Published in J Chem Inf Model on September 26, 2005
Deducing chemical structure from crystallographically determined atomic coordinates. Acta Crystallogr B (2011) 2.63
A rule-based algorithm for automatic bond type perception. J Cheminform (2012) 0.75
Synthetic genetic polymers capable of heredity and evolution. Science (2012) 3.59
Chemical evolution of a bacterium's genome. Angew Chem Int Ed Engl (2011) 2.09
A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity. Nucleic Acids Res (2009) 1.84
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects. J Clin Invest (2017) 1.39
A screen of chemical modifications identifies position-specific modification by UNA to most potently reduce siRNA off-target effects. Nucleic Acids Res (2010) 1.26
Analysis of the gamma-secretase interactome and validation of its association with tetraspanin-enriched microdomains. Nat Cell Biol (2009) 1.25
Deoxythreosyl phosphonate nucleosides as selective anti-HIV agents. J Am Chem Soc (2005) 1.24
Diagnostic accuracy of a new Leishmania PCR for clinical visceral leishmaniasis in Nepal and its role in diagnosis of disease. Trop Med Int Health (2008) 1.21
Phenolic profiling of caffeic acid O-methyltransferase-deficient poplar reveals novel benzodioxane oligolignols. Plant Physiol (2004) 1.19
A simplified and standardized polymerase chain reaction format for the diagnosis of leishmaniasis. J Infect Dis (2008) 1.14
Substituted 5-benzyl-2-phenyl-5H-imidazo[4,5-c]pyridines: a new class of pestivirus inhibitors. Bioorg Med Chem Lett (2006) 1.13
alpha-L-ribo-configured locked nucleic acid (alpha-L-LNA): synthesis and properties. J Am Chem Soc (2002) 1.09
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster. Chem Biol (2010) 1.07
Inhibition of MDR1 expression with altritol-modified siRNAs. Nucleic Acids Res (2007) 1.06
Nucleotide analogues containing 2-oxa-bicyclo[2.2.1]heptane and l-alpha-threofuranosyl ring systems: interactions with P2Y receptors. Bioorg Med Chem (2004) 1.04
Recognition of threosyl nucleotides by DNA and RNA polymerases. Nucleic Acids Res (2003) 1.02
A derivate of the antibiotic doxorubicin is a selective inhibitor of dengue and yellow fever virus replication in vitro. Antimicrob Agents Chemother (2010) 1.02
Discovery of 7-N-piperazinylthiazolo[5,4-d]pyrimidine analogues as a novel class of immunosuppressive agents with in vivo biological activity. J Med Chem (2010) 1.02
Post-transcriptional modification mapping in the Clostridium acetobutylicum 16S rRNA by mass spectrometry and reverse transcriptase assays. Nucleic Acids Res (2007) 0.98
Molecular analysis of archived blood slides reveals an atypical human Trypanosoma infection. Diagn Microbiol Infect Dis (2008) 0.98
A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics. PLoS One (2013) 0.98
Base pairing properties of D- and L-cyclohexene nucleic acids (CeNA). Oligonucleotides (2003) 0.97
Crystal structure of double helical hexitol nucleic acids. J Am Chem Soc (2002) 0.95
Investigation of the DNA-dependent cyclohexenyl nucleic acid polymerization and the cyclohexenyl nucleic acid-dependent DNA polymerization. Nucleic Acids Res (2005) 0.95
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target. Chem Biol (2010) 0.94
The naturally occurring N6-threonyl adenine in anticodon loop of Schizosaccharomyces pombe tRNAi causes formation of a unique U-turn motif. Nucleic Acids Res (2006) 0.94
T. cruzi OligoC-TesT: a simplified and standardized polymerase chain reaction format for diagnosis of Chagas disease. PLoS Negl Trop Dis (2009) 0.94
Structural characterization and biological evaluation of small interfering RNAs containing cyclohexenyl nucleosides. J Am Chem Soc (2007) 0.92
A methyl group controls conformational equilibrium in human mitochondrial tRNA(Lys). J Am Chem Soc (2007) 0.92
Comparative in vitro anti-hepatitis C virus activities of a selected series of polymerase, protease, and helicase inhibitors. Antimicrob Agents Chemother (2008) 0.92
Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing. Bioorg Med Chem Lett (2011) 0.91
Synthesis and evaluation of 5-substituted 2'-deoxyuridine monophosphate analogues as inhibitors of flavin-dependent thymidylate synthase in Mycobacterium tuberculosis. J Med Chem (2011) 0.91
Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain. World J Biol Chem (2011) 0.90
Synthesis and Antiviral Activity of the alpha-Analogues of 1,5-Anhydrohexitol Nucleosides (1,5-Anhydro-2,3-dideoxy-D-ribohexitol Nucleosides). J Org Chem (1997) 0.90
Pseudouridine detection improvement by derivatization with methyl vinyl sulfone and capillary HPLC-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.89
Increased uptake of antisense oligonucleotides by delivery as double stranded complexes. Biochem Pharmacol (2004) 0.89
Chemical incorporation of 1-methyladenosine into oligonucleotides. Nucleic Acids Res (2002) 0.88
Computational alanine scanning and free energy decomposition for E. coli type I signal peptidase with lipopeptide inhibitor complex. J Mol Graph Model (2007) 0.88
Replication of hexitol oligonucleotides as a prelude to the propagation of a third type of nucleic acid in vivo. C R Biol (2003) 0.88
A novel, highly selective inhibitor of pestivirus replication that targets the viral RNA-dependent RNA polymerase. J Virol (2006) 0.86
Synthesis and properties of phosphorylated 3'-O-beta-D-ribofuranosyl-2'-deoxythymidine. Nucleosides Nucleotides Nucleic Acids (2003) 0.86
Synthesis and antisense properties of fluoro cyclohexenyl nucleic acid (F-CeNA), a nuclease stable mimic of 2'-fluoro RNA. J Org Chem (2012) 0.86
Inhibition of MDR1 gene expression by chimeric HNA antisense oligonucleotides. Nucleic Acids Res (2004) 0.85
Design of bioactive peptides from naturally occurring μ-conotoxin structures. J Biol Chem (2012) 0.85
Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC. J Am Chem Soc (2008) 0.85
Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf. Eur J Pharmacol (2009) 0.85
Synthesis and properties of aminopropyl nucleic acids. Chembiochem (2005) 0.85
Chemical etiology of nucleic acids: aminopropyl nucleic acids (APNAs). Chem Biodivers (2007) 0.84
Insight into ligand selectivity in HCV NS5B polymerase: molecular dynamics simulations, free energy decomposition and docking. J Mol Model (2009) 0.83
Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis. Chem Biodivers (2012) 0.83
Glycosyl transferase activity of the Escherichia coli penicillin-binding protein 1b: specificity profile for the substrate. Biochemistry (2006) 0.83
Recognition of HNA and 1,5-anhydrohexitol nucleotides by DNA metabolizing enzymes. Biochim Biophys Acta (2002) 0.83
Hexitol nucleic acid-containing aptamers are efficient ligands of HIV-1 TAR RNA. Biochemistry (2005) 0.83
N-aminoimidazole derivatives inhibiting retroviral replication via a yet unidentified mode of action. J Med Chem (2003) 0.83
Synthesis and cleavage experiments of oligonucleotide conjugates with a diimidazole-derived catalytic center. Bioconjug Chem (2002) 0.82
Synthesis of homoceramides, novel ceramide analogues, and their lack of effect on the growth of hippocampal neurons. J Org Chem (2002) 0.82
Influence of the incorporation of a cyclohexenyl nucleic acid (CeNA) residue onto the sequence d(CGCGAATTCGCG). Nucleic Acids Res (2007) 0.82
Reinforced HNA backbone hydration in the crystal structure of a decameric HNA/RNA hybrid. J Am Chem Soc (2005) 0.82
Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants. J Med Chem (2008) 0.82
Cleavage of DNA without loss of genetic information by incorporation of a disaccharide nucleoside. Nucleic Acids Res (2003) 0.82
Complete NMR characterization of lychnose from Stellaria media (L.) Vill. Carbohydr Res (2006) 0.82
Structure-function elucidation of a new α-conotoxin, Lo1a, from Conus longurionis. J Biol Chem (2014) 0.81
Amino acid phosphoramidate nucleotides as alternative substrates for HIV-1 reverse transcriptase. Angew Chem Int Ed Engl (2007) 0.81
Thymidine and thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg Med Chem Lett (2003) 0.81
Enzymatic and structural analysis of inhibitors designed against Mycobacterium tuberculosis thymidylate kinase. New insights into the phosphoryl transfer mechanism. J Biol Chem (2002) 0.81
Synthesis of D-altritol nucleosides with a 3'-O-tert-butyldimethylsilyl protecting group. Nucleosides Nucleotides Nucleic Acids (2004) 0.81
