Published in Carcinogenesis on August 04, 2005
Cancer chemoprevention by dietary polyphenols: promising role for epigenetics. Biochem Pharmacol (2010) 1.63
In planta assays involving epigenetically silenced genes reveal inhibition of cytosine methylation by genistein. Plant Methods (2012) 1.38
Epigenetic targets of bioactive dietary components for cancer prevention and therapy. Clin Epigenetics (2010) 1.33
Epigenetic diet: impact on the epigenome and cancer. Epigenomics (2011) 1.33
Epigenetics and colorectal cancer pathogenesis. Cancers (Basel) (2013) 1.33
Epigenetic changes induced by curcumin and other natural compounds. Genes Nutr (2011) 1.28
DNA methylation impacts on learning and memory in aging. Neurobiol Aging (2007) 1.20
Dietary phytochemicals and cancer prevention: Nrf2 signaling, epigenetics, and cell death mechanisms in blocking cancer initiation and progression. Pharmacol Ther (2012) 1.13
Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy. Curr Genomics (2009) 1.11
A perspective on dietary phytochemicals and cancer chemoprevention: oxidative stress, nrf2, and epigenomics. Top Curr Chem (2013) 1.07
Epigenetic mechanisms in anti-cancer actions of bioactive food components--the implications in cancer prevention. Br J Pharmacol (2012) 1.03
Bioactive dietary supplements reactivate ER expression in ER-negative breast cancer cells by active chromatin modifications. PLoS One (2012) 1.02
Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. J Breast Cancer (2013) 1.01
Coffee drinking and pancreatic cancer risk: a meta-analysis of cohort studies. World J Gastroenterol (2011) 0.93
An overview of epigenetics and chemoprevention. FEBS Lett (2010) 0.92
Targeting the epigenome with bioactive food components for cancer prevention. J Nutrigenet Nutrigenomics (2012) 0.91
Coffee drinking and cutaneous melanoma risk in the NIH-AARP diet and health study. J Natl Cancer Inst (2015) 0.90
Coffee consumption and the risk of overall and fatal prostate cancer in the NIH-AARP Diet and Health Study. Cancer Causes Control (2013) 0.89
Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies. Oxid Med Cell Longev (2015) 0.88
Coffee intake and breast cancer risk in the NIH-AARP diet and health study cohort. Int J Cancer (2011) 0.88
Characterizing DNA methyltransferases with an ultrasensitive luciferase-linked continuous assay. Anal Chem (2011) 0.87
Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem (2013) 0.86
Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer. Front Oncol (2013) 0.86
Diet and epigenetics in colon cancer. World J Gastroenterol (2009) 0.85
Mandatory fortification with folic acid in the United States is associated with increased expression of DNA methyltransferase-1 in the cervix. Nutrition (2008) 0.85
Cocoa Consumption Alters the Global DNA Methylation of Peripheral Leukocytes in Humans with Cardiovascular Disease Risk Factors: A Randomized Controlled Trial. PLoS One (2013) 0.84
A real-time assay for CpG-specific cytosine-C5 methyltransferase activity. Nucleic Acids Res (2010) 0.84
Epigenetic regulation by selected dietary phytochemicals in cancer chemoprevention. Cancer Lett (2014) 0.84
Coffee consumption modifies risk of estrogen-receptor negative breast cancer. Breast Cancer Res (2011) 0.83
Reversal of hypermethylation and reactivation of genes by dietary polyphenolic compounds. Nutr Rev (2008) 0.82
Considering maternal dietary modulators for epigenetic regulation and programming of the fetal epigenome. Nutrients (2015) 0.82
Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line. Oxid Med Cell Longev (2015) 0.81
Dietary components as epigenetic-regulating agents against cancer. Biomedicine (Taipei) (2016) 0.81
Somatic Embryogenesis: Identified Factors that Lead to Embryogenic Repression. A Case of Species of the Same Genus. PLoS One (2015) 0.80
Therapeutic perspectives of epigenetically active nutrients. Br J Pharmacol (2014) 0.80
The silent estrogen receptor--can we make it speak? Cancer Biol Ther (2009) 0.79
