Published in Cancer Res on October 01, 2005
A cohort study of tumoral LINE-1 hypomethylation and prognosis in colon cancer. J Natl Cancer Inst (2008) 3.54
LINE-1 hypomethylation is inversely associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Int J Cancer (2008) 2.87
Association between global DNA hypomethylation in leukocytes and risk of breast cancer. Carcinogenesis (2009) 2.58
DNA methylation inhibitor 5-Aza-2'-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B. Mol Cell Biol (2007) 2.47
DNA methylation in glioblastoma: impact on gene expression and clinical outcome. BMC Genomics (2010) 2.32
Precision of pyrosequencing assay to measure LINE-1 methylation in colon cancer, normal colonic mucosa, and peripheral blood cells. J Mol Diagn (2010) 2.15
DNA hypomethylation arises later in prostate cancer progression than CpG island hypermethylation and contributes to metastatic tumor heterogeneity. Cancer Res (2008) 2.08
A novel role for mitochondria in regulating epigenetic modification in the nucleus. Cancer Biol Ther (2008) 2.03
Inviting instability: Transposable elements, double-strand breaks, and the maintenance of genome integrity. Mutat Res (2006) 2.00
Global DNA hypomethylation (LINE-1) in the normal colon and lifestyle characteristics and dietary and genetic factors. Cancer Epidemiol Biomarkers Prev (2009) 1.88
Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins. Oncogene (2007) 1.70
Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle (2010) 1.63
DNA methyltransferases, DNA damage repair, and cancer. Adv Exp Med Biol (2013) 1.57
Dietary folate, alcohol and B vitamins in relation to LINE-1 hypomethylation in colon cancer. Gut (2009) 1.54
Epigenomic diversity of colorectal cancer indicated by LINE-1 methylation in a database of 869 tumors. Mol Cancer (2010) 1.50
UHRF1 overexpression drives DNA hypomethylation and hepatocellular carcinoma. Cancer Cell (2014) 1.50
A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1. J Mol Cell Biol (2012) 1.42
Genome-wide tracking of unmethylated DNA Alu repeats in normal and cancer cells. Nucleic Acids Res (2007) 1.38
Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage. Clin Cancer Res (2011) 1.38
18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high. BMC Cancer (2007) 1.36
NGSmethDB: a database for next-generation sequencing single-cytosine-resolution DNA methylation data. Nucleic Acids Res (2010) 1.27
A high degree of LINE-1 hypomethylation is a unique feature of early-onset colorectal cancer. PLoS One (2012) 1.24
DNA methylation in peripheral blood measured by LUMA is associated with breast cancer in a population-based study. FASEB J (2012) 1.21
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Mol Cancer Res (2008) 1.19
Tumor heterogeneity: mechanisms and bases for a reliable application of molecular marker design. Int J Mol Sci (2012) 1.15
A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells. PLoS One (2008) 1.14
Concurrent hypermethylation of DNMT1, MGMT and EGFR genes in progression of gliomas. Diagn Pathol (2012) 1.11
Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy. Curr Genomics (2009) 1.11
Replication independent DNA double-strand break retention may prevent genomic instability. Mol Cancer (2010) 1.09
Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery. Hum Mol Genet (2010) 1.06
Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer. Cancer Causes Control (2010) 1.04
Expression of DNMT1 and DNMT3a are regulated by GLI1 in human pancreatic cancer. PLoS One (2011) 1.01
Further evidence against a direct genotoxic mode of action for arsenic-induced cancer. Toxicol Appl Pharmacol (2007) 1.01
Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis. Crit Rev Toxicol (2013) 0.97
Curcumin modulates DNA methylation in colorectal cancer cells. PLoS One (2013) 0.96
LINE-1 hypomethylation in gastric cancer, detected by bisulfite pyrosequencing, is associated with poor prognosis. Gastric Cancer (2012) 0.95
