Published in J Neurosci on August 10, 2005
Regulation of synaptic structure and function by FMRP-associated microRNAs miR-125b and miR-132. Neuron (2010) 3.96
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J Neurophysiol (2008) 2.46
The pathophysiology of fragile X (and what it teaches us about synapses). Annu Rev Neurosci (2012) 2.16
The state of synapses in fragile X syndrome. Neuroscientist (2009) 2.07
Toward fulfilling the promise of molecular medicine in fragile X syndrome. Annu Rev Med (2011) 1.96
Decreased nociceptive sensitization in mice lacking the fragile X mental retardation protein: role of mGluR1/5 and mTOR. J Neurosci (2007) 1.95
Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A (2007) 1.91
Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells. PLoS Genet (2010) 1.77
Circuit and plasticity defects in the developing somatosensory cortex of FMR1 knock-out mice. J Neurosci (2008) 1.72
Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice. Neuron (2010) 1.72
Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain. Neuron (2014) 1.70
Delayed stabilization of dendritic spines in fragile X mice. J Neurosci (2010) 1.69
Defective GABAergic neurotransmission and pharmacological rescue of neuronal hyperexcitability in the amygdala in a mouse model of fragile X syndrome. J Neurosci (2010) 1.69
Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development (2008) 1.52
Ablation of Fmrp in adult neural stem cells disrupts hippocampus-dependent learning. Nat Med (2011) 1.47
Downregulation of tonic GABAergic inhibition in a mouse model of fragile X syndrome. Cereb Cortex (2008) 1.45
Dendritic spine instability and insensitivity to modulation by sensory experience in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A (2010) 1.45
Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome. J Neurosci (2008) 1.42
Absence of metabotropic glutamate receptor-mediated plasticity in the neocortex of fragile X mice. Proc Natl Acad Sci U S A (2007) 1.37
A mouse model of the human Fragile X syndrome I304N mutation. PLoS Genet (2009) 1.36
Signals, synapses, and synthesis: how new proteins control plasticity. Front Neural Circuits (2009) 1.31
Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond. Neuropsychopharmacology (2011) 1.30
Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome. Proc Natl Acad Sci U S A (2010) 1.29
Ras and Rap signaling in synaptic plasticity and mental disorders. Neuroscientist (2010) 1.29
Fragile X syndrome and targeted treatment trials. Results Probl Cell Differ (2012) 1.27
The Drosophila fragile X mental retardation gene regulates sleep need. J Neurosci (2009) 1.25
Physiological activation of synaptic Rac>PAK (p-21 activated kinase) signaling is defective in a mouse model of fragile X syndrome. J Neurosci (2010) 1.22
Dissociation of social and nonsocial anxiety in a mouse model of fragile X syndrome. Neurosci Lett (2009) 1.22
Altered structural and functional synaptic plasticity with motor skill learning in a mouse model of fragile X syndrome. J Neurosci (2013) 1.20
Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Front Synaptic Neurosci (2010) 1.18
Long-term potentiation in the anterior cingulate cortex and chronic pain. Philos Trans R Soc Lond B Biol Sci (2013) 1.17
Fragile X mental retardation protein and synaptic plasticity. Mol Brain (2013) 1.12
Inhibition of GSK3β improves hippocampus-dependent learning and rescues neurogenesis in a mouse model of fragile X syndrome. Hum Mol Genet (2011) 1.09
RNA-binding protein FXR2 regulates adult hippocampal neurogenesis by reducing Noggin expression. Neuron (2011) 1.05
The GABA(A) receptor agonist THIP ameliorates specific behavioral deficits in the mouse model of fragile X syndrome. Dev Neurosci (2011) 1.04
Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS One (2011) 1.02
Transcranial magnetic stimulation provides means to assess cortical plasticity and excitability in humans with fragile x syndrome and autism spectrum disorder. Front Synaptic Neurosci (2010) 1.00
The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Mol Neurobiol (2009) 0.99
Behavioral phenotypes of genetic mouse models of autism. Genes Brain Behav (2015) 0.96
Excessive astrocyte-derived neurotrophin-3 contributes to the abnormal neuronal dendritic development in a mouse model of fragile X syndrome. PLoS Genet (2012) 0.96
Neuronal autophagy and neurodevelopmental disorders. Exp Neurobiol (2013) 0.96
Lithium reverses increased rates of cerebral protein synthesis in a mouse model of fragile X syndrome. Neurobiol Dis (2011) 0.94
