Published in J Appl Physiol (1985) on September 11, 2008
Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol (1985) (2009) 1.65
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. J Appl Physiol (1985) (2010) 1.47
Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals. J Appl Physiol (1985) (2008) 1.26
Control of translation initiation through integration of signals generated by hormones, nutrients, and exercise. J Biol Chem (2010) 1.15
Molecular networks of human muscle adaptation to exercise and age. PLoS Genet (2013) 1.14
REDD2 is enriched in skeletal muscle and inhibits mTOR signaling in response to leucine and stretch. Am J Physiol Cell Physiol (2009) 1.11
Skeletal muscle autophagy and protein breakdown following resistance exercise are similar in younger and older adults. J Gerontol A Biol Sci Med Sci (2012) 1.09
Reactive hyperemia is not responsible for stimulating muscle protein synthesis following blood flow restriction exercise. J Appl Physiol (1985) (2012) 1.06
Exercise, amino acids, and aging in the control of human muscle protein synthesis. Med Sci Sports Exerc (2011) 1.00
Age-related differences in lean mass, protein synthesis and skeletal muscle markers of proteolysis after bed rest and exercise rehabilitation. J Physiol (2015) 0.99
Skeletal muscle gene expression in response to resistance exercise: sex specific regulation. BMC Genomics (2010) 0.99
Resistance exercise, skeletal muscle FOXO3A, and 85-year-old women. J Gerontol A Biol Sci Med Sci (2010) 0.96
Exercise and amino acid anabolic cell signaling and the regulation of skeletal muscle mass. Nutrients (2012) 0.93
Anabolic and catabolic pathways regulating skeletal muscle mass. Curr Opin Clin Nutr Metab Care (2010) 0.93
Sarcopenia, cachexia and aging: diagnosis, mechanisms and therapeutic options - a mini-review. Gerontology (2014) 0.93
Aging differentially affects human skeletal muscle amino acid transporter expression when essential amino acids are ingested after exercise. Clin Nutr (2012) 0.91
The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men. Age (Dordr) (2014) 0.90
Sexually dimorphic effect of aging on skeletal muscle protein synthesis. Biol Sex Differ (2012) 0.87
Leucine-enriched amino acid ingestion after resistance exercise prolongs myofibrillar protein synthesis and amino acid transporter expression in older men. J Nutr (2014) 0.86
Integration of signals generated by nutrients, hormones, and exercise in skeletal muscle. Am J Clin Nutr (2013) 0.83
MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance. Am J Physiol Endocrinol Metab (2015) 0.83
Proteins regulating cap-dependent translation are downregulated during total knee arthroplasty. Am J Physiol Regul Integr Comp Physiol (2011) 0.82
Living in a box or call of the wild? Revisiting lifetime inactivity and sarcopenia. Antioxid Redox Signal (2011) 0.82
REDD2 expression in rat skeletal muscle correlates with nutrient-induced activation of mTORC1: responses to aging, immobilization, and remobilization. Am J Physiol Endocrinol Metab (2014) 0.82
The role of mTOR signalling in the regulation of skeletal muscle mass in a rodent model of resistance exercise. Sci Rep (2016) 0.80
Nutritionally essential amino acids and metabolic signaling in aging. Amino Acids (2012) 0.80
Skeletal muscle homeostasis and plasticity in youth and ageing: impact of nutrition and exercise. Acta Physiol (Oxf) (2015) 0.79
IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts. Eur J Appl Physiol (2010) 0.78
Emerging role for regulated in development and DNA damage 1 (REDD1) in the regulation of skeletal muscle metabolism. Am J Physiol Endocrinol Metab (2016) 0.78
Endurance Exercise Enhances the Effect of Strength Training on Muscle Fiber Size and Protein Expression of Akt and mTOR. PLoS One (2016) 0.77
Sexual dimorphism in skeletal muscle protein turnover. J Appl Physiol (1985) (2015) 0.76
Preserved skeletal muscle protein anabolic response to acute exercise and protein intake in well-treated rheumatoid arthritis patients. Arthritis Res Ther (2015) 0.76
Absence of morphological and molecular correlates of sarcopenia in the macaque tongue muscle styloglossus. Exp Gerontol (2016) 0.75
Protein Consumption and the Elderly: What Is the Optimal Level of Intake? Nutrients (2016) 0.75
