Published in J Biol Chem on October 03, 2005
Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus. J Mol Biol (2011) 1.39
Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. Biochemistry (2006) 1.12
Substrate-induced conformational changes occur in all cleaved forms of caspase-6. J Mol Biol (2010) 1.10
Death by caspase dimerization. Adv Exp Med Biol (2012) 1.04
Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker. Protein Expr Purif (2005) 0.84
The pro-peptide of proNGF: structure formation and intramolecular association with NGF. Protein Sci (2007) 0.84
Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice. Mamm Genome (2010) 0.83
A bifunctional allosteric site in the dimer interface of procaspase-3. Biophys Chem (2011) 0.83
Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration. Cell Death Dis (2011) 0.82
Folding and assembly kinetics of procaspase-3. Protein Sci (2009) 0.78
Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule and interstitial cell apoptosis in rats. Croat Med J (2008) 0.75
Redesigning the procaspase-8 dimer interface for improved dimerization. Protein Sci (2014) 0.75
Multiple proteolytic events in caspase-6 self-activation impact conformations of discrete structural regions. Proc Natl Acad Sci U S A (2017) 0.75
Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell (1995) 9.22
Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu Rev Biochem (1999) 8.16
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
Biochemical characteristics of caspases-3, -6, -7, and -8. J Biol Chem (1997) 3.04
Pro-caspase-3 is a major physiologic target of caspase-8. J Biol Chem (1998) 2.93
Crystal structure of a procaspase-7 zymogen: mechanisms of activation and substrate binding. Cell (2001) 2.39
The three-dimensional structure of apopain/CPP32, a key mediator of apoptosis. Nat Struct Biol (1996) 2.17
Structural basis for the activation of human procaspase-7. Proc Natl Acad Sci U S A (2001) 2.14
Requirement of pro-sequence for the production of active subtilisin E in Escherichia coli. J Biol Chem (1987) 1.94
Caspases: keys in the ignition of cell death. Chem Rev (2002) 1.91
The alpha-lytic protease pro-region does not require a physical linkage to activate the protease domain in vivo. Nature (1989) 1.91
Zinc is a potent inhibitor of the apoptotic protease, caspase-3. A novel target for zinc in the inhibition of apoptosis. J Biol Chem (1997) 1.88
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc Natl Acad Sci U S A (2001) 1.68
Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone. J Biol Chem (1997) 1.65
Regulation and critical role of potassium homeostasis in apoptosis. Prog Neurobiol (2003) 1.63
Caspase-6 is the direct activator of caspase-8 in the cytochrome c-induced apoptosis pathway: absolute requirement for removal of caspase-6 prodomain. Cell Death Differ (2002) 1.58
Resolution of the fluorescence equilibrium unfolding profile of trp aporepressor using single tryptophan mutants. Protein Sci (1993) 1.56
An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3. Biochemistry (2003) 1.39
Intramolecular chaperones: polypeptide extensions that modulate protein folding. Semin Cell Dev Biol (2000) 1.37
Human caspase-7 activity and regulation by its N-terminal peptide. J Biol Chem (2003) 1.37
Removal of the pro-domain does not affect the conformation of the procaspase-3 dimer. Biochemistry (2001) 1.33
Ion homeostasis and apoptosis. Curr Opin Cell Biol (2001) 1.33
Roles of cytoplasmic Ca2+ and intracellular Ca2+ stores in induction and suppression of apoptosis in S49 cells. Am J Physiol (1997) 1.28
Activation of the CPP32 protease in apoptosis induced by 1-beta-D-arabinofuranosylcytosine and other DNA-damaging agents. Blood (1996) 1.24
Potassium is a critical regulator of apoptotic enzymes in vitro and in vivo. Adv Enzyme Regul (1999) 1.15
Dimeric procaspase-3 unfolds via a four-state equilibrium process. Biochemistry (2001) 1.14
A necessary role for cell shrinkage in apoptosis. Biochem Pharmacol (1998) 1.12
Mutations in the procaspase-3 dimer interface affect the activity of the zymogen. Biochemistry (2003) 1.11
