Published in Eur J Appl Physiol on October 27, 2005
Housekeeping while brain's storming Validation of normalizing factors for gene expression studies in a murine model of traumatic brain injury. BMC Mol Biol (2008) 1.44
Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. J Physiol (2007) 1.34
The effects of cold water immersion and active recovery on inflammation and cell stress responses in human skeletal muscle after resistance exercise. J Physiol (2016) 1.26
Expression of growth-related genes in young and older human skeletal muscle following an acute stimulation of protein synthesis. J Appl Physiol (1985) (2008) 1.20
Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia. Dis Model Mech (2012) 1.08
Attenuated purinergic receptor function in patients with type 2 diabetes. Diabetes (2009) 1.07
Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions. Eur J Appl Physiol (2005) 1.07
Role of IL-6 in exercise training- and cold-induced UCP1 expression in subcutaneous white adipose tissue. PLoS One (2014) 1.05
Pronounced effects of acute endurance exercise on gene expression in resting and exercising human skeletal muscle. PLoS One (2012) 1.02
Pro- and anti-angiogenic factors in human skeletal muscle in response to acute exercise and training. J Physiol (2011) 1.01
Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response. PLoS One (2012) 0.93
Biochemical artifacts in experiments involving repeated biopsies in the same muscle. Physiol Rep (2014) 0.92
Inadequate protein intake affects skeletal muscle transcript profiles in older humans. Am J Clin Nutr (2007) 0.91
Sequential muscle biopsies during a 6-h tracer infusion do not affect human mixed muscle protein synthesis and muscle phenylalanine kinetics. Am J Physiol Endocrinol Metab (2008) 0.91
The decrease in mature myostatin protein in male skeletal muscle is developmentally regulated by growth hormone. J Physiol (2008) 0.89
PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS One (2013) 0.88
Human skeletal muscle biopsy procedures using the modified Bergström technique. J Vis Exp (2014) 0.88
Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle. Nutr Metab (Lond) (2012) 0.87
Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol (2014) 0.87
Role of PGC-1α in exercise training- and resveratrol-induced prevention of age-associated inflammation. Exp Gerontol (2013) 0.84
Short-term intensified cycle training alters acute and chronic responses of PGC1α and Cytochrome C oxidase IV to exercise in human skeletal muscle. PLoS One (2012) 0.84
Choosing a stable housekeeping gene and protein is essential in generating valid gene and protein expression results. Br J Cancer (2011) 0.83
Transcription patterns of genes encoding four metallothionein homologs in Daphnia pulex exposed to copper and cadmium are time- and homolog-dependent. Aquat Toxicol (2013) 0.83
Exercise training and work task induced metabolic and stress-related mRNA and protein responses in myalgic muscles. Biomed Res Int (2012) 0.82
Discovery of a mammalian splice variant of myostatin that stimulates myogenesis. PLoS One (2013) 0.80
Expression of the small conductance Ca²⁺-activated potassium channel subtype 3 (SK3) in rat uterus after stimulation with 17β-estradiol. PLoS One (2014) 0.80
Combined speed endurance and endurance exercise amplify the exercise-induced PGC-1α and PDK4 mRNA response in trained human muscle. Physiol Rep (2016) 0.79
Translational signalling, atrogenic and myogenic gene expression during unloading and reloading of skeletal muscle in myostatin-deficient mice. PLoS One (2014) 0.78
Effects of IL-6 on pyruvate dehydrogenase regulation in mouse skeletal muscle. Pflugers Arch (2013) 0.78
PGC-1 isoforms and their target genes are expressed differently in human skeletal muscle following resistance and endurance exercise. Physiol Rep (2015) 0.78
Altering the redox state of skeletal muscle by glutathione depletion increases the exercise-activation of PGC-1α. Physiol Rep (2014) 0.77
Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation. PLoS One (2014) 0.77
Rifampicin alters the expression of reference genes used to normalize real-time quantitative RT-PCR data. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.77