The Link between Dietary Protein Intake, Skeletal Muscle Function and Health in Older Adults. Healthcare (Basel) (2015) 0.75
Low-intensity aerobic exercise training: inhibition of skeletal muscle atrophy in high-fat-diet-induced ovariectomized rats. J Exerc Nutrition Biochem (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol (2002) 82.19
Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature (2005) 11.23
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo. Nat Cell Biol (2001) 10.85
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc Natl Acad Sci U S A (2005) 7.21
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol (2003) 6.32
Notch-mediated restoration of regenerative potential to aged muscle. Science (2003) 5.99
The regulation of Notch signaling controls satellite cell activation and cell fate determination in postnatal myogenesis. Dev Cell (2002) 5.70
hVps34 is a nutrient-regulated lipid kinase required for activation of p70 S6 kinase. J Biol Chem (2005) 5.22
Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol (2003) 5.01
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev (2008) 4.52
Mixed muscle protein synthesis and breakdown after resistance exercise in humans. Am J Physiol (1997) 3.27
Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol Cell Biol (2005) 3.14
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
Amino acids activate mTOR complex 1 via Ca2+/CaM signaling to hVps34. Cell Metab (2008) 2.96
mTOR-dependent activation of the transcription factor TIF-IA links rRNA synthesis to nutrient availability. Genes Dev (2004) 2.96
Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. J Nutr (2000) 2.93
A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly. Am J Physiol Endocrinol Metab (2006) 2.80
Stem cells in postnatal myogenesis: molecular mechanisms of satellite cell quiescence, activation and replenishment. Trends Cell Biol (2005) 2.74
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem J (2007) 2.69
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem (2005) 2.63
Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation. J Nutr (2000) 2.46
Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila. Cell Metab (2008) 2.32
Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab (2007) 2.26
Efficacy of 3 days/wk resistance training on myofiber hypertrophy and myogenic mechanisms in young vs. older adults. J Appl Physiol (1985) (2006) 2.25
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol (1985) (2008) 2.20
Aging is associated with diminished accretion of muscle proteins after the ingestion of a small bolus of essential amino acids. Am J Clin Nutr (2005) 2.15
Expression of IGF-I splice variants in young and old human skeletal muscle after high resistance exercise. J Physiol (2002) 2.09
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One (2007) 2.07
A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J Physiol (2007) 2.03
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature (2007) 2.01
Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol (1985) (2007) 2.01
Time course of myogenic and metabolic gene expression in response to acute exercise in human skeletal muscle. J Appl Physiol (1985) (2004) 1.85
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J Biol Chem (2006) 1.78
Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise. Am J Physiol Endocrinol Metab (2004) 1.58
Gene expression in human skeletal muscle: alternative normalization method and effect of repeated biopsies. Eur J Appl Physiol (2005) 1.58
Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol (2006) 1.57
Satellite cell numbers in young and older men 24 hours after eccentric exercise. Muscle Nerve (2006) 1.52
Branched-chain amino acids activate key enzymes in protein synthesis after physical exercise. J Nutr (2006) 1.50
Impact of resistance loading on myostatin expression and cell cycle regulation in young and older men and women. Am J Physiol Endocrinol Metab (2005) 1.49
c-Myc and eIF4F are components of a feedforward loop that links transcription and translation. Cancer Res (2008) 1.40
Myogenic gene expression at rest and after a bout of resistance exercise in young (18-30 yr) and old (80-89 yr) women. J Appl Physiol (1985) (2006) 1.36
Mechanical load increases muscle IGF-I and androgen receptor mRNA concentrations in humans. Am J Physiol Endocrinol Metab (2001) 1.34
