Published in Neuron on August 04, 2005
Correction of fragile X syndrome in mice. Neuron (2007) 6.51
Rapid translation of Arc/Arg3.1 selectively mediates mGluR-dependent LTD through persistent increases in AMPAR endocytosis rate. Neuron (2008) 3.48
Advances in the treatment of fragile X syndrome. Pediatrics (2009) 3.10
A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet (2009) 2.76
Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease. Neuron (2010) 2.67
Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice. Neurobiol Dis (2008) 2.52
Cerebellar LTD and pattern recognition by Purkinje cells. Neuron (2007) 2.18
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci (2012) 2.16
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors. Proc Natl Acad Sci U S A (2007) 2.10
The state of synapses in fragile X syndrome. Neuroscientist (2009) 2.07
Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu Rev Med (2011) 1.96
Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR. J Neurosci (2007) 1.95
Murine hippocampal neurons expressing Fmr1 gene premutations show early developmental deficits and late degeneration. Hum Mol Genet (2010) 1.95
Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid. J Neurosci (2010) 1.92
The intense world theory - a unifying theory of the neurobiology of autism. Front Hum Neurosci (2010) 1.91
Quantitative proteomic analysis of primary neurons reveals diverse changes in synaptic protein content in fmr1 knockout mice. Proc Natl Acad Sci U S A (2008) 1.91
FMR1: a gene with three faces. Biochim Biophys Acta (2009) 1.77
Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci (2008) 1.72
Cerebellar plasticity and motor learning deficits in a copy-number variation mouse model of autism. Nat Commun (2014) 1.58
Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development (2008) 1.52
Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms. Pharmacol Rev (2009) 1.40
The FMR1 gene and fragile X-associated tremor/ataxia syndrome. Am J Med Genet B Neuropsychiatr Genet (2009) 1.37
The cerebellum, sensitive periods, and autism. Neuron (2014) 1.36
A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet (2009) 1.36
3D pattern of brain abnormalities in Fragile X syndrome visualized using tensor-based morphometry. Neuroimage (2006) 1.34
Signals, synapses, and synthesis: how new proteins control plasticity. Front Neural Circuits (2009) 1.31
Fragile X: leading the way for targeted treatments in autism. Neurotherapeutics (2010) 1.31
H2-K(b) and H2-D(b) regulate cerebellar long-term depression and limit motor learning. Proc Natl Acad Sci U S A (2009) 1.31
Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology (2011) 1.30
Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A (2010) 1.29
Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential. Neuropharmacology (2008) 1.28
Regular patterns in cerebellar Purkinje cell simple spike trains. PLoS One (2007) 1.28
Ionotropic glutamate receptors & CNS disorders. CNS Neurol Disord Drug Targets (2008) 1.27
Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ (2012) 1.27
The Drosophila fragile X mental retardation gene regulates sleep need. J Neurosci (2009) 1.25
Enhanced endocannabinoid signaling elevates neuronal excitability in fragile X syndrome. J Neurosci (2010) 1.24
Altered hippocampal synaptic plasticity in the FMR1 gene family knockout mouse models. J Neurophysiol (2009) 1.24
Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei. Proc Natl Acad Sci U S A (2010) 1.24
Altered structural and functional synaptic plasticity with motor skill learning in a mouse model of fragile X syndrome. J Neurosci (2013) 1.20
The trouble with spines in fragile X syndrome: density, maturity and plasticity. Neuroscience (2012) 1.15
Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Mol Cell Neurosci (2008) 1.15
Fragile X mental retardation protein and synaptic plasticity. Mol Brain (2013) 1.12
Proteomic studies of a single CNS synapse type: the parallel fiber/purkinje cell synapse. PLoS Biol (2009) 1.11
Deactivation of L-type Ca current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei. Neuron (2010) 1.08
Cerebellar and extracerebellar involvement in mouse eyeblink conditioning: the ACDC model. Front Cell Neurosci (2010) 1.01
Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome. Psychopharmacology (Berl) (2011) 1.01
Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile x syndrome and autism spectrum disorder. Front Synaptic Neurosci (2010) 1.00
Is autism a disease of the cerebellum? An integration of clinical and pre-clinical research. Front Syst Neurosci (2013) 1.00
Emerging common molecular pathways for primary dystonia. Mov Disord (2013) 1.00
Emerging pharmacotherapies for neurodevelopmental disorders. J Dev Behav Pediatr (2010) 0.99