Oxytocin and vasopressin systems in genetic syndromes and neurodevelopmental disorders. Brain Res (2014) 0.93
Protein synthesis inhibitors, gene superinduction and memory: too little or too much protein? Neurobiol Learn Mem (2007) 0.93
Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in Fmr1 knockout mice. Neuroscience (2011) 0.93
Fruit flies and intellectual disability. Fly (Austin) (2009) 0.92
Genetic reduction of group 1 metabotropic glutamate receptors alters select behaviors in a mouse model for fragile X syndrome. Behav Brain Res (2011) 0.92
Reliability of eye tracking and pupillometry measures in individuals with fragile X syndrome. J Autism Dev Disord (2011) 0.91
Genetic reduction of muscarinic M4 receptor modulates analgesic response and acoustic startle response in a mouse model of fragile X syndrome (FXS). Behav Brain Res (2011) 0.89
Neuropeptide Release is Impaired in a Mouse Model of Fragile X Mental Retardation Syndrome. ACS Chem Neurosci (2010) 0.89
The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiol Dis (2010) 0.89
Impaired critical period plasticity in primary auditory cortex of fragile X model mice. J Neurosci (2013) 0.89
Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder. J Neurosci (2012) 0.88
Pharmacological rescue of cortical synaptic and network potentiation in a mouse model for fragile X syndrome. Neuropsychopharmacology (2014) 0.88
Lithium treatment alleviates impaired cognition in a mouse model of fragile X syndrome. Genes Brain Behav (2013) 0.88
Modeling fragile X syndrome in the Fmr1 knockout mouse. Intractable Rare Dis Res (2014) 0.88
MicroRNAs and intellectual disability (ID) in Down syndrome, X-linked ID, and Fragile X syndrome. Front Cell Neurosci (2013) 0.87
Hippocampal metaplasticity is required for the formation of temporal associative memories. J Neurosci (2014) 0.87
Regulation of mRNA transport, localization and translation in the nervous system of mammals (Review). Int J Mol Med (2014) 0.87
Pharmacological rescue of Ras signaling, GluA1-dependent synaptic plasticity, and learning deficits in a fragile X model. Genes Dev (2014) 0.86
Group I metabotropic glutamate receptor-mediated gene transcription and implications for synaptic plasticity and diseases. Front Pharmacol (2012) 0.86
Dendritic spine dysgenesis in autism related disorders. Neurosci Lett (2015) 0.85
Ca2+/calmodulin-dependent protein kinase IV links group I metabotropic glutamate receptors to fragile X mental retardation protein in cingulate cortex. J Biol Chem (2009) 0.85
Fragile X syndrome and model organisms: identifying potential routes of therapeutic intervention. Dis Model Mech (2010) 0.85
Shank mutant mice as an animal model of autism. Philos Trans R Soc Lond B Biol Sci (2013) 0.85
Interplay of amygdala and cingulate plasticity in emotional fear. Neural Plast (2011) 0.85
Emerging pharmacologic treatment options for fragile X syndrome. Appl Clin Genet (2015) 0.84
Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome. Front Cell Neurosci (2014) 0.84
Environmental enrichment reveals effects of genotype on hippocampal spine morphologies in the mouse model of Fragile X Syndrome. Cereb Cortex (2013) 0.84
Discrimination learning and attentional set formation in a mouse model of Fragile X. Behav Neurosci (2011) 0.84
Roles of CREB in the regulation of FMRP by group I metabotropic glutamate receptors in cingulate cortex. Mol Brain (2012) 0.83
The cyclic AMP phenotype of fragile X and autism. Neurosci Biobehav Rev (2008) 0.83
Bridging the interval: theory and neurobiology of trace conditioning. Behav Processes (2013) 0.83
Sex differences in brain plasticity: a new hypothesis for sex ratio bias in autism. Mol Autism (2015) 0.83
Aberrant neural function during emotion attribution in female subjects with fragile X syndrome. J Am Acad Child Adolesc Psychiatry (2008) 0.82
Impaired cognitive discrimination and discoordination of coupled theta-gamma oscillations in Fmr1 knockout mice. Neurobiol Dis (2016) 0.82
Synaptic plasticity in mouse models of autism spectrum disorders. Korean J Physiol Pharmacol (2012) 0.82
Increasing our understanding of human cognition through the study of Fragile X Syndrome. Dev Neurobiol (2013) 0.82
Behavioral and synaptic circuit features in a zebrafish model of fragile X syndrome. PLoS One (2013) 0.81
Olfactory discrimination learning in mice lacking the fragile X mental retardation protein. Neurobiol Learn Mem (2008) 0.80
Local protein synthesis in axonal growth cones: what is next? Cell Adh Migr (2007) 0.80