Human muscle gene expression following resistance exercise and blood flow restriction. Med Sci Sports Exerc (2008) 1.32
Cluster analysis tests the importance of myogenic gene expression during myofiber hypertrophy in humans. J Appl Physiol (1985) (2007) 1.31
Mind bomb-2 is an E3 ligase for Notch ligand. J Biol Chem (2005) 1.27
Effect of age on muscle hypertrophy induced by resistance training. J Gerontol A Biol Sci Med Sci (1996) 1.27
Time course of molecular responses of human skeletal muscle to acute bouts of resistance exercise. J Appl Physiol (1985) (2004) 1.22
Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women. J Appl Physiol (1985) (2005) 1.20
Myogenic protein expression before and after resistance loading in 26- and 64-yr-old men and women. J Appl Physiol (1985) (2004) 1.17
Mixed muscle and hepatic derived plasma protein metabolism is differentially regulated in older and younger men following resistance exercise. Am J Physiol Endocrinol Metab (2005) 1.15
Are exercise-induced genes induced by exercise? FASEB J (2004) 1.08
STAT3 signaling is activated in human skeletal muscle following acute resistance exercise. J Appl Physiol (1985) (2007) 1.08
Impaired expression of Notch signaling genes in aged human skeletal muscle. J Gerontol A Biol Sci Med Sci (2007) 1.07
mVps34 is activated by an acute bout of resistance exercise. Biochem Soc Trans (2007) 0.88
Activation of Ca(2+)-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca(2+) release. Acta Physiol (Oxf) (2007) 0.83
Overload-induced C-Myc oncoprotein is reduced in aged skeletal muscle. J Gerontol A Biol Sci Med Sci (1997) 0.82
Resistance exercise increases AMPK activity and reduces 4E-BP1 phosphorylation and protein synthesis in human skeletal muscle. J Physiol (2006) 3.08
Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation. Proc Natl Acad Sci U S A (2007) 3.06
Effective fiber hypertrophy in satellite cell-depleted skeletal muscle. Development (2011) 2.99
Rapamycin administration in humans blocks the contraction-induced increase in skeletal muscle protein synthesis. J Physiol (2009) 2.64
MicroRNA-1 and microRNA-133a expression are decreased during skeletal muscle hypertrophy. J Appl Physiol (1985) (2006) 2.63
Amino acid ingestion improves muscle protein synthesis in the young and elderly. Am J Physiol Endocrinol Metab (2003) 2.41
Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle. Am J Physiol Endocrinol Metab (2007) 2.26
Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care (2009) 2.26
Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol (2007) 2.22
Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. J Appl Physiol (1985) (2008) 2.20
Insulin resistance of muscle protein metabolism in aging. FASEB J (2006) 2.17
Identification of the circadian transcriptome in adult mouse skeletal muscle. Physiol Genomics (2007) 2.06
Evidence-based recommendations for optimal dietary protein intake in older people: a position paper from the PROT-AGE Study Group. J Am Med Dir Assoc (2013) 1.96
Role of dietary protein in the sarcopenia of aging. Am J Clin Nutr (2008) 1.91
Mechanical stimuli regulate rapamycin-sensitive signalling by a phosphoinositide 3-kinase-, protein kinase B- and growth factor-independent mechanism. Biochem J (2004) 1.89
Blood flow restriction during low-intensity resistance exercise increases S6K1 phosphorylation and muscle protein synthesis. J Appl Physiol (1985) (2007) 1.79
Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis. Skelet Muscle (2011) 1.68
Nutritional and contractile regulation of human skeletal muscle protein synthesis and mTORC1 signaling. J Appl Physiol (1985) (2009) 1.65
CLOCK and BMAL1 regulate MyoD and are necessary for maintenance of skeletal muscle phenotype and function. Proc Natl Acad Sci U S A (2010) 1.63
Evidence of MyomiR network regulation of beta-myosin heavy chain gene expression during skeletal muscle atrophy. Physiol Genomics (2009) 1.62
Mammalian target of rapamycin complex 1 activation is required for the stimulation of human skeletal muscle protein synthesis by essential amino acids. J Nutr (2011) 1.60
Early activation of mTORC1 signalling in response to mechanical overload is independent of phosphoinositide 3-kinase/Akt signalling. J Physiol (2011) 1.59
