Published in Nat Immunol on September 01, 2005
Interleukin-10 determines viral clearance or persistence in vivo. Nat Med (2006) 8.01
Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. Immunity (2007) 6.48
Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med (2010) 6.24
Enhancing SIV-specific immunity in vivo by PD-1 blockade. Nature (2008) 5.94
IL-21 is required to control chronic viral infection. Science (2009) 4.80
CD8+ T-cell memory in tumor immunology and immunotherapy. Immunol Rev (2006) 4.49
Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. J Exp Med (2006) 4.17
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol (2010) 4.06
Programmed death-1-induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection. Nat Med (2010) 3.81
From vaccines to memory and back. Immunity (2010) 3.30
Expanding roles for CD4⁺ T cells in immunity to viruses. Nat Rev Immunol (2012) 2.94
Enhancing therapeutic vaccination by blocking PD-1-mediated inhibitory signals during chronic infection. J Exp Med (2008) 2.81
Viral persistence redirects CD4 T cell differentiation toward T follicular helper cells. J Exp Med (2011) 2.48
High antigen levels are the cause of T cell exhaustion during chronic viral infection. Proc Natl Acad Sci U S A (2009) 2.42
Viral targeting of fibroblastic reticular cells contributes to immunosuppression and persistence during chronic infection. Proc Natl Acad Sci U S A (2007) 2.39
Elevated expression levels of inhibitory receptor programmed death 1 on simian immunodeficiency virus-specific CD8 T cells during chronic infection but not after vaccination. J Virol (2007) 2.21
Analysis of CD161 expression on human CD8+ T cells defines a distinct functional subset with tissue-homing properties. Proc Natl Acad Sci U S A (2010) 2.19
Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections. Cell Host Microbe (2008) 2.18
PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells. Int Immunol (2009) 2.10
Cell-intrinsic transforming growth factor-beta signaling mediates virus-specific CD8+ T cell deletion and viral persistence in vivo. Immunity (2009) 1.94
NFATc1 regulates PD-1 expression upon T cell activation. J Immunol (2008) 1.81
Emerging Tim-3 functions in antimicrobial and tumor immunity. Trends Immunol (2011) 1.79
Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B. PLoS Pathog (2007) 1.78
Decreased T cell reactivity to Epstein-Barr virus infected lymphoblastoid cell lines in multiple sclerosis. J Neurol Neurosurg Psychiatry (2008) 1.77
The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol (2009) 1.71
Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension. Respiration (2007) 1.67
Identification of an evolutionarily conserved transcriptional signature of CD8 memory differentiation that is shared by T and B cells. J Immunol (2008) 1.63
T cells maintain an exhausted phenotype after antigen withdrawal and population reexpansion. Nat Immunol (2013) 1.57
Plasmacytoid dendritic cells control T-cell response to chronic viral infection. Proc Natl Acad Sci U S A (2012) 1.56
Evidence of viral adaptation to HLA class I-restricted immune pressure in chronic hepatitis C virus infection. J Virol (2006) 1.54
Protective capacity of memory CD8+ T cells is dictated by antigen exposure history and nature of the infection. Immunity (2011) 1.53
Analysis of CD127 and KLRG1 expression on hepatitis C virus-specific CD8+ T cells reveals the existence of different memory T-cell subsets in the peripheral blood and liver. J Virol (2006) 1.52
Enumeration of functional T-cell subsets by fluorescence-immunospot defines signatures of pathogen burden in tuberculosis. PLoS One (2010) 1.45
Broadly directed virus-specific CD4+ T cell responses are primed during acute hepatitis C infection, but rapidly disappear from human blood with viral persistence. J Exp Med (2012) 1.43
CD8+ T cells in Trypanosoma cruzi infection. Curr Opin Immunol (2009) 1.36
Pharmacologic induction of CD8+ T cell memory: better living through chemistry. Sci Transl Med (2009) 1.34
Chronic but not acute virus infection induces sustained expansion of myeloid suppressor cell numbers that inhibit viral-specific T cell immunity. Immunity (2013) 1.33
Surviving the crash: transitioning from effector to memory CD8+ T cell. Semin Immunol (2009) 1.31
