HPeak: an HMM-based algorithm for defining read-enriched regions in ChIP-Seq data.

PubWeight™: 2.41‹?› | Rank: Top 2%

🔗 View Article (PMC 2912305)

Published in BMC Bioinformatics on July 02, 2010

Authors

Zhaohui S Qin1, Jianjun Yu, Jincheng Shen, Christopher A Maher, Ming Hu, Shanker Kalyana-Sundaram, Jindan Yu, Arul M Chinnaiyan

Author Affiliations

1: Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, 48109-2029, USA. qin@umich.edu

Articles citing this

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer. Nature (2014) 5.45

Evaluation of algorithm performance in ChIP-seq peak detection. PLoS One (2010) 3.99

Replication stress induces 53BP1-containing OPT domains in G1 cells. J Cell Biol (2011) 2.18

The histone acetyltransferase MOF is a key regulator of the embryonic stem cell core transcriptional network. Cell Stem Cell (2012) 2.17

Identifying dispersed epigenomic domains from ChIP-Seq data. Bioinformatics (2011) 2.10

An integrated ChIP-seq analysis platform with customizable workflows. BMC Bioinformatics (2011) 1.92

Discovering transcription factor binding sites in highly repetitive regions of genomes with multi-read analysis of ChIP-Seq data. PLoS Comput Biol (2011) 1.86

Practical guidelines for the comprehensive analysis of ChIP-seq data. PLoS Comput Biol (2013) 1.81

ChIP-chip versus ChIP-seq: lessons for experimental design and data analysis. BMC Genomics (2011) 1.80

Deep sequencing reveals distinct patterns of DNA methylation in prostate cancer. Genome Res (2011) 1.63

Cooperation between Polycomb and androgen receptor during oncogenic transformation. Genome Res (2011) 1.47

PeakRanger: a cloud-enabled peak caller for ChIP-seq data. BMC Bioinformatics (2011) 1.44

FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1. Mol Cell (2011) 1.14

Regulation of several androgen-induced genes through the repression of the miR-99a/let-7c/miR-125b-2 miRNA cluster in prostate cancer cells. Oncogene (2013) 1.12

AREM: aligning short reads from ChIP-sequencing by expectation maximization. J Comput Biol (2011) 1.05

PePr: a peak-calling prioritization pipeline to identify consistent or differential peaks from replicated ChIP-Seq data. Bioinformatics (2014) 1.04

Genome-wide localization of protein-DNA binding and histone modification by a Bayesian change-point method with ChIP-seq data. PLoS Comput Biol (2012) 0.98

Comparative annotation of functional regions in the human genome using epigenomic data. Nucleic Acids Res (2013) 0.94

RIPSeeker: a statistical package for identifying protein-associated transcripts from RIP-seq experiments. Nucleic Acids Res (2013) 0.93

Cell-Cycle Control of Bivalent Epigenetic Domains Regulates the Exit from Pluripotency. Stem Cell Reports (2015) 0.93

Combining multiple ChIP-seq peak detection systems using combinatorial fusion. BMC Genomics (2012) 0.92

Base-resolution methylation patterns accurately predict transcription factor bindings in vivo. Nucleic Acids Res (2015) 0.92

Enriched domain detector: a program for detection of wide genomic enrichment domains robust against local variations. Nucleic Acids Res (2014) 0.90

H2B ubiquitylation promotes RNA Pol II processivity via PAF1 and pTEFb. Mol Cell (2014) 0.90

ChIPseek, a web-based analysis tool for ChIP data. BMC Genomics (2014) 0.88

Impaired replication elongation in Tetrahymena mutants deficient in histone H3 Lys 27 monomethylation. Genes Dev (2013) 0.86

HMCan: a method for detecting chromatin modifications in cancer samples using ChIP-seq data. Bioinformatics (2013) 0.86

Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One (2011) 0.86

A survey of motif finding Web tools for detecting binding site motifs in ChIP-Seq data. Biol Direct (2014) 0.85

Processing and analyzing ChIP-seq data: from short reads to regulatory interactions. Brief Funct Genomics (2010) 0.84

Statistical Issues in the Analysis of ChIP-Seq and RNA-Seq Data. Genes (Basel) (2010) 0.83

Pinpointing transcription factor binding sites from ChIP-seq data with SeqSite. BMC Syst Biol (2011) 0.82

