Published in Proc Natl Acad Sci U S A on December 03, 2008
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature (2010) 3.55
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature (2010) 3.54
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PI3K/mTOR signaling regulates prostatic branching morphogenesis. Dev Biol (2011) 0.96
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Fascin regulates the migration of subventricular zone-derived neuroblasts in the postnatal brain. J Neurosci (2013) 0.94
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The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress. Oncogene (2013) 0.93
Surviving change: the metabolic journey of hematopoietic stem cells. Trends Cell Biol (2014) 0.93
Human TSC2-null fibroblast-like cells induce hair follicle neogenesis and hamartoma morphogenesis. Nat Commun (2011) 0.93
Transcriptional control of spermatogonial maintenance and differentiation. Semin Cell Dev Biol (2014) 0.93
PRAS40 prevents development of diabetic cardiomyopathy and improves hepatic insulin sensitivity in obesity. EMBO Mol Med (2014) 0.91
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lncRNA NBR2 modulates cancer cell sensitivity to phenformin through GLUT1. Cell Cycle (2016) 0.84
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BAF180 regulates cellular senescence and hematopoietic stem cell homeostasis through p21. Oncotarget (2016) 0.83
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The neural crest lineage as a driver of disease heterogeneity in Tuberous Sclerosis Complex and Lymphangioleiomyomatosis. Front Cell Dev Biol (2014) 0.82
A critical role for mTORC1 in erythropoiesis and anemia. Elife (2014) 0.82
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A cell-based fascin bioassay identifies compounds with potential anti-metastasis or cognition-enhancing functions. Dis Model Mech (2012) 0.80
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BAP1 inhibits the ER stress gene regulatory network and modulates metabolic stress response. Proc Natl Acad Sci U S A (2017) 0.78
mTOR Inhibition improves anaemia and reduces organ damage in a murine model of sickle cell disease. Br J Haematol (2016) 0.78
Suppression of IGF-I signals in neural stem cells enhances neurogenesis and olfactory function during aging. Aging Cell (2015) 0.78
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Fate through fat: lipid metabolism determines stem cell division outcome. Cell Metab (2012) 0.77
Exosomes mediate the acquisition of the disease phenotypes by cells with normal genome in tuberous sclerosis complex. Oncogene (2015) 0.77
Evidence that hematopoietic stem cell function is preserved during aging in long-lived S6K1 mutant mice. Oncotarget (2016) 0.77
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Pten Cell Autonomously Modulates the Hematopoietic Stem Cell Response to Inflammatory Cytokines. Stem Cell Reports (2016) 0.76
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Role of the mammalian target of rapamycin pathway in lentiviral vector transduction of hematopoietic stem cells. Curr Opin Hematol (2015) 0.75
Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest (2017) 0.75
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Loss of Folliculin Disrupts Hematopoietic Stem Cell Quiescence and Homeostasis Resulting in Bone Marrow Failure. Stem Cells (2016) 0.75
Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development. Nat Commun (2017) 0.75
Autophagy mediates cell cycle response by regulating nucleocytoplasmic transport of PAX6 in limbal stem cells under ultraviolet-A stress. PLoS One (2017) 0.75
Autophagy is a signature of a signaling network that maintains hematopoietic stem cells. PLoS One (2017) 0.75
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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell (2007) 12.33
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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature (2006) 11.86
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Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell (2005) 8.37
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature (2006) 7.35
Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet (2008) 7.30
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet (2002) 7.12
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The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J (2008) 6.32
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
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Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells. Nature (2004) 4.68
Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet (2005) 3.94
A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep (2001) 3.67
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol (2008) 3.50
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol (2000) 2.89
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A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A (2001) 2.35
Fascin, a novel target of beta-catenin-TCF signaling, is expressed at the invasive front of human colon cancer. Cancer Res (2007) 2.26
Stem cell trafficking in tissue development, growth, and disease. Cell (2008) 2.15
Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent. J Biol Chem (2004) 1.75
Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol Cell (2001) 1.52
The tuberin-hamartin complex negatively regulates beta-catenin signaling activity. J Biol Chem (2003) 1.20
A comprehensive catalogue of somatic mutations from a human cancer genome. Nature (2009) 24.27
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Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev (2007) 17.20
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The genomic complexity of primary human prostate cancer. Nature (2011) 14.06
A landscape of driver mutations in melanoma. Cell (2012) 12.61
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell (2007) 12.33
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science (2007) 10.60
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat Genet (2009) 10.21
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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. Cell (2007) 8.94
Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature (2004) 8.87
Highly recurrent TERT promoter mutations in human melanoma. Science (2013) 8.40
Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev (2003) 8.27
Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell (2004) 8.16
Braf(V600E) cooperates with Pten loss to induce metastatic melanoma. Nat Genet (2009) 7.81
LKB1 modulates lung cancer differentiation and metastasis. Nature (2007) 7.80
Melanoma genome sequencing reveals frequent PREX2 mutations. Nature (2012) 7.77
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Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway. Nature (2013) 6.53
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Telomere dysfunction induces metabolic and mitochondrial compromise. Nature (2011) 6.36
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature (2002) 6.10
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Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A (2006) 5.90
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A genetic screen for candidate tumor suppressors identifies REST. Cell (2005) 5.61
Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev (2006) 5.53
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Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell (2010) 5.08
High-resolution genomic profiles define distinct clinico-pathogenetic subgroups of multiple myeloma patients. Cancer Cell (2006) 5.01
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Suppression of ovarian follicle activation in mice by the transcription factor Foxo3a. Science (2003) 4.32
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