Antimicrobial, Anthelmintic Activities and Characterisation of Functional Phenolic Acids of Achyranthes aspera Linn.: A Medicinal Plant Used for the Treatment of Wounds and Ringworm in East Africa. Front Pharmacol (2015) 0.79
Coffee and tea consumption in relation to prostate cancer prognosis. Cancer Causes Control (2013) 0.79
Coffee consumption and risk of breast cancer: an up-to-date meta-analysis. PLoS One (2013) 0.79
Coffee and black tea consumption and breast cancer mortality in a cohort of Swedish women. Br J Cancer (2012) 0.78
Elucidating the genetic basis of antioxidant status in lettuce (Lactuca sativa). Hortic Res (2015) 0.78
The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC Biochem (2011) 0.78
The epigenome as a potential mediator of cancer and disease prevention in prenatal development. Nutr Rev (2013) 0.78
Higher Caffeinated Coffee Intake Is Associated with Reduced Malignant Melanoma Risk: A Meta-Analysis Study. PLoS One (2016) 0.77
Blockage of TGFβ-SMAD2 by demethylation-activated miR-148a is involved in caffeic acid-induced inhibition of cancer stem cell-like properties in vitro and in vivo. FEBS Open Bio (2015) 0.77
Association between green tea/coffee consumption and biliary tract cancer: A population-based cohort study in Japan. Cancer Sci (2016) 0.77
Effect of coffee consumption on the risk of gastric cancer: a systematic review and meta-analysis of prospective cohort studies. PLoS One (2015) 0.77
O-methylation of catechol estrogens by human placental catechol-o-methyltransferase: interindividual differences in sensitivity to heat inactivation and to inhibition by dietary polyphenols. Drug Metab Dispos (2010) 0.76
Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients (2015) 0.76
Epigenetic mechanisms underlying diet-sourced compounds in the prevention and treatment of gastrointestinal cancer. Anticancer Agents Med Chem (2012) 0.76
Severe periodontitis is inversely associated with coffee consumption in the maintenance phase of periodontal treatment. Nutrients (2014) 0.76
Methylation and its role in the disposition of tanshinol, a cardiovascular carboxylic catechol from Salvia miltiorrhiza roots (Danshen). Acta Pharmacol Sin (2015) 0.76
Organotypic culture of breast tumor explants as a multicellular system for the screening of natural compounds with antineoplastic potential. Biomed Res Int (2015) 0.75
Anticancer Natural Compounds as Epigenetic Modulators of Gene Expression. Curr Genomics (2017) 0.75
New Insights into the Epigenetics of Hepatocellular Carcinoma. Biomed Res Int (2017) 0.75
Hill coefficients of dietary polyphenolic enzyme inhibitiors: can beneficial health effects of dietary polyphenols be explained by allosteric enzyme denaturing? J Chem Biol (2011) 0.75
Comparative cytotoxicity of artemisinin and cisplatin and their interactions with chlorogenic acids in MCF7 breast cancer cells. ChemMedChem (2014) 0.75
Impact of brown rice-specific γ-oryzanol on epigenetic modulation of dopamine D2 receptors in brain striatum in high-fat-diet-induced obesity in mice. Diabetologia (2017) 0.75
Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol Pharmacol (2005) 1.78
Characterization of the oxidative metabolites of 17beta-estradiol and estrone formed by 15 selectively expressed human cytochrome p450 isoforms. Endocrinology (2003) 1.77
Mechanism of glutamate-induced neurotoxicity in HT22 mouse hippocampal cells. Eur J Pharmacol (2009) 1.48
Docosahexaenoic acid induces apoptosis in MCF-7 cells in vitro and in vivo via reactive oxygen species formation and caspase 8 activation. PLoS One (2010) 1.16
Mechanism for the protective effect of resveratrol against oxidative stress-induced neuronal death. Free Radic Biol Med (2010) 1.13
Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells. Free Radic Biol Med (2010) 1.12
Neuronal gap junctions are required for NMDA receptor-mediated excitotoxicity: implications in ischemic stroke. J Neurophysiol (2010) 1.10
Indoleamine 2,3-dioxygenase tissue distribution and cellular localization in mice: implications for its biological functions. J Histochem Cytochem (2009) 1.09
