Published in Respir Med on September 30, 2005
Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. Respir Res (2011) 1.51
Inhaled drugs to reduce exacerbations in patients with chronic obstructive pulmonary disease: a network meta-analysis. BMC Med (2009) 1.37
Pharmacotherapies for chronic obstructive pulmonary disease: a multiple treatment comparison meta-analysis. Clin Epidemiol (2011) 1.21
Long-acting beta-agonists in the management of chronic obstructive pulmonary disease: current and future agents. Respir Res (2010) 1.21
Efficacy and safety of fixed-dose combinations of aclidinium bromide/formoterol fumarate: the 24-week, randomized, placebo-controlled AUGMENT COPD study. Respir Res (2014) 1.12
Aclidinium bromide and formoterol fumarate as a fixed-dose combination in COPD: pooled analysis of symptoms and exacerbations from two six-month, multicentre, randomised studies (ACLIFORM and AUGMENT). Respir Res (2015) 1.11
Systemic and bronchodilator effects of inhaled rac-formoterol in subjects with chronic obstructive pulmonary disease: a dose-response study. Br J Clin Pharmacol (2008) 0.98
The safety of long-acting β2-agonists in the treatment of stable chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2013) 0.95
Changing patterns in long-acting bronchodilator trials in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2011) 0.93
Formoterol in the management of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis (2008) 0.89
Can the anti-inflammatory activities of β2-agonists be harnessed in the clinical setting? Drug Des Devel Ther (2013) 0.86
A review of the most common patient-reported outcomes in COPD--revisiting current knowledge and estimating future challenges. Int J Chron Obstruct Pulmon Dis (2015) 0.81
Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: phase III study results. BMC Pulm Med (2011) 0.80
Role of arformoterol in the management of COPD. Int J Chron Obstruct Pulmon Dis (2008) 0.77
Copd. BMJ Clin Evid (2011) 0.77
Olodaterol attenuates citric acid-induced cough in naïve and ovalbumin-sensitized and challenged guinea pigs. PLoS One (2015) 0.77
Comparison and optimal use of fixed combinations in the management of COPD. Int J Chron Obstruct Pulmon Dis (2007) 0.76
Efficacy and safety of conventional long acting β2- agonists: systematic review and meta-analysis. Caspian J Intern Med (2016) 0.75
Copd. BMJ Clin Evid (2008) 0.75
Mortality and drug therapy in patients with chronic obstructive pulmonary disease: a network meta-analysis. BMC Pulm Med (2015) 0.75
Long-term outcomes in chronic obstructive pulmonary disease patients: exploring the effects of inhalatory devices and their influence on the outcome. Clinicoecon Outcomes Res (2016) 0.75
Spotlight on glycopyrronium/formoterol fumarate inhalation aerosol in the management of COPD: design, development, and place in therapy. Int J Chron Obstruct Pulmon Dis (2017) 0.75
Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med (2011) 7.92
Gastrointestinal tolerability and effectiveness of rofecoxib versus naproxen in the treatment of osteoarthritis: a randomized, controlled trial. Ann Intern Med (2003) 6.77
Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet (2004) 6.17
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet (2009) 4.40
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet (2009) 4.29
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
From COPD to chronic systemic inflammatory syndrome? Lancet (2007) 4.13
Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA (2010) 4.08
Management of non-small-cell lung cancer: recent developments. Lancet (2013) 3.51
Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial. JAMA (2013) 3.13
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12
"Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids. Am J Respir Crit Care Med (2004) 2.77
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med (2009) 2.56
Cardiovascular safety in patients receiving roflumilast for the treatment of COPD. Chest (2013) 2.42
Internet-based self-management plus education compared with usual care in asthma: a randomized trial. Ann Intern Med (2009) 2.37
Muscular exercise can cause highly pathological liver function tests in healthy men. Br J Clin Pharmacol (2007) 2.30
Treating COPD--the TORCH trial, P values, and the Dodo. N Engl J Med (2007) 2.26
Systemic manifestations of COPD. Chest (2011) 2.25
The antimicrobial peptide LL-37 activates innate immunity at the airway epithelial surface by transactivation of the epidermal growth factor receptor. J Immunol (2003) 2.15
Antiinflammatory effects of the phosphodiesterase-4 inhibitor cilomilast (Ariflo) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2003) 2.13