Inducible Cre transgenic mouse strain for skeletal muscle-specific gene targeting. Skelet Muscle (2012) 1.58
Novel noninvasive breath test method for screening individuals at risk for diabetes. Diabetes Care (2008) 1.57
MicroRNA-206 is overexpressed in the diaphragm but not the hindlimb muscle of mdx mouse. Am J Physiol Cell Physiol (2007) 1.57
Altered activity of signaling pathways in diaphragm and tibialis anterior muscle of dystrophic mice. Exp Biol Med (Maywood) (2004) 1.56
Excess leucine intake enhances muscle anabolic signaling but not net protein anabolism in young men and women. J Nutr (2010) 1.51
Aerobic exercise overcomes the age-related insulin resistance of muscle protein metabolism by improving endothelial function and Akt/mammalian target of rapamycin signaling. Diabetes (2007) 1.50
An increase in essential amino acid availability upregulates amino acid transporter expression in human skeletal muscle. Am J Physiol Endocrinol Metab (2010) 1.48
Blood flow restriction exercise stimulates mTORC1 signaling and muscle protein synthesis in older men. J Appl Physiol (1985) (2010) 1.47
Effect of insulin on human skeletal muscle protein synthesis is modulated by insulin-induced changes in muscle blood flow and amino acid availability. Am J Physiol Endocrinol Metab (2006) 1.46
Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids. Am J Physiol Endocrinol Metab (2008) 1.45
Aging and microRNA expression in human skeletal muscle: a microarray and bioinformatics analysis. Physiol Genomics (2010) 1.43
Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrinol Metab (2012) 1.41
Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy. Am J Physiol Cell Physiol (2005) 1.36
Leucine-enriched nutrients and the regulation of mammalian target of rapamycin signalling and human skeletal muscle protein synthesis. Curr Opin Clin Nutr Metab Care (2008) 1.34
Pulsatile portal vein insulin delivery enhances hepatic insulin action and signaling. Diabetes (2012) 1.32
Human muscle gene expression following resistance exercise and blood flow restriction. Med Sci Sports Exerc (2008) 1.32
Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J Clin Invest (2002) 1.31
Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice. J Clin Invest (2010) 1.30
Response of rat muscle to acute resistance exercise defined by transcriptional and translational profiling. J Physiol (2002) 1.29
mTOR function in skeletal muscle hypertrophy: increased ribosomal RNA via cell cycle regulators. Am J Physiol Cell Physiol (2005) 1.27
Cellular mechanisms regulating protein synthesis and skeletal muscle hypertrophy in animals. J Appl Physiol (1985) (2008) 1.26
Insulin stimulates human skeletal muscle protein synthesis via an indirect mechanism involving endothelial-dependent vasodilation and mammalian target of rapamycin complex 1 signaling. J Clin Endocrinol Metab (2010) 1.24
Essential amino acid and carbohydrate ingestion before resistance exercise does not enhance postexercise muscle protein synthesis. J Appl Physiol (1985) (2008) 1.22
Muscle protein breakdown has a minor role in the protein anabolic response to essential amino acid and carbohydrate intake following resistance exercise. Am J Physiol Regul Integr Comp Physiol (2010) 1.20
Essential amino acids increase microRNA-499, -208b, and -23a and downregulate myostatin and myocyte enhancer factor 2C mRNA expression in human skeletal muscle. J Nutr (2009) 1.20
Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab (2007) 1.19
Bone and skeletal muscle: neighbors with close ties. J Bone Miner Res (2013) 1.19
Basal muscle intracellular amino acid kinetics in women and men. Am J Physiol Endocrinol Metab (2006) 1.18
The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility. Am J Physiol Cell Physiol (2013) 1.16
Short-term insulin and nutritional energy provision do not stimulate muscle protein synthesis if blood amino acid availability decreases. Am J Physiol Endocrinol Metab (2005) 1.14
Intracellular signaling specificity in response to uniaxial vs. multiaxial stretch: implications for mechanotransduction. Am J Physiol Cell Physiol (2004) 1.14
Pharmacological vasodilation improves insulin-stimulated muscle protein anabolism but not glucose utilization in older adults. Diabetes (2010) 1.13