Detection of mRNA for the tax1/rex1 gene of human T-cell leukemia virus type I in fresh peripheral blood mononuclear cells of adult T-cell leukemia patients and viral carriers by using the polymerase chain reaction.

PubWeight™: 2.49‹?› | Rank: Top 2%

🔗 View Article (PMC 297674)

Published in Proc Natl Acad Sci U S A on July 01, 1989

Authors

T Kinoshita1, M Shimoyama, K Tobinai, M Ito, S Ito, S Ikeda, K Tajima, K Shimotohno, T Sugimura

Author Affiliations

1: Virology Division, National Cancer Center Research Institute, Tokyo, Japan.

Articles citing this

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A (1990) 9.98

Analysis of splicing patterns of human spumaretrovirus by polymerase chain reaction reveals complex RNA structures. J Virol (1991) 2.51

Protein isoforms encoded by the pX region of human T-cell leukemia/lymphotropic virus type I. Proc Natl Acad Sci U S A (1992) 2.20

Expression of alternatively spliced human T-lymphotropic virus type I pX mRNA in infected cell lines and in primary uncultured cells from patients with adult T-cell leukemia/lymphoma and healthy carriers. Proc Natl Acad Sci U S A (1992) 2.05

Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc Natl Acad Sci U S A (1990) 1.93

5'-long terminal repeat-selective CpG methylation of latent human T-cell leukemia virus type 1 provirus in vitro and in vivo. J Virol (2002) 1.77

Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line. J Virol (1990) 1.67

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells. Blood (2008) 1.61

Circulating anti-Tax cytotoxic T lymphocytes from human T-cell leukemia virus type I-infected people, with and without tropical spastic paraparesis, recognize multiple epitopes simultaneously. J Virol (1994) 1.50

Identification of alternatively spliced mRNAs encoding potential new regulatory proteins in cattle infected with bovine leukemia virus. J Virol (1993) 1.42

Human T-cell leukemia virus type 1 Tax requires direct access to DNA for recruitment of CREB binding protein to the viral promoter. Mol Cell Biol (1998) 1.41

Human T-cell leukemia-lymphoma virus type I (HTLV-I) expression in fresh peripheral blood mononuclear cells from patients with tropical spastic paraparesis/HTLV-I-associated myelopathy. J Virol (1991) 1.36

Role of Tax protein in human T-cell leukemia virus type-I leukemogenicity. Retrovirology (2004) 1.32

In vivo transcription of the bovine leukemia virus tax/rex region in normal and neoplastic lymphocytes of cattle and sheep. J Virol (1991) 1.26

Human T-cell leukemia virus type I infection of monocytes and microglial cells in primary human cultures. Proc Natl Acad Sci U S A (1992) 1.24

Naturally occurring variants of human T-cell leukemia virus type I Tax protein impair its recognition by cytotoxic T lymphocytes and the transactivation function of Tax. J Virol (1995) 1.15

T-cell activation by autologous human T-cell leukemia virus type I-infected T-cell clones. Proc Natl Acad Sci U S A (1992) 1.08

Detection of human T cell lymphotropic virus type I proviral DNA and its gene expression in synovial cells in chronic inflammatory arthropathy. J Clin Invest (1991) 1.07

Viral oncogenes, noncoding RNAs, and RNA splicing in human tumor viruses. Int J Biol Sci (2010) 1.05

Temporal regulation of viral and cellular gene expression during human T-lymphotropic virus type I-mediated lymphocyte immortalization. J Virol (1991) 1.03

Lymphoid organs as a major reservoir for human T-cell leukemia virus type 1 in experimentally infected squirrel monkeys (Saimiri sciureus): provirus expression, persistence, and humoral and cellular immune responses. J Virol (2000) 1.03

Activation of bovine leukemia virus transcription in lymphocytes from infected sheep: rapid transition through early to late gene expression. J Virol (1992) 1.03

Expression of human T lymphotropic virus type 1 (HTLV-1) tax/rex gene in fresh bronchoalveolar lavage cells of HTLV-1-infected individuals. Clin Exp Immunol (1994) 1.03

Tax-independent constitutive IkappaB kinase activation in adult T-cell leukemia cells. Neoplasia (2004) 0.99

HTLV-1 and apoptosis: role in cellular transformation and recent advances in therapeutic approaches. Apoptosis (2008) 0.99