Distinct profiles of cytotoxic granules in memory CD8 T cells correlate with function, differentiation stage, and antigen exposure. J Virol (2009) 1.27
Memory generation and maintenance of CD8+ T cell function during viral persistence. J Immunol (2007) 1.23
Emergence of distinct multiarmed immunoregulatory antigen-presenting cells during persistent viral infection. Cell Host Microbe (2012) 1.22
Distinct effector memory CD4+ T cell signatures in latent Mycobacterium tuberculosis infection, BCG vaccination and clinically resolved tuberculosis. PLoS One (2012) 1.19
The role of LAT in increased CD8+ T cell exhaustion in trigeminal ganglia of mice latently infected with herpes simplex virus 1. J Virol (2011) 1.18
Enhancing virus-specific immunity in vivo by combining therapeutic vaccination and PD-L1 blockade in chronic hepadnaviral infection. PLoS Pathog (2014) 1.16
A major histocompatibility complex class I-dependent subset of memory phenotype CD8+ cells. J Exp Med (2006) 1.15
Chronic hepatitis C viral infection subverts vaccine-induced T-cell immunity in humans. Hepatology (2016) 1.12
CD80 and CD86 control antiviral CD8+ T-cell function and immune surveillance of murine gammaherpesvirus 68. J Virol (2006) 1.11
Granzyme B production distinguishes recently activated CD8(+) memory cells from resting memory cells. Cell Immunol (2007) 1.08
Persistence versus escape: Aspergillus terreus and Aspergillus fumigatus employ different strategies during interactions with macrophages. PLoS One (2012) 1.08
A dominant role for the immunoproteasome in CD8+ T cell responses to murine cytomegalovirus. PLoS One (2011) 1.08
Race between retroviral spread and CD4+ T-cell response determines the outcome of acute Friend virus infection. J Virol (2009) 1.05
The role of IL-10 in regulating immunity to persistent viral infections. Curr Top Microbiol Immunol (2011) 1.04
Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection. J Immunol (2012) 1.04
Suppressive CD8+ T cells arise in the absence of CD4 help and compromise control of persistent virus. J Immunol (2011) 1.02
T cell exhaustion during persistent viral infections. Virology (2015) 1.00
Translating insights from persistent LCMV infection into anti-HIV immunity. Immunol Res (2010) 1.00
Regulatory T cells in viral hepatitis. World J Gastroenterol (2007) 0.99
Dynamics of T-cell responses and memory T cells during primary simian immunodeficiency virus infection in cynomolgus macaques. J Virol (2007) 0.99
The rhesus macaque pediatric SIV infection model - a valuable tool in understanding infant HIV-1 pathogenesis and for designing pediatric HIV-1 prevention strategies. Curr HIV Res (2009) 0.97
IL-10 restricts memory T cell inflation during cytomegalovirus infection. J Immunol (2010) 0.97
Human leukocyte antigen class II associations with hepatitis C virus clearance and virus-specific CD4 T cell response among Caucasians and African Americans. Hepatology (2008) 0.97
Human cytomegalovirus-specific CD8(+) T-cell expansions contain long-lived cells that retain functional capacity in both young and elderly subjects. Immunology (2010) 0.97
The skin: where malaria infection and the host immune response begin. Semin Immunopathol (2012) 0.95
Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults. Eur J Immunol (2012) 0.94
Modulation of CD4⁺ T cell responses following splenectomy in hepatitis C virus-related liver cirrhosis. Clin Exp Immunol (2011) 0.94
CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection. J Hepatol (2010) 0.93
Long-term programming of antigen-specific immunity from gene expression signatures in the PBMC of rhesus macaques immunized with an SIV DNA vaccine. PLoS One (2011) 0.93
Therapeutic vaccines in HBV: lessons from HCV. Med Microbiol Immunol (2015) 0.93
The early kinetics of cytomegalovirus-specific CD8+ T-cell responses are not affected by antigen load or the absence of perforin or gamma interferon. J Virol (2008) 0.92
Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options. Retrovirology (2015) 0.92
Transcriptional regulation of effector and memory CD8+ T cell fates. Curr Opin Immunol (2013) 0.91
Opposing positive and negative regulation of T cell activity during viral persistence. Curr Opin Immunol (2010) 0.91