Identification of Sex and Female's Reproductive Stage in Commercial Fish Species through the Quantification of Ribosomal Transcripts in Gonads. PLoS One (2016) 0.76
Endurance training in early life results in long-term programming of heart mass in rats. Physiol Rep (2016) 0.76
Protein and Amino Acid Supplementation Does Not Alter Proteolytic Gene Expression following Immobilization. J Nutr Metab (2011) 0.75
Parvalbumin gene transfer impairs skeletal muscle contractility in old mice. Hum Gene Ther (2012) 0.75
Ammonium Chloride Ingestion Attenuates Exercise-Induced mRNA Levels in Human Muscle. PLoS One (2015) 0.75
PGC-1α promotes exercise-induced autophagy in mouse skeletal muscle. Physiol Rep (2016) 0.75
Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem (1987) 281.19
Quantification of mRNA using real-time reverse transcription PCR (RT-PCR): trends and problems. J Mol Endocrinol (2002) 12.69
Quantitative real-time reverse transcription polymerase chain reaction: normalization to rRNA or single housekeeping genes is inappropriate for human tissue biopsies. Anal Biochem (2002) 4.84
Cells in stress: transcriptional activation of heat shock genes. Science (1993) 4.83
Characterization of PicoGreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation. Anal Biochem (1997) 4.58
Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol (2003) 4.34
Direct comparison of GAPDH, beta-actin, cyclophilin, and 28S rRNA as internal standards for quantifying RNA levels under hypoxia. Biochem Biophys Res Commun (1999) 3.21
A method for the absolute quantification of cDNA using real-time PCR. J Immunol Methods (2003) 2.93
Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab (2000) 2.52
Sources of variability and effect of experimental approach on expression profiling data interpretation. BMC Bioinformatics (2002) 2.31
Real-time RT-PCR analysis of housekeeping genes in human skeletal muscle following acute exercise. Physiol Genomics (2004) 1.87
Effects of exercise on GLUT-4 and glycogenin gene expression in human skeletal muscle. J Appl Physiol (1985) (2000) 1.87
Transcription occurs in pulses in muscle fibers. Genes Dev (1998) 1.77
Immunological changes in human skeletal muscle and blood after eccentric exercise and multiple biopsies. J Physiol (2000) 1.63
Single muscle fiber gene expression in human skeletal muscle: validation of internal control with exercise. Biochem Biophys Res Commun (2004) 1.41
Induction of vascular endothelial growth factor and hypoxia-inducible factor-1alpha by global ischemia in rat brain. Neuroscience (2000) 1.26
Are exercise-induced genes induced by exercise? FASEB J (2004) 1.08
Variability of fiber type distributions within human muscles. J Appl Physiol Respir Environ Exerc Physiol (1982) 1.08
Effects of exercise and insulin on insulin signaling proteins in human skeletal muscle. Med Sci Sports Exerc (1999) 1.06
Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle. Diabetes (2003) 1.06
Exercise induces a transient increase in transcription of the GLUT-4 gene in skeletal muscle. Am J Physiol (1993) 1.05
Free radicals, exercise, apoptosis, and heat shock proteins. Exerc Immunol Rev (2001) 1.02
Skeletal muscle lipoprotein lipase: molecular regulation and physiological effects in relation to exercise. Exerc Sport Sci Rev (1998) 1.00
Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle. Am J Physiol (1998) 0.99
Regulation of hexokinase II activity and expression in human muscle by moderate exercise. Am J Physiol (1998) 0.85
Fasting-induced changes in the expression of genes controlling substrate metabolism in the rat heart. J Lipid Res (2001) 0.84
Oxidative DNA damage and repair in skeletal muscle of humans exposed to high-altitude hypoxia. Toxicology (2003) 0.81
Determination of single-stranded oligodeoxynucleotides by capillary gel electrophoresis with laser induced fluorescence and on column derivatization. J Chromatogr A (1996) 0.81
Human skeletal muscle creatine transporter mRNA and protein expression in healthy, young males and females. Mol Cell Biochem (2003) 0.80
Optimal use of the fluorescent PicoGreen dye for quantitative analysis of amplified polymerase chain reaction products on microplate. Anal Biochem (2000) 0.79
Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans. J Clin Invest (2009) 5.66
"Live high-train low" using normobaric hypoxia: a double-blinded, placebo-controlled study. J Appl Physiol (1985) (2011) 4.80
Exercise induces transient transcriptional activation of the PGC-1alpha gene in human skeletal muscle. J Physiol (2003) 4.34
Evidence for a release of brain-derived neurotrophic factor from the brain during exercise. Exp Physiol (2009) 2.27
Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol (2009) 2.20
Effects of alpha-AMPK knockout on exercise-induced gene activation in mouse skeletal muscle. FASEB J (2005) 2.17
Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. J Physiol (2013) 2.10
Type II skeletal myofibers possess unique properties that potentiate mitochondrial H(2)O(2) generation. Am J Physiol Cell Physiol (2005) 2.08
K+-dependent paradoxical membrane depolarization and Na+ overload, major and reversible contributors to weakness by ion channel leaks. Proc Natl Acad Sci U S A (2009) 1.77
Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity. Cell Metab (2006) 1.76
Induction of endogenous uncoupling protein 3 suppresses mitochondrial oxidant emission during fatty acid-supported respiration. J Biol Chem (2007) 1.76
Exercise and improved insulin sensitivity in older women: evidence of the enduring benefits of higher intensity training. J Appl Physiol (1985) (2005) 1.75
Lipid-induced mitochondrial stress and insulin action in muscle. Cell Metab (2012) 1.71
PGC-1alpha is not mandatory for exercise- and training-induced adaptive gene responses in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2007) 1.71
Antioxidant supplementation enhances the exercise-induced increase in mitochondrial uncoupling protein 3 and endothelial nitric oxide synthase mRNA content in human skeletal muscle. Free Radic Biol Med (2007) 1.70
Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol (2009) 1.67
Linking mitochondrial bioenergetics to insulin resistance via redox biology. Trends Endocrinol Metab (2012) 1.64
Mitochondrial respiratory capacity and content are normal in young insulin-resistant obese humans. Diabetes (2013) 1.55
ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine. Am J Physiol Regul Integr Comp Physiol (2008) 1.47
Mitochondrial antioxidative capacity regulates muscle glucose uptake in the conscious mouse: effect of exercise and diet. J Appl Physiol (1985) (2012) 1.43
Lipid-induced insulin resistance affects women less than men and is not accompanied by inflammation or impaired proximal insulin signaling. Diabetes (2010) 1.41
5'-AMP-activated protein kinase activity and subunit expression in exercise-trained human skeletal muscle. J Appl Physiol (1985) (2002) 1.37
The role of PGC-1alpha on mitochondrial function and apoptotic susceptibility in muscle. Am J Physiol Cell Physiol (2009) 1.36
Higher skeletal muscle alpha2AMPK activation and lower energy charge and fat oxidation in men than in women during submaximal exercise. J Physiol (2006) 1.34
Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. J Physiol (2007) 1.34
Diet-induced muscle insulin resistance is associated with extracellular matrix remodeling and interaction with integrin alpha2beta1 in mice. Diabetes (2011) 1.33
Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle. Biochem J (2011) 1.31
Methods for assessing mitochondrial function in diabetes. Diabetes (2013) 1.31
PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch (2010) 1.29
Simvastatin impairs ADP-stimulated respiration and increases mitochondrial oxidative stress in primary human skeletal myotubes. Free Radic Biol Med (2011) 1.24
Influence of pre-exercise muscle glycogen content on exercise-induced transcriptional regulation of metabolic genes. J Physiol (2002) 1.22
5'AMP activated protein kinase expression in human skeletal muscle: effects of strength training and type 2 diabetes. J Physiol (2005) 1.22
PGC-1alpha mediates exercise-induced skeletal muscle VEGF expression in mice. Am J Physiol Endocrinol Metab (2009) 1.20
Transcriptional regulation of pyruvate dehydrogenase kinase 4 in skeletal muscle during and after exercise. Proc Nutr Soc (2004) 1.17