Oncogene-dependent apoptosis in extracts from drug-resistant cells. Genes Dev (1997) 1.03
Ammonia-induced apoptosis is accelerated at higher pH in gastric surface mucous cells. Am J Physiol Gastrointest Liver Physiol (2002) 1.01
Activation of the c-Jun N-terminal kinase/stress-activated protein kinase pathway by overexpression of caspase-8 and its homologs. J Biol Chem (1999) 1.00
pH effects on the stability and dimerization of procaspase-3. Protein Sci (2004) 0.96
Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3. Biochem J (2004) 0.95
Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity. Am J Physiol Cell Physiol (2001) 0.90
The short prodomain influences caspase-3 activation in HeLa cells. Biochem J (2000) 0.88
Zinc uptake and metabolism by hepatocytes. Fed Proc (1986) 0.88
Pro- and anti-apoptotic effects of K+ in HeLa cells. FEBS Lett (1998) 0.85
Neurotrophic factor deprivation-induced death. Ann N Y Acad Sci (1993) 0.82
An uncleavable procaspase-3 mutant has a lower catalytic efficiency but an active site similar to that of mature caspase-3. Biochemistry (2003) 1.39
A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J (2009) 1.33
CpeR is an activator required for expression of the phycoerythrin operon (cpeBA) in the cyanobacterium Fremyella diplosiphon and is encoded in the phycoerythrin linker-polypeptide operon (cpeCDESTR). Mol Microbiol (2002) 1.16
Evaluation of the DNA binding tendencies of the transition state regulator AbrB. Biochemistry (2004) 1.16
Role of loop bundle hydrogen bonds in the maturation and activity of (Pro)caspase-3. Biochemistry (2006) 1.12
Mutations in the procaspase-3 dimer interface affect the activity of the zymogen. Biochemistry (2003) 1.11
Targeting cell death in tumors by activating caspases. Curr Cancer Drug Targets (2008) 1.10
Death by caspase dimerization. Adv Exp Med Biol (2012) 1.04
Equilibrium and kinetic folding of an alpha-helical Greek key protein domain: caspase recruitment domain (CARD) of RICK. Biochemistry (2003) 0.98
Practical approaches to protein folding and assembly: spectroscopic strategies in thermodynamics and kinetics. Methods Enzymol (2009) 0.96
pH effects on the stability and dimerization of procaspase-3. Protein Sci (2004) 0.96
Ionic interactions near the loop L4 are important for maintaining the active-site environment and the dimer stability of (pro)caspase 3. Biochem J (2004) 0.95
Substitutions of prolines examine their role in kinetic trap formation of the caspase recruitment domain (CARD) of RICK. Protein Sci (2006) 0.91
The C-terminal tail of Arabidopsis 14-3-3omega functions as an autoinhibitor and may contain a tenth alpha-helix. Plant J (2003) 0.88
Kinetic traps in the folding/unfolding of procaspase-1 CARD domain. Protein Sci (2004) 0.87
The potential for caspases in drug discovery. Curr Opin Drug Discov Devel (2010) 0.86
Protein folding: are we there yet? Arch Biochem Biophys (2008) 0.84
Novel protein purification system utilizing an N-terminal fusion protein and a caspase-3 cleavable linker. Protein Expr Purif (2005) 0.84
Allosteric modulation of caspase 3 through mutagenesis. Biosci Rep (2012) 0.84
Rapid folding and unfolding of Apaf-1 CARD. J Mol Biol (2007) 0.83
A bifunctional allosteric site in the dimer interface of procaspase-3. Biophys Chem (2011) 0.83
Thermodynamic, enzymatic and structural effects of removing a salt bridge at the base of loop 4 in (pro)caspase-3. Arch Biochem Biophys (2011) 0.80
Minimizing frustration by folding in an aqueous environment. Arch Biochem Biophys (2007) 0.80
Lengthening the intersubunit linker of procaspase 3 leads to constitutive activation. Biochemistry (2013) 0.80
Folding and assembly kinetics of procaspase-3. Protein Sci (2009) 0.78
Modifying caspase-3 activity by altering allosteric networks. Biochemistry (2014) 0.78
Slow folding and assembly of a procaspase-3 interface variant. Biochemistry (2013) 0.77
Redesigning the procaspase-8 dimer interface for improved dimerization. Protein Sci (2014) 0.75
Characterization and enzymatic degradation of Sup35NM, a yeast prion-like protein. Protein Sci (2005) 0.75