Published in Dev Cell on October 01, 2005
p53 and E2f: partners in life and death. Nat Rev Cancer (2009) 3.06
Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell (2008) 2.40
Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell (2010) 1.92
The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol (2006) 1.85
Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet (2006) 1.66
Retinoblastoma family genes. Oncogene (2006) 1.61
Division and apoptosis of E2f-deficient retinal progenitors. Nature (2009) 1.55
Loss of dE2F compromises mitochondrial function. Dev Cell (2013) 1.47
Specific killing of Rb mutant cancer cells by inactivating TSC2. Cancer Cell (2010) 1.42
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol (2006) 1.31
Hepatitis B virus X protein via the p38MAPK pathway induces E2F1 release and ATR kinase activation mediating p53 apoptosis. J Biol Chem (2008) 1.23
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet (2008) 1.21
Regulation of apoptosis of rbf mutant cells during Drosophila development. Dev Biol (2008) 1.20
Functional dissection of the ash2 and ash1 transcriptomes provides insights into the transcriptional basis of wing phenotypes and reveals conserved protein interactions. Genome Biol (2007) 1.18
Conserved RB functions in development and tumor suppression. Protein Cell (2011) 1.15
Apoptotic cells can induce non-autonomous apoptosis through the TNF pathway. Elife (2013) 1.11
E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1. EMBO J (2012) 1.09
Mutations in String/CDC25 inhibit cell cycle re-entry and neurodegeneration in a Drosophila model of Ataxia telangiectasia. Genes Dev (2008) 1.03
dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1. Mol Cell Biol (2007) 1.00
E2F1 death pathways as targets for cancer therapy. J Cell Mol Med (2007) 0.97
The Drosophila ortholog of MLL3 and MLL4, trithorax related, functions as a negative regulator of tissue growth. Mol Cell Biol (2013) 0.96
Dampened activity of E2F1-DP and Myb-MuvB transcription factors in Drosophila endocycling cells. J Cell Sci (2010) 0.95
mir-11 limits the proapoptotic function of its host gene, dE2f1. Genes Dev (2011) 0.94
The rb pathway and cancer therapeutics. Curr Drug Targets (2009) 0.93
E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila. Dev Biol (2010) 0.93
Regulation of Drosophila melanogaster pro-apoptotic gene hid. Apoptosis (2009) 0.90
Coordinated expression of cell death genes regulates neuroblast apoptosis. Development (2011) 0.90
Mitochondrial fusion is regulated by Reaper to modulate Drosophila programmed cell death. Cell Death Differ (2011) 0.88
S phase-coupled E2f1 destruction ensures homeostasis in proliferating tissues. PLoS Genet (2012) 0.87
The role of the retinoblastoma/E2F1 tumor suppressor pathway in the lesion recognition step of nucleotide excision repair. DNA Repair (Amst) (2009) 0.87
Targeting Rb inactivation in cancers by synthetic lethality. Am J Cancer Res (2011) 0.87
Hyperactivated Wnt signaling induces synthetic lethal interaction with Rb inactivation by elevating TORC1 activities. PLoS Genet (2014) 0.83
The pro-apoptotic activity of Drosophila Rbf1 involves dE2F2-dependent downregulation of diap1 and buffy mRNA. Cell Death Dis (2014) 0.82
E2F and cell survival: context really is key. Dev Cell (2005) 0.81
The dREAM/Myb-MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin. Dev Biol (2012) 0.79
Upregulation of E2F8 promotes cell proliferation and tumorigenicity in breast cancer by modulating G1/S phase transition. Oncotarget (2016) 0.78
E2F6 associates with BRG1 in transcriptional regulation. PLoS One (2012) 0.77
Capicua regulates proliferation and survival of RB-deficient cells in Drosophila. Biol Open (2012) 0.76
Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation. PLoS Biol (2016) 0.76
The Sound of Silence: Signaling by Apoptotic Cells. Curr Top Dev Biol (2015) 0.75
Cell death regulates muscle fiber number. Dev Biol (2016) 0.75
Different cell cycle modifications repress apoptosis at different steps independent of developmental signaling in Drosophila. Mol Biol Cell (2016) 0.75
ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling. J Cell Sci (2016) 0.75