Direct observation of two cyclohexenyl (CeNA) ring conformations in duplex DNA. Artif DNA PNA XNA (2010) 0.81
Difference in conformational diversity between nucleic acids with a six-membered 'sugar' unit and natural 'furanose' nucleic acids. Nucleic Acids Res (2003) 0.80
Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors. Bioorg Med Chem (2010) 0.80
Self-complementary sequence context in mature miRNAs. Biochem Biophys Res Commun (2010) 0.80
Comparison of library screening techniques used in the development of dsDNA ligands. Bioorg Med Chem Lett (2003) 0.80
Characterization of the posttranscriptional modifications in Legionella pneumophila small-subunit ribosomal RNA. Chem Biodivers (2008) 0.80
Synthesis of modified peptidoglycan precursor analogues for the inhibition of glycosyltransferase. J Am Chem Soc (2012) 0.80
Enzymatically catalyzed DNA synthesis using L-Asp-dGMP, L-Asp-dCMP, and L-Asp-dTMP. Chem Biodivers (2008) 0.80
Discovery of an acyclic nucleoside phosphonate that inhibits Mycobacterium tuberculosis ThyX based on the binding mode of a 5-alkynyl substrate analogue. ChemMedChem (2013) 0.80
Nucleoside Phosphate-Conjugates Come of Age: Catalytic Transformation, Polymerase Recognition and Antiviral Properties. Curr Med Chem (2015) 0.80
Database searching for thymidine and thymidylate kinase inhibitors using three-dimensional structure-based methods. J Enzyme Inhib Med Chem (2002) 0.80
Discovery of dual death-associated protein related apoptosis inducing protein kinase 1 and 2 inhibitors by a scaffold hopping approach. J Med Chem (2014) 0.80
Evaluation of the type I signal peptidase as antibacterial target for biofilm-associated infections of Staphylococcus epidermidis. Microbiology (2009) 0.79
Helical structure of xylose-DNA. J Am Chem Soc (2010) 0.79
Use of RNA in drug design. Expert Opin Drug Discov (2007) 0.79
Aspartic acid based nucleoside phosphoramidate prodrugs as potent inhibitors of hepatitis C virus replication. Org Biomol Chem (2015) 0.79
1-O-Hexadecyl-2-desoxy-2-amino-sn-glycerol, a substrate for human sphingosine kinase. Biochim Biophys Acta (2002) 0.79
Discovery of bicyclic thymidine analogues as selective and high-affinity inhibitors of Mycobacterium tuberculosis thymidine monophosphate kinase. J Med Chem (2004) 0.79
HNA and ANA high-affinity arrays for detections of DNA and RNA single-base mismatches. Biosens Bioelectron (2008) 0.79
Ribavirin derivatives with a hexitol moiety: synthesis and antiviral evaluation. Antivir Chem Chemother (2003) 0.79
Substrate based peptide aldehyde inhibits bacterial type I signal peptidase. Bioorg Med Chem Lett (2009) 0.79
Structural basis for the role of LYS220 as proton donor for nucleotidyl transfer in HIV-1 reverse transcriptase. Biophys Chem (2011) 0.79
Binary genetic cassettes for selecting XNA-templated DNA synthesis in vivo. Angew Chem Int Ed Engl (2013) 0.79
Enzymatic polymerization of phosphonate nucleosides. Chembiochem (2008) 0.79
Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA): an orthogonal nucleic acid candidate. Chemistry (2011) 0.79
Inhibition of human immunodeficiency virus type 1 transcription by N-aminoimidazole derivatives. Virology (2007) 0.78
Synthesis and evaluation of thymidine-5'-O-monophosphate analogues as inhibitors of Mycobacterium tuberculosis thymidylate kinase. Bioorg Med Chem Lett (2002) 0.78
Detection of RNA hybridization by pyrene-labeled probes. Chembiochem (2009) 0.78
Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase. Angew Chem Int Ed Engl (2007) 0.78
Inhibition of hepatitis B virus replication in vivo using lipoplexes containing altritol-modified antiviral siRNAs. Artif DNA PNA XNA (2010) 0.78
Synthesis of an apionucleoside family and discovery of a prodrug with anti-HIV activity. J Org Chem (2014) 0.78
Influence of threose nucleoside units on the catalytic activity of a hammerhead ribozyme. Chem Biodivers (2004) 0.78
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase. Antiviral Res (2009) 0.78
3-Phosphono-L-alanine as pyrophosphate mimic for DNA synthesis using HIV-1 reverse transcriptase. Org Biomol Chem (2010) 0.78