Published in J Allergy Clin Immunol on April 09, 2007
Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma. Am J Respir Crit Care Med (2013) 4.95
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients. J Allergy Clin Immunol (2012) 2.24
Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol (2007) 1.80
Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD. Chest (2010) 1.73
Use of exhaled nitric oxide measurement to identify a reactive, at-risk phenotype among patients with asthma. Am J Respir Crit Care Med (2010) 1.68
Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med (2008) 1.45
Molecular phenotyping of severe asthma using pattern recognition of bronchoalveolar lavage-derived cytokines. J Allergy Clin Immunol (2008) 1.42
Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med (2008) 1.40
Fibrocyte localization to the airway smooth muscle is a feature of asthma. J Allergy Clin Immunol (2008) 1.35
Bone marrow-derived mesenchymal stromal cells inhibit Th2-mediated allergic airways inflammation in mice. Stem Cells (2011) 1.33
Predicting intermediate phenotypes in asthma using bronchoalveolar lavage-derived cytokines. Clin Transl Sci (2010) 1.25
Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry. Thorax (2010) 1.15
Granulocyte-macrophage colony-stimulating factor expression in induced sputum and bronchial mucosa in asthma and COPD. Thorax (2009) 1.14
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PLoS One (2012) 1.07
Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma. J Immunol (2010) 1.07
Assessment of the lung microstructure in patients with asthma using hyperpolarized 3He diffusion MRI at two time scales: comparison with healthy subjects and patients with COPD. J Magn Reson Imaging (2008) 0.97
Expression and activation of the oxytocin receptor in airway smooth muscle cells: Regulation by TNFalpha and IL-13. Respir Res (2010) 0.95
Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids. J Allergy Clin Immunol (2007) 0.94
Attenuation of antigen-induced airway hyperresponsiveness and inflammation in CXCR3 knockout mice. Respir Res (2011) 0.89
Etanercept prevents airway hyperresponsiveness by protecting neuronal M2 muscarinic receptors in antigen-challenged guinea pigs. Br J Pharmacol (2009) 0.88
Does airway smooth muscle express an inflammatory phenotype in asthma? Br J Pharmacol (2011) 0.86
Strategies for molecular classification of asthma using bipartite network analysis of cytokine expression. Curr Allergy Asthma Rep (2012) 0.86
Identification of subtypes of refractory asthma in Korean patients by cluster analysis. Lung (2012) 0.85
Cytokine and anti-cytokine therapy in asthma: ready for the clinic? Clin Exp Immunol (2009) 0.85
Clinical heterogeneity in the severe asthma research program. Ann Am Thorac Soc (2013) 0.84
Collaborative interactions between type 2 innate lymphoid cells and antigen-specific CD4+ Th2 cells exacerbate murine allergic airway diseases with prominent eosinophilia. J Immunol (2015) 0.84
An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma. PLoS One (2012) 0.84
Body mass index and comorbidities in adult severe asthmatics. Biomed Res Int (2014) 0.83
The soluble tumor necrosis factor-alpha receptor suppresses airway inflammation in a murine model of acute asthma. Yonsei Med J (2009) 0.83
The GINA asthma strategy report: what's new for primary care? NPJ Prim Care Respir Med (2015) 0.82
The efficacy of tiotropium as a steroid-sparing agent in severe asthma. Can Respir J (2009) 0.82
The role of tiotropium in the management of asthma. Asia Pac Allergy (2012) 0.82
Recommendation for optimal management of severe refractory asthma. J Asthma Allergy (2010) 0.81
Severe asthma in children. J Allergy Clin Immunol Pract (2014) 0.80
Do mast cells link obesity and asthma? Allergy (2012) 0.80
An elevated body mass index increases lung volume but reduces airflow in Italian schoolchildren. PLoS One (2015) 0.80
Obstructive Sleep Apnea Risk, Asthma Burden, and Lower Airway Inflammation in Adults in the Severe Asthma Research Program (SARP) II. J Allergy Clin Immunol Pract (2015) 0.79
Interleukin-1β mediates virus-induced m2 muscarinic receptor dysfunction and airway hyperreactivity. Am J Respir Cell Mol Biol (2014) 0.79
Neutralizing TNFα restores glucocorticoid sensitivity in a mouse model of neutrophilic airway inflammation. Mucosal Immunol (2015) 0.78
Variable expression of cysteinyl leukotriene type I receptor splice variants in asthmatic females with different promoter haplotypes. BMC Immunol (2009) 0.77