Characterising ChIP-seq binding patterns by model-based peak shape deconvolution. BMC Genomics (2013) 0.82

BIMMER: a novel algorithm for detecting differential DNA methylation regions from MBDCap-seq data. BMC Bioinformatics (2014) 0.81

High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping. BMC Genomics (2015) 0.81

PolyaPeak: detecting transcription factor binding sites from ChIP-seq using peak shape information. PLoS One (2014) 0.81

Accounting for immunoprecipitation efficiencies in the statistical analysis of ChIP-seq data. BMC Bioinformatics (2013) 0.80

Statistical challenges in analyzing methylation and long-range chromosomal interaction data. Stat Biosci (2016) 0.79

GPUmotif: an ultra-fast and energy-efficient motif analysis program using graphics processing units. PLoS One (2012) 0.79

BIDCHIPS: bias decomposition and removal from ChIP-seq data clarifies true binding signal and its functional correlates. Epigenetics Chromatin (2015) 0.78

A comprehensive promoter landscape identifies a novel promoter for CD133 in restricted tissues, cancers, and stem cells. Front Genet (2013) 0.78

histoneHMM: Differential analysis of histone modifications with broad genomic footprints. BMC Bioinformatics (2015) 0.78

The lncRNA landscape of breast cancer reveals a role for DSCAM-AS1 in breast cancer progression. Nat Commun (2016) 0.78

A signal processing approach for enriched region detection in RNA polymerase II ChIP-seq data. BMC Bioinformatics (2012) 0.77

A novel Bayesian change-point algorithm for genome-wide analysis of diverse ChIPseq data types. J Vis Exp (2012) 0.77

Peak Finder Metaserver - a novel application for finding peaks in ChIP-seq data. BMC Bioinformatics (2013) 0.77

Integrative analysis of deep sequencing data identifies estrogen receptor early response genes and links ATAD3B to poor survival in breast cancer. PLoS Comput Biol (2013) 0.77

Sparsely correlated hidden Markov models with application to genome-wide location studies. Bioinformatics (2013) 0.77

NEXT-peak: a normal-exponential two-peak model for peak-calling in ChIP-seq data. BMC Genomics (2013) 0.76

Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Mol Cell Endocrinol (2014) 0.76

Bayesian hidden Markov models to identify RNA-protein interaction sites in PAR-CLIP. Biometrics (2014) 0.76

Features that define the best ChIP-seq peak calling algorithms. Brief Bioinform (2016) 0.76

Normalization of high dimensional genomics data where the distribution of the altered variables is skewed. PLoS One (2011) 0.76

A wavelet approach to detect enriched regions and explore epigenomic landscapes. J Comput Biol (2014) 0.76

Some Statistical Strategies for DAE-seq Data Analysis: Variable Selection and Modeling Dependencies among Observations. J Am Stat Assoc (2014) 0.75

T-KDE: a method for genome-wide identification of constitutive protein binding sites from multiple ChIP-seq data sets. BMC Genomics (2014) 0.75

Global analysis of transcription factor-binding sites in yeast using ChIP-Seq. Methods Mol Biol (2014) 0.75

groHMM: a computational tool for identifying unannotated and cell type-specific transcription units from global run-on sequencing data. BMC Bioinformatics (2015) 0.75

biomvRhsmm: genomic segmentation with hidden semi-Markov model. Biomed Res Int (2014) 0.75

Articles cited by this

The human genome browser at UCSC. Genome Res (2002) 168.23

Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods (2008) 126.81

High-resolution profiling of histone methylations in the human genome. Cell (2007) 85.74

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature (2007) 65.18

Genome-wide mapping of in vivo protein-DNA interactions. Science (2007) 64.92

Model-based analysis of ChIP-Seq (MACS). Genome Biol (2008) 51.63

Genome-wide profiles of STAT1 DNA association using chromatin immunoprecipitation and massively parallel sequencing. Nat Methods (2007) 45.04

Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes. Genome Res (2005) 44.08

Genome-wide location and function of DNA binding proteins. Science (2000) 31.25

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell (2008) 28.29

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. Nat Biotechnol (2008) 21.72

ChIP-seq accurately predicts tissue-specific activity of enhancers. Nature (2009) 18.38

Dynamic regulation of nucleosome positioning in the human genome. Cell (2008) 15.60

An integrated software system for analyzing ChIP-chip and ChIP-seq data. Nat Biotechnol (2008) 13.96

Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association. Nat Genet (2001) 13.05

MatInspector and beyond: promoter analysis based on transcription factor binding sites. Bioinformatics (2005) 11.75

Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data. Nat Methods (2008) 11.61

PeakSeq enables systematic scoring of ChIP-seq experiments relative to controls. Nat Biotechnol (2009) 11.28

Design and analysis of ChIP-seq experiments for DNA-binding proteins. Nat Biotechnol (2008) 10.10

Genome-wide identification of in vivo protein-DNA binding sites from ChIP-Seq data. Nucleic Acids Res (2008) 8.89

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell (2010) 6.76

FindPeaks 3.1: a tool for identifying areas of enrichment from massively parallel short-read sequencing technology. Bioinformatics (2008) 6.53

TileMap: create chromosomal map of tiling array hybridizations. Bioinformatics (2005) 5.68

ChIP-Seq of ERalpha and RNA polymerase II defines genes differentially responding to ligands. EMBO J (2009) 5.36

Mapping protein-DNA interactions in vivo with formaldehyde: evidence that histone H4 is retained on a highly transcribed gene. Cell (1988) 5.08

ChIP-seq: using high-throughput sequencing to discover protein-DNA interactions. Methods (2009) 4.69

Mapping of transcription factor binding regions in mammalian cells by ChIP: comparison of array- and sequencing-based technologies. Genome Res (2007) 4.59

ChIP-seq: welcome to the new frontier. Nat Methods (2007) 4.56

Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks. BMC Bioinformatics (2008) 4.41

Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver. Genome Res (2009) 4.11

Mapping Polycomb-repressed domains in the bithorax complex using in vivo formaldehyde cross-linked chromatin. Cell (1993) 4.01

Efficient yeast ChIP-Seq using multiplex short-read DNA sequencing. BMC Genomics (2009) 3.22

A hidden Markov model for analyzing ChIP-chip experiments on genome tiling arrays and its application to p53 binding sequences. Bioinformatics (2005) 3.06

Transcript mapping with high-density oligonucleotide tiling arrays. Bioinformatics (2006) 2.94

An HMM approach to genome-wide identification of differential histone modification sites from ChIP-seq data. Bioinformatics (2008) 2.85

A practical comparison of methods for detecting transcription factor binding sites in ChIP-seq experiments. BMC Genomics (2009) 2.70

GeneTrack--a genomic data processing and visualization framework. Bioinformatics (2008) 2.51

BayesPeak: Bayesian analysis of ChIP-seq data. BMC Bioinformatics (2009) 2.47

Genomic location analysis by ChIP-Seq. J Cell Biochem (2009) 2.44

On the detection and refinement of transcription factor binding sites using ChIP-Seq data. Nucleic Acids Res (2010) 1.67

ChIPping away at gene regulation. EMBO Rep (2008) 1.54

Parameter estimation for robust HMM analysis of ChIP-chip data. BMC Bioinformatics (2008) 1.48

A hidden Markov model approach for determining expression from genomic tiling micro arrays. BMC Bioinformatics (2006) 1.40

Hierarchical hidden Markov model with application to joint analysis of ChIP-chip and ChIP-seq data. Bioinformatics (2009) 1.23

Integrating quantitative information from ChIP-chip experiments into motif finding. Biostatistics (2007) 1.15

Epigenetics meets next-generation sequencing. Epigenetics (2008) 1.14

ChIP-chip for genome-wide analysis of protein binding in mammalian cells. Curr Protoc Mol Biol (2007) 1.11

Articles by these authors

Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science (2005) 39.06

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78

The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature (2002) 18.30

Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature (2012) 18.23

ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia (2004) 17.08

Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79

The Sorghum bicolor genome and the diversification of grasses. Nature (2009) 14.62

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells. Proc Natl Acad Sci U S A (2003) 13.68

ProbeMatch: rapid alignment of oligonucleotides to genome allowing both gaps and mismatches. Bioinformatics (2009) 13.34

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05

Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature (2009) 12.58

The mutational landscape of lethal castration-resistant prostate cancer. Nature (2012) 11.82

Transcriptome sequencing to detect gene fusions in cancer. Nature (2009) 11.63

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature (2007) 10.94

Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia (2007) 10.74

TEAD mediates YAP-dependent gene induction and growth control. Genes Dev (2008) 9.88

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression. Proc Natl Acad Sci U S A (2004) 9.42