Resistance exercise alters MRF and IGF-I mRNA content in human skeletal muscle. J Appl Physiol (1985) (2003) 1.16
PDH-E1alpha dephosphorylation and activation in human skeletal muscle during exercise: effect of intralipid infusion. Diabetes (2006) 1.12
The role of haemoglobin mass on VO(2)max following normobaric 'live high-train low' in endurance-trained athletes. Br J Sports Med (2012) 1.12
Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells. J Clin Invest (2015) 1.12
Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration. Am J Physiol Endocrinol Metab (2003) 1.12
Erythropoietin receptor in human skeletal muscle and the effects of acute and long-term injections with recombinant human erythropoietin on the skeletal muscle. J Appl Physiol (1985) (2008) 1.11
AMP-activated protein kinase activates transcription of the UCP3 and HKII genes in rat skeletal muscle. Am J Physiol Endocrinol Metab (2002) 1.10
Attenuated purinergic receptor function in patients with type 2 diabetes. Diabetes (2009) 1.07
Control of gene expression and mitochondrial biogenesis in the muscular adaptation to endurance exercise. Essays Biochem (2006) 1.07
Regular endurance training reduces the exercise induced HIF-1alpha and HIF-2alpha mRNA expression in human skeletal muscle in normoxic conditions. Eur J Appl Physiol (2005) 1.07
PGC-1alpha is required for training-induced prevention of age-associated decline in mitochondrial enzymes in mouse skeletal muscle. Exp Gerontol (2010) 1.06
Effect of short-term fasting and refeeding on transcriptional regulation of metabolic genes in human skeletal muscle. Diabetes (2003) 1.06
Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α. Exp Gerontol (2013) 1.04
Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. Metabolism (2005) 1.02
Dissociation of AMPK activity and ACCbeta phosphorylation in human muscle during prolonged exercise. Biochem Biophys Res Commun (2002) 1.02
Novel role for thioredoxin reductase-2 in mitochondrial redox adaptations to obesogenic diet and exercise in heart and skeletal muscle. J Physiol (2013) 1.01
Role of PGC-1α in exercise and fasting-induced adaptations in mouse liver. Am J Physiol Regul Integr Comp Physiol (2011) 1.01
Bed rest reduces metabolic protein content and abolishes exercise-induced mRNA responses in human skeletal muscle. Am J Physiol Endocrinol Metab (2011) 1.00
PGC-1{alpha} is required for AICAR-induced expression of GLUT4 and mitochondrial proteins in mouse skeletal muscle. Am J Physiol Endocrinol Metab (2010) 0.99
PGC-1beta is downregulated by training in human skeletal muscle: no effect of training twice every second day vs. once daily on expression of the PGC-1 family. J Appl Physiol (1985) (2007) 0.99
Mitochondrial glutathione depletion reveals a novel role for the pyruvate dehydrogenase complex as a key H2O2-emitting source under conditions of nutrient overload. Free Radic Biol Med (2013) 0.99
Relative workload determines exercise-induced increases in PGC-1alpha mRNA. Med Sci Sports Exerc (2010) 0.97
Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women. Am J Physiol Endocrinol Metab (2010) 0.97
Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle. Am J Physiol Endocrinol Metab (2004) 0.96
Effect of acute exercise and exercise training on VEGF splice variants in human skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2004) 0.95
Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats. Free Radic Biol Med (2010) 0.95
GLUT4 and glycogen synthase are key players in bed rest-induced insulin resistance. Diabetes (2012) 0.94
Potassium kinetics in human muscle interstitium during repeated intense exercise in relation to fatigue. Pflugers Arch (2004) 0.94
Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle. Blood (2007) 0.93
Skeletal muscle PGC-1α is required for maintaining an acute LPS-induced TNFα response. PLoS One (2012) 0.93
LIF is a contraction-induced myokine stimulating human myocyte proliferation. J Appl Physiol (1985) (2011) 0.93
Submaximal ADP-stimulated respiration is impaired in ZDF rats and recovered by resveratrol. J Physiol (2013) 0.93
