Published in Epilepsy Curr on August 01, 2005
The potential of antiseizure drugs and agents that act on novel molecular targets as antiepileptogenic treatments. Neurotherapeutics (2014) 0.93
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Vascular-specific growth factors and blood vessel formation. Nature (2000) 14.42
VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet (2004) 3.60
Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex. J Neurosci (2004) 3.17
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Powerful anticonvulsant action of IL-1 receptor antagonist on intracerebral injection and astrocytic overexpression in mice. Proc Natl Acad Sci U S A (2000) 2.08
Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur J Neurosci (2000) 2.00
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VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol (2004) 1.39
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VEGF: a critical player in neurodegeneration. J Clin Invest (2004) 1.29
Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain. Neuroscience (2002) 1.24
Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. Adv Exp Med Biol (2004) 1.17
The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia (2010) 6.23
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med (2010) 4.61
Sox2 deficiency causes neurodegeneration and impaired neurogenesis in the adult mouse brain. Development (2004) 3.75
Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol (2005) 2.90
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis (2007) 2.81
Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci (2010) 1.87
Anticonvulsant and antiepileptogenic effects mediated by adeno-associated virus vector neuropeptide Y expression in the rat hippocampus. J Neurosci (2004) 1.66
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. Brain (2008) 1.64
Glia and epilepsy: excitability and inflammation. Trends Neurosci (2013) 1.49
Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci (2002) 1.44
Tumor necrosis factor-alpha inhibits seizures in mice via p75 receptors. Ann Neurol (2005) 1.41
Seizure-induced brain-borne inflammation sustains seizure recurrence and blood-brain barrier damage. Ann Neurol (2012) 1.41
Glia activation and cytokine increase in rat hippocampus by kainic acid-induced status epilepticus during postnatal development. Neurobiol Dis (2003) 1.39
Interleukin Converting Enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production. Neurobiol Dis (2008) 1.39
Interleukin-1β biosynthesis inhibition reduces acute seizures and drug resistant chronic epileptic activity in mice. Neurotherapeutics (2011) 1.36
Reduced anxiety and improved stress coping ability in mice lacking NPY-Y2 receptors. Eur J Neurosci (2003) 1.36
Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy. Brain (2008) 1.36
Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma. Ann N Y Acad Sci (2007) 1.35
Recombinant AAV-mediated expression of galanin in rat hippocampus suppresses seizure development. Eur J Neurosci (2003) 1.32
Delayed administration of erythropoietin and its non-erythropoietic derivatives ameliorates chronic murine autoimmune encephalomyelitis. J Neuroimmunol (2005) 1.26
Inactivation of caspase-1 in rodent brain: a novel anticonvulsive strategy. Epilepsia (2006) 1.24
Acute encephalopathy with inflammation-mediated status epilepticus. Lancet Neurol (2011) 1.24
Significance of MDR1 and multiple drug resistance in refractory human epileptic brain. BMC Med (2004) 1.23
Epilepsy biomarkers. Epilepsia (2013) 1.19
Modulator effects of interleukin-1beta and tumor necrosis factor-alpha on AMPA-induced excitotoxicity in mouse organotypic hippocampal slice cultures. J Neurosci (2005) 1.19
Inflammation and prevention of epileptogenesis. Neurosci Lett (2011) 1.18
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia (2006) 1.17
Inflammatory response and glia activation in developing rat hippocampus after status epilepticus. Epilepsia (2005) 1.16
Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain (2011) 1.16
High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products. Exp Neurol (2011) 1.13
The anti-epileptic actions of neuropeptide Y in the hippocampus are mediated by Y and not Y receptors. Eur J Neurosci (2005) 1.10
Astrocyte immune responses in epilepsy. Glia (2012) 1.09
Age-dependent vascular changes induced by status epilepticus in rat forebrain: implications for epileptogenesis. Neurobiol Dis (2009) 1.07
Gene therapy in epilepsy: the focus on NPY. Peptides (2006) 1.04
Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity. Neurobiol Dis (2011) 1.04
