Published in J Biomol Screen on August 01, 2005
Simple colorimetric trypanothione reductase-based assay for high-throughput screening of drugs against Leishmania intracellular amastigotes. Antimicrob Agents Chemother (2013) 0.80
Microscale screening of antibody libraries as maytansinoid antibody-drug conjugates. MAbs (2016) 0.76
The resurgence of covalent drugs. Nat Rev Drug Discov (2011) 4.09
The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance. Proc Natl Acad Sci U S A (2003) 2.07
Structural conservation of druggable hot spots in protein-protein interfaces. Proc Natl Acad Sci U S A (2011) 1.95
Small-molecule inhibition of TNF-alpha. Science (2005) 1.83
Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret. Nat Chem Biol (2006) 1.68
The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Curr Opin Chem Biol (2009) 1.46
Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol (2007) 1.44
Disease mutations in RUNX1 and RUNX2 create nonfunctional, dominant-negative, or hypomorphic alleles. EMBO J (2007) 1.44
Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site. Structure (2008) 1.39
N-terminally PEGylated human interferon-beta-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model. Bioconjug Chem (2006) 1.33
Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). Bioorg Med Chem Lett (2003) 1.27
SM16, an orally active TGF-beta type I receptor inhibitor prevents myofibroblast induction and vascular fibrosis in the rat carotid injury model. Arterioscler Thromb Vasc Biol (2008) 1.26
Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA. Biochemistry (2005) 1.23
Intracellular TGF-beta receptor blockade abrogates Smad-dependent fibroblast activation in vitro and in vivo. J Invest Dermatol (2006) 1.22
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF. J Biol Chem (2003) 1.17
Comparison of gene expression patterns induced by treatment of human umbilical vein endothelial cells with IFN-alpha 2b vs. IFN-beta 1a: understanding the functional relationship between distinct type I interferons that act through a common receptor. J Interferon Cytokine Res (2002) 1.11
Prospective, randomized evaluation of a personal digital assistant-based research tool in the emergency department. BMC Med Inform Decis Mak (2008) 1.03
Direct cloning of double-stranded RNAs from RNase protection analysis reveals processing patterns of C/D box snoRNAs and provides evidence for widespread antisense transcript expression. Nucleic Acids Res (2011) 1.01
Formation of virus-like clusters is an intrinsic property of the tumor necrosis factor family member BAFF (B cell activating factor). Biochemistry (2006) 0.99
Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces. J Chem Inf Model (2012) 0.95
Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion. J Biol Chem (2007) 0.94
Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1. Biochemistry (2002) 0.92
Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta. Mol Endocrinol (2010) 0.92
Comprehensive experimental and computational analysis of binding energy hot spots at the NF-κB essential modulator/IKKβ protein-protein interface. J Am Chem Soc (2013) 0.91
Comparison of effects of rosuvastatin (10 mg) versus atorvastatin (40 mg) on rho kinase activity in caucasian men with a previous atherosclerotic event. Am J Cardiol (2008) 0.90
Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism. ACS Chem Biol (2011) 0.90
Understanding cytokine and growth factor receptor activation mechanisms. Crit Rev Biochem Mol Biol (2012) 0.88
Quality assessment and analysis of Biogen Idec compound library. J Biomol Screen (2006) 0.87
Determining the affinity and stoichiometry of interactions between unmodified proteins in solution using Biacore. Anal Biochem (2013) 0.86
Identification and characterization of kava-derived compounds mediating TNF-alpha suppression. Chem Biol Drug Des (2009) 0.84
Stereoselectivity of enoyl-CoA hydratase results from preferential activation of one of two bound substrate conformers. Chem Biol (2002) 0.84
Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin. Biochemistry (2005) 0.84
Mutation of nonessential cysteines shows that the NF-κB essential modulator forms a constitutive noncovalent dimer that binds IκB kinase-β with high affinity. Biochemistry (2013) 0.81
Binding efficiency of protein-protein complexes. Biochemistry (2012) 0.80
Duplexed, bead-based competitive assay for inhibitors of protein kinases. Cytometry A (2007) 0.80
Effect of divalent cations on the affinity and selectivity of alpha4 integrins towards the integrin ligands vascular cell adhesion molecule-1 and mucosal addressin cell adhesion molecule-1: Ca2+ activation of integrin alpha4beta1 confers a distinct ligand specificity. Cell Commun Adhes (2003) 0.80
A kinase-focused compound collection: compilation and screening strategy. Chem Biol Drug Des (2006) 0.77
2-Aminoimidazoles inhibitors of TGF-beta receptor 1. Bioorg Med Chem Lett (2008) 0.77
Utilization of fluorescence polarization and time resolved fluorescence resonance energy transfer assay formats for SAR studies: Src kinase as a model system. J Biomol Screen (2004) 0.77
New Frontiers in Druggability. J Med Chem (2015) 0.77
A cell-free electrochemiluminescence assay for measuring beta1-integrin-ligand interactions. Anal Biochem (2002) 0.76
Disulfide-mediated stabilization of the IκB kinase binding domain of NF-κB essential modulator (NEMO). Biochemistry (2014) 0.75
Critical challenges and emerging paradigms in drug discovery. Curr Opin Chem Biol (2010) 0.75
A rapid, fluorescence-based assay for detecting antigenic modulation of the acetylcholine receptor on human cell lines. Cytometry B Clin Cytom (2009) 0.75
In vitro characterization of an acetylcholine receptor-transferrin fusion protein for the treatment of myasthenia gravis. Autoimmunity (2010) 0.75