Mega-dose vitamin C attenuated lung inflammation in mouse asthma model. Anat Cell Biol (2010) 0.77
Number, activation, and differentiation of circulating fibrocytes correlate with asthma severity. J Allergy Clin Immunol (2015) 0.76
Synthetic response of stimulated respiratory epithelium: modulation by prednisolone and iKK2 inhibition. Chest (2013) 0.76
Oral administration of heat-inactivated Lactobacillus plantarum K37 modulated airway hyperresponsiveness in ovalbumin-sensitized BALB/c mice. PLoS One (2014) 0.76
Clinical asthma phenotyping: A trial for bridging gaps in asthma management. World J Clin Pediatr (2015) 0.76
The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients. Inflammation (2015) 0.76
Epithelial ciliated beating cells essential for ex vivo ALI culture growth. BMC Pulm Med (2017) 0.75
Unusual asthma syndromes and their management. Ther Adv Chronic Dis (2011) 0.75
A critical role for IRF5 in regulating allergic airway inflammation. Mucosal Immunol (2016) 0.75
A novel human anti-VCAM-1 monoclonal antibody ameliorates airway inflammation and remodelling. J Cell Mol Med (2013) 0.75
[Factors associated with a severe asthma in asthmatic patients followed at Pneumo-phthisiology National Hospital of Cotonou (Benin) in 2014]. Pan Afr Med J (2015) 0.75
Characteristics of Allergic Pulmonary Inflammation in CXCR3Knockout Mice Sensitized and Challenged with House Dust Mite Protein. PLoS One (2016) 0.75
Air pollution and health. Lancet (2002) 9.57
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med (2009) 9.38
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial. Lancet (2002) 8.57
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J (2013) 8.39
Can guideline-defined asthma control be achieved? The Gaining Optimal Asthma ControL study. Am J Respir Crit Care Med (2004) 8.39
Mepolizumab and exacerbations of refractory eosinophilic asthma. N Engl J Med (2009) 8.36
Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature (2002) 8.28
Tiotropium versus salmeterol for the prevention of exacerbations of COPD. N Engl J Med (2011) 7.92
Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research Program. Am J Respir Crit Care Med (2009) 7.17
Mast-cell infiltration of airway smooth muscle in asthma. N Engl J Med (2002) 6.52
Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research Program. J Allergy Clin Immunol (2007) 6.33
2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J (2014) 6.32
Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med (2010) 6.19
Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet (2004) 6.17
Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med (2005) 6.05
Role of deficient type III interferon-lambda production in asthma exacerbations. Nat Med (2006) 5.90
Efficacy of esomeprazole for treatment of poorly controlled asthma. N Engl J Med (2009) 5.90
Riociguat for the treatment of pulmonary arterial hypertension. N Engl J Med (2013) 5.60
Early intervention with budesonide in mild persistent asthma: a randomised, double-blind trial. Lancet (2003) 5.10
Oral glucocorticoid-sparing effect of mepolizumab in eosinophilic asthma. N Engl J Med (2014) 4.95
Evidence of a role of tumor necrosis factor alpha in refractory asthma. N Engl J Med (2006) 4.83
Long-term intravenous epoprostenol infusion in primary pulmonary hypertension: prognostic factors and survival. J Am Coll Cardiol (2002) 4.79
Persistent activation of an innate immune response translates respiratory viral infection into chronic lung disease. Nat Med (2008) 4.70
Randomized comparison of strategies for reducing treatment in mild persistent asthma. N Engl J Med (2007) 4.40
Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials. Lancet (2009) 4.40
Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. J Allergy Clin Immunol (2010) 4.38
Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials. Lancet (2009) 4.29
Chronic obstructive pulmonary disease phenotypes: the future of COPD. Am J Respir Crit Care Med (2010) 4.19
From COPD to chronic systemic inflammatory syndrome? Lancet (2007) 4.13
Mediastinoscopy vs endosonography for mediastinal nodal staging of lung cancer: a randomized trial. JAMA (2010) 4.08
Management of asthma based on exhaled nitric oxide in addition to guideline-based treatment for inner-city adolescents and young adults: a randomised controlled trial. Lancet (2008) 4.06
Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations. Nat Genet (2011) 3.68
