Pharmacologic and toxicologic evaluation of C. novyi-NT spores.

PubWeight™: 1.14‹?› | Rank: Top 10%

🔗 View Article (PMID 16162850)

Published in Toxicol Sci on September 14, 2005

Authors

Luis A Diaz1, Ian Cheong, Catherine A Foss, Xiaosong Zhang, Brock A Peters, Nishant Agrawal, Chetan Bettegowda, Baktiar Karim, Guosheng Liu, Khalid Khan, Xin Huang, Manu Kohli, Long H Dang, Paul Hwang, Ahava Vogelstein, Elizabeth Garrett-Mayer, Barry Kobrin, Martin Pomper, Shibin Zhou, Kenneth W Kinzler, Bert Vogelstein, David L Huso

Author Affiliations

1: Howard Hughes Medical Institute, The Johns Hopkins School of Medicine, Baltimore, MD 21231, USA.

Associated clinical trials:

One Time Injection of Bacteria to Treat Solid Tumors That Have Not Responded to Standard Therapy | NCT00358397

Articles citing this

Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses. Sci Transl Med (2014) 2.69

Bacteria in cancer therapy: a novel experimental strategy. J Biomed Sci (2010) 1.50

Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT. PLoS One (2007) 1.15

Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens. Biochim Biophys Acta (2010) 1.02

Optimized clostridium-directed enzyme prodrug therapy improves the antitumor activity of the novel DNA cross-linking agent PR-104. Cancer Res (2008) 1.00

Evaluation of Clostridium novyi-NT spores in dogs with naturally occurring tumors. Am J Vet Res (2012) 0.95

Spore coat architecture of Clostridium novyi NT spores. J Bacteriol (2007) 0.95

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo. Oncotarget (2014) 0.91

Clostridium novyi-NT can cause regression of orthotopically implanted glioblastomas in rats. Oncotarget (2015) 0.86

Bacteriolytic therapy of experimental pancreatic carcinoma. World J Gastroenterol (2010) 0.85

Escherichia coli Nissle 1917 targets and restrains mouse B16 melanoma and 4T1 breast tumors through expression of azurin protein. Appl Environ Microbiol (2012) 0.82

Bacterial immunotherapy of gastrointestinal tumors. Langenbecks Arch Surg (2011) 0.76

Combining anaerobic bacterial oncolysis with vaccination that blocks interleukin-10 signaling may achieve better outcomes for late stage cancer management. Hum Vaccin Immunother (2016) 0.75

Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy. Microb Cell Fact (2015) 0.75

Cancer of the Peripheral Nerve in Neurofibromatosis Type 1. Neurotherapeutics (2017) 0.75

Branched Gold Nanoparticle Coating of Clostridium novyi-NT Spores for CT-Guided Intratumoral Injection. Small (2016) 0.75

Imaging virus-associated cancer. Curr Pharm Des (2008) 0.75

Articles by these authors

The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12

Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02

IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41

High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94

Cancer genome landscapes. Science (2013) 25.33

Cancer genes and the pathways they control. Nat Med (2004) 24.22

Human genome sequencing using unchained base reads on self-assembling DNA nanoarrays. Science (2009) 21.24

Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature (2010) 17.38

Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol (2009) 13.52

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08

Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet (2006) 12.98

Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc Natl Acad Sci U S A (2003) 12.91

The colorectal microRNAome. Proc Natl Acad Sci U S A (2006) 11.59

Allelic variation in human gene expression. Science (2002) 11.42

Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12

Diverse somatic mutation patterns and pathway alterations in human cancers. Nature (2010) 10.83

Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78

Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52

Circulating mutant DNA to assess tumor dynamics. Nat Med (2007) 10.33

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26

Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome. Science (2006) 10.25

The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature (2012) 10.17

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40

Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol (2007) 9.29

Using the transcriptome to annotate the genome. Nat Biotechnol (2002) 9.04

Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36

The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34

Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell (2005) 7.87

The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther (2004) 7.82

Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature (2002) 7.46

A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 7.45

Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (2009) 7.39

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol (2005) 7.25

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A (2013) 6.88

The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83

Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol (2006) 6.60

Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin-cyclophosphamide chemotherapy. Cancer Immunol Immunother (2008) 6.55

The antisense transcriptomes of human cells. Science (2008) 6.29

Detection and quantification of rare mutations with massively parallel sequencing. Proc Natl Acad Sci U S A (2011) 6.29

Development of personalized tumor biomarkers using massively parallel sequencing. Sci Transl Med (2010) 6.08

The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations. Science (2007) 6.01

Detection and quantification of mutations in the plasma of patients with colorectal tumors. Proc Natl Acad Sci U S A (2005) 5.91

Inactivation of hCDC4 can cause chromosomal instability. Nature (2004) 5.71

Eliminating catheter-related bloodstream infections in the intensive care unit. Crit Care Med (2004) 5.47

Mutational analysis of the tyrosine kinome in colorectal cancers. Science (2003) 5.43

Colorectal cancer: mutations in a signalling pathway. Nature (2005) 5.42

Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science (2009) 5.31