Complete bovine leukemia virus (BLV) provirus is conserved in BLV-infected cattle throughout the course of B-cell lymphosarcoma development. J Virol (1998) 0.98

Differential transactivation of the intercellular adhesion molecule 1 gene promoter by Tax1 and Tax2 of human T-cell leukemia viruses. J Virol (1996) 0.98

Among all human T-cell leukemia virus type 1 proteins, tax, polymerase, and envelope proteins are predicted as preferential targets for the HLA-A2-restricted cytotoxic T-cell response. J Virol (1996) 0.98

Adult T cell leukemia lymphoma. Front Biosci (2004) 0.97

Massive depletion of bovine leukemia virus proviral clones located in genomic transcriptionally active sites during primary infection. PLoS Pathog (2013) 0.97

Characterisation of fibroblast-like cells in pannus lesions of patients with rheumatoid arthritis sharing properties of fibroblasts and chondrocytes. Ann Rheum Dis (1997) 0.97

Human T-cell lymphotropic virus type 1-infected T lymphocytes impair catabolism and uptake of glutamate by astrocytes via Tax-1 and tumor necrosis factor alpha. J Virol (2000) 0.96

Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene. J Clin Invest (1993) 0.96

Bovine leukemia virus gene expression in vivo. J Virol (1992) 0.94

Establishment of a seronegative human T-cell leukemia virus type 1 (HTLV-1) carrier state in rats inoculated with a syngeneic HTLV-1-immortalized T-cell line preferentially expressing Tax. J Virol (1999) 0.93

Interferon-α (IFN-α) suppresses HTLV-1 gene expression and cell cycling, while IFN-α combined with zidovudine induces p53 signaling and apoptosis in HTLV-1-infected cells. Retrovirology (2013) 0.93

Humoral hypercalcemia of malignancy: severe combined immunodeficient/beige mouse model of adult T-cell lymphoma independent of human T-cell lymphotropic virus type-1 tax expression. Am J Pathol (2001) 0.93

Transmission of human T-cell leukemia virus type 1 to mice. J Virol (1998) 0.93

The cellular stress response enhances human T-cell lymphotropic virus type 1 basal gene expression through the core promoter region of the long terminal repeat. J Virol (1997) 0.92

De novo human T-cell leukemia virus type 1 infection of human lymphocytes in NOD-SCID, common gamma-chain knockout mice. J Virol (2006) 0.92

Effect of lamivudine on transmission of human T-cell lymphotropic virus type 1 to adult peripheral blood mononuclear cells in vitro. Antimicrob Agents Chemother (2002) 0.92

Stromal cell-mediated suppression of human T-cell leukemia virus type 1 expression in vitro and in vivo by type I interferon. J Virol (2009) 0.91

Do T cells cause HTLV-1-associated disease?: a taxing problem. Clin Exp Immunol (1994) 0.90

Sexual transmission of human T-cell leukemia virus type I associated with the presence of anti-Tax antibody. Proc Natl Acad Sci U S A (1991) 0.90

Up-regulation of human T lymphotropic virus type 1 (HTLV-1) tax/rex mRNA in infected lung tissues. Clin Exp Immunol (2000) 0.89

T helper cell activation and human retroviral pathogenesis. Microbiol Rev (1996) 0.88

Is human T-cell lymphotropic virus type I really silent? Philos Trans R Soc Lond B Biol Sci (2000) 0.86

Transcriptional regulation of parathyroid hormone-related protein promoter P3 by ETS-1 in adult T-cell leukemia/lymphoma. Leukemia (2005) 0.86

PTHrP gene expression in cancer: do all paths lead to Ets? Crit Rev Eukaryot Gene Expr (2005) 0.86

Repression of tax expression is associated both with resistance of human T-cell leukemia virus type 1-infected T cells to killing by tax-specific cytotoxic T lymphocytes and with impaired tumorigenicity in a rat model. J Virol (2004) 0.86

Correlation of major histocompatibility complex class I downregulation with resistance of human T-cell leukemia virus type 1-infected T cells to cytotoxic T-lymphocyte killing in a rat model. J Virol (2002) 0.85

Expression of tumor invasion factors determines systemic engraftment and induction of humoral hypercalcemia in a mouse model of adult T-cell leukemia. Vet Pathol (2009) 0.85

Chemokine synthesis and cellular inflammatory changes in lungs of mice bearing p40tax of human T-lymphotropic virus type 1. Clin Exp Immunol (2000) 0.85

