Published in Bioorg Med Chem on July 27, 2005
Chemical analysis, antioxidant, antichemotactic and monoamine oxidase inhibition effects of some pteridophytes from Brazil. Pharmacogn Mag (2014) 0.77
3-Coumaranone derivatives as inhibitors of monoamine oxidase. Drug Des Devel Ther (2015) 0.75
2-acetylphenol analogs as potent reversible monoamine oxidase inhibitors. Drug Des Devel Ther (2015) 0.75
Antimitotic and antiproliferative activities of chalcones: forward structure-activity relationship. J Med Chem (2008) 1.69
Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency. J Hepatol (2007) 1.38
Synthesis and biological evaluation of direct thrombin inhibitors bearing 4-(piperidin-1-yl)pyridine at the P1 position with potent anticoagulant activity. J Med Chem (2013) 1.23
Drug-protein binding: a critical review of analytical tools. Anal Bioanal Chem (2010) 1.21
HDAC6 as a target for neurodegenerative diseases: what makes it different from the other HDACs? Mol Neurodegener (2013) 1.12
Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem (2010) 1.04
Structure-activity relationships in 1,4-benzodioxan-related compounds. 7. Selectivity of 4-phenylchroman analogues for alpha(1)-adrenoreceptor subtypes. J Med Chem (2002) 1.03
Structures of human monoamine oxidase B complexes with selective noncovalent inhibitors: safinamide and coumarin analogs. J Med Chem (2007) 1.03
Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol (2009) 1.00
Design, synthesis and biological evaluation of indane-2-arylhydrazinylmethylene-1,3-diones and indol-2-aryldiazenylmethylene-3-ones as beta-amyloid aggregation inhibitors. Eur J Med Chem (2009) 0.96
9,10-Anthraquinone hinders beta-aggregation: how does a small molecule interfere with Abeta-peptide amyloid fibrillation? Protein Sci (2009) 0.94
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein. J Med Chem (2011) 0.94
Optimized liquid chromatography-mass spectrometry approach for the isolation of minor stress biomarkers in plant extracts and their identification by capillary nuclear magnetic resonance. J Chromatogr A (2007) 0.93
Design, synthesis, and 3D QSAR of novel potent and selective aromatase inhibitors. J Med Chem (2004) 0.92
Impact of species-dependent differences on screening, design, and development of MAO B inhibitors. J Med Chem (2006) 0.92
Quantitative structure-permeation relationship for iontophoretic transport across the skin. J Control Release (2007) 0.91
Immobilized artificial membrane HPLC in drug research. J Med Chem (2003) 0.89
Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities. Eur J Med Chem (2010) 0.89
UPLC-TOF-MS for plant metabolomics: a sequential approach for wound marker analysis in Arabidopsis thaliana. J Chromatogr B Analyt Technol Biomed Life Sci (2008) 0.88
CE can identify small molecules that selectively target soluble oligomers of amyloid beta protein and display antifibrillogenic activity. Electrophoresis (2009) 0.88
Improving quantitative structure-activity relationships through multiobjective optimization. J Chem Inf Model (2009) 0.88
Inactivation of the glutamine/amino acid transporter ASCT2 by 1,2,3-dithiazoles: proteoliposomes as a tool to gain insights in the molecular mechanism of action and of antitumor activity. Toxicol Appl Pharmacol (2012) 0.88
Parallel artificial membrane permeability assay: a new membrane for the fast prediction of passive human skin permeability. J Med Chem (2006) 0.86
Carbamate prodrug concept for hydroxamate HDAC inhibitors. ChemMedChem (2011) 0.86
Ferulenol specifically inhibits succinate ubiquinone reductase at the level of the ubiquinone cycle. Biochem Biophys Res Commun (2007) 0.86
Evaluation of neonatal BH4 loading test in neonates screened for hyperphenylalaninemia. Early Hum Dev (2008) 0.85
Screening of matrix metalloproteinases available from the protein data bank: insights into biological functions, domain organization, and zinc binding groups. J Chem Inf Model (2007) 0.85
Ultra high pressure liquid chromatography for crude plant extract profiling. J AOAC Int (2011) 0.85
Edaravone derivatives containing NO-donor functions. J Med Chem (2009) 0.85
Breast cancer resistance protein (BCRP/ABCG2): new inhibitors and QSAR studies by a 3D linear solvation energy approach. Eur J Pharm Sci (2009) 0.84
Rapid determination of pK (a) values of 20 amino acids by CZE with UV and capacitively coupled contactless conductivity detections. Anal Bioanal Chem (2007) 0.84
Molecular electrocatalysis for oxygen reduction by cobalt porphyrins adsorbed at liquid/liquid interfaces. J Am Chem Soc (2010) 0.84
Analytical tools for the physicochemical profiling of drug candidates to predict absorption/distribution. Anal Bioanal Chem (2009) 0.84
Liposome/water lipophilicity: methods, information content, and pharmaceutical applications. Med Res Rev (2004) 0.83
Stereoselective Inhibition of the hERG1 Potassium Channel. Front Pharmacol (2010) 0.83
QSAR and QSPR studies of a highly structured physicochemical domain. J Chem Inf Model (2006) 0.83
Methodologies to assess drug permeation through the blood-brain barrier for pharmaceutical research. Pharm Res (2013) 0.83
Quantitative structure-permeation relationships for solute transport across silicone membranes. Pharm Res (2002) 0.82
High throughput UV method for the estimation of thermodynamic solubility and the determination of the solubility in biorelevant media. Eur J Pharm Sci (2007) 0.82