FOXO3 regulates the CD8 T cell response to a chronic viral infection. J Virol (2012) 0.91
Immunity to polyomavirus infection: the polyomavirus-mouse model. Semin Cancer Biol (2009) 0.91
HCV-HIV coinfection: simple messages from a complex disease. PLoS Med (2007) 0.91
Control of virus-specific CD8+ T-cell exhaustion and immune-mediated pathology by E3 ubiquitin ligase Cbl-b during chronic viral infection. J Virol (2008) 0.91
An adjuvanted polyprotein HIV-1 vaccine induces polyfunctional cross-reactive CD4+ T cell responses in seronegative volunteers. Clin Infect Dis (2011) 0.91
Induction and maintenance of protective CD8+ T cells against malaria liver stages: implications for vaccine development. Mem Inst Oswaldo Cruz (2011) 0.90
Virological footprint of CD4+ T-cell responses during chronic hepatitis C virus infection. J Gen Virol (2010) 0.89
Cutting edge: activation of virus-specific CD4 T cells throughout γ-herpesvirus latency. J Immunol (2011) 0.89
Structured observations reveal slow HIV-1 CTL escape. PLoS Genet (2015) 0.88
Anaplasma marginale infection with persistent high-load bacteremia induces a dysfunctional memory CD4+ T lymphocyte response but sustained high IgG titers. Clin Vaccine Immunol (2010) 0.88
Rapid deletion of antigen-specific CD4+ T cells following infection represents a strategy of immune evasion and persistence for Anaplasma marginale. J Immunol (2008) 0.88
The ambiguity in immunology. Front Immunol (2012) 0.87
Significantly skewed memory CD8+ T cell subsets in HIV-1 infected infants during the first year of life. Clin Immunol (2008) 0.87
In vivo and in vitro techniques for comparative study of antiviral T-cell responses in the amphibian Xenopus. Biol Proced Online (2008) 0.87
Hepatitis C virus-specific cytotoxic T cell response restoration after treatment-induced hepatitis C virus control. World J Gastroenterol (2015) 0.87
Epstein-Barr virus: silent companion or causative agent of chronic liver disease? World J Gastroenterol (2010) 0.87
Blocking type I interferon signaling rescues lymphocytes from oxidative stress, exhaustion, and apoptosis in a streptozotocin-induced mouse model of type I diabetes. Oxid Med Cell Longev (2013) 0.86
Protective antigen-independent CD8 T cell memory is maintained during {gamma}-herpesvirus persistence. J Immunol (2009) 0.86
Influence of genome-scale RNA structure disruption on the replication of murine norovirus--similar replication kinetics in cell culture but attenuation of viral fitness in vivo. Nucleic Acids Res (2013) 0.86
CD8(+) T cells from mice transnuclear for a TCR that recognizes a single H-2K(b)-restricted MHV68 epitope derived from gB-ORF8 help control infection. Cell Rep (2012) 0.86
Adaptive immunity to murine skin commensals. Proc Natl Acad Sci U S A (2014) 0.86
Cell-type-specific tyrosine phosphorylation of the herpes simplex virus tegument protein VP11/12 encoded by gene UL46. J Virol (2008) 0.85
Clinical development of monoclonal antibody-based drugs in HIV and HCV diseases. BMC Med (2013) 0.84
The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy. EMBO Mol Med (2011) 0.84
Body surface projection of action potential duration alternans: a combined clinical-modeling study with implications for improving T-wave alternans detection. Heart Rhythm (2009) 2.11
Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing (2011) 1.19
CMV and Immunosenescence: from basics to clinics. Immun Ageing (2012) 1.17
A randomized controlled trial of cognitive behavior therapy tailored to psychological adaptation to an implantable cardioverter defibrillator. Psychosom Med (2011) 0.97
Inappropriate therapy from a defibrillator complicating transcoronary ablation of septal hypertrophy in a patient with hypertrophic obstructive cardiomyopathy. Pacing Clin Electrophysiol (2004) 0.92
Determinants of implantable defibrillator discharges in high-risk patients with hypertrophic cardiomyopathy. Heart (2007) 0.78
Uncovering phantom shocks in cardiac patients with an implantable cardioverter defibrillator. Pacing Clin Electrophysiol (2013) 0.76
Videoconferencing in a hospital school: removing barriers. J Audiov Media Med (2004) 0.75
Consulting children and young people on what makes a good nurse. Nurs Child Young People (2012) 0.75