Synaptic NMDA receptor-mediated currents in anterior piriform cortex are reduced in the adult fragile X mouse. Neuroscience (2012) 0.80
Abnormal emotional learning in a rat model of autism exposed to valproic acid in utero. Front Behav Neurosci (2014) 0.79
Corticosterone-induced enhancement of memory and synaptic Arc protein in the medial prefrontal cortex. Neurobiol Learn Mem (2014) 0.79
Multiple approaches to investigate the transport and activity-dependent release of BDNF and their application in neurogenetic disorders. Neural Plast (2012) 0.79
Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome. Mol Neurodegener (2012) 0.79
CaMKIV over-expression boosts cortical 4-7 Hz oscillations during learning and 1-4 Hz delta oscillations during sleep. Mol Brain (2010) 0.79
Abnormal intrinsic dynamics of dendritic spines in a fragile X syndrome mouse model in vivo. Sci Rep (2016) 0.78
The role of glycogen synthase kinase-3 signaling in neurodevelopment and fragile X syndrome. Int J Physiol Pathophysiol Pharmacol (2012) 0.78
Pathological plasticity in fragile X syndrome. Neural Plast (2012) 0.78
Lithium: a promising treatment for fragile X syndrome. ACS Chem Neurosci (2014) 0.78
Neonatal ketamine exposure causes impairment of long-term synaptic plasticity in the anterior cingulate cortex of rats. Neuroscience (2014) 0.77
Fragile X mental retardation protein (FMRP) and the spinal sensory system. Results Probl Cell Differ (2012) 0.77
Developing and validating trace fear conditioning protocols in C57BL/6 mice. J Neurosci Methods (2013) 0.77
Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proc Natl Acad Sci U S A (2014) 0.77
Normal Performance of Fmr1 Mice on a Touchscreen Delayed Nonmatching to Position Working Memory Task. eNeuro (2016) 0.77
Deficits in LTP induction by 5-HT2A receptor antagonist in a mouse model for fragile X syndrome. PLoS One (2012) 0.77
Amygdala regulation of fear and emotionality in fragile X syndrome. Dev Neurosci (2011) 0.77
Emotion potentiated startle in fragile X syndrome. J Autism Dev Disord (2014) 0.76
Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron (2005) 2.97
Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain. Sci Transl Med (2011) 2.67
Cl- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1. J Physiol (2004) 2.42
Genome sequencing and comparison of two nonhuman primate animal models, the cynomolgus and Chinese rhesus macaques. Nat Biotechnol (2011) 2.37
Alleviating neuropathic pain hypersensitivity by inhibiting PKMzeta in the anterior cingulate cortex. Science (2010) 2.11
The Jak/STAT pathway is involved in synaptic plasticity. Neuron (2012) 2.02
Enhancement of learning and memory by elevating brain magnesium. Neuron (2010) 2.00
Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain. Proc Natl Acad Sci U S A (2003) 1.93
Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci (2005) 1.87
Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci (2008) 1.84
Sleep deprivation impairs cAMP signalling in the hippocampus. Nature (2009) 1.83
Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron (2002) 1.79
Pavlovian fear memory induced by activation in the anterior cingulate cortex. Mol Pain (2005) 1.73
Calcium calmodulin-dependent protein kinase IV is required for fear memory. Nat Neurosci (2002) 1.70
FMRP acts as a key messenger for dopamine modulation in the forebrain. Neuron (2008) 1.59
Stability of recent and remote contextual fear memory. Learn Mem (2006) 1.57
Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice. J Neurosci (2006) 1.45
Enhanced presynaptic neurotransmitter release in the anterior cingulate cortex of mice with chronic pain. J Neurosci (2006) 1.43
Neuronal and microglial mechanisms of neuropathic pain. Mol Brain (2011) 1.41
Upregulation of CREB-mediated transcription enhances both short- and long-term memory. J Neurosci (2011) 1.41
Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex. J Neurophysiol (2005) 1.40
Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem (2004) 1.38
Impaired NMDA receptor-mediated postsynaptic function and blunted NMDA receptor-dependent persistent pain in mice lacking postsynaptic density-93 protein. J Neurosci (2003) 1.37
Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc Natl Acad Sci U S A (2004) 1.36
Synaptic imbalance, stereotypies, and impaired social interactions in mice with altered neuroligin 2 expression. J Neurosci (2008) 1.35
The channel kinase, TRPM7, is required for early embryonic development. Proc Natl Acad Sci U S A (2011) 1.29