Integrative molecular concept modeling of prostate cancer progression. Nat Genet (2006) 8.49

Whole-genome analysis informs breast cancer response to aromatase inhibition. Nature (2012) 8.03

TMPRSS2:ERG fusion-associated deletions provide insight into the heterogeneity of prostate cancer. Cancer Res (2006) 7.61

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science (2008) 7.59

Autoantibody signatures in prostate cancer. N Engl J Med (2005) 7.56

Meta-analysis of microarrays: interstudy validation of gene expression profiles reveals pathway dysregulation in prostate cancer. Cancer Res (2002) 7.29

Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer. Cell (2009) 7.09

An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell (2010) 6.76

Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol (2011) 6.54

The emergence of lncRNAs in cancer biology. Cancer Discov (2011) 6.32

Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell (2012) 6.09

TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion. Am J Surg Pathol (2007) 6.09

Recurrent gene fusions in prostate cancer. Nat Rev Cancer (2008) 6.08

Integrative genomic and proteomic analysis of prostate cancer reveals signatures of metastatic progression. Cancer Cell (2005) 6.04

The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02

A hierarchical network of transcription factors governs androgen receptor-dependent prostate cancer growth. Mol Cell (2007) 5.99

Role of the TMPRSS2-ERG gene fusion in prostate cancer. Neoplasia (2008) 5.92

Androgen-independent prostate cancer is a heterogeneous group of diseases: lessons from a rapid autopsy program. Cancer Res (2004) 5.88

Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med (2011) 5.82

DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. N Engl J Med (2015) 5.39

Chimeric transcript discovery by paired-end transcriptome sequencing. Proc Natl Acad Sci U S A (2009) 5.30

EML4-ALK fusion lung cancer: a rare acquired event. Neoplasia (2008) 5.22

miR-24 Inhibits cell proliferation by targeting E2F2, MYC, and other cell-cycle genes via binding to "seedless" 3'UTR microRNA recognition elements. Mol Cell (2009) 5.22

alpha-Methylacyl coenzyme A racemase as a tissue biomarker for prostate cancer. JAMA (2002) 5.07

TMPRSS2:ETV4 gene fusions define a third molecular subtype of prostate cancer. Cancer Res (2006) 4.99

Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma. Nat Med (2010) 4.81

Integrative analysis of the cancer transcriptome. Nat Genet (2005) 4.44

Integrative genomics analysis reveals silencing of beta-adrenergic signaling by polycomb in prostate cancer. Cancer Cell (2007) 4.43

Expressed pseudogenes in the transcriptional landscape of human cancers. Cell (2012) 4.22

Sex differences in drug abuse. Front Neuroendocrinol (2007) 4.01

Probabilistic model of the human protein-protein interaction network. Nat Biotechnol (2005) 3.99

Activating ESR1 mutations in hormone-resistant metastatic breast cancer. Nat Genet (2013) 3.96

A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res (2007) 3.82

Multiplex biomarker approach for determining risk of prostate-specific antigen-defined recurrence of prostate cancer. J Natl Cancer Inst (2003) 3.73

Antibody-based detection of ERG rearrangement-positive prostate cancer. Neoplasia (2010) 3.66

Characterization of TMPRSS2:ETV5 and SLC45A3:ETV5 gene fusions in prostate cancer. Cancer Res (2008) 3.59

Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst (2008) 3.55

Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer. Cancer Cell (2011) 3.53

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis. Genes Dev (2012) 3.48

Molecular characterization of neuroendocrine prostate cancer and identification of new drug targets. Cancer Discov (2011) 3.43

The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex. Nat Genet (2013) 3.39

The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation. Genes Dev (2010) 3.37

Comprehensive assessment of TMPRSS2 and ETS family gene aberrations in clinically localized prostate cancer. Mod Pathol (2007) 3.37

A first-generation multiplex biomarker analysis of urine for the early detection of prostate cancer. Cancer Res (2008) 3.35

Induced chromosomal proximity and gene fusions in prostate cancer. Science (2009) 3.31

Identification of targetable FGFR gene fusions in diverse cancers. Cancer Discov (2013) 3.13

Molecular concepts analysis links tumors, pathways, mechanisms, and drugs. Neoplasia (2007) 3.06

Characterization of TMPRSS2-ETS gene aberrations in androgen-independent metastatic prostate cancer. Cancer Res (2008) 3.02