Concentration-dependent mitogenic and antiproliferative actions of 2-methoxyestradiol in estrogen receptor-positive human breast cancer cells. J Steroid Biochem Mol Biol (2004) 1.04
Strong inhibitory effects of common tea catechins and bioflavonoids on the O-methylation of catechol estrogens catalyzed by human liver cytosolic catechol-O-methyltransferase. Drug Metab Dispos (2004) 1.01
EPA, an omega-3 fatty acid, induces apoptosis in human pancreatic cancer cells: role of ROS accumulation, caspase-8 activation, and autophagy induction. J Cell Biochem (2013) 0.99
Resveratrol attenuates the anticancer efficacy of paclitaxel in human breast cancer cells in vitro and in vivo. Eur J Cancer (2010) 0.99
Role of cyclin B1/Cdc2 up-regulation in the development of mitotic prometaphase arrest in human breast cancer cells treated with nocodazole. PLoS One (2011) 0.95
Induction of a reversible, non-cytotoxic S-phase delay by resveratrol: implications for a mechanism of lifespan prolongation and cancer protection. Br J Pharmacol (2009) 0.92
Mechanism of 2-methoxyestradiol-induced apoptosis and growth arrest in human breast cancer cells. Mol Carcinog (2009) 0.91
Characterization of the estrogenic activities of zearalenone and zeranol in vivo and in vitro. J Steroid Biochem Mol Biol (2006) 0.90
Beneficial effect of 17β-estradiol on hyperglycemia and islet β-cell functions in a streptozotocin-induced diabetic rat model. Toxicol Appl Pharmacol (2010) 0.90
Biochemical and molecular modeling studies of the O-methylation of various endogenous and exogenous catechol substrates catalyzed by recombinant human soluble and membrane-bound catechol-O-methyltransferases. Chem Res Toxicol (2007) 0.89
Protein disulfide isomerase is a multifunctional regulator of estrogenic status in target cells. J Steroid Biochem Mol Biol (2008) 0.89
Critical role of the JNK-p53-GADD45α apoptotic cascade in mediating oxidative cytotoxicity in hippocampal neurons. Br J Pharmacol (2011) 0.89
Rapid generation of mitochondrial superoxide induces mitochondrion-dependent but caspase-independent cell death in hippocampal neuronal cells that morphologically resembles necroptosis. Toxicol Appl Pharmacol (2012) 0.88
Human pancreas-specific protein disulfide-isomerase (PDIp) can function as a chaperone independently of its enzymatic activity by forming stable complexes with denatured substrate proteins. Biochem J (2010) 0.87
Pancreas-specific protein disulfide isomerase has a cell type-specific expression in various mouse tissues and is absent in human pancreatic adenocarcinoma cells: implications for its functions. J Mol Histol (2009) 0.87
Human pancreas-specific protein disulfide isomerase homolog (PDIp) is an intracellular estrogen-binding protein that modulates estrogen levels and actions in target cells. J Steroid Biochem Mol Biol (2009) 0.87
In vitro and in vivo estrogenic activity of chlorinated derivatives of bisphenol A. Toxicology (2005) 0.86
Suppression of T-cell response and prolongation of allograft survival in a rat model by tryptophan catabolites. Eur J Pharmacol (2009) 0.86
Critical role of cyclin B1/Cdc2 up-regulation in the induction of mitotic prometaphase arrest in human breast cancer cells treated with 2-methoxyestradiol. Biochim Biophys Acta (2012) 0.85
Selective insensitivity of ZR-75-1 human breast cancer cells to 2-methoxyestradiol: evidence for type II 17beta-hydroxysteroid dehydrogenase as the underlying cause. Cancer Res (2005) 0.85
Structural basis for certain naturally occurring bioflavonoids to function as reducing co-substrates of cyclooxygenase I and II. PLoS One (2010) 0.84
Human cytochrome P450 3A7 has a distinct high catalytic activity for the 16alpha-hydroxylation of estrone but not 17beta-estradiol. Cancer Res (2003) 0.84
NADPH-dependent metabolism of estrone by human liver microsomes. J Pharmacol Exp Ther (2002) 0.84
Strong activation of cyclooxygenase I and II catalytic activity by dietary bioflavonoids. J Lipid Res (2008) 0.84
Characterization of the estradiol-binding site structure of human protein disulfide isomerase (PDI). PLoS One (2011) 0.84
