Published in Nature on October 28, 2010
Collecting Solid Tumor Tissue to Identify New Treatments | NCT01658917
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med (2012) 44.56
Cancer genome landscapes. Science (2013) 25.33
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples. Nat Biotechnol (2013) 16.13
Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing. Nature (2012) 14.33
Pancreatic cancer. Lancet (2004) 11.63
Clonal evolution in cancer. Nature (2012) 11.07
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
The life history of 21 breast cancers. Cell (2012) 10.59
Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34
EMT and dissemination precede pancreatic tumor formation. Cell (2012) 9.27
Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer (2012) 6.82
Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells. Nature (2011) 6.39
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science (2014) 6.09
The causes and consequences of genetic heterogeneity in cancer evolution. Nature (2013) 5.91
Tracking the clonal origin of lethal prostate cancer. J Clin Invest (2013) 5.79
Hepatocellular carcinoma: clinical frontiers and perspectives. Gut (2014) 5.79
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci U S A (2013) 5.68
Genome-wide detection of single-nucleotide and copy-number variations of a single human cell. Science (2012) 5.50
Tumour heterogeneity and cancer cell plasticity. Nature (2013) 5.47
Cancer stem cells: impact, heterogeneity, and uncertainty. Cancer Cell (2012) 5.44
Rethinking ovarian cancer: recommendations for improving outcomes. Nat Rev Cancer (2011) 5.28
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature (2015) 5.15
The tissue organization field theory of cancer: a testable replacement for the somatic mutation theory. Bioessays (2011) 5.01
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes. Nat Genet (2012) 4.82
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science (2013) 4.42
Clonal competition with alternating dominance in multiple myeloma. Blood (2012) 4.39
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing. Science (2014) 4.28
Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach. Nat Commun (2014) 4.16
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05
Single-cell sequencing-based technologies will revolutionize whole-organism science. Nat Rev Genet (2013) 4.03
Tumour heterogeneity in the clinic. Nature (2013) 3.92
The evolutionary history of lethal metastatic prostate cancer. Nature (2015) 3.59
Intratumor heterogeneity: evolution through space and time. Cancer Res (2012) 3.45
Computational modeling of pancreatic cancer reveals kinetics of metastasis suggesting optimum treatment strategies. Cell (2012) 3.39
Evolution of the cancer genome. Nat Rev Genet (2012) 3.24
JointSNVMix: a probabilistic model for accurate detection of somatic mutations in normal/tumour paired next-generation sequencing data. Bioinformatics (2012) 3.21
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation. Proc Natl Acad Sci U S A (2013) 3.15
Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma. Nat Genet (2011) 3.10
Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development. Nat Med (2014) 3.09
Patient-derived xenograft models: an emerging platform for translational cancer research. Cancer Discov (2014) 2.98
The seed and soil hypothesis revisited--the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer (2011) 2.87
Heterogeneity in breast cancer. J Clin Invest (2011) 2.86
Human cancers express mutator phenotypes: origin, consequences and targeting. Nat Rev Cancer (2011) 2.77
Tumor metastasis: moving new biological insights into the clinic. Nat Med (2013) 2.71
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 2.71
Origins of lymphatic and distant metastases in human colorectal cancer. Science (2017) 2.65
Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64
Addressing genetic tumor heterogeneity through computationally predictive combination therapy. Cancer Discov (2013) 2.59
Cancer heterogeneity: implications for targeted therapeutics. Br J Cancer (2013) 2.56
MicroRNAs in NF-kappaB signaling. J Mol Cell Biol (2011) 2.50
The Pediatric Cancer Genome Project. Nat Genet (2012) 2.49
Origins of metastatic traits. Cancer Cell (2013) 2.49
Genome-wide copy number analysis of single cells. Nat Protoc (2012) 2.47
Applying what we know to accelerate cancer prevention. Sci Transl Med (2012) 2.43
Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer. Nat Genet (2017) 2.42
