Published in PLoS One on December 14, 2010
Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis. Lancet Infect Dis (2011) 4.00
Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med (2013) 3.03
Functional Signatures of Human CD4 and CD8 T Cell Responses to Mycobacterium tuberculosis. Front Immunol (2014) 1.28
Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states. PLoS One (2011) 1.24
T-cell immunophenotyping distinguishes active from latent tuberculosis. J Infect Dis (2013) 1.18
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection. J Clin Invest (2011) 1.07
Single-cell protein analysis. Curr Opin Biotechnol (2011) 1.05
Immunodiagnosis of tuberculosis: a dynamic view of biomarker discovery. Clin Microbiol Rev (2011) 1.01
Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults. Eur J Immunol (2012) 0.94
Reconfigurable microfluidics combined with antibody microarrays for enhanced detection of T-cell secreted cytokines. Biomicrofluidics (2013) 0.93
Diagnosing latent tuberculosis in high-risk individuals: rising to the challenge in high-burden areas. J Infect Dis (2011) 0.87
Reduced frequency of memory T cells and increased Th17 responses in patients with active tuberculosis. Clin Vaccine Immunol (2012) 0.87
Stepping up ELISpot: Multi-Level Analysis in FluoroSpot Assays. Cells (2014) 0.86
Use of antigen-specific interleukin-2 to differentiate between cattle vaccinated with Mycobacterium bovis BCG and cattle infected with M. bovis. Clin Vaccine Immunol (2013) 0.84
BTLA exhibits immune memory for αβ T cells in patients with active pulmonary tuberculosis. Am J Transl Res (2014) 0.84
Clinical significance of interleukin-2/gamma interferon ratios in Mycobacterium tuberculosis-specific T-cell signatures. Clin Vaccine Immunol (2011) 0.81
Differences in antigen-specific CD4+ responses to opportunistic infections in HIV infection. Immun Inflamm Dis (2015) 0.80
PD-1 Expression and Cytokine Secretion Profiles of Mycobacterium tuberculosis-Specific CD4+ T-Cell Subsets; Potential Correlates of Containment in HIV-TB Co-Infection. PLoS One (2016) 0.80
Distinguishing Latent from Active Mycobacterium tuberculosis Infection Using Elispot Assays: Looking Beyond Interferon-gamma. Cells (2012) 0.79
Immune response to mycobacterial infection: lessons from flow cytometry. Clin Dev Immunol (2013) 0.79
The use of glass substrates with bi-functional silanes for designing micropatterned cell-secreted cytokine immunoassays. Biomaterials (2011) 0.79
Utility of T-Cell Interferon-γ Release Assays for Etiological Diagnosis of Classic Fever of Unknown Origin in a High Tuberculosis Endemic Area - a pilot prospective cohort. PLoS One (2016) 0.78
Specific in vitro interferon-gamma and IL-2 production as biomarkers during treatment of chronic Q fever. Front Microbiol (2015) 0.77
Comparison of ELISpot and FluoroSpot in the Analysis of Swine Flu-Specific IgG and IgA Secretion by in Vivo Activated Human B Cells. Cells (2012) 0.77
Kinetics of Mycobacterium tuberculosis-specific IFN-γ responses and sputum bacillary clearance in HIV-infected adults during treatment of pulmonary tuberculosis. Tuberculosis (Edinb) (2015) 0.75
Combined antigen-specific interferon-γ and interleukin-2 release assay (FluoroSpot) for the diagnosis of Mycobacterium tuberculosis infection. PLoS One (2015) 0.75
Triple Cytokine FluoroSpot Analysis of Human Antigen-Specific IFN-γ, IL-17A and IL-22 Responses. Cells (2014) 0.75
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature (1999) 34.47
Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med (2007) 11.80
T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol (2008) 11.65
Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet (2003) 8.30