Temporal patterns of inputs to cerebellum necessary and sufficient for trace eyelid conditioning. J Neurophysiol (2010) 0.99
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
Modulation of neuritogenesis by a protein implicated in X-linked mental retardation. J Neurosci (2009) 0.97
Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Proc Natl Acad Sci U S A (2007) 0.97
New roles for the cerebellum in health and disease. Front Syst Neurosci (2013) 0.96
Loss of the fragile X mental retardation protein decouples metabotropic glutamate receptor dependent priming of long-term potentiation from protein synthesis. J Neurophysiol (2010) 0.96
The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior. J Neurosci (2008) 0.95
The effect of an mGluR5 inhibitor on procedural memory and avoidance discrimination impairments in Fmr1 KO mice. Genes Brain Behav (2012) 0.95
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism. Neurosci Biobehav Rev (2014) 0.94
Cerebellar-dependent expression of motor learning during eyeblink conditioning in head-fixed mice. J Neurosci (2014) 0.94
Lock-and-key mechanisms of cerebellar memory recall based on rebound currents. J Neurophysiol (2007) 0.94
Generation and characterization of FMR1 knockout zebrafish. PLoS One (2009) 0.93
Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice. Neuroscience (2011) 0.93
Reorganization of circuits underlying cerebellar modulation of prefrontal cortical dopamine in mouse models of autism spectrum disorder. Cerebellum (2013) 0.92
Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome. Behav Brain Res (2011) 0.92
Enhancement of both long-term depression induction and optokinetic response adaptation in mice lacking delphilin. PLoS One (2008) 0.91
Metabotropic glutamate receptor-mediated use-dependent down-regulation of synaptic excitability involves the fragile X mental retardation protein. J Neurophysiol (2008) 0.90
The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiol Dis (2010) 0.89
Ultrastructural analysis of the functional domains in FMRP using primary hippocampal mouse neurons. Neurobiol Dis (2009) 0.89
The development of cortical columns: role of Fragile X mental retardation protein. J Physiol (2009) 0.89
Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology (2014) 0.88
Synaptic plasticity, neural circuits, and the emerging role of altered short-term information processing in schizophrenia. Front Synaptic Neurosci (2014) 0.87
Cerebellar associative sensory learning defects in five mouse autism models. Elife (2015) 0.87
Children with autism spectrum disorders show abnormal conditioned response timing on delay, but not trace, eyeblink conditioning. Neuroscience (2013) 0.87
Synaptic retinoic acid signaling and homeostatic synaptic plasticity. Neuropharmacology (2012) 0.86
A presynaptic role for FMRP during protein synthesis-dependent long-term plasticity in Aplysia. Learn Mem (2010) 0.86
Motor learning of mice lacking cerebellar Purkinje cells. Front Neuroanat (2013) 0.86
RNA reigns in neurons. Neuron (2005) 0.86
Identifying essential cell types and circuits in autism spectrum disorders. Int Rev Neurobiol (2013) 0.85
Savings and extinction of conditioned eyeblink responses in fragile X syndrome. Genes Brain Behav (2008) 0.85
Lipid signaling in cytosolic phospholipase A2alpha-cyclooxygenase-2 cascade mediates cerebellar long-term depression and motor learning. Proc Natl Acad Sci U S A (2010) 0.85
Dendritic spine dysgenesis in autism related disorders. Neurosci Lett (2015) 0.85
FMRP regulates neurogenesis in vivo in Xenopus laevis tadpoles. eNeuro (2015) 0.85
Cellular mechanisms and behavioral consequences of Kv1.2 regulation in the rat cerebellum. J Neurosci (2012) 0.85
The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome. Front Cell Neurosci (2014) 0.85
STDP and Mental Retardation: Dysregulation of Dendritic Excitability in Fragile X Syndrome. Front Synaptic Neurosci (2010) 0.84
RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function. EMBO Rep (2006) 0.84
Fragile X Mental Retardation Protein (FMRP) controls diacylglycerol kinase activity in neurons. Proc Natl Acad Sci U S A (2016) 0.84
The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders. Front Neurosci (2015) 0.83
Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism. Mol Autism (2015) 0.83
Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome. Behav Brain Res (2013) 0.83
Synaptic plasticity in mouse models of autism spectrum disorders. Korean J Physiol Pharmacol (2012) 0.82
Delay eyeblink classical conditioning is impaired in Fragile X syndrome. Behav Neurosci (2009) 0.82
Reevaluation of the role of parallel fiber synapses in delay eyeblink conditioning in mice using Cbln1 as a tool. Front Neural Circuits (2013) 0.82