Molecular approach to human leukemia: isolation and characterization of the first human retrovirus HTLV-1 and its impact on tumorigenesis in adult T-cell leukemia. Proc Jpn Acad Ser B Phys Biol Sci (2010) 0.84

cis-Acting inhibitory elements within the pol-env region of human T-cell leukemia virus type 1 possibly involved in viral persistence. J Virol (1997) 0.84

Effect of phosphonated carbocyclic 2'-oxa-3'-aza-nucleoside on human T-cell leukemia virus type 1 infection in vitro. Antimicrob Agents Chemother (2007) 0.83

The roles of acquired and innate immunity in human T-cell leukemia virus type 1-mediated diseases. Front Microbiol (2012) 0.83

How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)? Curr Opin Virol (2015) 0.82

Is There a Role for HTLV-1-Specific CTL in Adult T-Cell Leukemia/Lymphoma? Leuk Res Treatment (2011) 0.82

Oncogenes and RNA splicing of human tumor viruses. Emerg Microbes Infect (2014) 0.82

Human T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL). Iran J Basic Med Sci (2013) 0.81

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State. Leuk Res Treatment (2011) 0.81

Constitutive IL-2 expression in HTLV-I-infected leukaemic T cell lines. Clin Exp Immunol (1991) 0.81

Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation. Retrovirology (2005) 0.79

A novel animal model of thymic tumour: development of epithelial thymoma in transgenic rats carrying human T lymphocyte virus type I pX gene. Int J Exp Pathol (2002) 0.79

HTLV-1-infected CD4+ T-cells display alternative exon usages that culminate in adult T-cell leukemia. Retrovirology (2014) 0.78

Selective infection of human T-lymphotropic virus type 1 (HTLV-1)-infected cells by chimeric human immunodeficiency viruses containing HTLV-1 tax response elements in the long terminal repeat. J Virol (1995) 0.78

Influence of human T lymphotrophic virus type I on diffuse pan-bronchiolitis. Clin Exp Immunol (2004) 0.77

HIV-1 blocks the signaling adaptor MAVS to evade antiviral host defense after sensing of abortive HIV-1 RNA by the host helicase DDX3. Nat Immunol (2016) 0.75

Articles cited by this

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19

Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77

Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A (1980) 30.08

An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A. N Engl J Med (1987) 14.37

Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sci U S A (1983) 14.09

Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease. Proc Natl Acad Sci U S A (1982) 12.84

HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature (1987) 10.70

Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood (1977) 10.69

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature (1981) 9.25

Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science (1984) 9.14

A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine. Cell (1987) 7.25

The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats. Science (1985) 6.60

Regulation of the human interleukin-2 receptor alpha chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV-I. Cell (1987) 4.76

A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus. Science (1985) 4.56

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro. Proc Natl Acad Sci U S A (1988) 4.40

Functional activation of the long terminal repeat of human T-cell leukemia virus type I by a trans-acting factor. Proc Natl Acad Sci U S A (1985) 4.24

Transcriptional (p40x) and post-transcriptional (p27x-III) regulators are required for the expression and replication of human T-cell leukemia virus type I genes. Proc Natl Acad Sci U S A (1987) 4.10

Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-1-encoded p40x and T3/Ti complex triggering. Cell (1987) 4.10

Direct evidence that p40x of human T-cell leukemia virus type I is a trans-acting transcriptional activator. EMBO J (1986) 3.86

Activation of interleukin 2 and interleukin 2 receptor (Tac) promoter expression by the trans-activator (tat) gene product of human T-cell leukemia virus, type I. Proc Natl Acad Sci U S A (1987) 3.43

c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1988) 3.24

Chronic progressive myelopathy associated with elevated antibodies to human T-lymphotropic virus type I and adult T-cell leukemialike cells. Ann Neurol (1987) 2.99

HIV/HTLV gene nomenclature. Nature (1988) 2.72

Developmental expression of PDGF, TGF-alpha, and TGF-beta genes in preimplantation mouse embryos. Science (1988) 2.70

Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood (1981) 2.53

mRNA phenotyping by enzymatic amplification of randomly primed cDNA. Nucleic Acids Res (1988) 2.29

Two cis-acting elements responsible for posttranscriptional trans-regulation of gene expression of human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1988) 2.25

Human T-cell leukemia virus (HTLV-I) transcripts in fresh and cultured cells of patients with adult T-cell leukemia. Proc Natl Acad Sci U S A (1984) 2.17