Predictive value of a whole blood IFN-gamma assay for the development of active tuberculosis disease after recent infection with Mycobacterium tuberculosis. Am J Respir Crit Care Med (2008) 5.81
Superior control of HIV-1 replication by CD8+ T cells is reflected by their avidity, polyfunctionality, and clonal turnover. J Exp Med (2007) 5.58
Biomarkers and diagnostics for tuberculosis: progress, needs, and translation into practice. Lancet (2010) 4.71
T cells and viral persistence: lessons from diverse infections. Nat Immunol (2005) 4.12
Emerging concepts in the immunopathogenesis of AIDS. Annu Rev Med (2009) 3.94
Direct ex vivo analysis of antigen-specific IFN-gamma-secreting CD4 T cells in Mycobacterium tuberculosis-infected individuals: associations with clinical disease state and effect of treatment. J Immunol (2001) 3.79
Multifunctional CD4(+) T cells correlate with active Mycobacterium tuberculosis infection. Eur J Immunol (2010) 3.71
Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol (2007) 3.18
Multifunctional, high-level cytokine-producing Th1 cells in the lung, but not spleen, correlate with protection against Mycobacterium tuberculosis aerosol challenge in mice. J Immunol (2008) 3.04
Functional heterogeneity of memory CD4 T cell responses in different conditions of antigen exposure and persistence. J Immunol (2005) 3.04
Presence of HIV-1 Gag-specific IFN-gamma+IL-2+ and CD28+IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection. J Immunol (2002) 2.95
Diagnosing tuberculosis infection in the 21st century: new tools to tackle an old enemy. Chest (2007) 2.90
Improved diagnostic evaluation of suspected tuberculosis. Ann Intern Med (2008) 2.85
Functional signatures of protective antiviral T-cell immunity in human virus infections. Immunol Rev (2006) 2.75
Detection of polyfunctional Mycobacterium tuberculosis-specific T cells and association with viral load in HIV-1-infected persons. J Infect Dis (2008) 2.64
Functional signatures in antiviral T-cell immunity for monitoring virus-associated diseases. Nat Rev Immunol (2006) 2.52
Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. J Immunol (2007) 2.40
Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact. Ann Intern Med (2008) 2.36
Within-subject variability of interferon-g assay results for tuberculosis and boosting effect of tuberculin skin testing: a systematic review. PLoS One (2009) 2.34
Pattern and diversity of cytokine production differentiates between Mycobacterium tuberculosis infection and disease. Eur J Immunol (2009) 2.16
The novel tuberculosis vaccine, AERAS-402, induces robust and polyfunctional CD4+ and CD8+ T cells in adults. Am J Respir Crit Care Med (2010) 2.03
Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication. Eur J Immunol (2008) 1.70
Single-cytokine-producing CD4 memory cells predominate in type 1 and type 2 immunity. J Immunol (2000) 1.61
Polyfunctional CD4(+) and CD8(+) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment. J Immunol (2010) 1.45
A 100 year update on diagnosis of tuberculosis infection. Br Med Bull (2009) 1.40
Tuberculosis treatment effect on T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens. Eur Respir J (2009) 1.31
A Fluorospot assay to detect single T lymphocytes simultaneously producing multiple cytokines. J Immunol Methods (2003) 1.29
Polyfunctional T cells in human tuberculosis. Eur J Immunol (2010) 1.25
IL-2 absorption affects IFN-gamma and IL-5, but not IL-4 producing memory T cells in double color cytokine ELISPOT assays. Cell Immunol (2005) 1.10
Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis. Am J Respir Crit Care Med (2009) 1.09
CD4 and CD8 T-cell responses to mycobacterial antigens in African children. Am J Respir Crit Care Med (2010) 1.04
T Cells and Tuberculosis: Beyond Interferon-gamma. J Infect Dis (2008) 1.02
