Published in Acta Neuropathol on March 04, 2008
Brain P-gp and Inflammation in People With Epilepsy | NCT01663545
Neuroinflammation in delirium: a postmortem case-control study. Rejuvenation Res (2011) 1.11
VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions. Proc Natl Acad Sci U S A (2014) 0.95
mTOR signaling in epilepsy: insights from malformations of cortical development. Cold Spring Harb Perspect Med (2015) 0.93
Vascular endothelial growth factor-B expression in postischemic rat brain. Vasc Cell (2013) 0.84
Pathogenetic mechanisms of focal cortical dysplasia. Epilepsia (2014) 0.83
The yin and yang of VEGF and PEDF: multifaceted neurotrophic factors and their potential in the treatment of Parkinson's Disease. Int J Mol Sci (2010) 0.82
Anti-human vascular endothelial growth factor (VEGF) antibody selection for immunohistochemical staining of proliferating blood vessels. J Histochem Cytochem (2010) 0.81
VEGF receptor-2 (Flk-1) overexpression in mice counteracts focal epileptic seizures. PLoS One (2012) 0.79
Morphological Plasticity of Emerging Purkinje Cells in Response to Exogenous VEGF. Front Mol Neurosci (2017) 0.75
Insights into the Mechanisms Involved in Protective Effects of VEGF-B in Dopaminergic Neurons. Parkinsons Dis (2017) 0.75
Downregulation of CD47 and CD200 in patients with focal cortical dysplasia type IIb and tuberous sclerosis complex. J Neuroinflammation (2016) 0.75
Measurement of protein using bicinchoninic acid. Anal Biochem (1985) 74.03
Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol (1996) 15.20
Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc Natl Acad Sci U S A (2002) 5.09
VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest (2003) 4.74
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet (2001) 4.66
Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5' enhancer. Circ Res (1995) 4.55
Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia (2005) 3.87
Blood-brain barrier leakage may lead to progression of temporal lobe epilepsy. Brain (2006) 3.86
Macrophages and angiogenesis. J Leukoc Biol (1994) 3.85
VEGF links hippocampal activity with neurogenesis, learning and memory. Nat Genet (2004) 3.60
Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci U S A (2000) 3.06
Terminology and classification of the cortical dysplasias. Neurology (2004) 2.99
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis (2007) 2.81
Vascular endothelial growth factor B, a novel growth factor for endothelial cells. Proc Natl Acad Sci U S A (1996) 2.71
From angiogenesis to neuropathology. Nature (2005) 2.56
Biology of vascular endothelial growth factors. FEBS Lett (2006) 2.26
Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus. Eur J Neurosci (2000) 2.00
Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proc Natl Acad Sci U S A (1998) 1.96
Gene profile of electroconvulsive seizures: induction of neurotrophic and angiogenic factors. J Neurosci (2003) 1.95
Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues. Am J Physiol (1993) 1.93
Vascular endothelial growth factor-B promotes in vivo angiogenesis. Circ Res (2003) 1.92
Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia. Oncogene (1997) 1.85
Angiogenesis: update 2005. J Thromb Haemost (2005) 1.85
Hypoxia-induced vascular endothelial growth factor expression causes vascular leakage in the brain. Brain (2002) 1.84
Angiogenesis is associated with blood-brain barrier permeability in temporal lobe epilepsy. Brain (2007) 1.83
The role of vascular endothelial growth factor in angiogenesis. Acta Haematol (2001) 1.82
The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J (2006) 1.64
HIF-1: using two hands to flip the angiogenic switch. Cancer Metastasis Rev (2000) 1.63
IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol (2006) 1.57
The IL-1beta system in epilepsy-associated malformations of cortical development. Neurobiol Dis (2006) 1.56
Molecular and functional diversity of vascular endothelial growth factors. Mol Divers (2006) 1.50
Signaling via vascular endothelial growth factor receptors. Exp Cell Res (1999) 1.49
Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. J Neuropathol Exp Neurol (1999) 1.48
Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat. J Neuropathol Exp Neurol (1998) 1.46
VEGF-mediated inflammation precedes angiogenesis in adult brain. Exp Neurol (2004) 1.39
Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin Cell Dev Biol (2002) 1.35