Genistein targets the cancerous inhibitor of PP2A to induce growth inhibition and apoptosis in breast cancer cells. Int J Oncol (2016) 0.75
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
A novel retinoblastoma therapy from genomic and epigenetic analyses. Nature (2012) 5.02
The E2F transcriptional network: old acquaintances with new faces. Oncogene (2005) 4.87
Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol (2008) 3.81
YAP-dependent induction of amphiregulin identifies a non-cell-autonomous component of the Hippo pathway. Nat Cell Biol (2009) 3.26
E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature (2008) 3.24
Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci (2004) 2.89
Native E2F/RBF complexes contain Myb-interacting proteins and repress transcription of developmentally controlled E2F target genes. Cell (2004) 2.89
Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev (2003) 2.73
A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol (2002) 2.73
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol (2006) 2.60
Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev (2010) 2.55
Loss of pRB causes centromere dysfunction and chromosomal instability. Genes Dev (2010) 2.50
KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors. Cell (2013) 2.34
CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase. Mol Cell (2010) 2.29
Mitochondrial disruption in Drosophila apoptosis. Dev Cell (2007) 2.18
The Drosophila tumor suppressors Expanded and Merlin differentially regulate cell cycle exit, apoptosis, and Wingless signaling. Dev Biol (2006) 1.85
Quantitatively determined survivin expression levels are of prognostic value in human gliomas. J Clin Oncol (2002) 1.74
Apoptosis in Drosophila: neither fish nor fowl (nor man, nor worm). J Cell Sci (2005) 1.69
The retinoblastoma protein regulates pericentric heterochromatin. Mol Cell Biol (2006) 1.68
Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet (2006) 1.66
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription. Nucleic Acids Res (2005) 1.61
Conserved antagonism between JMJD2A/KDM4A and HP1γ during cell cycle progression. Mol Cell (2010) 1.55
A SIRT1-LSD1 corepressor complex regulates Notch target gene expression and development. Mol Cell (2011) 1.55
reaper is required for neuroblast apoptosis during Drosophila development. Development (2002) 1.55
RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev (2008) 1.53
RB: mitotic implications of a tumour suppressor. Nat Rev Cancer (2012) 1.51
Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J (2002) 1.49
Loss of dE2F compromises mitochondrial function. Dev Cell (2013) 1.47
Pumilio facilitates miRNA regulation of the E2F3 oncogene. Genes Dev (2012) 1.36
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol (2006) 1.31
Loss of RBF1 changes glutamine catabolism. Genes Dev (2013) 1.30
pRB, a tumor suppressor with a stabilizing presence. Trends Cell Biol (2011) 1.25
Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis. Nat Cell Biol (2002) 1.24
E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage. PLoS Genet (2008) 1.21
Capicua regulates cell proliferation downstream of the receptor tyrosine kinase/ras signaling pathway. Curr Biol (2007) 1.20
p55, the Drosophila ortholog of RbAp46/RbAp48, is required for the repression of dE2F2/RBF-regulated genes. Mol Cell Biol (2004) 1.17
Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle (2005) 1.17
Functional antagonism between histone H3K4 demethylases in vivo. Genes Dev (2011) 1.16
RBF binding to both canonical E2F targets and noncanonical targets depends on functional dE2F/dDP complexes. Mol Cell Biol (2012) 1.14
G1 cyclin-dependent kinases are insufficient to reverse dE2F2-mediated repression. Genes Dev (2003) 1.14
Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev (2011) 1.13
Combined inactivation of pRB and hippo pathways induces dedifferentiation in the Drosophila retina. PLoS Genet (2010) 1.10
dDP is needed for normal cell proliferation. Mol Cell Biol (2005) 1.10
Dissection of DIAP1 functional domains via a mutant replacement strategy. J Biol Chem (2004) 1.10
Dp1 is required for extra-embryonic development. Development (2003) 1.08