Adipose tissue interleukin-18 mRNA and plasma interleukin-18: effect of obesity and exercise. Obesity (Silver Spring) (2007) 0.92
Reduced volume but increased training intensity elevates muscle Na+-K+ pump alpha1-subunit and NHE1 expression as well as short-term work capacity in humans. Am J Physiol Regul Integr Comp Physiol (2007) 0.92
Sucrose counteracts the anti-inflammatory effect of fish oil in adipose tissue and increases obesity development in mice. PLoS One (2011) 0.91
Targeted metabolomics connects thioredoxin-interacting protein (TXNIP) to mitochondrial fuel selection and regulation of specific oxidoreductase enzymes in skeletal muscle. J Biol Chem (2014) 0.91
Mitochondrial biogenesis and angiogenesis in skeletal muscle of the elderly. Exp Gerontol (2011) 0.91
Mitochondrial creatine kinase activity and phosphate shuttling are acutely regulated by exercise in human skeletal muscle. J Physiol (2012) 0.90
Exercise-induced liver chemokine CXCL-1 expression is linked to muscle-derived interleukin-6 expression. J Physiol (2011) 0.90
The contraction induced increase in gene expression of peroxisome proliferator-activated receptor (PPAR)-gamma coactivator 1alpha (PGC-1alpha), mitochondrial uncoupling protein 3 (UCP3) and hexokinase II (HKII) in primary rat skeletal muscle cells is dependent on reactive oxygen species. Biochim Biophys Acta (2006) 0.90
AMP-activated protein kinase regulates nicotinamide phosphoribosyl transferase expression in skeletal muscle. J Physiol (2013) 0.89
Nitric oxide production is a proximal signaling event controlling exercise-induced mRNA expression in human skeletal muscle. FASEB J (2007) 0.89
Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther (2013) 0.89
Carbohydrate metabolism during prolonged exercise and recovery: interactions between pyruvate dehydrogenase, fatty acids, and amino acids. J Appl Physiol (1985) (2006) 0.88
The anticancer agent doxorubicin disrupts mitochondrial energy metabolism and redox balance in skeletal muscle. Free Radic Biol Med (2013) 0.88
Acclimatization to 4100 m does not change capillary density or mRNA expression of potential angiogenesis regulatory factors in human skeletal muscle. J Exp Biol (2004) 0.88
PGC-1α is required for exercise- and exercise training-induced UCP1 up-regulation in mouse white adipose tissue. PLoS One (2013) 0.88
Lack of AMPKalpha2 enhances pyruvate dehydrogenase activity during exercise. Am J Physiol Endocrinol Metab (2007) 0.88
Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. J Appl Physiol (1985) (2009) 0.88
Role of vitamin C and E supplementation on IL-6 in response to training. J Appl Physiol (1985) (2011) 0.87
Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol (2014) 0.87
Na,K-ATPase activity in mouse muscle is regulated by AMPK and PGC-1α. J Membr Biol (2011) 0.86
Low muscle glycogen and elevated plasma free fatty acid modify but do not prevent exercise-induced PDH activation in human skeletal muscle. Diabetes (2009) 0.86
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKKbeta Action in a Fiber-Type Specific Manner. J Obes (2010) 0.86
Subcellular localization and mechanism of secretion of vascular endothelial growth factor in human skeletal muscle. FASEB J (2013) 0.86
Evaluation of functional erythropoietin receptor status in skeletal muscle in vivo: acute and prolonged studies in healthy human subjects. PLoS One (2012) 0.85
Exercise-induced pyruvate dehydrogenase activation is not affected by 7 days of bed rest. J Appl Physiol (1985) (2011) 0.84
The mRNA expression profile of metabolic genes relative to MHC isoform pattern in human skeletal muscles. J Appl Physiol (1985) (2006) 0.84
Transgenic mice with astrocyte-targeted production of interleukin-6 are resistant to high-fat diet-induced increases in body weight and body fat. Brain Behav Immun (2009) 0.84
Identification of a novel malonyl-CoA IC(50) for CPT-I: implications for predicting in vivo fatty acid oxidation rates. Biochem J (2012) 0.84
Regulation of PDH in human arm and leg muscles at rest and during intense exercise. Am J Physiol Endocrinol Metab (2007) 0.84
Interleukin-18 activates skeletal muscle AMPK and reduces weight gain and insulin resistance in mice. Diabetes (2013) 0.84