Detection of HIV-1 RNA sequences by in vitro DNA amplification. Nucleic Acids Res (1988) 1.90

Cell surface phenotypes and expression of viral antigens of various human cell lines carrying human T-cell leukemia virus. Int J Cancer (1984) 1.89

Activation of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia virus type I p40x protein and bovine papilloma virus encoded E2 protein. Nucleic Acids Res (1988) 1.86

Establishment and characterization of 10 cell lines derived from patients with adult T-cell leukemia. Proc Natl Acad Sci U S A (1983) 1.50

A new agglutination test for serum antibodies to adult T-cell leukemia virus. Gan (1984) 1.48

Detection of lymphocytes producing a human retrovirus associated with adult T-cell leukemia by syncytia induction assay. Proc Natl Acad Sci U S A (1983) 1.43

Complete nucleotide sequence of the chromosomal gene for human IL-4 and its expression. J Immunol (1989) 1.42

A retrovirus associated with human adult T-cell leukemia: in vitro activation. Gan (1982) 1.38

Rat lymphoid cell lines with human T cell leukemia virus production. I. Biological and serological characterization. J Exp Med (1984) 1.33

Expression of the HTLV-1 genome and its association with a unique T-cell malignancy. Biochim Biophys Acta (1987) 1.18

Nucleotide sequence of the protease-coding region in an infectious DNA of simian retrovirus (STLV) of the HTLV-I family. Virology (1986) 1.02

Optimal conditions for hybridization with oligonucleotides: a study with myc-oncogene DNA probes. Anal Biochem (1988) 1.00

Atypical adult T-cell leukemia-lymphoma: diverse clinical manifestations of adult T-cell leukemia-lymphoma. Jpn J Clin Oncol (1983) 0.99

Transformation of rabbit lymphocytes with T-cell leukemia virus. Gan (1983) 0.94

Prevalence of antibodies to human T-cell leukemia/lymphoma virus type I and human immunodeficiency virus in Japanese immigrant colonies in Bolivia and Bolivian natives. Jpn J Cancer Res (1987) 0.87

Effect of human serum anti-HTLV antibodies on viral antigen induction in vitro cultured peripheral lymphocytes from adult T-cell leukemia patients and healthy virus carriers. Int J Cancer (1985) 0.87

Demonstration of viral antigen p24 in circulating immune complexes of two patients with human T-cell leukaemia/lymphoma virus (HTLV) positive lymphoma. Lancet (1984) 0.85

Adult T-cell leukemia/lymphoma not associated with human T-cell leukemia virus type I. Proc Natl Acad Sci U S A (1986) 0.85

Expression of HTLV-I in serum of HTLV-I-related subjects and the early detection of overt ATL in HTLV-I carriers. J Immunol (1987) 0.84

Adult T-cell leukaemia antigen in renal glomerulus. Lancet (1983) 0.83

Articles by these authors

Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase) Science (1996) 15.88

Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase). J Biol Chem (1996) 10.51

Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A (1990) 9.98

A perpendicular-anisotropy CoFeB-MgO magnetic tunnel junction. Nat Mater (2010) 7.78

Long-term consequences of Kawasaki disease. A 10- to 21-year follow-up study of 594 patients. Circulation (1996) 7.29

Gene mapping of the putative structural region of the hepatitis C virus genome by in vitro processing analysis. Proc Natl Acad Sci U S A (1991) 7.15

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues. Oncogene (2006) 6.61

Gene Ontology annotations and resources. Nucleic Acids Res (2012) 6.13

Sequence of retrovirus provirus resembles that of bacterial transposable elements. Nature (1980) 5.95

Alcohol, tobacco and breast cancer--collaborative reanalysis of individual data from 53 epidemiological studies, including 58,515 women with breast cancer and 95,067 women without the disease. Br J Cancer (2002) 5.83

Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol (1993) 5.41

The enteric surface coat on cat intestinal microvilli. J Cell Biol (1965) 5.31

Rho-associated kinase, a novel serine/threonine kinase, as a putative target for small GTP binding protein Rho. EMBO J (1996) 5.14

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene. Science (1997) 4.62

Peopling of the Americas, founded by four major lineages of mitochondrial DNA. Mol Biol Evol (1993) 4.50

Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas. Proc Natl Acad Sci U S A (1995) 4.28