[High-fat diet intake can be questioned]. Lakartidningen (2008) 2.05
The European Respiratory Society plans its future: the 2013-2018 strategic plan. Eur Respir J (2014) 2.02
The Asthma-COPD Overlap Syndrome. N Engl J Med (2015) 1.99
H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res (2010) 1.98
Severe asthma in adults: what are the important questions? J Allergy Clin Immunol (2007) 1.85
An electronic nose in the discrimination of patients with non-small cell lung cancer and COPD. Lung Cancer (2008) 1.80
Management, morbidity and mortality of COPD during an 11-year period: an observational retrospective epidemiological register study in Sweden (PATHOS). Prim Care Respir J (2014) 1.78
Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR. PLoS One (2011) 1.78
International Primary Care Respiratory Group (IPCRG) Guidelines: management of chronic obstructive pulmonary disease (COPD). Prim Care Respir J (2006) 1.74
Effect of fluticasone with and without salmeterol on pulmonary outcomes in chronic obstructive pulmonary disease: a randomized trial. Ann Intern Med (2009) 1.70
EBUS-TBNA for the diagnosis of central parenchymal lung lesions not visible at routine bronchoscopy. Lung Cancer (2008) 1.69
Bronchial inflammation and airway responses to deep inspiration in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2007) 1.68
Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis (2009) 1.65
Inhibition of the Trichoderma reesei cellulases by cellobiose is strongly dependent on the nature of the substrate. Biotechnol Bioeng (2004) 1.64
An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2015) 1.63
Reduction in sputum neutrophil and eosinophil numbers by the PDE4 inhibitor roflumilast in patients with COPD. Thorax (2007) 1.62
EBUS-TBNA for the clarification of PET positive intra-thoracic lymph nodes-an international multi-centre experience. J Thorac Oncol (2009) 1.60
Are rhinovirus-induced airway responses in asthma aggravated by chronic allergen exposure? Am J Respir Crit Care Med (2003) 1.56
Blood pressure levels and risk of cardiovascular events and mortality in type-2 diabetes: cohort study of 34 009 primary care patients. J Hypertens (2013) 1.49
MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res (2010) 1.49
An electronic nose in the discrimination of patients with asthma and controls. J Allergy Clin Immunol (2007) 1.40
Analysis of subcarinal lymph nodes in (suspected) non-small-cell lung cancer after a negative transbronchial needle aspiration -- what's next? A preliminary report. Respiration (2005) 1.39
Screening for Helicobacter pylori in Idiopathic Pulmonary Fibrosis Lung Biopsies. Respiration (2015) 1.39
Drug safety in COPD revisited: what is the number needed to analyze? Chest (2012) 1.38
Point: were industry-sponsored roflumilast trials appropriate? Yes. Chest (2014) 1.36
Markers of disease severity in chronic obstructive pulmonary disease. Pulm Pharmacol Ther (2005) 1.33
Human neutrophil defensins induce lung epithelial cell proliferation in vitro. J Leukoc Biol (2002) 1.30
Endosonography for lung cancer staging: one scope fits all? Chest (2010) 1.30
Diaphragm plication in adult patients with diaphragm paralysis leads to long-term improvement of pulmonary function and level of dyspnea. Eur J Cardiothorac Surg (2007) 1.26
Endoscopic ultrasound added to mediastinoscopy for preoperative staging of patients with lung cancer. JAMA (2005) 1.24
Traffic-related air pollution associated with prevalence of asthma and COPD/chronic bronchitis. A cross-sectional study in Southern Sweden. Int J Health Geogr (2009) 1.24
Transcriptional response of bronchial epithelial cells to Pseudomonas aeruginosa: identification of early mediators of host defense. Physiol Genomics (2005) 1.23
A prospective clinical study of theophylline safety in 3810 elderly with asthma or COPD. Respir Med (2004) 1.21
Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors. Int Arch Allergy Immunol (2006) 1.20
Drop-out and attendance in pulmonary rehabilitation: the role of clinical and psychosocial variables. Respir Med (2009) 1.19
Chronic sinusitis in severe asthma is related to sputum eosinophilia. J Allergy Clin Immunol (2002) 1.19
Acute abdominal pain: diagnostic impact of immediate CT scanning. World J Surg (2007) 1.18
A vision statement on guideline development for respiratory disease: the example of COPD. Lancet (2008) 1.18
Interstitial lung disease in polymyositis and dermatomyositis: longitudinal evaluation by pulmonary function and radiology. Arthritis Rheum (2008) 1.18
Processive action of cellobiohydrolase Cel7A from Trichoderma reesei is revealed as 'burst' kinetics on fluorescent polymeric model substrates. Biochem J (2005) 1.18