Metabolic pathways promoting cancer cell survival and growth. Nat Cell Biol (2015) 2.35
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma. Nat Genet (2015) 2.27
Survival among patients with pancreatic cancer and long-standing or recent-onset diabetes mellitus. J Clin Oncol (2014) 2.21
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer. Genome Biol (2011) 2.11
miRNA biomarkers in cyst fluid augment the diagnosis and management of pancreatic cysts. Clin Cancer Res (2012) 2.10
Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer. Clin Cancer Res (2015) 2.09
Mathematical model identifies blood biomarker-based early cancer detection strategies and limitations. Sci Transl Med (2011) 2.07
Detection of tumor PIK3CA status in metastatic breast cancer using peripheral blood. Clin Cancer Res (2012) 2.07
Reliable detection of subclonal single-nucleotide variants in tumour cell populations. Nat Commun (2012) 2.06
Cancer epigenetics: tumor heterogeneity, plasticity of stem-like states, and drug resistance. Mol Cell (2014) 1.99
Genetic and phenotypic diversity in breast tumor metastases. Cancer Res (2014) 1.96
Evolutionary medicine: its scope, interest and potential. Proc Biol Sci (2012) 1.94
Whole genome sequencing of matched primary and metastatic acral melanomas. Genome Res (2011) 1.90
SciClone: inferring clonal architecture and tracking the spatial and temporal patterns of tumor evolution. PLoS Comput Biol (2014) 1.88
Metastatic stem cells: sources, niches, and vital pathways. Cell Stem Cell (2014) 1.88
DNA Methylation and Somatic Mutations Converge on the Cell Cycle and Define Similar Evolutionary Histories in Brain Tumors. Cancer Cell (2015) 1.87
Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing. Cell (2014) 1.85
Mechanisms governing metastatic dormancy and reactivation. Cell (2013) 1.81
Comparative genomic analysis of primary and synchronous metastatic colorectal cancers. PLoS One (2014) 1.80
Clonal evolution enhances leukemia-propagating cell frequency in T cell acute lymphoblastic leukemia through Akt/mTORC1 pathway activation. Cancer Cell (2014) 1.79
A refined molecular taxonomy of breast cancer. Oncogene (2011) 1.78
The cancer antigenome. EMBO J (2012) 1.78
The evolving concept of cancer and metastasis stem cells. J Cell Biol (2012) 1.76
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions. Genome Biol (2014) 1.76
Subclonal diversification of primary breast cancer revealed by multiregion sequencing. Nat Med (2015) 1.74
Small cell and large cell neuroendocrine carcinomas of the pancreas are genetically similar and distinct from well-differentiated pancreatic neuroendocrine tumors. Am J Surg Pathol (2012) 1.71
Radiomics: Images Are More than Pictures, They Are Data. Radiology (2015) 1.68
The cancer stem cell niche: how essential is the niche in regulating stemness of tumor cells? Cell Stem Cell (2015) 1.66
A spatial model predicts that dispersal and cell turnover limit intratumour heterogeneity. Nature (2015) 1.66
Targeting mTOR dependency in pancreatic cancer. Gut (2014) 1.65
DNA methylation alterations exhibit intraindividual stability and interindividual heterogeneity in prostate cancer metastases. Sci Transl Med (2013) 1.63
Roles for KRAS in pancreatic tumor development and progression. Gastroenterology (2013) 1.61
Time to progression of pancreatic ductal adenocarcinoma from low-to-high tumour stages. Gut (2015) 1.59
What does physics have to do with cancer? Nat Rev Cancer (2011) 1.59
New biomarkers and targets in pancreatic cancer and their application to treatment. Nat Rev Gastroenterol Hepatol (2012) 1.57
Overcoming implementation challenges of personalized cancer therapy. Nat Rev Clin Oncol (2012) 1.56
Prediagnostic serum biomarkers as early detection tools for pancreatic cancer in a large prospective cohort study. PLoS One (2014) 1.55
Quantitative imaging in cancer evolution and ecology. Radiology (2013) 1.55
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets. Cancer Discov (2015) 1.51
MRI with hyperpolarised [1-13C]pyruvate detects advanced pancreatic preneoplasia prior to invasive disease in a mouse model. Gut (2015) 1.51
A critical analysis of the clinical use of incretin-based therapies: The benefits by far outweigh the potential risks. Diabetes Care (2013) 1.51
Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer. Nat Commun (2015) 1.49
Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine (2015) 1.49
Tumor immunosurveillance in human cancers. Cancer Metastasis Rev (2011) 1.48