PI3Kγ is required for NMDA receptor-dependent long-term depression and behavioral flexibility. Nat Neurosci (2011) 1.28
Resting microglial motility is independent of synaptic plasticity in mammalian brain. J Neurophysiol (2008) 1.27
Kainate receptor-mediated synaptic transmission in the adult anterior cingulate cortex. J Neurophysiol (2005) 1.26
A behavioral model of neuropathic pain induced by ligation of the common peroneal nerve in mice. J Pain (2005) 1.24
Increased anxiety-like behavior and enhanced synaptic efficacy in the amygdala of GluR5 knockout mice. PLoS One (2007) 1.22
Targeting the NMDA receptor subunit NR2B for the treatment of neuropathic pain. Neurotherapeutics (2009) 1.21
Calmodulin regulates synaptic plasticity in the anterior cingulate cortex and behavioral responses: a microelectroporation study in adult rodents. J Neurosci (2003) 1.21
The role of hippocampal GluR1 and GluR2 receptors in manic-like behavior. J Neurosci (2008) 1.19
Genetic reduction of chronic muscle pain in mice lacking calcium/calmodulin-stimulated adenylyl cyclases. Mol Pain (2006) 1.17
ATP-induced chemotaxis of microglial processes requires P2Y receptor-activated initiation of outward potassium currents. Glia (2007) 1.16
Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci (2007) 1.15
Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice. J Neurosci (2005) 1.14
Bidirectional microglia-neuron communication in the healthy brain. Neural Plast (2013) 1.09
Upregulation of calcium/calmodulin-dependent protein kinase IV improves memory formation and rescues memory loss with aging. J Neurosci (2008) 1.09
Hot receptors in the brain. Mol Pain (2006) 1.09
Selective activation of microglia in spinal cord but not higher cortical regions following nerve injury in adult mouse. Mol Pain (2008) 1.09
The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa. Nucleic Acids Res (2003) 1.07
NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation. Philos Trans R Soc Lond B Biol Sci (2013) 1.05
Enhanced quantal release of excitatory transmitter in anterior cingulate cortex of adult mice with chronic pain. Mol Pain (2009) 1.04
An increase in synaptic NMDA receptors in the insular cortex contributes to neuropathic pain. Sci Signal (2013) 1.03
Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn. J Neurosci (2002) 1.03
Glutamate acts as a neurotransmitter for gastrin releasing peptide-sensitive and insensitive itch-related synaptic transmission in mammalian spinal cord. Mol Pain (2011) 1.03
Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur J Neurosci (2005) 1.02
Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. Mol Brain (2008) 1.02
Genetic evidence for adenylyl cyclase 1 as a target for preventing neuronal excitotoxicity mediated by N-methyl-D-aspartate receptors. J Biol Chem (2006) 1.02
Genetic and pharmacological studies of GluR5 modulation of inhibitory synaptic transmission in the anterior cingulate cortex of adult mice. Dev Neurobiol (2007) 1.01
Activation of Erk in the anterior cingulate cortex during the induction and expression of chronic pain. Mol Pain (2008) 1.01
Requirement of extracellular signal-regulated kinase/mitogen-activated protein kinase for long-term potentiation in adult mouse anterior cingulate cortex. Mol Pain (2007) 1.01
Contribution of CaMKIV to injury and fear-induced ultrasonic vocalizations in adult mice. Mol Pain (2005) 1.00
Fragile X mental retardation protein is required for chemically-induced long-term potentiation of the hippocampus in adult mice. J Neurochem (2009) 1.00
Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. Dev Neurobiol (2007) 1.00
Induction of neuronal vascular endothelial growth factor expression by cAMP in the dentate gyrus of the hippocampus is required for antidepressant-like behaviors. J Neurosci (2009) 0.99
Experiences with assisted peritoneal dialysis in China. Perit Dial Int (2011) 0.98
Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons. Eur J Neurosci (2007) 0.98
Malfunction of respiratory-related neuronal activity in Na+, K+-ATPase alpha2 subunit-deficient mice is attributable to abnormal Cl- homeostasis in brainstem neurons. J Neurosci (2004) 0.98
Genetic enhancement of trace fear memory and cingulate potentiation in mice overexpressing Ca2+/calmodulin-dependent protein kinase IV. Eur J Neurosci (2008) 0.98
Roles of the AMPA receptor subunit GluA1 but not GluA2 in synaptic potentiation and activation of ERK in the anterior cingulate cortex. Mol Pain (2009) 0.98