Dopamine Release and Uptake Impairments and Behavioral Alterations Observed in Mice that Model Fragile X Mental Retardation Syndrome. ACS Chem Neurosci (2010) 0.82
X-linked disorders with cerebellar dysgenesis. Orphanet J Rare Dis (2011) 0.82
Eyeblink conditioning: a non-invasive biomarker for neurodevelopmental disorders. J Autism Dev Disord (2015) 0.82
Neural expression of the transcription factor THAP1 during development in rat. Neuroscience (2012) 0.82
Lack of Connexin43-mediated bergmann glial gap junctional coupling does not affect cerebellar long-term depression, motor coordination, or eyeblink conditioning. Front Behav Neurosci (2008) 0.82
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
The genome sequence of Drosophila melanogaster. Science (2000) 74.32
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17. Nature (1998) 15.24
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci U S A (1998) 12.61
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem (1996) 10.51
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature (1984) 8.02
Existence of distinct sodium channel messenger RNAs in rat brain. Nature (1986) 7.87
A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. N Engl J Med (1996) 7.66
Absence of expression of the FMR-1 gene in fragile X syndrome. Cell (1991) 7.04
The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome. N Engl J Med (1995) 6.73
Stages of progression in drug involvement from adolescence to adulthood: further evidence for the gateway theory. J Stud Alcohol (1992) 6.71
Adverse reactions to ionic and nonionic contrast media. A report from the Japanese Committee on the Safety of Contrast Media. Radiology (1990) 6.04
Bone morphogenetic protein-2 converts the differentiation pathway of C2C12 myoblasts into the osteoblast lineage. J Cell Biol (1994) 5.93
Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol (1985) 5.70
Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes. Immunity (1999) 5.50
Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature (1996) 5.48
Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14
Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF/RANKL-RANK interaction. J Exp Med (2000) 5.02
Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A (1984) 4.97
Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits. Proc Natl Acad Sci U S A (1997) 4.73
Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62
Rapid isolation of DNA probes within specific chromosome regions by interspersed repetitive sequence polymerase chain reaction. Genomics (1990) 4.34
Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG/OCIF inhibits osteoclastogenesis in vitro. Endocrinology (1998) 4.29
DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum Mol Genet (1992) 4.22
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell (2000) 3.90
Human cytotoxic response in vitro to trinitrophenyl-modified autologous cells. I. T cell recognition of TNP in association with widely shared antigens. J Immunol (1978) 3.90
Origin of proteins in sporulation. Annu Rev Biochem (1968) 3.86
A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice. Diabetes (1997) 3.83
Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice. Immunity (1999) 3.78
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene (1990) 3.66
Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell (2001) 3.64
Genomic rearrangement in NEMO impairs NF-kappaB activation and is a cause of incontinentia pigmenti. The International Incontinentia Pigmenti (IP) Consortium. Nature (2000) 3.61
A point mutation in the FMR-1 gene associated with fragile X mental retardation. Nat Genet (1993) 3.58
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem (1999) 3.55
TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science (1996) 3.48
Hemagglutinin-specific enzyme-linked immunosorbent assay for antibodies to influenza A and B viruses. J Clin Microbiol (1981) 3.46
Magnesium transport in Escherichia coli. Inhibition by cobaltous ion. J Biol Chem (1971) 3.43
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43
Induction of IRF-3/-7 kinase and NF-kappaB in response to double-stranded RNA and virus infection: common and unique pathways. Genes Cells (2001) 3.42
T-wave alternans negative coronary patients with low ejection and benefit from defibrillator implantation. Lancet (2003) 3.36
Triplet repeat mutations in human disease. Science (1992) 3.35
Role of inorganic polyphosphate in promoting ribosomal protein degradation by the Lon protease in E. coli. Science (2001) 3.35
From beer to crack: developmental patterns of drug involvement. Am J Public Health (1993) 3.33
A mutation in human CMP-sialic acid hydroxylase occurred after the Homo-Pan divergence. Proc Natl Acad Sci U S A (1998) 3.26
Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. Radiat Res (1994) 3.25