Automated analysis of two- and three-color fluorescent Elispot (Fluorospot) assays for cytokine secretion. Comput Methods Programs Biomed (2008) 1.01
Decay kinetics of an interferon gamma release assay with anti-tuberculosis therapy in newly diagnosed tuberculosis cases. PLoS One (2010) 1.00
Biomarkers of disease activity, cure, and relapse in tuberculosis. Clin Chest Med (2009) 0.94
Plasmodium falciparum apical membrane antigen 1 vaccine elicits multifunctional CD4 cytokine-producing and memory T cells. Vaccine (2009) 0.94
CD4+ T cell responses in hepatitis C virus infection. World J Gastroenterol (2007) 0.93
Development of a dual color enzyme-linked immunospot assay for simultaneous detection of murine T helper type 1- and T helper type 2-cells. Immunopharmacology (1998) 0.91
T-cell interferon-gamma release assays: can we do better? Eur Respir J (2008) 0.87
Comparison of T-cell-based assay with tuberculin skin test for diagnosis of Mycobacterium tuberculosis infection in a school tuberculosis outbreak. Lancet (2003) 8.30
Decreased histone deacetylase activity in chronic obstructive pulmonary disease. N Engl J Med (2005) 6.13
Effect of BCG vaccination on risk of Mycobacterium tuberculosis infection in children with household tuberculosis contact: a prospective community-based study. Lancet (2005) 4.82
Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am J Respir Crit Care Med (2005) 4.72
Screening of immigrants in the UK for imported latent tuberculosis: a multicentre cohort study and cost-effectiveness analysis. Lancet Infect Dis (2011) 4.00
Dynamic antigen-specific T-cell responses after point-source exposure to Mycobacterium tuberculosis. Am J Respir Crit Care Med (2006) 3.98
Rapid detection of active and latent tuberculosis infection in HIV-positive individuals by enumeration of Mycobacterium tuberculosis-specific T cells. AIDS (2002) 3.47
Characterization and management of paradoxical upgrading reactions in HIV-uninfected patients with lymph node tuberculosis. Clin Infect Dis (2005) 3.35
IL-33-dependent type 2 inflammation during rhinovirus-induced asthma exacerbations in vivo. Am J Respir Crit Care Med (2014) 3.32
Rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage enzyme-linked immunospot. Am J Respir Crit Care Med (2006) 3.12
Diagnosis of tuberculosis in South African children with a T-cell-based assay: a prospective cohort study. Lancet (2004) 3.07
Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med (2013) 3.03
Improved diagnostic evaluation of suspected tuberculosis. Ann Intern Med (2008) 2.85
Retracted The effects of a monoclonal antibody directed against tumor necrosis factor-alpha in asthma. Am J Respir Crit Care Med (2006) 2.72
Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with tuberculous intrathoracic lymphadenopathy: a multicentre study. Thorax (2011) 2.60
Dynamic relationship between IFN-gamma and IL-2 profile of Mycobacterium tuberculosis-specific T cells and antigen load. J Immunol (2007) 2.40
Performance of a T-cell-based diagnostic test for tuberculosis infection in HIV-infected individuals is independent of CD4 cell count. AIDS (2005) 2.38
Incidence of multidrug-resistant tuberculosis in urban and rural India and implications for prevention. Clin Infect Dis (2003) 2.38
Prognostic value of a T-cell-based, interferon-gamma biomarker in children with tuberculosis contact. Ann Intern Med (2008) 2.36
Outgrowth of the bacterial airway microbiome after rhinovirus exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2013) 2.28
A comparison between two strategies for monitoring hepatic function during antituberculous therapy. Am J Respir Crit Care Med (2011) 2.22
Glenoid rim fracture in contact athletes with absorbable suture anchor reconstruction. Arthroscopy (2008) 2.20
Comparing cannabis with tobacco. BMJ (2003) 2.08