Effects of cigarette smoke condensate on proliferation and wound closure of bronchial epithelial cells in vitro: role of glutathione. Respir Res (2005) 1.17
N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell (2011) 1.17
Beclometasone-formoterol as maintenance and reliever treatment in patients with asthma: a double-blind, randomised controlled trial. Lancet Respir Med (2013) 1.15
Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell Stem Cell (2008) 1.15
Chronic obstructive pulmonary disease and exacerbations: patient insights from the global Hidden Depths of COPD survey. BMC Pulm Med (2013) 1.14
Asthma treatment preference study: a conjoint analysis of preferred drug treatments. Chest (2004) 1.14
Eotaxin-2 and eotaxin-3 expression is associated with persistent eosinophilic bronchial inflammation in patients with asthma after allergen challenge. J Allergy Clin Immunol (2005) 1.12
Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am J Respir Cell Mol Biol (2003) 1.11
Pulmonary complications of polymyositis and dermatomyositis. Semin Respir Crit Care Med (2007) 1.10
Mediastinal restaging: EUS-FNA offers a new perspective. Lung Cancer (2003) 1.09
Phosphodiesterase-4 inhibitor therapy for lung diseases. Am J Respir Crit Care Med (2013) 1.08
Weekly self-monitoring and treatment adjustment benefit patients with partly controlled and uncontrolled asthma: an analysis of the SMASHING study. Respir Res (2010) 1.06
Novel concepts of neuropeptide-based drug therapy: vasoactive intestinal polypeptide and its receptors. Eur J Pharmacol (2006) 1.05
Markers of exacerbation severity in chronic obstructive pulmonary disease. Respir Res (2006) 1.04
Smoking status and anti-inflammatory macrophages in bronchoalveolar lavage and induced sputum in COPD. Respir Res (2011) 1.04
Asymptomatic worsening of airway inflammation during low-dose allergen exposure in asthma: protection by inhaled steroids. Am J Respir Crit Care Med (2002) 1.03
Does roflumilast decrease exacerbations in severe COPD patients not controlled by inhaled combination therapy? The REACT study protocol. Int J Chron Obstruct Pulmon Dis (2012) 1.03
Epithelial differentiation is a determinant in the production of eotaxin-2 and -3 by bronchial epithelial cells in response to IL-4 and IL-13. Mol Immunol (2006) 1.02
Predictors of poor asthma control in European adults. J Asthma (2003) 1.02
Illness perceptions and COPD: an emerging field for COPD patient management. J Asthma (2008) 1.01
Consistency of sputum eosinophilia in difficult-to-treat asthma: a 5-year follow-up study. J Allergy Clin Immunol (2009) 1.01
Bleeding into the intraluminal thrombus in abdominal aortic aneurysms is associated with rupture. J Vasc Surg (2008) 1.01
Endoscopic ultrasound-guided fine-needle aspiration in the diagnosis and staging of lung cancer and its impact on surgical staging. J Clin Oncol (2005) 1.00
Role of defensins in inflammatory lung disease. Ann Med (2002) 0.99
Extracellular matrix composition in COPD. Eur Respir J (2012) 0.98
Characterisation of exacerbation risk and exacerbator phenotypes in the POET-COPD trial. Respir Res (2013) 0.98
EUS-guided FNA of centrally located lung tumours following a non-diagnostic bronchoscopy. Lung Cancer (2005) 0.98
A guide to guidelines for professional societies and other developers of recommendations: introduction to integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report. Proc Am Thorac Soc (2012) 0.98
Mediastinal-esophageal fistulae after EUS-FNA of tuberculosis of the mediastinum. Gastrointest Endosc (2009) 0.98
Effect of local anaesthesia and/or analgesia on pain responses induced by piglet castration. Acta Vet Scand (2011) 0.98
Cost-effectiveness of Internet-based self-management compared with usual care in asthma. PLoS One (2011) 0.97
Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis. Mol Cell Biol (2003) 0.97
How to integrate multiple comorbidities in guideline development: article 10 in Integrating and coordinating efforts in COPD guideline development. An official ATS/ERS workshop report. Proc Am Thorac Soc (2012) 0.97
Function and regulation of let-7 family microRNAs. Microrna (2012) 0.96
Recent developments on cellulases and carbohydrate-binding modules with cellulose affinity. Biotechnol Lett (2004) 0.96
Illness perceptions about asthma are determinants of outcome. J Asthma (2008) 0.96
Greater weight loss and hormonal changes after 6 months diet with carbohydrates eaten mostly at dinner. Obesity (Silver Spring) (2011) 0.95
Interaction between smoking and genetic factors in the development of chronic bronchitis. Am J Respir Crit Care Med (2007) 0.95