing on behavioral sensitization and cocaine self-administration. Behav Brain Res (2007) 0.95
Species and gender differences affect the metabolism of emodin via glucuronidation. AAPS J (2010) 0.94
Mechanisms responsible for poor oral bioavailability of paeoniflorin: Role of intestinal disposition and interactions with sinomenine. Pharm Res (2006) 0.94
Viral vector-mediated overexpression of estrogen receptor-alpha in striatum enhances the estradiol-induced motor activity in female rats and estradiol-modulated GABA release. J Neurosci (2009) 0.94
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Ethanol administration exacerbates the abnormalities in hepatic lipid oxidation in genetically obese mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.93
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The role of efflux transporters on the transport of highly toxic aconitine, mesaconitine, hypaconitine, and their hydrolysates, as determined in cultured Caco-2 and transfected MDCKII cells. Toxicol Lett (2012) 0.92
Systematic studies of sulfation and glucuronidation of 12 flavonoids in the mouse liver S9 fraction reveal both unique and shared positional preferences. J Agric Food Chem (2012) 0.92
Regioselective sulfation and glucuronidation of phenolics: insights into the structural basis. Curr Drug Metab (2011) 0.91
ATF5 is overexpressed in epithelial ovarian carcinomas and interference with its function increases apoptosis through the downregulation of Bcl-2 in SKOV-3 cells. Int J Gynecol Pathol (2012) 0.91
Bioavailability and pharmacokinetics of genistein: mechanistic studies on its ADME. Anticancer Agents Med Chem (2012) 0.90
Accuracy of IgM antibody testing, FQ-PCR and culture in laboratory diagnosis of acute infection by Mycoplasma pneumoniae in adults and adolescents with community-acquired pneumonia. BMC Infect Dis (2013) 0.90
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Validated LC-MS/MS method for the determination of maackiain and its sulfate and glucuronide in blood: application to pharmacokinetic and disposition studies. J Pharm Biomed Anal (2011) 0.89
Regioselective glucuronidation of flavonols by six human UGT1A isoforms. Pharm Res (2011) 0.89
A porcine collagen-derived matrix as a carrier for recombinant human bone morphogenetic protein-2 enhances spinal fusion in rats. Spine J (2008) 0.89
High efficient degradation of dyes with lignin peroxidase coupled with glucose oxidase. J Biotechnol (2006) 0.89
Ratio of γ-H2AX level in lymphocytes to that in granulocytes detected using flow cytometry as a potential biodosimeter for radiation exposure. Radiat Environ Biophys (2014) 0.88
Highly variable contents of phenolics in St. John's Wort products affect their transport in the human intestinal Caco-2 cell model: pharmaceutical and biopharmaceutical rationale for product standardization. J Agric Food Chem (2010) 0.88
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UDP-glucuronosyltransferase (UGT) 1A9-overexpressing HeLa cells is an appropriate tool to delineate the kinetic interplay between breast cancer resistance protein (BRCP) and UGT and to rapidly identify the glucuronide substrates of BCRP. Drug Metab Dispos (2011) 0.88
Variable isoflavone content of red clover products affects intestinal disposition of biochanin A, formononetin, genistein, and daidzein. J Altern Complement Med (2008) 0.88
Pachymic acid inhibits cell growth and modulates arachidonic acid metabolism in nonsmall cell lung cancer A549 cells. Mol Carcinog (2010) 0.88
In vitro pharmacodynamics of AZD5206 against Staphylococcus aureus. Antimicrob Agents Chemother (2012) 0.88
Role of HD2 genes in seed germination and early seedling growth in Arabidopsis. Plant Cell Rep (2011) 0.88
Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells. J Agric Food Chem (2014) 0.87
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Neuregulin-1/ErbB signaling is impaired in the rat model of diabetic cardiomyopathy. Cardiovasc Pathol (2012) 0.87
A porcine model of intervertebral disc degeneration induced by annular injury characterized with magnetic resonance imaging and histopathological findings. Laboratory investigation. J Neurosurg Spine (2008) 0.87