Characterization of the CD4+ T cell response to Epstein-Barr virus during primary and persistent infection. J Exp Med (2003) 2.01
Increased risk of Mycobacterium tuberculosis infection in household child contacts exposed to passive tobacco smoke. Pediatr Infect Dis J (2014) 1.97
Ex vivo characterization of early secretory antigenic target 6-specific T cells at sites of active disease in pleural tuberculosis. Clin Infect Dis (2004) 1.88
Transcriptional blood signatures distinguish pulmonary tuberculosis, pulmonary sarcoidosis, pneumonias and lung cancers. PLoS One (2013) 1.86
Evaluation of immigrant tuberculosis screening in industrialized countries. Emerg Infect Dis (2012) 1.81
Rhinovirus-induced interferon production is not deficient in well controlled asthma. Thorax (2013) 1.77
T cell-based tracking of multidrug resistant tuberculosis infection after brief exposure. Am J Respir Crit Care Med (2004) 1.70
Counting antigen-specific T cells: a new approach for monitoring response to tuberculosis treatment? Clin Infect Dis (2004) 1.68
Magnetic resonance imaging of the hip: detection of labral and chondral abnormalities using noncontrast imaging. Arthroscopy (2005) 1.60
Enzyme-linked immunospot and tuberculin skin testing to detect latent tuberculosis infection. Am J Respir Crit Care Med (2005) 1.58
Hamstring muscle complex: an imaging review. Radiographics (2005) 1.55
A comparison of magnetic resonance imaging, sonography, and radiography of the hand in patients with early rheumatoid arthritis. J Rheumatol (2004) 1.55
Single-dose immunogenicity and protective efficacy of simian adenoviral vectors against Plasmodium berghei. Eur J Immunol (2008) 1.50
High incidence of the Beijing genotype among multidrug-resistant isolates of Mycobacterium tuberculosis in a tertiary care center in Mumbai, India. Clin Infect Dis (2005) 1.47
Evaluation of the hamstring muscle complex following acute injury. Skeletal Radiol (2003) 1.47
Overview of the National Health Educator Competencies Update Project, 1998-2004. Health Educ Behav (2005) 1.46
Retracted Skin-derived fibroblasts for the treatment of refractory Achilles tendinosis: preliminary short-term results. J Bone Joint Surg Am (2012) 1.42
Thrombotic microangiopathy complicating pegylated interferon treatment of hepatitis C infection. Am J Hematol (2011) 1.40
Rhinovirus 16-induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients. J Allergy Clin Immunol (2012) 1.35
Rv3615c is a highly immunodominant RD1 (Region of Difference 1)-dependent secreted antigen specific for Mycobacterium tuberculosis infection. Proc Natl Acad Sci U S A (2011) 1.35
Characterization of a Mycobacterium tuberculosis peptide that is recognized by human CD4+ and CD8+ T cells in the context of multiple HLA alleles. J Immunol (2004) 1.34
Toll-like receptor 2, 3, and 4 expression and function in human airway smooth muscle. J Allergy Clin Immunol (2006) 1.31
Evaluation of T-cell responses to novel RD1- and RD2-encoded Mycobacterium tuberculosis gene products for specific detection of human tuberculosis infection. Infect Immun (2004) 1.30
Evaluation of the immortalised mouse brain capillary endothelial cell line, b.End3, as an in vitro blood-brain barrier model for drug uptake and transport studies. Brain Res (2003) 1.28
Whole-blood flow-cytometric analysis of antigen-specific CD4 T-cell cytokine profiles distinguishes active tuberculosis from non-active states. PLoS One (2011) 1.24
Ultrasound guided dry needling and autologous blood injection for patellar tendinosis. Br J Sports Med (2007) 1.22
Community-based evaluation of immigrant tuberculosis screening using interferon γ release assays and tuberculin skin testing: observational study and economic analysis. Thorax (2012) 1.21
