Published in J Am Chem Soc on September 14, 2005
Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. Bioorg Med Chem Lett (2006) 1.14
Iridium-catalyzed allylation of chiral β-stereogenic alcohols: bypassing discrete formation of epimerizable aldehydes. Org Lett (2012) 0.93
Natural products synthesis: enabling tools to penetrate Nature's secrets of biogenesis and biomechanism. J Org Chem (2011) 0.85
Regioselectivity of Pictet-Spengler Cyclization Reactions to Construct the Pentacyclic Frameworks of the Ecteinascidin-Saframycin Class of Tetrahydroisoquinoline Antitumor Antibiotics. Tetrahedron Lett (2007) 0.78
Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis. J Org Chem (2008) 0.77
Syntheses of Highly Functionalized δ,γ-Unsaturated-α-Amino Acids. Tetrahedron (2006) 0.75
Synthetic studies on lemonomycin: construction of the tetracyclic core. Tetrahedron (2013) 0.75
Chemistry and biology of the tetrahydroisoquinoline antitumor antibiotics. Chem Rev (2002) 2.43
Chemistry and biology of biosynthetic Diels-Alder reactions. Angew Chem Int Ed Engl (2003) 2.39
Notoamides A-D: prenylated indole alkaloids isolated from a marine-derived fungus, Aspergillus sp. Angew Chem Int Ed Engl (2007) 2.33
Isolation, structure elucidation, and biomimetic total synthesis of versicolamide B, and the isolation of antipodal (-)-stephacidin A and (+)-notoamide B from Aspergillus versicolor NRRL 35600. Angew Chem Int Ed Engl (2008) 2.06
A concise, biomimetic total synthesis of stephacidin A and notoamide B. Angew Chem Int Ed Engl (2007) 2.06
A concise total synthesis of the notoamides C and D. Angew Chem Int Ed Engl (2007) 1.86
Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc (2008) 1.64
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem Biol (2004) 1.52
Isolation of antipodal (-)-versicolamide B and notoamides L-N from a marine-derived Aspergillus sp. Org Lett (2009) 1.35
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. J Am Chem Soc (2009) 1.33
Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp. J Am Chem Soc (2009) 1.32
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol (2011) 1.26
Concise, Biomimetic Total Synthesis of d,l-Marcfortine C. Tetrahedron (2007) 1.25
Improved biomimetic total synthesis of D,L-stephacidin A. Org Lett (2007) 1.25
Synthetic Studies on the Ambiguine Family of Alkaloids: Construction of the ABCD Ring System. Tetrahedron Lett (2011) 1.25
Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Org Lett (2009) 1.23
Asymmetric total syntheses of (+)- and (-)-versicolamide B and biosynthetic implications. Nat Chem (2009) 1.22
Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. J Am Chem Soc (2010) 1.22
Concise, asymmetric total synthesis of spirotryprostatin A. Org Lett (2003) 1.21
Enantiomeric natural products: occurrence and biogenesis. Angew Chem Int Ed Engl (2012) 1.19
Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids. J Nat Prod (2012) 1.19
Asymmetric total synthesis of (-)-VM55599: establishment of the absolute stereochemistry and biogenetic implications. J Am Chem Soc (2002) 1.16
Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. Bioorg Med Chem Lett (2006) 1.14
Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry (2003) 1.12
Biomimetic total synthesis of malbrancheamide and malbrancheamide B. J Org Chem (2008) 1.12
Studies on the biosynthesis of paraherquamide A and VM99955. A theoretical study of intramolecular Diels-Alder cycloaddition. J Org Chem (2003) 1.12
Synthetic approaches to the bicyclo[2.2.2]diazaoctane ring system common to the paraherquamides, stephacidins and related prenylated indole alkaloids. Chem Soc Rev (2009) 1.10
Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Blood (2011) 1.09
Concise, asymmetric, stereocontrolled total synthesis of stephacidins A, B and notoamide B. J Am Chem Soc (2007) 1.08
Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids. J Am Chem Soc (2011) 1.06
Synthetic studies on quinine: quinuclidine construction via a ketone enolate regio- and diastereoselective Pd-mediated allylic alkylation. Org Lett (2006) 1.06
Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors. Nat Prod Rep (2009) 1.06
Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Org Lett (2008) 1.04
Taxoid metabolism: Taxoid 14beta-hydroxylase is a cytochrome P450-dependent monooxygenase. Arch Biochem Biophys (2003) 1.03
Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm (2012) 1.02
STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S. Heterocycles (2010) 1.01
A concise, total synthesis of the TMC-95A/B proteasome inhibitors. Proc Natl Acad Sci U S A (2004) 1.00
Biosynthetic studies of the notoamides: isotopic synthesis of stephacidin A and incorporation into notoamide B and sclerotiamide. Org Lett (2011) 1.00
A concise total synthesis of (+)-FR900482 and (+)-FR66979. J Org Chem (2004) 0.99
Molecular analysis of a 4-dimethylallyltryptophan synthase from Malbranchea aurantiaca. J Biol Chem (2008) 0.98
Concise enantioselective synthesis of (+)-FR66979 and (+)-FR900482: dimethyldioxirane-mediated construction of the hydroxylamine hemiketal. Angew Chem Int Ed Engl (2002) 0.97
Protein kinase Cδ inactivation inhibits cellular proliferation and decreases survival in human neuroendocrine tumors. Endocr Relat Cancer (2011) 0.97
Differential effects of FR900482 and FK317 on apoptosis, IL-2 gene expression, and induction of vascular leak syndrome. Chem Biol (2002) 0.96
Asymmetric synthesis of (2S,3R)-capreomycidine and the total synthesis of capreomycin IB. J Am Chem Soc (2003) 0.95
A concise asymmetric synthesis of the ADE fragment of nakadomarin A. Org Lett (2004) 0.94
Synthesis of notoamide J: a potentially pivotal intermediate in the biosynthesis of several prenylated indole alkaloids. J Org Chem (2010) 0.93
Synthetic Studies on Palau'amine. Construction of the Cyclopentane Core via an Asymmetric 1,3-Dipolar Cycloaddition. Tetrahedron Lett (2010) 0.93
Studies on the biosynthesis of the notoamides: synthesis of an isotopomer of 6-hydroxydeoxybrevianamide E and biosynthetic incorporation into notoamide J. J Org Chem (2011) 0.93
Asymmetric total synthesis of (-)-cribrostatin 4 (renieramycin H). Angew Chem Int Ed Engl (2007) 0.92
Protein kinase C-δ inactivation inhibits the proliferation and survival of cancer stem cells in culture and in vivo. BMC Cancer (2014) 0.91
The early stages of taxol biosynthesis: an interim report on the synthesis and identification of early pathway metabolites. Nat Prod Rep (2012) 0.91
Administering cultured Taxus cells with early precursors reveals bifurcations in the taxoid biosynthetic pathway. Phytochemistry (2006) 0.91
Improved total synthesis of the potent HDAC inhibitor FK228 (FR-901228). Org Lett (2008) 0.90
Synthetic and biosynthetic studies on FR900482 and mitomycin C: an efficient and stereoselective hydroxymethylation of an advanced benzazocane intermediate. Org Lett (2007) 0.89
Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B. Org Lett (2012) 0.89
Total synthesis of hapalindoles J and U. J Org Chem (2011) 0.89
Studies on taxol biosynthesis. Preparation of taxa-4(20),11(12)-dien-5 alpha-acetoxy-10 beta-ol by deoxygenation of a taxadiene tetraacetate obtained from Japanese yew. J Org Chem (2002) 0.89
Toward palau'amine: Hg(OTf)2-catalyzed synthesis of the cyclopentane core. Chemistry (2009) 0.89
Biomimetic nucleation of hydroxyapatite crystals mediated by Antheraea pernyi silk sericin promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells. Biomacromolecules (2014) 0.87
Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7 oxygenation is not required for the inhibition of protein synthesis. Angew Chem Int Ed Engl (2005) 0.86
Studies on the Biosynthesis of the Stephacidin and Notoamide Natural Products: A Stereochemical and Genetic Conundrum. Isr J Chem (2011) 0.86
Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs. Bioorg Med Chem Lett (2013) 0.85
Synthesis of potential early-stage intermediates in the biosynthesis of FR900482 and mitomycin C. Org Lett (2009) 0.85
Synthetic studies on Et-743. Asymmetric, stereocontrolled construction of the tetrahydroisoquinoline core via radical cyclization on a glyoxalimine. Org Lett (2006) 0.84
Studies on the biosynthesis of asperparaline A: origin of the spirosuccinimde ring system. J Am Chem Soc (2003) 0.83
Calmodulin inhibitory activity of the malbrancheamides and various analogs. Bioorg Med Chem Lett (2008) 0.83
Rabe rest in peace: confirmation of the rabe-kindler conversion of D-quinotoxine into quinine: experimental affirmation of the Woodward-Doering formal total synthesis of quinine. Angew Chem Int Ed Engl (2008) 0.83
A concise formal total synthesis of TMC-95A/B proteasome inhibitors. Org Lett (2003) 0.83
