Published in J Biol Chem on September 01, 2005
A revised pathway proposed for Staphylococcus aureus wall teichoic acid biosynthesis based on in vitro reconstitution of the intracellular steps. Chem Biol (2008) 1.52
Use of CDP-glycerol as an alternate acceptor for the teichoic acid polymerase reveals that membrane association regulates polymer length. J Bacteriol (2008) 0.89
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nat Struct Mol Biol (2010) 0.88
The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis. J Biol Chem (2009) 0.85
Conformation of the phosphate D-alanine zwitterion in bacterial teichoic acid from nuclear magnetic resonance spectroscopy. Biochemistry (2009) 0.85
The Amino terminus of Bacillus subtilis TagB possesses separable localization and functional properties. J Bacteriol (2007) 0.83
The Capsule Polymerase CslB of Neisseria meningitidis Serogroup L Catalyzes the Synthesis of a Complex Trimeric Repeating Unit Comprising Glycosidic and Phosphodiester Linkages. J Biol Chem (2015) 0.78
Antibiotic resistance-the need for global solutions. Lancet Infect Dis (2013) 15.01
Identification of drugs including a dopamine receptor antagonist that selectively target cancer stem cells. Cell (2012) 4.13
Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway. J Bacteriol (2006) 2.49
An allosteric inhibitor of substrate recognition by the SCF(Cdc4) ubiquitin ligase. Nat Biotechnol (2010) 1.88
High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones. Chem Biol (2007) 1.85
Wall teichoic acid polymers are dispensable for cell viability in Bacillus subtilis. J Bacteriol (2006) 1.84
Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy. Nat Chem Biol (2011) 1.84
Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. Chem Biol (2004) 1.75
Studies of the interaction of Escherichia coli YjeQ with the ribosome in vitro. J Bacteriol (2004) 1.66
Chemical probes of Escherichia coli uncovered through chemical-chemical interaction profiling with compounds of known biological activity. Chem Biol (2010) 1.63
YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics. Biochemistry (2002) 1.58
PhoR autokinase activity is controlled by an intermediate in wall teichoic acid metabolism that is sensed by the intracellular PAS domain during the PhoPR-mediated phosphate limitation response of Bacillus subtilis. Mol Microbiol (2014) 1.47
Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms. Mol Microbiol (2006) 1.45
Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus. Biochemistry (2004) 1.43
High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase. Chem Biol (2004) 1.42
Teichoic acid is an essential polymer in Bacillus subtilis that is functionally distinct from teichuronic acid. J Bacteriol (2004) 1.39
A high-throughput pharmacoviral approach identifies novel oncolytic virus sensitizers. Mol Ther (2010) 1.38
Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function. Biochem J (2005) 1.33
Inhibition of WTA synthesis blocks the cooperative action of PBPs and sensitizes MRSA to β-lactams. ACS Chem Biol (2012) 1.29
Cooperative and critical roles for both G domains in the GTPase activity and cellular function of ribosome-associated Escherichia coli EngA. J Bacteriol (2006) 1.26
The TagB protein in Bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in vitro. J Biol Chem (2005) 1.22
Purified, recombinant TagF protein from Bacillus subtilis 168 catalyzes the polymerization of glycerol phosphate onto a membrane acceptor in vitro. J Biol Chem (2003) 1.19
Genetic interaction screens with ordered overexpression and deletion clone sets implicate the Escherichia coli GTPase YjeQ in late ribosome biogenesis. J Bacteriol (2008) 1.19
Are essential genes really essential? Trends Microbiol (2009) 1.18
The N-acetylmannosamine transferase catalyzes the first committed step of teichoic acid assembly in Bacillus subtilis and Staphylococcus aureus. J Bacteriol (2009) 1.16
Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis. J Bacteriol (2002) 1.14
Understanding ribosome assembly: the structure of in vivo assembled immature 30S subunits revealed by cryo-electron microscopy. RNA (2011) 1.14
Identification of pharmacological chaperones for Gaucher disease and characterization of their effects on beta-glucocerebrosidase by hydrogen/deuterium exchange mass spectrometry. Chembiochem (2008) 1.10
Antibiotics as probes of biological complexity. Nat Chem Biol (2011) 1.09
Chemical genomics in Escherichia coli identifies an inhibitor of bacterial lipoprotein targeting. Nat Chem Biol (2009) 1.09
CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values. Biochim Biophys Acta (2003) 1.08
Quantitative mass spectrometry catalogues Salmonella pathogenicity island-2 effectors and identifies their cognate host binding partners. J Biol Chem (2011) 1.06
Non-ribosomal factors in ribosome subunit assembly are emerging targets for new antibacterial drugs. Curr Opin Pharmacol (2006) 1.06
Probing teichoic acid genetics with bioactive molecules reveals new interactions among diverse processes in bacterial cell wall biogenesis. Chem Biol (2009) 1.04
Metabolic suppression identifies new antibacterial inhibitors under nutrient limitation. Nat Chem Biol (2013) 1.04
Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function. J Med Chem (2007) 1.02
A FACS-based approach to engineering artificial riboswitches. Chembiochem (2008) 1.00
Probing the active site of YjeE: a vital Escherichia coli protein of unknown function. Biochem J (2004) 0.99
The wall teichoic acid polymerase TagF efficiently synthesizes poly(glycerol phosphate) on the TagB product lipid III. Chembiochem (2008) 0.98
High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate. Bioorg Med Chem Lett (2003) 0.98
Experimental screening of dihydrofolate reductase yields a "test set" of 50,000 small molecules for a computational data-mining and docking competition. J Biomol Screen (2005) 0.96
Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor. RNA (2011) 0.95
Collapsing the proton motive force to identify synergistic combinations against Staphylococcus aureus. Chem Biol (2013) 0.95
High-throughput screening identifies novel inhibitors of the acetyltransferase activity of Escherichia coli GlmU. Antimicrob Agents Chemother (2009) 0.95
Small and lethal: searching for new antibacterial compounds with novel modes of action. Biochem Cell Biol (2008) 0.94
The yjeQ gene is required for virulence of Staphylococcus aureus. Infect Immun (2006) 0.93
A high-throughput screen of the GTPase activity of Escherichia coli EngA to find an inhibitor of bacterial ribosome biogenesis. J Biomol Screen (2013) 0.92
New screens and targets in antibacterial drug discovery. Curr Opin Microbiol (2009) 0.92
Using a riboswitch sensor to examine coenzyme B(12) metabolism and transport in E. coli. Chem Biol (2010) 0.92
Discovery of antibiotic adjuvants. Nat Biotechnol (2013) 0.91
Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism. Biochim Biophys Acta (2005) 0.90
Use of CDP-glycerol as an alternate acceptor for the teichoic acid polymerase reveals that membrane association regulates polymer length. J Bacteriol (2008) 0.89
The pathogenic Escherichia coli type III secreted protease NleC degrades the host acetyltransferase p300. Cell Microbiol (2011) 0.88
Duplication of teichoic acid biosynthetic genes in Staphylococcus aureus leads to functionally redundant poly(ribitol phosphate) polymerases. J Bacteriol (2008) 0.88
Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nat Struct Mol Biol (2010) 0.88
Isolation of the rstA gene as a multicopy suppressor of YjeE, an essential ATPase of unknown function in Escherichia coli. J Bacteriol (2007) 0.87
A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region. J Med Chem (2006) 0.86
The ATPase activity of an 'essential' Bacillus subtilis enzyme, YdiB, is required for its cellular function and is modulated by oligomerization. Microbiology (2009) 0.86
Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome. Mol Cell Proteomics (2013) 0.85
The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis. J Biol Chem (2009) 0.85
Chemical genomic approaches to study model microbes. Chem Biol (2010) 0.84
Ribosome biogenesis; the KsgA protein throws a methyl-mediated switch in ribosome assembly. Mol Microbiol (2008) 0.83
The Amino terminus of Bacillus subtilis TagB possesses separable localization and functional properties. J Bacteriol (2007) 0.83
Studies of the genetics, function, and kinetic mechanism of TagE, the wall teichoic acid glycosyltransferase in Bacillus subtilis 168. J Biol Chem (2011) 0.83
Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity. Angew Chem Int Ed Engl (2006) 0.83
Drug discovery: Not as fab as we thought. Nature (2009) 0.81
An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase. J Comb Chem (2004) 0.79
Phenotypic investigations of the depletion of EngA in Escherichia coli are consistent with a role in ribosome biogenesis. FEMS Microbiol Lett (2014) 0.79
The worm turns for antimicrobial discovery. Nat Biotechnol (2006) 0.79
Bacterial identification and subtyping using DNA microarray and DNA sequencing. Methods Mol Biol (2012) 0.78
Identification of a toxic peptide through bidirectional expression of small RNAs. Chembiochem (2009) 0.78
Microbiology: antibiotic stops 'ping-pong' match. Nature (2006) 0.78
Clinical Practice Recommendations for the Management and Prevention of Cisplatin-Induced Hearing Loss Using Pharmacogenetic Markers. Ther Drug Monit (2016) 0.77
Degradation of MAC13243 and studies of the interaction of resulting thiourea compounds with the lipoprotein targeting chaperone LolA. Bioorg Med Chem Lett (2013) 0.76
High-throughput screening of model bacteria. Methods Mol Biol (2009) 0.76
Host factor reveals the intrinsic enzymatic activity of a bacterial effector. Future Microbiol (2008) 0.75
Isolation of DNA aptamers for CDP-ribitol synthase, and characterization of their inhibitory and structural properties. Chembiochem (2007) 0.75
Thermodynamic and NMR analysis of inhibitor binding to dihydrofolate reductase. Bioorg Med Chem (2010) 0.75
Exploiting the sensitivity of nutrient transporter deletion strains in discovery of natural product antimetabolites. ACS Infect Dis (2017) 0.75
Polymyxin B analog SPR741 potentiates antibiotics against Gram-negative bacteria and uniquely perturbs the outer membrane. ACS Infect Dis (2019) 0.75
A dual reporter system for detecting RNA interactions in bacterial cells. Chembiochem (2014) 0.75