Published in PLoS Genet on April 22, 2010
Characterization of the cell of origin for small cell lung cancer. Cell Cycle (2011) 2.62
Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration. Nat Rev Mol Cell Biol (2011) 2.52
Maintaining differentiated cellular identity. Nat Rev Genet (2012) 1.32
Loss of RBF1 changes glutamine catabolism. Genes Dev (2013) 1.30
A kinase shRNA screen links LATS2 and the pRB tumor suppressor. Genes Dev (2011) 1.30
Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J Cell Sci (2010) 1.18
Conserved RB functions in development and tumor suppression. Protein Cell (2011) 1.15
Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev (2011) 1.13
A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity. PLoS Genet (2012) 0.95
Gene expression profiling identifies different sub-types of retinoblastoma. Br J Cancer (2013) 0.93
What do mechanotransduction, Hippo, Wnt, and TGFβ have in common? YAP and TAZ as key orchestrating molecules in ocular health and disease. Exp Eye Res (2013) 0.90
How the cell cycle impacts chromatin architecture and influences cell fate. Front Genet (2015) 0.87
Rb deficiency during Drosophila eye development deregulates EMC, causing defects in the development of photoreceptors and cone cells. J Cell Sci (2011) 0.84
The BTB-zinc finger transcription factor abrupt acts as an epithelial oncogene in Drosophila melanogaster through maintaining a progenitor-like cell state. PLoS Genet (2013) 0.83
Organ size control is dominant over Rb family inactivation to restrict proliferation in vivo. Cell Rep (2014) 0.82
Involvement of YAP, TAZ and HSP90 in contact guidance and intercellular junction formation in corneal epithelial cells. PLoS One (2014) 0.79
Sweet DREAMs for Hippo. Genes Dev (2011) 0.78
Regulators of pluripotency and their implications in regenerative medicine. Stem Cells Cloning (2015) 0.78
Drosophila as a Potential Model for Ocular Tumors. Ocul Oncol Pathol (2015) 0.77
Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila. Development (2015) 0.77
Defining a new vision for the retinoblastoma gene: report from the 3rd International Rb Meeting. Cell Div (2013) 0.75
Regulation of cell polarity determinants by the Retinoblastoma tumor suppressor protein. Sci Rep (2016) 0.75
mTORC1 maintains the tumorigenicity of SSEA-4(+) high-grade osteosarcoma. Sci Rep (2015) 0.75
The hallmarks of cancer. Cell (2000) 113.05
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell (2008) 14.17
Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control. Genes Dev (2007) 13.05
Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell (2007) 13.04
Effects of an Rb mutation in the mouse. Nature (1992) 11.06
The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell (2005) 10.61
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature (1992) 8.16
hippo encodes a Ste-20 family protein kinase that restricts cell proliferation and promotes apoptosis in conjunction with salvador and warts. Cell (2003) 7.43
Expression of baculovirus P35 prevents cell death in Drosophila. Development (1994) 7.16
salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell (2002) 7.15
Requirement for a functional Rb-1 gene in murine development. Nature (1992) 6.87
Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (1993) 6.84
The Drosophila Mst ortholog, hippo, restricts growth and cell proliferation and promotes apoptosis. Cell (2003) 6.48
Hippo signaling in organ size control. Genes Dev (2007) 6.29
Acute mutation of retinoblastoma gene function is sufficient for cell cycle re-entry. Nature (2003) 6.01
The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network. Nat Rev Cancer (2007) 5.78
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell (2001) 5.14
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell (1996) 5.13
Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development (2007) 4.80
Emerging roles of E2Fs in cancer: an exit from cell cycle control. Nat Rev Cancer (2009) 4.66
Senseless, a Zn finger transcription factor, is necessary and sufficient for sensory organ development in Drosophila. Cell (2000) 4.20
Pocket proteins and cell cycle control. Oncogene (2005) 4.11
Extra-embryonic function of Rb is essential for embryonic development and viability. Nature (2003) 3.92
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell (2007) 3.82
Conserved functions of the pRB and E2F families. Nat Rev Mol Cell Biol (2008) 3.81
In vivo regulation of Yorkie phosphorylation and localization. Development (2008) 3.51
The eyes absent gene: genetic control of cell survival and differentiation in the developing Drosophila eye. Cell (1993) 3.08
The retinoblastoma gene family in differentiation and development. Oncogene (1999) 2.95
The retinoblastoma protein acts as a transcriptional coactivator required for osteogenic differentiation. Mol Cell (2001) 2.93
The Fat and Warts signaling pathways: new insights into their regulation, mechanism and conservation. Development (2008) 2.86
Proliferation of functional hair cells in vivo in the absence of the retinoblastoma protein. Science (2005) 2.81
