Published in Arch Ophthalmol on August 01, 2005
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Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell (2004) 9.41
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
Highly recurrent TERT promoter mutations in human melanoma. Science (2013) 8.40
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77
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Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat Genet (2011) 6.89
High-resolution genomic profiles of human lung cancer. Proc Natl Acad Sci U S A (2005) 6.52
Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A (2006) 5.90
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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65
A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell (2006) 5.01
p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation. Nature (2008) 5.00
Marked genomic differences characterize primary and secondary glioblastoma subtypes and identify two distinct molecular and clinical secondary glioblastoma entities. Cancer Res (2006) 4.80
Feedback circuit among INK4 tumor suppressors constrains human glioblastoma development. Cancer Cell (2008) 4.71
Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell (2006) 4.68
SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature (2011) 4.57
An X chromosome gene, WTX, is commonly inactivated in Wilms tumor. Science (2007) 4.00
Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation. Mol Cell (2009) 3.85
High-resolution characterization of the pancreatic adenocarcinoma genome. Proc Natl Acad Sci U S A (2004) 3.75
Prognostically relevant gene signatures of high-grade serous ovarian carcinoma. J Clin Invest (2012) 3.64
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature (2010) 3.54
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FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell (2009) 3.37
Passenger deletions generate therapeutic vulnerabilities in cancer. Nature (2012) 3.11
Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell (2002) 3.06
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02
GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer. Nature (2009) 2.77
Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev (2004) 2.75
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mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization. Proc Natl Acad Sci U S A (2008) 2.48
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res (2007) 2.45
High-resolution global profiling of genomic alterations with long oligonucleotide microarray. Cancer Res (2004) 2.45
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med (2012) 2.26
PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network. Cancer Discov (2011) 2.14
p16(Ink4a) in melanocyte senescence and differentiation. J Natl Cancer Inst (2002) 2.09
Viscocanalostomy in rhesus monkeys. Arch Ophthalmol (2004) 2.04
Diverse mechanisms of somatic structural variations in human cancer genomes. Cell (2013) 2.00
Proinvasion metastasis drivers in early-stage melanoma are oncogenes. Cancer Cell (2011) 1.99
Integrative genome comparison of primary and metastatic melanomas. PLoS One (2010) 1.97
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microRNA regulatory network inference identifies miR-34a as a novel regulator of TGF-β signaling in glioblastoma. Cancer Discov (2012) 1.94
Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J Biol Chem (2014) 1.92
Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A (2008) 1.92
Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Proc Natl Acad Sci U S A (2010) 1.91
Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell (2012) 1.91
Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis (2006) 1.85
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice. Nat Genet (2005) 1.84
Non-germline genetically engineered mouse models for translational cancer research. Nat Rev Cancer (2010) 1.80
Chimeric mouse tumor models reveal differences in pathway activation between ERBB family- and KRAS-dependent lung adenocarcinomas. Nat Biotechnol (2009) 1.76
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell (2012) 1.75
From the Cover: Neutralization of terminal differentiation in gliomagenesis. Proc Natl Acad Sci U S A (2013) 1.71
Spectrum of somatic mitochondrial mutations in five cancers. Proc Natl Acad Sci U S A (2012) 1.63
Towards patient-based cancer therapeutics. Nat Biotechnol (2010) 1.63
Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A (2004) 1.61
Amplification of CDK4 and MDM2 in malignant melanoma. Genes Chromosomes Cancer (2006) 1.60
Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types. Cancer Res (2007) 1.60
The INK4a/ARF locus and melanoma. Oncogene (2003) 1.57
A survey of intragenic breakpoints in glioblastoma identifies a distinct subset associated with poor survival. Genes Dev (2013) 1.55
A genome-wide screen reveals functional gene clusters in the cancer genome and identifies EphA2 as a mitogen in glioblastoma. Cancer Res (2006) 1.54
The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models. Genome Biol (2013) 1.54
Bcl2L12-mediated inhibition of effector caspase-3 and caspase-7 via distinct mechanisms in glioblastoma. Proc Natl Acad Sci U S A (2008) 1.52
Migration of intradermally injected quantum dots to sentinel organs in mice. Toxicol Sci (2007) 1.48
Signaling from the Golgi: mechanisms and models for Golgi phosphoprotein 3-mediated oncogenesis. Clin Cancer Res (2010) 1.46
Slitlamp, specular, and light microscopic findings of human donor corneas after laser-assisted in situ keratomileusis. Arch Ophthalmol (2004) 1.46
The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia. Blood (2011) 1.45
Postnatal depression in mothers bringing infants to the emergency department. Arch Dis Child (2012) 1.45
Array-CGH reveals recurrent genomic changes in Merkel cell carcinoma including amplification of L-Myc. J Invest Dermatol (2008) 1.42
Inactivation of LEF1 in T-cell acute lymphoblastic leukemia. Blood (2010) 1.40
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Histopathology of radial keratotomy. Arch Ophthalmol (2005) 1.39
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Bcl2L12 inhibits post-mitochondrial apoptosis signaling in glioblastoma. Genes Dev (2007) 1.38
How to ensure our readers' trust: the proper attribution of authors and contributors. Am J Ophthalmol (2008) 1.38
Mig-6 controls EGFR trafficking and suppresses gliomagenesis. Proc Natl Acad Sci U S A (2010) 1.38
STAR RNA-binding protein Quaking suppresses cancer via stabilization of specific miRNA. Genes Dev (2012) 1.38
Alu elements mediate MYB gene tandem duplication in human T-ALL. J Exp Med (2007) 1.37
Double minute chromosomes in glioblastoma multiforme are revealed by precise reconstruction of oncogenic amplicons. Cancer Res (2013) 1.35
Mitochondria, calcium, and calpain are key mediators of resveratrol-induced apoptosis in breast cancer. Mol Pharmacol (2007) 1.35
Inhibitor of differentiation 4 drives brain tumor-initiating cell genesis through cyclin E and notch signaling. Genes Dev (2008) 1.34
Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Natl Acad Sci U S A (2003) 1.32
Expression of the receptor tyrosine kinase Axl promotes ocular melanoma cell survival. Cancer Res (2004) 1.32
Lineage-specific transcriptional regulation of DICER by MITF in melanocytes. Cell (2010) 1.31
Genetic analysis of Pten and Ink4a/Arf interactions in the suppression of tumorigenesis in mice. Proc Natl Acad Sci U S A (2002) 1.30
The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: IV. Local treatment failure and enucleation in the first 5 years after brachytherapy. COMS report no. 19. Ophthalmology (2002) 1.29
Both products of the mouse Ink4a/Arf locus suppress melanoma formation in vivo. Oncogene (2003) 1.29