Asymmetric Synthesis of the Core of AMPTD, the Key Amino Acid of Microsclerodermins F-I. Tetrahedron Lett (2009) 0.82
Unified total syntheses of fawcettimine class alkaloids: fawcettimine, fawcettidine, lycoflexine, and lycoposerramine B. J Org Chem (2012) 0.82
Synthetic studies on ecteinascidin-743: constructing a versatile pentacyclic intermediate for the synthesis of ecteinascidins and saframycins. Org Lett (2003) 0.82
Total synthesis of (-)-tetrazomine. Determination of the stereochemistry of tetrazomine and the synthesis and biological activity of tetrazomine analogues. J Am Chem Soc (2002) 0.82
Intravenous and subcutaneous weight-based dosing of the low molecular weight heparin tinzaparin (Innohep) in end-stage renal disease patients undergoing chronic hemodialysis. Am J Kidney Dis (2002) 0.82
Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches. Chem Rev (2013) 0.81
Study on the biosynthesis of the notoamides: Pinacol-type rearrangement of the isoprenyl unit in deoxybrevianamide E and 6-hydroxydeoxybrevianamide E. Tetrahedron Lett (2011) 0.81
Isolation of notoamide S and enantiomeric 6-epi-stephacidin A from the fungus Aspergillus amoenus: biogenetic implications. Org Lett (2015) 0.81
Protein kinase Cδ is a therapeutic target in malignant melanoma with NRAS mutation. ACS Chem Biol (2014) 0.79
Notoamide E: Biosynthetic incorporation into notoamides C and D in cultures of Aspergillus versicolor NRRL 35600. Tetrahedron Lett (2011) 0.79
Studies on Taxol Biosynthesis: Preparation of Taxadiene-diol- and triol-Derivatives by Deoxygenation of Taxusin. Tetrahedron (2008) 0.79
A divergent strategy for the synthesis of secologanin derived natural products. J Org Chem (2010) 0.79
Studies on Paraherquamide Biosynthesis: Synthesis of Deuterium-Labeled 7-Hydroxy-Pre-Paraherquamide, a Putative Precursor of Paraherquamides A, E & F. Tetrahedron (2009) 0.79
Epidithiodioxopiperazines. occurrence, synthesis and biogenesis. Nat Prod Rep (2014) 0.79
Comparative pharmacokinetic properties and antitumor activity of the marine HDACi Largazole and Largazole peptide isostere. Cancer Chemother Pharmacol (2015) 0.78
Regioselectivity of Pictet-Spengler Cyclization Reactions to Construct the Pentacyclic Frameworks of the Ecteinascidin-Saframycin Class of Tetrahydroisoquinoline Antitumor Antibiotics. Tetrahedron Lett (2007) 0.78
Effects of photochemically activated alkylating agents of the FR900482 family on chromatin. Chem Biol (2007) 0.78
Detection of VM55599 and preparaherquamide from Aspergillus japonicus and Penicillium fellutanum: biosynthetic implications. J Nat Prod (2008) 0.78
Synthesis and DNA cross-linking of a phototriggered FR900482 mitosene progenitor. Org Lett (2002) 0.78
Synthesis of (+/-)-Oleocanthal via a Tandem Intramolecular Michael Cyclization-HWE Olefination. Tetrahedron Lett (2009) 0.78
Studies on Taxol® Biosynthesis. Preparation and Tritium Labeling of Biosynthetic intermediates by Deoxygenation of a Taxadiene Tetra-acetate Obtained from Japanese Yew. J Labelled Comp Radiopharm (2008) 0.77
A Diastereoselective Intramolecular Pauson-Khand Approach to the Construction of the BC Ring System in Tuberostemoninol. Tetrahedron Asymmetry (2008) 0.77
Synthetic studies on Et-743. Assembly of the pentacyclic core and a formal total synthesis. J Org Chem (2008) 0.77
Studies Towards Paraherquamides E & F and Related C-labeled Putative Biosynthetic Intermediates: Stereocontrolled Synthesis of the α-Alkyl-β-Methylproline Ring System. Tetrahedron (2008) 0.76
Coupling of activated esters to gramines in the presence of ethyl propiolate under mild conditions. Tetrahedron Lett (2007) 0.76
Ambulance diversion: economic and policy considerations. Ann Emerg Med (2006) 0.76
The costs of visits to emergency departments--revisited. Ann Emerg Med (2005) 0.75
Synthetic Studies Towards MPC1001: Preparation of a β-hydroxyl-Tyrosine Derivative. Tetrahedron Lett (2012) 0.75
Synthetic Studies Towards the Mitomycins: Construction of the Tetracyclic Core via a Reductive Aminocyclization Reaction. Tetrahedron Lett (2009) 0.75
Asymmetric synthesis of (+)-negamycin. J Org Chem (2002) 0.75
A concise asymmetric synthesis of the marine hepatotoxin 7-epicylindrospermopsin. Angew Chem Int Ed Engl (2004) 0.75
SYNTHETIC STUDIES ON MPC1001: A DIPOLAR CYCLOADDITION APPROACH TO THE PYRROLIDINE RING SYSTEM. Heterocycles (2012) 0.75