Published in J Am Chem Soc on December 28, 2011
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The natural product avrainvillamide binds to the oncoprotein nucleophosmin. J Am Chem Soc (2007) 1.07
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Calmodulin inhibitory activity of the malbrancheamides and various analogs. Bioorg Med Chem Lett (2008) 0.83
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Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from cyanobionts. ACS Chem Biol (2006) 1.94
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Structural basis for macrolactonization by the pikromycin thioesterase. Nat Chem Biol (2006) 1.79
Total synthesis and biological mode of action of largazole: a potent class I histone deacetylase inhibitor. J Am Chem Soc (2008) 1.64
Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: functional identification of a mechanistically diverse enzyme pair. J Am Chem Soc (2006) 1.55
Cytochrome p450 taxadiene 5alpha-hydroxylase, a mechanistically unusual monooxygenase catalyzing the first oxygenation step of taxol biosynthesis. Chem Biol (2004) 1.52
Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS One (2008) 1.46
Structural and mechanistic insights into polyketide macrolactonization from polyketide-based affinity labels. Nat Chem Biol (2006) 1.45
Intramolecular chiral relay at stereogenic nitrogen. Synthesis and application of a new chiral auxiliary derived from (1R,2S)-norephedrine and acetone. J Org Chem (2004) 1.43
Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Appl Environ Microbiol (2004) 1.42
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GNAT-like strategy for polyketide chain initiation. Science (2007) 1.36
Polyketide decarboxylative chain termination preceded by o-sulfonation in curacin a biosynthesis. J Am Chem Soc (2009) 1.35
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Diversity of P450 enzymes in the biosynthesis of natural products. Nat Prod Rep (2012) 1.34
Synthesis and conformation-activity relationships of the peptide isosteres of FK228 and largazole. J Am Chem Soc (2009) 1.33
Isolation of notoamide E, a key precursor in the biosynthesis of prenylated indole alkaloids in a marine-derived fungus, Aspergillus sp. J Am Chem Soc (2009) 1.32
Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. J Biol Chem (2002) 1.31
bryA: an unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chem Biol (2004) 1.27
Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743. ACS Chem Biol (2011) 1.26
Concise, Biomimetic Total Synthesis of d,l-Marcfortine C. Tetrahedron (2007) 1.25
Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics. Chem Biol (2008) 1.25
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Improved biomimetic total synthesis of D,L-stephacidin A. Org Lett (2007) 1.25
Characterization of the initial enzymatic steps of barbamide biosynthesis. J Nat Prod (2006) 1.25
Synthesis and histone deacetylase inhibitory activity of largazole analogs: alteration of the zinc-binding domain and macrocyclic scaffold. Org Lett (2009) 1.23
Asymmetric total syntheses of (+)- and (-)-versicolamide B and biosynthetic implications. Nat Chem (2009) 1.22
Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp. J Am Chem Soc (2010) 1.22
New tricks from ancient algae: natural products biosynthesis in marine cyanobacteria. Curr Opin Chem Biol (2009) 1.22
Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis. J Bacteriol (2006) 1.22
Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis. Biochemistry (2007) 1.21
Concise, asymmetric total synthesis of spirotryprostatin A. Org Lett (2003) 1.21
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The unique mechanistic transformations involved in the biosynthesis of modular natural products from marine cyanobacteria. Nat Prod Rep (2010) 1.19
Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. J Am Chem Soc (2007) 1.18
Merging the potential of microbial genetics with biological and chemical diversity: an even brighter future for marine natural product drug discovery. Nat Prod Rep (2003) 1.18
Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula. Insights into a decarboxylase involved in polyketide chain beta-branching. J Biol Chem (2007) 1.18
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Structural basis for binding specificity between subclasses of modular polyketide synthase docking domains. ACS Chem Biol (2009) 1.17
Asymmetric total synthesis of (-)-VM55599: establishment of the absolute stereochemistry and biogenetic implications. J Am Chem Soc (2002) 1.16
Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. J Am Chem Soc (2005) 1.15
Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. J Am Chem Soc (2005) 1.15
Antitumor activity of tetrahydroisoquinoline analogues 3-epi-jorumycin and 3-epi-renieramycin G. Bioorg Med Chem Lett (2006) 1.14
Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase. Proc Natl Acad Sci U S A (2009) 1.13
Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. Chembiochem (2005) 1.13
Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). BMC Genomics (2008) 1.12
Taxus metabolomics: methyl jasmonate preferentially induces production of taxoids oxygenated at C-13 in Taxus x media cell cultures. Phytochemistry (2003) 1.12
Biomimetic total synthesis of malbrancheamide and malbrancheamide B. J Org Chem (2008) 1.12
Studies on the biosynthesis of paraherquamide A and VM99955. A theoretical study of intramolecular Diels-Alder cycloaddition. J Org Chem (2003) 1.12
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Histone deacetylase inhibitors are potent inducers of gene expression in latent EBV and sensitize lymphoma cells to nucleoside antiviral agents. Blood (2011) 1.09
Developing tools for engineering hybrid polyketide synthetic pathways. Curr Opin Biotechnol (2006) 1.09
Isolation and characterization of tirandamycins from a marine-derived Streptomyces sp. J Nat Prod (2009) 1.08
Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. Microbiology (2007) 1.08
Concise, asymmetric, stereocontrolled total synthesis of stephacidins A, B and notoamide B. J Am Chem Soc (2007) 1.08
Conformational switch triggered by alpha-ketoglutarate in a halogenase of curacin A biosynthesis. Proc Natl Acad Sci U S A (2010) 1.08
Enzymatic assembly of the bis-indole core of rebeccamycin. J Am Chem Soc (2006) 1.08
Identification of the tirandamycin biosynthetic gene cluster from Streptomyces sp. 307-9. Chembiochem (2010) 1.07
Asymmetric total syntheses of (-)-jorumycin, (-)-renieramycin G, 3-epi-jorumycin, and 3-epi-renieramycin G. J Am Chem Soc (2005) 1.07
Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. Chem Biol (2007) 1.07
Tirandamycin biosynthesis is mediated by co-dependent oxidative enzymes. Nat Chem (2011) 1.06
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Discovery, biological activity, synthesis and potential therapeutic utility of naturally occurring histone deacetylase inhibitors. Nat Prod Rep (2009) 1.06
Synthetic studies on quinine: quinuclidine construction via a ketone enolate regio- and diastereoselective Pd-mediated allylic alkylation. Org Lett (2006) 1.06
Structural and functional analysis of AsbF: origin of the stealth 3,4-dihydroxybenzoic acid subunit for petrobactin biosynthesis. Proc Natl Acad Sci U S A (2008) 1.06
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Premalbrancheamide: synthesis, isotopic labeling, biosynthetic incorporation, and detection in cultures of Malbranchea aurantiaca. Org Lett (2008) 1.04
Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. J Am Chem Soc (2014) 1.04
Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol (2006) 1.04
Biochemical and structural characterization of the tautomycetin thioesterase: analysis of a stereoselective polyketide hydrolase. Angew Chem Int Ed Engl (2010) 1.04
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In vivo and in vitro trans-acylation by BryP, the putative bryostatin pathway acyltransferase derived from an uncultured marine symbiont. Chem Biol (2008) 1.03
Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. BMC Genomics (2007) 1.02
Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways. Medchemcomm (2012) 1.02
Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthetic pathways. Protein Sci (2004) 1.02