Adult Asthma Consensus Guidelines update 2003. Can Respir J (2004) 3.61
Diagnosis and management of cough executive summary: ACCP evidence-based clinical practice guidelines. Chest (2006) 3.59
Acute exacerbations of chronic obstructive pulmonary disease: identification of biologic clusters and their biomarkers. Am J Respir Crit Care Med (2011) 3.58
Management of non-small-cell lung cancer: recent developments. Lancet (2013) 3.51
Guidelines on diagnosis and treatment of pulmonary arterial hypertension. The Task Force on Diagnosis and Treatment of Pulmonary Arterial Hypertension of the European Society of Cardiology. Eur Heart J (2004) 3.51
Mepolizumab treatment in patients with severe eosinophilic asthma. N Engl J Med (2014) 3.50
Early detection of pulmonary arterial hypertension in systemic sclerosis: a French nationwide prospective multicenter study. Arthritis Rheum (2005) 3.44
Lansoprazole for children with poorly controlled asthma: a randomized controlled trial. JAMA (2012) 3.40
Asthma endotypes: a new approach to classification of disease entities within the asthma syndrome. J Allergy Clin Immunol (2011) 3.35
Overdiagnosis of asthma in obese and nonobese adults. CMAJ (2008) 3.23
Nitric oxide in health and disease of the respiratory system. Physiol Rev (2004) 3.15
Endosonography vs conventional bronchoscopy for the diagnosis of sarcoidosis: the GRANULOMA randomized clinical trial. JAMA (2013) 3.13
Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on Severe Asthma. J Allergy Clin Immunol (2010) 3.12
Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet (2002) 3.11
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma. Am J Respir Crit Care Med (2010) 3.11
Global asthma prevalence in adults: findings from the cross-sectional world health survey. BMC Public Health (2012) 3.01
Airway remodeling-associated mediators in moderate to severe asthma: effect of steroids on TGF-beta, IL-11, IL-17, and type I and type III collagen expression. J Allergy Clin Immunol (2003) 2.98
Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension. Circulation (2005) 2.98
Pathologic assessment of vasculopathies in pulmonary hypertension. J Am Coll Cardiol (2004) 2.93
Pathogenesis of asthma. Clin Exp Allergy (2008) 2.93
Pulmonary arterial hypertension in patients treated by dasatinib. Circulation (2012) 2.87
Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilation. J Appl Physiol (1985) (2007) 2.83
Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma. Am J Respir Crit Care Med (2004) 2.81
Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation. J Allergy Clin Immunol (2004) 2.80
Reslizumab for poorly controlled, eosinophilic asthma: a randomized, placebo-controlled study. Am J Respir Crit Care Med (2011) 2.80
"Refractory" eosinophilic airway inflammation in severe asthma: effect of parenteral corticosteroids. Am J Respir Crit Care Med (2004) 2.77
The airway epithelium: structural and functional properties in health and disease. Respirology (2003) 2.73
Defective epithelial barrier function in asthma. J Allergy Clin Immunol (2011) 2.73
The mouse trap: It still yields few answers in asthma. Am J Respir Crit Care Med (2006) 2.68
A randomized, double-blind, placebo-controlled study of tumor necrosis factor-alpha blockade in severe persistent asthma. Am J Respir Crit Care Med (2009) 2.56
Effects of an anti-TSLP antibody on allergen-induced asthmatic responses. N Engl J Med (2014) 2.53
Dysregulated renin-angiotensin-aldosterone system contributes to pulmonary arterial hypertension. Am J Respir Crit Care Med (2012) 2.52
Platelet-derived growth factor expression and function in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med (2008) 2.48
New formula for predicting mean pulmonary artery pressure using systolic pulmonary artery pressure. Chest (2004) 2.47
How cigarette smoke skews immune responses to promote infection, lung disease and cancer. Nat Rev Immunol (2009) 2.46
Expression of genes involved in oxidative stress responses in airway epithelial cells of smokers with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2006) 2.44
Cardiovascular safety in patients receiving roflumilast for the treatment of COPD. Chest (2013) 2.42
Canadian Thoracic Society Asthma Management Continuum--2010 Consensus Summary for children six years of age and over, and adults. Can Respir J (2010) 2.42
School examinations enhance airway inflammation to antigen challenge. Am J Respir Crit Care Med (2002) 2.41