Prolongation of rat major histocompatibility complex-compatible cardiac allograft survival during pregnancy. J Heart Lung Transplant (2009) 0.83
Mechanism of dinitrochlorobenzene-induced dermatitis in mice: role of specific antibodies in pathogenesis. PLoS One (2009) 0.83
Synthesis of 7alpha-substituted derivatives of 17beta-estradiol. Steroids (2006) 0.83
Synergism between the anticancer actions of 2-methoxyestradiol and microtubule-disrupting agents in human breast cancer. Cancer Res (2005) 0.82
Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies. PLoS One (2010) 0.82
Physiologic levels of 2-methoxyestradiol interfere with nongenomic signaling of 17beta-estradiol in human breast cancer cells. Clin Cancer Res (2006) 0.82
Growth-stimulatory effect of resveratrol in human cancer cells. Mol Carcinog (2010) 0.81
Characterization of the estradiol-binding site structure of human pancreas-specific protein disulfide isomerase: indispensable role of the hydrogen bond between His278 and the estradiol 3-hydroxyl group. Biochemistry (2010) 0.81
Characterization of the oestrogenic activity of non-aromatic steroids: are there male-specific endogenous oestrogen receptor modulators? Br J Pharmacol (2009) 0.80
Human pancreas-specific protein disulfide isomerase homolog (PDIp) is redox-regulated through formation of an inter-subunit disulfide bond. Arch Biochem Biophys (2009) 0.80
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Brain Res (2012) 0.80
Chemical synthesis and biochemical characterization of a biotinylated derivative of 17beta-estradiol with a long side chain covalently attached to its C-7alpha position. Steroids (2008) 0.79
Unique effect of the pregnancy hormone estriol on antigen-induced production of specific antibodies in female BALB/c mice. Steroids (2007) 0.79
Effect of clofibrate administration on the esterification and deesterification of steroid hormones by liver and extrahepatic tissues in rats. Biochem Pharmacol (2002) 0.78
Estriol has different effects from 17β-estradiol in modulating mouse splenocyte function under inflammatory conditions. J Immunotoxicol (2011) 0.78
Role of cyclin B1/Cdc2 in mediating Bcl-XL phosphorylation and apoptotic cell death following nocodazole-induced mitotic arrest. Mol Carcinog (2012) 0.78
NADPH-dependent formation of polar and nonpolar estrogen metabolites following incubations of 17 beta-estradiol with human liver microsomes. Drug Metab Dispos (2004) 0.78
Synthesis of novel estrogen receptor antagonists using metal-catalyzed coupling reactions and characterization of their biological activity. J Med Chem (2013) 0.77
Myricetin and quercetin are naturally occurring co-substrates of cyclooxygenases in vivo. Prostaglandins Leukot Essent Fatty Acids (2009) 0.77
Characterization of a novel human catechol-O-methyl-transferase mutant with triplet point mutations. Int J Mol Med (2008) 0.77
Naturally-occurring estradiol-17beta-fatty acid esters, but not estradiol-17beta, preferentially induce mammary tumorigenesis in female rats: implications for an important role in human breast cancer. Toxicol Appl Pharmacol (2008) 0.77
Structural characterization of the binding interactions of various endogenous estrogen metabolites with human estrogen receptor α and β subtypes: a molecular modeling study. PLoS One (2013) 0.75
Both PDI and PDIp can attack the native disulfide bonds in thermally-unfolded RNase and form stable disulfide-linked complexes. Biochim Biophys Acta (2011) 0.75
Identification of a novel haplotype of the human catechol-O-methyltransferase gene. Pharmacogenet Genomics (2009) 0.75
PDIp is a major intracellular oestrogen-storage protein that modulates tissue levels of oestrogen in the pancreas. Biochem J (2012) 0.75
Chemical synthesis of two novel diaryl ether dimers of estradiol-17beta. Steroids (2004) 0.75
Natural compounds as cancer chemopreventive and chemotherapeutic agents: insights gained from mechanistic and pharmacologic studies. Anticancer Agents Med Chem (2012) 0.75
Chemical synthesis of six novel 17beta-estradiol and estrone dimers and study of their formation catalyzed by human cytochrome P450 isoforms. J Med Chem (2007) 0.75