Patterns of brain angiogenesis after vascular endothelial growth factor administration in vitro and in vivo. Proc Natl Acad Sci U S A (1998) 1.33
Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures. J Neurosci (2005) 1.30
Altered expression patterns of group I and II metabotropic glutamate receptors in multiple sclerosis. Brain (2003) 1.29
Vascular endothelial growth factor-B (VEGFB) stimulates neurogenesis: evidence from knockout mice and growth factor administration. Dev Biol (2005) 1.28
Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis. Med Sci Monit (2004) 1.28
Complement activation in experimental and human temporal lobe epilepsy. Neurobiol Dis (2007) 1.25
Angiogenic and astroglial responses to vascular endothelial growth factor administration in adult rat brain. Neuroscience (2002) 1.24
Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience (2007) 1.23
Receptors of vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in fetal and adult human kidney: localization and [125I]VEGF binding sites. J Am Soc Nephrol (1998) 1.22
Molecular and cellular mechanisms of neuroprotection by vascular endothelial growth factor. J Neurosci Res (2004) 1.22
VEGF activates divergent intracellular signaling components to regulate retinal progenitor cell proliferation and neuronal differentiation. Development (2006) 1.21
Vascular endothelial growth factor and its receptor, KDR, in human brain tissue after ischemic stroke. Lab Invest (1999) 1.18
Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. Adv Exp Med Biol (2004) 1.17
Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia. J Histochem Cytochem (2002) 1.14
Evidence of activated microglia in focal cortical dysplasia. J Neuroimmunol (2006) 1.14
Induction of vascular endothelial growth factor receptors and phosphatidylinositol 3'-kinase/Akt signaling by global cerebral ischemia in the rat. Neuroscience (2000) 1.12
Vascular endothelial growth factor induces chemotaxis and proliferation of microglial cells. J Neuroimmunol (2002) 1.09
Neurogenic effect of vascular endothelial growth factor during germ layer formation of human embryonic stem cells. FEBS Lett (2006) 1.08
Expression and distribution of vascular endothelial growth factor protein in human brain tumors. Acta Neuropathol (1997) 1.07
Increased severity of cerebral ischemic injury in vascular endothelial growth factor-B-deficient mice. J Cereb Blood Flow Metab (2004) 1.07
Different networks, common growth factors: shared growth factors and receptors of the vascular and the nervous system. Acta Neuropathol (2007) 1.05
Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol (2006) 1.04
Molecular pathways of endothelial cell activation for (targeted) pharmacological intervention of chronic inflammatory diseases. Curr Vasc Pharmacol (2005) 1.03
Localization of VEGF-B in the mouse embryo suggests a paracrine role of the growth factor in the developing vasculature. Dev Dyn (1999) 1.01
The biology of vascular endothelial growth factor-B (VEGF-B). Pulm Pharmacol Ther (2005) 1.01
Endothelial growth factor receptors in human fetal heart. Circulation (1999) 0.99
Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 in rat hippocampus after transient forebrain ischemia. J Neurotrauma (2007) 0.96
Expression and cell distribution of group I and group II metabotropic glutamate receptor subtypes in taylor-type focal cortical dysplasia. Epilepsia (2003) 0.96
Expression of vascular endothelial growth factor by reactive astrocytes and associated neoangiogenesis. Brain Res (2000) 0.95
Combined use of subdural and intracerebral electrodes in preoperative evaluation of epilepsy. Neurosurgery (1990) 0.93
Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease. Neuroreport (2006) 0.93
Differential expression of vascular endothelial growth factor-A (VEGF-A) and VEGF-B after brain injury. J Neuropathol Exp Neurol (2002) 0.90
A neuropathological study of two autopsy cases of syndromic hemimegalencephaly. Neuropathol Appl Neurobiol (2007) 0.90
Decreased expression of VEGF-A in rat experimental autoimmune encephalomyelitis and in cerebrospinal fluid mononuclear cells from patients with multiple sclerosis. Scand J Immunol (2006) 0.89
Vascular endothelial growth factor and its receptor Flk-1 are expressed in the hippocampus following entorhinal deafferentation. Neuroscience (2005) 0.88
Recent advances in the neuropathology of focal lesions in epilepsy. Expert Rev Neurother (2004) 0.87