Complete nucleotide sequence of an infectious clone of human T-cell leukemia virus type II: an open reading frame for the protease gene. Proc Natl Acad Sci U S A (1985) 4.28

Amplification of c-erbB-2 oncogene in human adenocarcinomas in vivo. Lancet (1986) 3.93

Formation of infectious progeny virus after insertion of herpes simplex thymidine kinase gene into DNA of an avian retrovirus. Cell (1981) 3.80

Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med (2000) 3.74

Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus. Proc Natl Acad Sci U S A (1993) 3.68

Requirement of multiple copies of a 21-nucleotide sequence in the U3 regions of human T-cell leukemia virus type I and type II long terminal repeats for trans-acting activation of transcription. Proc Natl Acad Sci U S A (1986) 3.60

Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J Biol Chem (1999) 3.55

Metalloproteinase-mediated release of human Fas ligand. J Exp Med (1995) 3.53

Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivo. J Cell Biol (1999) 3.43

Phosphorylation of hepatitis C virus-encoded nonstructural protein NS5A. J Virol (1995) 3.41

Structure of the 3' terminus of the hepatitis C virus genome. J Virol (1996) 3.40

Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II. Science (1984) 3.39

Axin, a negative regulator of the wnt signaling pathway, directly interacts with adenomatous polyposis coli and regulates the stabilization of beta-catenin. J Biol Chem (1998) 3.39

Cytoplasmic filaments of Amoeba proteus. I. The role of filaments in consistency changes and movement. J Cell Biol (1970) 3.38

Collagen degradation by host-derived enzymes during aging. J Dent Res (2004) 3.30

Phosphorylation of axin, a Wnt signal negative regulator, by glycogen synthase kinase-3beta regulates its stability. J Biol Chem (1999) 3.22

A simple and rapid method for generating a deletion by PCR. Nucleic Acids Res (1991) 3.20

DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol (1999) 3.17

Drugs in pregnancy. N Engl J Med (1998) 3.14

Rho-associated kinase directly induces smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1997) 3.12

Hypervariable regions in the putative glycoprotein of hepatitis C virus. Biochem Biophys Res Commun (1991) 3.09

The presence of ancient human T-cell lymphotropic virus type I provirus DNA in an Andean mummy. Nat Med (1999) 2.99

Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology (2000) 2.99

cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity. Proc Natl Acad Sci U S A (1987) 2.97

Columns for visual features of objects in monkey inferotemporal cortex. Nature (1992) 2.93

Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Nature (1993) 2.91

Production of two phosphoproteins from the NS5A region of the hepatitis C viral genome. Biochem Biophys Res Commun (1994) 2.89

Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol (1997) 2.89

Regulation of myosin phosphatase by a specific interaction with cGMP- dependent protein kinase Ialpha. Science (1999) 2.84

A mutation in the gene encoding steroidogenic factor-1 causes XY sex reversal and adrenal failure in humans. Nat Genet (1999) 2.83

Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome. Neuron (2005) 2.82

Flexible bronchofiberscope. Keio J Med (1968) 2.82

Climbing fibre induced depression of both mossy fibre responsiveness and glutamate sensitivity of cerebellar Purkinje cells. J Physiol (1982) 2.80

Home blood pressure measurement has a stronger predictive power for mortality than does screening blood pressure measurement: a population-based observation in Ohasama, Japan. J Hypertens (1998) 2.77

Complications of pedicle screw fixation in reconstructive surgery of the cervical spine. Spine (Phila Pa 1976) (2000) 2.77

The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. Proc Natl Acad Sci U S A (1998) 2.76

Hepatitis C virus-encoded nonstructural protein NS4A has versatile functions in viral protein processing. J Virol (1995) 2.76

Humoral immune response to hypervariable region 1 of the putative envelope glycoprotein (gp70) of hepatitis C virus. J Virol (1993) 2.74

Improvement in visual sensitivity by changes in local context: parallel studies in human observers and in V1 of alert monkeys. Neuron (1995) 2.74

Hepatitis C virus structural proteins assemble into viruslike particles in insect cells. J Virol (1998) 2.71

A novel human SRB/MED-containing cofactor complex, SMCC, involved in transcription regulation. Mol Cell (1999) 2.71

Nucleotide sequence analysis of the long terminal repeat of human T-cell leukemia virus type II. Proc Natl Acad Sci U S A (1984) 2.67

C-myc transcript is induced in rat liver at a very early stage of regeneration or by cycloheximide treatment. Nature (1984) 2.63

