Published in Free Radic Biol Med on September 01, 2005
Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. Curr Opin Gastroenterol (2012) 1.17
Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones. Mutat Res (2011) 0.95
Molecular targets related to inflammation and insulin resistance and potential interventions. J Biomed Biotechnol (2012) 0.88
The effects of choline on hepatic lipid metabolism, mitochondrial function and antioxidative status in human hepatic C3A cells exposed to excessive energy substrates. Nutrients (2014) 0.83
Mechanism of choline deficiency and membrane alteration in postural orthostatic tachycardia syndrome primary skin fibroblasts. FASEB J (2014) 0.79
Choline and betaine consumption lowers cancer risk: a meta-analysis of epidemiologic studies. Sci Rep (2016) 0.75
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell (2008) 2.65
An Aging Interventions Testing Program: study design and interim report. Aging Cell (2007) 2.54
Factors influencing body composition in persons with spinal cord injury: a cross-sectional study. J Appl Physiol (1985) (2003) 2.23
Antioxidants in central nervous system diseases: preclinical promise and translational challenges. J Alzheimers Dis (2008) 1.88
New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med (2004) 1.78
Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis. Neurobiol Dis (2003) 1.51
Synthesis and characterization of a practically better DEPMPO-type spin trap, 5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO). Free Radic Res (2006) 1.31
Protein modifications by 4-hydroxynonenal and 4-hydroxyhexenal in light-exposed rat retina. Invest Ophthalmol Vis Sci (2005) 1.25
On the relation of oxidative stress to neuroinflammation: lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. Antioxid Redox Signal (2006) 1.17
The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice. J Neurochem (2004) 1.15
Free radical trap phenyl-N-tert-butylnitrone protects against light damage but does not rescue P23H and S334ter rhodopsin transgenic rats from inherited retinal degeneration. J Neurosci (2003) 1.14
Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem (2002) 1.13
Primary glia expressing the G93A-SOD1 mutation present a neuroinflammatory phenotype and provide a cellular system for studies of glial inflammation. J Neuroinflammation (2006) 1.11
Modification of lupus-associated 60-kDa Ro protein with the lipid oxidation product 4-hydroxy-2-nonenal increases antigenicity and facilitates epitope spreading. Free Radic Biol Med (2005) 1.09
Bacillus anthracis peptidoglycan stimulates an inflammatory response in monocytes through the p38 mitogen-activated protein kinase pathway. PLoS One (2008) 1.07
Toll-like receptor (TLR) 2 induced through TLR4 signaling initiated by Helicobacter pylori cooperatively amplifies iNOS induction in gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol (2007) 1.06
An oxygen radical absorbance capacity-like assay that directly quantifies the antioxidant's scavenging capacity against AAPH-derived free radicals. Anal Biochem (2008) 1.05
Nitrone-related therapeutics: potential of NXY-059 for the treatment of acute ischaemic stroke. CNS Drugs (2004) 1.04
Stimulation of perivascular nitric oxide synthesis by oxygen. Am J Physiol Heart Circ Physiol (2002) 1.04
Identification of lanthionine synthase C-like protein-1 as a prominent glutathione binding protein expressed in the mammalian central nervous system. Biochemistry (2007) 1.03
Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets. J Alzheimers Dis (2004) 1.03
Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model. Free Radic Biol Med (2007) 1.01
LINE-1 hypomethylation in a choline-deficiency-induced liver cancer in rats: dependence on feeding period. J Biomed Biotechnol (2006) 1.00
Alpha-phenyl-N-tert-butylnitrone (PBN) prevents light-induced degeneration of the retina by inhibiting RPE65 protein isomerohydrolase activity. J Biol Chem (2011) 0.99
A survey of sesamin and composition of tocopherol variability from seeds of eleven diverse sesame (Sesamum indicum L.) genotypes using HPLC-PAD-ECD. Phytochem Anal (2008) 0.99
Reactive oxygen species and protein oxidation in aging: a look back, a look ahead. Arch Biochem Biophys (2002) 0.98
Visualization of the protective ability of a free radical trapping compound against rat C6 and F98 gliomas with diffusion tensor fiber tractography. J Magn Reson Imaging (2008) 0.96
Mechanism of protection from light-induced retinal degeneration by the synthetic antioxidant phenyl-N-tert-butylnitrone. Invest Ophthalmol Vis Sci (2005) 0.95
Multiparametric assessment of the anti-glioma properties of OKN007 by magnetic resonance imaging. J Magn Reson Imaging (2010) 0.95
Anti-inflammatory effects of tocopherol metabolites. Biochem Biophys Res Commun (2004) 0.94
Antioxidants reduce cellular and functional changes induced by intense noise in the inner ear and cochlear nucleus. J Assoc Res Otolaryngol (2014) 0.93
Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet. Cancer Sci (2003) 0.92
Oxygen radical absorbance capacity (ORAC) of cyclodextrin-solubilized flavonoids, resveratrol and astaxanthin as measured with the ORAC-EPR method. J Clin Biochem Nutr (2011) 0.92
The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide (2002) 0.91
Interleukin-10 protects against inflammation-mediated degeneration of dopaminergic neurons in substantia nigra. Neurobiol Aging (2007) 0.91
Effects of PBN and OKN007 in rodent glioma models assessed by 1H MR spectroscopy. Free Radic Biol Med (2011) 0.90
The human sulfatase 2 inhibitor 2,4-disulfonylphenyl-tert-butylnitrone (OKN-007) has an antitumor effect in hepatocellular carcinoma mediated via suppression of TGFB1/SMAD2 and Hedgehog/GLI1 signaling. Genes Chromosomes Cancer (2012) 0.90
Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition. Mol Cell Biochem (2002) 0.90
Inhalation of environmental stressors & chronic inflammation: autoimmunity and neurodegeneration. Mutat Res (2008) 0.89
Selective degeneration of synapses in the dorsal cochlear nucleus of chinchilla following acoustic trauma and effects of antioxidant treatment. Hear Res (2011) 0.89
Free radicals and the pathogenesis of type 1 diabetes: beta-cell cytokine-mediated free radical generation via cyclooxygenase-2. Diabetes (2003) 0.88
Multiple free-radical scavenging capacity in serum. J Clin Biochem Nutr (2012) 0.88
Catalytic nanoceria are preferentially retained in the rat retina and are not cytotoxic after intravitreal injection. PLoS One (2013) 0.88
Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. Free Radic Biol Med (2008) 0.87
Serum hydroxyl radical scavenging capacity as quantified with iron-free hydroxyl radical source. J Clin Biochem Nutr (2009) 0.86
Effects of delayed and extended antioxidant treatment on acute acoustic trauma. Free Radic Res (2011) 0.85
Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol (2013) 0.84
Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet. Cancer Lett (2004) 0.84
Reduced formation of oxidative stress biomarkers and migration of mononuclear phagocytes in the cochleae of chinchilla after antioxidant treatment in acute acoustic trauma. Int J Otolaryngol (2011) 0.84
Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo. Antiviral Res (2005) 0.83
Histamine stimulation of MMP-1(collagenase-1) secretion and gene expression in gastric epithelial cells: role of EGFR transactivation and the MAP kinase pathway. Int J Biochem Cell Biol (2007) 0.83
Immuno-spin trapping from biochemistry to medicine: advances, challenges, and pitfalls. Focus on protein-centered radicals. Biochim Biophys Acta (2013) 0.83
Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase. Antioxid Redox Signal (2005) 0.81
Analysis of sertraline in postmortem fluids and tissues in 11 aviation accident victims. J Anal Toxicol (2013) 0.81
Effects of iron and phytic acid on production of extracellular radicals by Enterococcus faecalis. Exp Biol Med (Maywood) (2004) 0.81
DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes. Oncol Rep (2006) 0.80
Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. Free Radic Res (2007) 0.80
High static pressure alters spin trapping rates in solution. Dependence on the structure of nitrone spin traps. Org Biomol Chem (2006) 0.80
Oxygen treatment triggers cognitive impairment in Alzheimer's transgenic mice. Neuroreport (2009) 0.80
Interleukin-10 overexpression mediates phenyl-N-tert-butyl nitrone protection from endotoxemia. Shock (2002) 0.80
Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes. Free Radic Biol Med (2004) 0.80
Five-year longitudinal bone evaluations in individuals with chronic complete spinal cord injury. J Spinal Cord Med (2008) 0.80
Nitric oxide production by primary liver cells isolated from amino acid diet-fed rats. Methods Enzymol (2005) 0.80
Effects of antioxidant treatment on blast-induced brain injury. PLoS One (2013) 0.79
Antioxidant therapy with N-acetylcysteine plus mesalamine accelerates mucosal healing in a rodent model of colitis. Dig Dis Sci (2006) 0.79
Oxidative modification of proteins in cell signaling. Antioxid Redox Signal (2005) 0.79
HPLC-electrochemical detection of tocopherol products as indicators of reactive nitrogen intermediates. Methods Enzymol (2005) 0.77
Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet. Cancer Sci (2005) 0.77
Spin trapping of nitric oxide with the iron-dithiocarbamate complex: chemistry and biology. Antioxid Redox Signal (2004) 0.76
alpha-Phenyl-N-tert-butylnitrone provides protection from dextran sulfate sodium-induced colitis in mice. Antioxid Redox Signal (2002) 0.76
Synthesis of 6-formylpterin nucleoside analogs and their ROS generation activities in the presence of NADH in the dark. Org Biomol Chem (2007) 0.75
Stability of the putative neurotoxin tryptamine-4,5-dione. Chem Res Toxicol (2003) 0.75