Antiepileptic effects of botulinum neurotoxin E. J Neurosci (2005) 1.03
Inflammatory events in hippocampal slice cultures prime neuronal susceptibility to excitotoxic injury: a crucial role of P2X7 receptor-mediated IL-1beta release. J Neurochem (2008) 1.01
Disulfide-containing high mobility group box-1 promotes N-methyl-D-aspartate receptor function and excitotoxicity by activating Toll-like receptor 4-dependent signaling in hippocampal neurons. Antioxid Redox Signal (2014) 1.00
Blood-brain barrier dysfunction-induced inflammatory signaling in brain pathology and epileptogenesis. Epilepsia (2012) 0.95
Neuropeptide Y overexpression using recombinant adeno-associated viral vectors. Neurotherapeutics (2009) 0.93
Determinants of drug brain uptake in a rat model of seizure-associated malformations of cortical development. Neurobiol Dis (2006) 0.92
A pilot study on brain-to-plasma partition of 10,11-dyhydro-10-hydroxy-5H-dibenzo(b,f)azepine-5-carboxamide and MDR1 brain expression in epilepsy patients not responding to oxcarbazepine. Epilepsia (2005) 0.91
Finding a better drug for epilepsy: antiinflammatory targets. Epilepsia (2012) 0.91
Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures. Neurobiol Dis (2013) 0.90
NPY gene transfer in the hippocampus attenuates synaptic plasticity and learning. Hippocampus (2008) 0.88
IL-1β is induced in reactive astrocytes in the somatosensory cortex of rats with genetic absence epilepsy at the onset of spike-and-wave discharges, and contributes to their occurrence. Neurobiol Dis (2011) 0.86
In vivo imaging of glia activation using 1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity. Epilepsia (2012) 0.86
Long-lasting pro-ictogenic effects induced in vivo by rat brain exposure to serum albumin in the absence of concomitant pathology. Epilepsia (2012) 0.85
In vitro responsiveness of human-drug-resistant tissue to antiepileptic drugs: insights into the mechanisms of pharmacoresistance. Brain Res (2006) 0.84
Pilocarpine-induced seizures revisited: what does the model mimic? Epilepsy Curr (2009) 0.83
Does brain inflammation mediate pathological outcomes in epilepsy? Adv Exp Med Biol (2014) 0.83
Selective and persistent upregulation of mdr1b mRNA and P-glycoprotein in the parahippocampal cortex of chronic epileptic rats. Epilepsy Res (2004) 0.83
Growth-associated protein 43 expression in hippocampal molecular layer of chronic epileptic rats treated with cycloheximide. Epilepsia (2005) 0.82
Status epilepticus-induced pathologic plasticity in a rat model of focal cortical dysplasia. Brain (2011) 0.82
The dual role of TNF-α and its receptors in seizures. Exp Neurol (2013) 0.81
Neuronal hyperexcitability and seizures are associated with changes in glial-neuronal interactions in the hippocampus of a mouse model of epilepsy with mental retardation. J Neurochem (2010) 0.81
Innate immunity and inflammation in temporal lobe epilepsy: new emphasis on the role of complement activation. Epilepsy Curr (2008) 0.81
VEGF as a target for neuroprotection. Epilepsy Curr (2008) 0.80
Epileptogenic role of astrocyte dysfunction. Epilepsy Curr (2008) 0.79
Plasticity of somatostatin and somatostatin sst2A receptors in the rat dentate gyrus during kindling epileptogenesis. Eur J Neurosci (2004) 0.78
Leukocyte-endothelial adhesion mechanisms in epilepsy: cheers and jeers. Epilepsy Curr (2009) 0.78
Expression of glutamate receptor subtypes in the spinal cord of control and mnd mice, a model of motor neuron disorder. J Neurosci Res (2002) 0.77
Epileptic encephalitis: the role of the innate and adaptive immune system. Brain Pathol (2012) 0.77
Basic mechanisms of MCD in animal models. Epileptic Disord (2009) 0.77
Immunity activation in brain cells in epilepsy: mechanistic insights and pathological consequences. Neuropediatrics (2013) 0.76
On demand up-regulation of therapeutic genes in the brain: fiction or reality? Epilepsy Curr (2007) 0.75
Brain Inflammation and Seizures. Epilepsy Curr (2004) 0.75
Brain Autonomous Mechanisms of Seizure-Induced BBB Dysfunction. Epilepsy Curr (2012) 0.75
Neuropeptide Y and Y1 receptors in kindling epileptogenesis. Epilepsy Curr (2005) 0.75
Tissue plasminogen activator, neuroserpin, and seizures. Epilepsy Curr (2005) 0.75
The toll receptor family: from microbial recognition to seizures. Epilepsy Curr (2006) 0.75
Novel concepts in epileptogenesis and its prevention. Neurotherapeutics (2014) 0.75
WONOEP XI: Workshop summary by the Scientific Organizing Committee. Epilepsia (2012) 0.75
Fourth conference on epileptogenesis, May 23-26, 2007, Pisa, Italy. Epilepsia (2008) 0.75
Third conference on epileptogenesis. S Servolo Island, Venice, Italy, July 27-30, 2005. Epilepsia (2006) 0.75