Differentiated horizontal interneurons clonally expand to form metastatic retinoblastoma in mice. Cell (2007) 2.61
Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol (1996) 2.44
The tumour suppressor Hippo acts with the NDR kinases in dendritic tiling and maintenance. Nature (2006) 2.19
Extracellular signals responsible for spatially regulated proliferation in the differentiating Drosophila eye. Dev Cell (2005) 2.09
Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev (1996) 2.06
Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes Dev (2008) 2.05
The growth regulators warts/lats and melted interact in a bistable loop to specify opposite fates in Drosophila R8 photoreceptors. Cell (2005) 2.00
Signal integration during development: mechanisms of EGFR and Notch pathway function and cross-talk. Crit Rev Biochem Mol Biol (2006) 1.82
The EGF receptor defines domains of cell cycle progression and survival to regulate cell number in the developing Drosophila eye. Cell (2001) 1.73
Spacing differentiation in the developing Drosophila eye: a fibrinogen-related lateral inhibitor encoded by scabrous. Science (1990) 1.64
Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J (2000) 1.63
Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. EMBO J (1996) 1.61
A double-assurance mechanism controls cell cycle exit upon terminal differentiation in Drosophila. Dev Cell (2007) 1.55
RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3. Genes Dev (2008) 1.53
The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development. Mol Cancer Res (2008) 1.43
The retinoblastoma tumor-suppressor gene, the exception that proves the rule. Oncogene (2006) 1.41
Rb-mediated neuronal differentiation through cell-cycle-independent regulation of E2f3a. PLoS Biol (2007) 1.37
senseless repression of rough is required for R8 photoreceptor differentiation in the developing Drosophila eye. Neuron (2001) 1.35
A gradient of epidermal growth factor receptor signaling determines the sensitivity of rbf1 mutant cells to E2F-dependent apoptosis. Mol Cell Biol (2006) 1.31
Differential splicing generates a nervous system-specific form of Drosophila neuroglian. Neuron (1990) 1.26
Loss of heterozygosity of the RB gene is a poor prognostic factor in patients with osteosarcoma. J Clin Oncol (1996) 1.26
Warts is required for PI3K-regulated growth arrest, autophagy, and autophagic cell death in Drosophila. Curr Biol (2008) 1.16
Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet (2008) 1.00
Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev (2003) 2.73
Drosophila E2F1 has context-specific pro- and antiapoptotic properties during development. Dev Cell (2005) 2.12
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation. Mol Cell (2008) 1.93
Distinct mechanisms of E2F regulation by Drosophila RBF1 and RBF2. EMBO J (2002) 1.49
Loss of dE2F compromises mitochondrial function. Dev Cell (2013) 1.47
Spider web glue: two proteins expressed from opposite strands of the same DNA sequence. Biomacromolecules (2009) 1.44
Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1. Proc Natl Acad Sci U S A (2011) 1.28
Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle (2005) 1.17
Cooperation between dE2F1 and Yki/Sd defines a distinct transcriptional program necessary to bypass cell cycle exit. Genes Dev (2011) 1.13
FoxM1 regulates mammary luminal cell fate. Cell Rep (2012) 1.08
dE2F2-independent rescue of proliferation in cells lacking an activator dE2F1. Mol Cell Biol (2007) 1.00
Context-dependent requirement for dE2F during oncogenic proliferation. PLoS Genet (2008) 1.00
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation. Proc Natl Acad Sci U S A (2012) 0.99
mir-11 limits the proapoptotic function of its host gene, dE2f1. Genes Dev (2011) 0.94
Selective targeting of histone methylation. Cell Cycle (2011) 0.92
Specific role of the SR protein splicing factor B52 in cell cycle control in Drosophila. Mol Cell Biol (2006) 0.90
The archipelago tumor suppressor gene limits rb/e2f-regulated apoptosis in developing Drosophila tissues. Curr Biol (2009) 0.89
Expression of polycomb targets predicts breast cancer prognosis. Mol Cell Biol (2013) 0.88
Mosaic genetic screen for suppressors of the de2f1 mutant phenotype in Drosophila. Genetics (2009) 0.86
Tuberous sclerosis complex 1 regulates dE2F1 expression during development and cooperates with RBF1 to control proliferation and survival. PLoS Genet (2010) 0.85
Genome-wide analysis using ChIP to identify isoform-specific gene targets. J Vis Exp (2010) 0.85
The diverse roles of RNA helicases in RNAi. Cell Cycle (2009) 0.84
Drosophila GAGA factor is required for full activation of the dE2f1-Yki/Sd transcriptional program. Cell Cycle (2012) 0.84
Co-regulation of histone-modifying enzymes in cancer. PLoS One (2011) 0.83
Notch-dependent expression of the archipelago ubiquitin ligase subunit in the Drosophila eye. Development (2010) 0.83
Mutation of the DEAD-box helicase belle downregulates the cyclin-dependent kinase inhibitor Dacapo. Cell Cycle (2010) 0.78