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase. J Med Chem (2011) 0.82
Indole alkaloids of Psychotria as multifunctional cholinesterases and monoamine oxidases inhibitors. Phytochemistry (2012) 0.82
Retention time prediction for dereplication of natural products (CxHyOz) in LC-MS metabolite profiling. Phytochemistry (2014) 0.82
1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor. Bioorg Med Chem (2008) 0.81
Analysis of X-ray structures of matrix metalloproteinases via chaotic map clustering. BMC Bioinformatics (2010) 0.81
Identification of compounds that inhibit growth of 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine-resistant cancer cells. Mol Cancer Ther (2005) 0.81
NO-donor COX-2 inhibitors. New nitrooxy-substituted 1,5-diarylimidazoles endowed with COX-2 inhibitory and vasodilator properties. J Med Chem (2007) 0.81
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase. Bioorg Med Chem (2012) 0.81
Immobilized artificial membrane liquid chromatography: proposed guidelines for technical optimization of retention measurements. J Chromatogr A (2002) 0.81
The permeability P-glycoprotein: a focus on enantioselectivity and brain distribution. Expert Opin Drug Metab Toxicol (2010) 0.81
A chemocentric approach to the identification of cancer targets. PLoS One (2012) 0.81
Gd-BOPTA transport into rat hepatocytes: pharmacokinetic analysis of dynamic magnetic resonance images using a hollow-fiber bioreactor. Invest Radiol (2004) 0.81
In vitro screening assays to identify natural or synthetic acetylcholinesterase inhibitors: thin layer chromatography versus microplate methods. Eur J Pharm Sci (2007) 0.81
A 3D linear solvation energy model to quantify the affinity of flavonoid derivatives toward P-glycoprotein. Eur J Pharm Sci (2008) 0.81
An integrated approach to ligand- and structure-based drug design: development and application to a series of serine protease inhibitors. J Chem Inf Model (2008) 0.80
Lipophilicity Profiles of Ampholytes. Chem Rev (1997) 0.80
New high throughput screening method for drug release measurements. Eur J Pharm Biopharm (2013) 0.80
Screening of non-alkaloidal natural compounds as acetylcholinesterase inhibitors. Chem Biodivers (2004) 0.80
In silico and in vitro filters for the fast estimation of skin permeation and distribution of new chemical entities. J Med Chem (2007) 0.80
Coumarin, chromone, and 4(3H)-pyrimidinone novel bicyclic and tricyclic derivatives as antiplatelet agents: synthesis, biological evaluation, and comparative molecular field analysis. Bioorg Med Chem (2003) 0.80
Isolation and quantification by high-performance liquid chromatography-ion-trap mass spectrometry of androgen sulfoconjugates in human urine. J Chromatogr A (2008) 0.80
Block of the hERG channel by bupivacaine: Electrophysiological and modeling insights towards stereochemical optimization. Eur J Med Chem (2011) 0.80
Exploration of the pharmacophore of 3-alkyl-5-arylimidazolidinediones as new CB(1) cannabinoid receptor ligands and potential antagonists: synthesis, lipophilicity, affinity, and molecular modeling. J Med Chem (2002) 0.80
Global analytical strategy to measure drug-plasma protein interactions: from high-throughput to in-depth analysis. Drug Discov Today (2013) 0.80
Theoretical and experimental exploration of the lipophilicity of zwitterionic drugs in the 1,2-dichloroethane/water system. Pharm Res (2002) 0.79
A k-NN algorithm for predicting the oral sub-chronic toxicity in the rat. ALTEX (2014) 0.79
A fast screening strategy for characterizing peptide delivery by transdermal iontophoresis. J Control Release (2009) 0.79
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. Bioorg Med Chem (2008) 0.79
Quantitative structure-permeation relationships (QSPeRs) to predict skin permeation: a critical evaluation. Pharm Res (2004) 0.79
New serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) receptor antagonists: synthesis, pharmacology, 3D-QSAR, and molecular modeling of (aminoalkyl)benzo and heterocycloalkanones. J Med Chem (2002) 0.79
Integration of QSAR models for bioconcentration suitable for REACH. Sci Total Environ (2013) 0.79
Neuronal nicotinic acetylcholine receptor agonists: pharmacophores, evolutionary QSAR and 3D-QSAR models. Curr Top Med Chem (2004) 0.79
NO-donor melatonin derivatives: synthesis and in vitro pharmacological characterization. J Pineal Res (2007) 0.79
Hollow fiber bioreactor: new development for the study of contrast agent transport into hepatocytes by magnetic resonance imaging. Biotechnol Bioeng (2004) 0.79
Strategies of multi-objective optimization in drug discovery and development. Expert Opin Drug Discov (2011) 0.79
Determination of pKa values by capillary zone electrophoresis with a dynamic coating procedure. J Sep Sci (2005) 0.78
Hepatocyte hollow-fibre bioreactors: design, set-up, validation and applications. J Pharm Pharmacol (2003) 0.78
First selective dual inhibitors of tau phosphorylation and Beta-amyloid aggregation, two major pathogenic mechanisms in Alzheimer's disease. ACS Chem Neurosci (2014) 0.78
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: design, synthesis, structure-affinity and structure-selectivity relationships. Bioorg Med Chem (2008) 0.78
Computer-aided structure-based design of multitarget leads for Alzheimer's disease. J Chem Inf Model (2014) 0.78