A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse. Biochim Biophys Acta (1998) 0.85
Neurodevelopmental disorders as a cause of seizures: neuropathologic, genetic, and mechanistic considerations. Brain Pathol (2002) 0.85
The role of vascular endothelial growth factor in neurogenesis in adult brain. Mini Rev Med Chem (2006) 0.84
Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. Epilepsia (2004) 0.82
Analysis of the promoter region of the human VEGF-related factor gene. Biochem Biophys Res Commun (1997) 0.82
Expression of vascular endothelial growth factor-b in human astrocytoma. Neuro Oncol (2000) 0.79
Immunohistochemical localization of vascular endothelial growth factor receptors-1, -2 and -3 in human spinal cord: altered expression in amyotrophic lateral sclerosis. Neuropathol Appl Neurobiol (2004) 0.79
VEGF and seizures: cross-talk between endothelial and neuronal environments. Epilepsy Curr (2005) 0.77
IDH1 mutations at residue p.R132 (IDH1(R132)) occur frequently in high-grade gliomas but not in other solid tumors. Hum Mutat (2009) 7.68
The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia (2010) 6.23
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS One (2008) 5.86
Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. Brain (2006) 5.36
TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol (2007) 5.02
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat Med (2010) 4.61
Detection of human papillomavirus in human focal cortical dysplasia type IIB. Ann Neurol (2012) 3.71
Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis (2007) 2.81
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol (2009) 2.76
tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia. Nat Genet (2008) 2.28
Intramuscular administration of AAV1-lipoprotein lipase S447X lowers triglycerides in lipoprotein lipase-deficient patients. Arterioscler Thromb Vasc Biol (2008) 2.10
New autopsy findings in different brain regions of a preterm neonate with kernicterus: neurovascular alterations and up-regulation of efflux transporters. Pediatr Neurol (2013) 2.01
Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy. J Neurosci (2006) 1.88
mTOR cascade activation distinguishes tubers from focal cortical dysplasia. Ann Neurol (2004) 1.85
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia (2013) 1.82
The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma. Acta Neuropathol (2010) 1.80
A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors. J Clin Invest (2011) 1.79
Embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma, and medulloepithelioma share molecular similarity and comprise a single clinicopathological entity. Acta Neuropathol (2013) 1.68
Epilepsy and brain inflammation. Exp Neurol (2011) 1.67
Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J Neurosci (2004) 1.66
Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures. Epilepsia (2003) 1.60
MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response. PLoS One (2012) 1.59
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathol (2013) 1.59
Fractalkine/CX3CL1 modulates GABAA currents in human temporal lobe epilepsy. Epilepsia (2013) 1.50
In vivo detection of cerebral cortical microinfarcts with high-resolution 7T MRI. J Cereb Blood Flow Metab (2012) 1.49
T-cell-mediated inflammatory activity in the stellate ganglia of patients with ion-channel disease and severe ventricular arrhythmias. Circ Arrhythm Electrophysiol (2014) 1.45
Limbic seizures induce P-glycoprotein in rodent brain: functional implications for pharmacoresistance. J Neurosci (2002) 1.44
Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteins. Eur J Neurosci (2003) 1.44
Global democratic consensus on neuropathological disease criteria. Lancet Neurol (2002) 1.44
Biallelic TSC gene inactivation in tuberous sclerosis complex. Neurology (2010) 1.39
OTX1 and OTX2 expression correlates with the clinicopathologic classification of medulloblastomas. J Neuropathol Exp Neurol (2006) 1.39
Glia as a source of cytokines: implications for neuronal excitability and survival. Epilepsia (2008) 1.38
Pontocerebellar hypoplasia type 2: a neuropathological update. Acta Neuropathol (2007) 1.32
Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. Brain (2011) 1.28
Expression and distribution of id helix-loop-helix proteins in human astrocytic tumors. Glia (2002) 1.20