Mitochondrial involvement in cell death of non-mammalian eukaryotes. Biochim Biophys Acta (2010) 1.07
The Chk1/Cdc25A pathway as activators of the cell cycle in neuronal death induced by camptothecin. J Neurosci (2006) 1.06
Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J (2007) 1.04
Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech (2011) 1.00
CD26/DPP4 levels in peripheral blood and T cells in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab (2013) 1.00
Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet (2008) 1.00
dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1. Mol Cell Biol (2007) 1.00
H4K20 methylation regulates quiescence and chromatin compaction. Mol Biol Cell (2013) 0.99
Three regions of the pRB pocket domain affect its inactivation by human papillomavirus E7 proteins. J Virol (2002) 0.98
pRb, a local chromatin organizer with global possibilities. Chromosoma (2009) 0.98
The multiple connections between pRB and cell metabolism. Curr Opin Cell Biol (2013) 0.95
A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity. PLoS Genet (2012) 0.95
mir-11 limits the proapoptotic function of its host gene, dE2f1. Genes Dev (2011) 0.94
Drosophila RB proteins repress differentiation-specific genes via two different mechanisms. Mol Cell Biol (2010) 0.93
grim promotes programmed cell death of Drosophila microchaete glial cells. Mech Dev (2010) 0.92
The Drosophila homolog of the putative phosphatidylserine receptor functions to inhibit apoptosis. Development (2007) 0.92
Bayesian mixture models for the incorporation of prior knowledge to inform genetic association studies. Genet Epidemiol (2010) 0.92
Specific role of the SR protein splicing factor B52 in cell cycle control in Drosophila. Mol Cell Biol (2006) 0.90
Drosophila Mi-2 negatively regulates dDREF by inhibiting its DNA-binding activity. Mol Cell Biol (2002) 0.90
Coordinated expression of cell death genes regulates neuroblast apoptosis. Development (2011) 0.90
Human TFDP3, a novel DP protein, inhibits DNA binding and transactivation by E2F. J Biol Chem (2006) 0.89
The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol (2009) 0.89
Liver X receptor agonist inhibits proliferation of ovarian carcinoma cells stimulated by oxidized low density lipoprotein. Gynecol Oncol (2009) 0.88
Inside an enigma: do mitochondria contribute to cell death in Drosophila? Apoptosis (2009) 0.86
Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Genetics (2009) 0.86
A dual role for the dREAM/MMB complex in the regulation of differentiation-specific E2F/RB target genes. Mol Cell Biol (2012) 0.85
Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet (2010) 0.85
The diverse roles of RNA helicases in RNAi. Cell Cycle (2009) 0.84
Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. J Cell Sci (2011) 0.84
The Drosophila homolog of human tumor suppressor TSC-22 promotes cellular growth, proliferation, and survival. Proc Natl Acad Sci U S A (2008) 0.84
Drosophila GAGA factor is required for full activation of the dE2f1-Yki/Sd transcriptional program. Cell Cycle (2012) 0.84
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development (2010) 0.83
Melanocortins induce interleukin 6 gene expression and secretion through melanocortin receptors 2 and 5 in 3T3-L1 adipocytes. J Mol Endocrinol (2010) 0.83
How the states stack up: disparities in substance abuse outpatient treatment completion rates for minorities. Drug Alcohol Depend (2013) 0.83
Engulfment mechanism of apoptotic cells. Curr Opin Cell Biol (2002) 0.82
Phosphorylation puts the pRb tumor suppressor into shape. Genes Dev (2012) 0.79
Apoptotic cells can deliver chemotherapeutics to engulfing macrophages and suppress inflammatory cytokine production. J Biol Chem (2012) 0.78
In vivo regulation of E2F1 by Polycomb group genes in Drosophila. G3 (Bethesda) (2012) 0.78
Mutation of the DEAD-box helicase belle downregulates the cyclin-dependent kinase inhibitor Dacapo. Cell Cycle (2010) 0.78
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Invest (2015) 0.78
The caudal homeodomain protein activates Drosophila E2F gene expression. Nucleic Acids Res (2002) 0.78