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
Genetic instabilities in human cancers. Nature (1998) 22.76
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40
Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer (2009) 14.17
Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52
High-resolution genomic profiling of chromosomal aberrations using Infinium whole-genome genotyping. Genome Res (2006) 10.45
Signatures of mutation and selection in the cancer genome. Nature (2010) 9.75
Pancreatic cancer. Annu Rev Pathol (2008) 6.96
Development of personalized tumor biomarkers using massively parallel sequencing. Sci Transl Med (2010) 6.08
Advanced pancreatic carcinoma: current treatment and future challenges. Nat Rev Clin Oncol (2010) 5.07
A model of human tumor dormancy: an angiogenic switch from the nonangiogenic phenotype. J Natl Cancer Inst (2006) 4.44
Immortalizing the complexity of cancer metastasis: genetic features of lethal metastatic pancreatic cancer obtained from rapid autopsy. Cancer Biol Ther (2005) 3.28
Critical determinants of metastasis. Semin Cancer Biol (2002) 3.12
The pathology and genetics of metastatic pancreatic cancer. Arch Pathol Lab Med (2009) 2.16
Cell production rates in human tissues and tumours and their significance. Part II: clinical data. Eur J Surg Oncol (2000) 1.95
Relationship between labeling indices of Ki-67 and BrdUrd in human malignant tumors. Cancer (1988) 1.91
The time of occurrence of liver metastasis in carcinoma of the pancreas. Int J Pancreatol (1995) 1.90
Cell proliferative activity in intraductal papillary-mucinous neoplasms and invasive ductal adenocarcinomas of the pancreas: an immunohistochemical study. Arch Pathol Lab Med (1998) 1.81
Evaluation of GATA-4 and GATA-5 methylation profiles in human pancreatic cancers indicate promoter methylation patterns distinct from other human tumor types. Cancer Biol Ther (2007) 1.69
Growth process of small pancreatic carcinoma: a case report with imaging observation for 22 months. World J Gastroenterol (2008) 1.55
The consensus coding sequences of human breast and colorectal cancers. Science (2006) 60.02
An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36
The genomic landscapes of human breast and colorectal cancers. Science (2007) 38.12
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science (2008) 36.02
IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41
High frequency of mutations of the PIK3CA gene in human cancers. Science (2004) 27.94
Cancer genome landscapes. Science (2013) 25.33
Cancer genes and the pathways they control. Nat Med (2004) 24.22
Antibody neutralization and escape by HIV-1. Nature (2003) 21.48
International network of cancer genome projects. Nature (2010) 20.35
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell (2003) 15.43
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell (2005) 14.21
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency. N Engl J Med (2015) 13.08
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations. Proc Natl Acad Sci U S A (2003) 12.91
The colorectal microRNAome. Proc Natl Acad Sci U S A (2006) 11.59
Allelic variation in human gene expression. Science (2002) 11.42
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science (2011) 11.12
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science (2010) 10.78
Comparative lesion sequencing provides insights into tumor evolution. Proc Natl Acad Sci U S A (2008) 10.52
Circulating mutant DNA to assess tumor dynamics. Nat Med (2007) 10.33
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science (2011) 10.26
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers. Nature (2012) 10.17
Quantitative analysis of culture using millions of digitized books. Science (2010) 9.86
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature (2011) 9.70
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature (2002) 9.40
A simple rule for the evolution of cooperation on graphs and social networks. Nature (2006) 9.31
Using the transcriptome to annotate the genome. Nat Biotechnol (2002) 9.04
Pancreatic cancer. Lancet (2011) 8.54
Detection of circulating tumor DNA in early- and late-stage human malignancies. Sci Transl Med (2014) 8.36
The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell (2005) 7.87
The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol Ther (2004) 7.82
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature (2002) 7.46
Exomic sequencing identifies PALB2 as a pancreatic cancer susceptibility gene. Science (2009) 7.39