Malformations of cortical development and epilepsies: neuropathological findings with emphasis on focal cortical dysplasia. Epileptic Disord (2009) 1.20
Immune responses to intramuscular administration of alipogene tiparvovec (AAV1-LPL(S447X)) in a phase II clinical trial of lipoprotein lipase deficiency gene therapy. Hum Gene Ther (2014) 1.19
Astrocytes produce interferon-alpha and CXCL10, but not IL-6 or CXCL8, in Aicardi-Goutières syndrome. Glia (2008) 1.18
Expression and cellular distribution of multidrug resistance-related proteins in the hippocampus of patients with mesial temporal lobe epilepsy. Epilepsia (2004) 1.17
Inhibition of the multidrug transporter P-glycoprotein improves seizure control in phenytoin-treated chronic epileptic rats. Epilepsia (2006) 1.17
Evaluation of the innate and adaptive immunity in type I and type II focal cortical dysplasias. Epilepsia (2010) 1.17
Retinoic acid induces blood-brain barrier development. J Neurosci (2013) 1.17
Diffuse cerebral intravascular coagulation and cerebral infarction in pneumococcal meningitis. Neurocrit Care (2010) 1.16
Decreased numbers of progenitor cells but no response to antidepressant drugs in the hippocampus of elderly depressed patients. Neuropharmacology (2010) 1.16
Activation of Toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development. Brain (2011) 1.16
Brain-computer interfacing based on cognitive control. Ann Neurol (2010) 1.15
Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation. Epilepsia (2012) 1.15
Induction of the Wnt inhibitor, Dickkopf-1, is associated with neurodegeneration related to temporal lobe epilepsy. Epilepsia (2007) 1.14
LIN28A immunoreactivity is a potent diagnostic marker of embryonal tumor with multilayered rosettes (ETMR). Acta Neuropathol (2012) 1.12
Localization of breast cancer resistance protein (BCRP) in microvessel endothelium of human control and epileptic brain. Epilepsia (2005) 1.12
Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors. Brain Pathol (2009) 1.12
Characterization of a pneumococcal meningitis mouse model. BMC Infect Dis (2012) 1.11
Neuroinflammation in delirium: a postmortem case-control study. Rejuvenation Res (2011) 1.11
EZH2-regulated DAB2IP is a medulloblastoma tumor suppressor and a positive marker for survival. Clin Cancer Res (2012) 1.10
Long-term epilepsy-associated tumors. Brain Pathol (2012) 1.10
Material-specific recognition memory deficits elicited by unilateral hippocampal electrical stimulation. J Neurosci (2004) 1.09
FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch Neurol (2010) 1.08
Current perspectives on antiangiogenesis strategies in the treatment of malignant gliomas. Brain Res Brain Res Rev (2004) 1.08
Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy. Epilepsia (2008) 1.07
Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain (2007) 1.07
Mouse models to study the effect of cardiovascular risk factors on brain structure and cognition. J Cereb Blood Flow Metab (2013) 1.06
Pharmacological activation of mGlu4 metabotropic glutamate receptors inhibits the growth of medulloblastomas. J Neurosci (2006) 1.06
Phosphoinositide 3-kinases upregulate system xc(-) via eukaryotic initiation factor 2α and activating transcription factor 4 - A pathway active in glioblastomas and epilepsy. Antioxid Redox Signal (2014) 1.05
The membrane attack complex of the complement system is essential for rapid Wallerian degeneration. J Neurosci (2007) 1.05
SGCE isoform characterization and expression in human brain: implications for myoclonus-dystonia pathogenesis? Eur J Hum Genet (2010) 1.05
ALS-associated mutations in FUS disrupt the axonal distribution and function of SMN. Hum Mol Genet (2013) 1.04
COX-2 inhibition controls P-glycoprotein expression and promotes brain delivery of phenytoin in chronic epileptic rats. Neuropharmacology (2009) 1.03
Possible role of the innate immunity in temporal lobe epilepsy. Epilepsia (2007) 1.03
Up-regulation of hippocampal metabotropic glutamate receptor 5 in temporal lobe epilepsy patients. Brain (2005) 1.02
Finding a better drug for epilepsy: the mTOR pathway as an antiepileptogenic target. Epilepsia (2012) 1.02
Metabotropic glutamate receptors in glial cells. Neurochem Res (2008) 1.02
Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Epilepsia (2011) 1.01
Clinicopathological and immunohistochemical findings in an autopsy case of tuberous sclerosis complex. Neuropathology (2008) 0.99