Growth factor-based therapies provide additional benefit beyond physical therapy in resistant elbow tendinopathy: a prospective, single-blind, randomised trial of autologous blood injections versus platelet-rich plasma injections. Br J Sports Med (2011) 1.21
Undetected multidrug-resistant tuberculosis amplified by first-line therapy in mixed infection. Emerg Infect Dis (2013) 1.20
Magnetic resonance imaging findings of injuries to the calf muscle complex. Skeletal Radiol (2007) 1.19
T-cell immunophenotyping distinguishes active from latent tuberculosis. J Infect Dis (2013) 1.18
Multidrug-resistant tuberculosis (MDR-TB) treatment in the UK: a study of injectable use and toxicity in practice. J Antimicrob Chemother (2011) 1.16
Ethnicity and mycobacterial lineage as determinants of tuberculosis disease phenotype. Thorax (2012) 1.14
Tuberculin skin testing underestimates a high prevalence of latent tuberculosis infection in hemodialysis patients. Kidney Int (2004) 1.11
Antimycobacterial, antiprotozoal and cytotoxic potential of twenty-one brown algae (Phaeophyceae) from British and Irish waters. Phytother Res (2010) 1.08
Interferon gamma assays for tuberculosis. Lancet Infect Dis (2005) 1.08
Importance of onsite cytopathology at endobronchial ultrasound. Am J Respir Crit Care Med (2013) 1.08
A mycolic acid-specific CD1-restricted T cell population contributes to acute and memory immune responses in human tuberculosis infection. J Clin Invest (2011) 1.07
Localization of a highly active pool of type II phosphatidylinositol 4-kinase in a p97/valosin-containing-protein-rich fraction of the endoplasmic reticulum. Biochem J (2003) 1.06
Return to competitive play after hamstring injuries involving disruption of the central tendon. Am J Sports Med (2012) 1.05
IGRAs--the gateway to T cell based TB diagnosis. Methods (2013) 1.02
Efficacy and safety of vertebroplasty for treatment of painful osteoporotic vertebral fractures: a randomised controlled trial [ACTRN012605000079640]. BMC Musculoskelet Disord (2008) 1.02
T-cell-based diagnosis of neonatal multidrug-resistant latent tuberculosis infection. Pediatrics (2007) 1.01
BCG vaccination: 90 years on and still so much to learn ... Thorax (2010) 1.00
Early diagnosis of subclinical multidrug-resistant tuberculosis. Ann Intern Med (2004) 0.99
A novel flow cytometric assay of human whole blood neutrophil and monocyte CD11b levels: upregulation by chemokines is related to receptor expression, comparison with neutrophil shape change, and effects of a chemokine receptor (CXCR2) antagonist. Pulm Pharmacol Ther (2006) 0.99
Identifying recent Mycobacterium tuberculosis transmission in the setting of high HIV and TB burden. Thorax (2010) 0.98
Mycobacterium tuberculosis-specific cellular immune profiles suggest bacillary persistence decades after spontaneous cure in untreated tuberculosis. J Infect Dis (2010) 0.98
International spread of MDR TB from Tugela Ferry, South Africa. Emerg Infect Dis (2011) 0.97
Novel M tuberculosis antigen-specific T-cells are early markers of infection and disease progression. PLoS One (2011) 0.96
Modelling the impacts of new diagnostic tools for tuberculosis in developing countries to enhance policy decisions. Health Care Manag Sci (2012) 0.95
Imaging of hamstring injuries: therapeutic implications. Eur Radiol (2006) 0.95
Use of T cell-based diagnosis of tuberculosis infection to optimize interpretation of tuberculin skin testing for child tuberculosis contacts. Clin Infect Dis (2009) 0.94
Predominance of heterosubtypic IFN-γ-only-secreting effector memory T cells in pandemic H1N1 naive adults. Eur J Immunol (2012) 0.94
The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. J Allergy Clin Immunol (2011) 0.94
Comparison of screening strategies to improve the diagnosis of latent tuberculosis infection in the HIV-positive population: a cohort study. BMJ Open (2012) 0.93