Loss of all ndh genes as determined by sequencing the entire chloroplast genome of the black pine Pinus thunbergii. Proc Natl Acad Sci U S A (1994) 2.63

Electrical behaviour of the motoneurone membrane during intracellularly applied current steps. J Physiol (1965) 2.60

Role of Ahch in gonadal development and gametogenesis. Nat Genet (1998) 2.60

Choice behavior of rats in a concurrent-chains schedule: Amount and delay of reinforcement. J Exp Anal Behav (1982) 2.59

Hyperammonaemia and Helicobacter pylori. Lancet (1995) 2.59

Determinations of the DNA sequence of the mreB gene and of the gene products of the mre region that function in formation of the rod shape of Escherichia coli cells. J Bacteriol (1988) 2.59

A novel sequence found at the 3' terminus of hepatitis C virus genome. Biochem Biophys Res Commun (1995) 2.58

Molecular cloning of hepatitis C virus genome from a single Japanese carrier: sequence variation within the same individual and among infected individuals. Virus Res (1992) 2.56

Suppressive effects of estradiol on dimethylnitrosamine-induced fibrosis of the liver in rats. Hepatology (1999) 2.55

Structure and function of the glycocalyx. Fed Proc (1969) 2.53

Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Motil (1998) 2.53

Loss of heterozygosity on chromosomes 3, 13, and 17 in small-cell carcinoma and on chromosome 3 in adenocarcinoma of the lung. Proc Natl Acad Sci U S A (1987) 2.50

Interleukin 7 production and function in stromal cell-dependent B cell development. J Exp Med (1989) 2.49

Importance of 5'-terminal blocking structure to stabilize mRNA in eukaryotic protein synthesis. Proc Natl Acad Sci U S A (1977) 2.45

Retained asymptomatic third molars and risk for second molar pathology. J Dent Res (2013) 2.43

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans. Blood (2001) 2.39

Rhamnolipids produced by Pseudomonas aeruginosa grown on n-paraffin (mixture of C 12 , C 13 and C 14 fractions). J Antibiot (Tokyo) (1971) 2.39

Loss of intervening sequences in genomic mouse alpha-globin DNA inserted in an infectious retrovirus vector. Nature (1982) 2.38

Two hepatitis C virus glycoprotein E2 products with different C termini. J Virol (1994) 2.38

Prognostic significance of blood pressure and heart rate variabilities: the Ohasama study. Hypertension (2000) 2.35

E-cadherin gene mutations in human gastric carcinoma cell lines. Proc Natl Acad Sci U S A (1994) 2.35

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc Natl Acad Sci U S A (1987) 2.34

Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes. J Exp Med (1979) 2.34

A naturally immunogenic virion-associated protein specific for HIV-2 and SIV. Nature (1988) 2.33

Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Mol Cell Biol (1998) 2.33

Synthesis of DNA during meiosis. Proc Natl Acad Sci U S A (1966) 2.33

Clinical application of pulsed Doppler tissue imaging for assessing abnormal left ventricular relaxation. Am J Cardiol (1997) 2.31

SCA17, a novel autosomal dominant cerebellar ataxia caused by an expanded polyglutamine in TATA-binding protein. Hum Mol Genet (2001) 2.30

Altered expression of the retinoblastoma (RB) gene in small-cell carcinoma of the lung. Oncogene (1988) 2.29

B cell subpopulations separated by CD27 and crucial collaboration of CD27+ B cells and helper T cells in immunoglobulin production. Eur J Immunol (1997) 2.29

Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1984) 2.28

Ca,P-rich layer formed on high-strength bioactive glass-ceramic A-W. J Biomed Mater Res (1990) 2.22

Long-lasting depression of parallel fiber-Purkinje cell transmission induced by conjunctive stimulation of parallel fibers and climbing fibers in the cerebellar cortex. Neurosci Lett (1982) 2.21

Membrane hyperpolarization inhibits agonist-induced synthesis of inositol 1,4,5-trisphosphate in rabbit mesenteric artery. J Physiol (1992) 2.20

Phytochrome action in Oryza sativa L. 3. The separation of photoperceptive site and growing zone in coleoptiles, and auxin transport as effector system. Dev Growth Differ (1969) 2.19

Characterization of epidermal growth factor receptor gene expression in malignant and normal human cell lines. Proc Natl Acad Sci U S A (1984) 2.18

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation. J Clin Invest (2000) 2.18