Length of uninterrupted CGG repeats determines instability in the FMR1 gene. Nat Genet (1994) 3.22
Patterns of drug use from adolescence to young adulthood: III. Predictors of progression. Am J Public Health (1984) 3.22
Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert with cyclooxygenase-2. J Biol Chem (2000) 3.19
Cerebellar LTD and learning-dependent timing of conditioned eyelid responses. Science (2003) 3.19
Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction. J Exp Med (2000) 3.14
Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12
Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice. J Biol Chem (1997) 3.09
Cloning and sequencing of the gene encoding Toho-2, a class A beta-lactamase preferentially inhibited by tazobactam. Antimicrob Agents Chemother (1998) 3.06
Expression of functional sodium channels from cloned cDNA. Nature (1986) 2.95
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci U S A (2001) 2.95
The consequences in young adulthood of adolescent drug involvement. An overview. Arch Gen Psychiatry (1986) 2.93
Columns for visual features of objects in monkey inferotemporal cortex. Nature (1992) 2.93
Alternative splicing of beta-galactosidase mRNA generates the classic lysosomal enzyme and a beta-galactosidase-related protein. J Biol Chem (1989) 2.91
Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. Science (1999) 2.84
A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet (1999) 2.83
Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol (1982) 2.80
Complications of pedicle screw fixation in reconstructive surgery of the cervical spine. Spine (Phila Pa 1976) (2000) 2.77
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76
Patterns of drug use from adolescence to young adulthood: II. Sequences of progression. Am J Public Health (1984) 2.75
Improvement in visual sensitivity by changes in local context: parallel studies in human observers and in V1 of alert monkeys. Neuron (1995) 2.74
Establishment of Escherichia coli cells with an integrated high copy number plasmid. Mol Gen Genet (1980) 2.74
The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family. EMBO J (1987) 2.72
Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation. EMBO J (1997) 2.71
A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71
Cytotoxic activities of gut mucosal lymphoid cells in guinea pigs. J Immunol (1978) 2.70
Early-onset parkinsonism associated with PINK1 mutations: frequency, genotypes, and phenotypes. Neurology (2005) 2.69
Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome. Nat Genet (1993) 2.69
The effector cells in human peripheral blood mediating mitogen-induced cellular cytotoxicity and antibody-dependent cellular cytotoxicity. J Immunol (1976) 2.65
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem (1996) 2.64
The Lowe's oculocerebrorenal syndrome gene encodes a protein highly homologous to inositol polyphosphate-5-phosphatase. Nature (1992) 2.64
RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis. Biochem Biophys Res Commun (1998) 2.62
X-linked situs abnormalities result from mutations in ZIC3. Nat Genet (1997) 2.62
A novel therapy for internal hemorrhoids: ligation of the hemorrhoidal artery with a newly devised instrument (Moricorn) in conjunction with a Doppler flowmeter. Am J Gastroenterol (1995) 2.61
Secretory and systemic immunological response in children infected with live attenuated influenza A virus vaccines. Infect Immun (1982) 2.61
Electrical behaviour of the motoneurone membrane during intracellularly applied current steps. J Physiol (1965) 2.60
Large expansion of the ATTCT pentanucleotide repeat in spinocerebellar ataxia type 10. Nat Genet (2000) 2.60
Role of Ahch in gonadal development and gametogenesis. Nat Genet (1998) 2.60
Choice behavior of rats in a concurrent-chains schedule: Amount and delay of reinforcement. J Exp Anal Behav (1982) 2.59
Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells. J Bacteriol (1988) 2.59
Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Motil (1998) 2.53
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease. Neurology (2007) 2.51
Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction. Proc Natl Acad Sci U S A (1989) 2.49
Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med (1989) 2.49
Primary structure and processing of lysosomal alpha-glucosidase; homology with the intestinal sucrase-isomaltase complex. EMBO J (1988) 2.44
Retained asymptomatic third molars and risk for second molar pathology. J Dent Res (2013) 2.43
A monoclonal antibody 7G7/B6, binds to an epitope on the human interleukin-2 (IL-2) receptor that is distinct from that recognized by IL-2 or anti-Tac. Hybridoma (1985) 2.41
Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood (2001) 2.39