Genomic hypomethylation and CpG island hypermethylation in prostatic intraepithelial neoplasm. Virchows Arch (2008) 0.94
Prospective study of genomic hypomethylation of leukocyte DNA and colorectal cancer risk. Cancer Epidemiol Biomarkers Prev (2012) 0.91
African trypanosomes contain 5-methylcytosine in nuclear DNA. Eukaryot Cell (2008) 0.91
Methylation markers for urine-based detection of bladder cancer: the next generation of urinary markers for diagnosis and surveillance of bladder cancer. Adv Urol (2012) 0.90
Lack of evidence for green tea polyphenols as DNA methylation inhibitors in murine prostate. Cancer Prev Res (Phila) (2009) 0.90
Epigenetic mechanisms and genome stability. Clin Epigenetics (2011) 0.89
Melanoma epigenetics: novel mechanisms, markers, and medicines. Lab Invest (2014) 0.89
DNA methylation changes in ex-adenoma carcinoma of the large intestine. Virchows Arch (2010) 0.89
Targeting epigenetic regulations in cancer. Acta Biochim Biophys Sin (Shanghai) (2015) 0.88
LINE1 and Alu repetitive element DNA methylation in tumors and white blood cells from epithelial ovarian cancer patients. Gynecol Oncol (2013) 0.88
Recreational and household physical activity at different time points and DNA global methylation. Eur J Cancer (2013) 0.88
Opposing roles of Dnmt1 in early- and late-stage murine prostate cancer. Mol Cell Biol (2010) 0.87
Transformation of MCF-10A cells by random mutagenesis with frameshift mutagen ICR191: a model for identifying candidate breast-tumor suppressors. Mol Cancer (2008) 0.87
DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos. Development (2015) 0.84
Spectral karyotyping to study chromosome abnormalities in humans and mice with polycystic kidney disease. J Vis Exp (2012) 0.84
Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair (Amst) (2008) 0.83
Specific gene hypomethylation and cancer: new insights into coding region feature trends. Bioinformation (2009) 0.83
Alu and LINE-1 hypomethylation is associated with HER2 enriched subtype of breast cancer. PLoS One (2014) 0.83
Bypass of cell cycle arrest induced by transient DNMT1 post-transcriptional silencing triggers aneuploidy in human cells. Cell Div (2012) 0.83
Helicobacter pylori-infection-associated CpG island hypermethylation in the stomach and its possible association with polycomb repressive marks. Virchows Arch (2008) 0.82
Epigenetics: a promising paradigm for better understanding and managing pain. J Pain (2013) 0.81
Methylation status of long interspersed element-1 in advanced gastric cancer and its prognostic implication. Gastric Cancer (2015) 0.81
The Mechanobiology of Aging. Annu Rev Biomed Eng (2015) 0.81
Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites. Nucleic Acids Res (2015) 0.80
Expression of SPRR3 is associated with tumor cell proliferation and invasion in glioblastoma multiforme. Oncol Lett (2013) 0.79
DNA hypomethylation of interleukin 8 in clear cell renal cell carcinoma. Oncol Lett (2012) 0.78
Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem (2014) 0.78
Altered LINE-1 Methylation in Mothers of Children with Down Syndrome. PLoS One (2015) 0.78
Associations between genetic variation in one-carbon metabolism and LINE-1 DNA methylation in histologically normal breast tissues. Epigenetics (2015) 0.77
Cancer: evolutionary, genetic and epigenetic aspects. Clin Epigenetics (2010) 0.77
UHRF1 regulation of Dnmt1 is required for pre-gastrula zebrafish development. Dev Biol (2016) 0.77
The molecular pathogenesis of colorectal cancer and its potential application to colorectal cancer screening. Dig Dis Sci (2014) 0.76
LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review. Surg Today (2017) 0.76
Is DNA methylation the new guardian of the genome? Mol Cytogenet (2017) 0.75
The epigenetic landscape of Alu repeats delineates the structural and functional genomic architecture of colon cancer cells. Genome Res (2016) 0.75
Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms. World J Gastroenterol (2016) 0.75
UHRF1 regulates global DNA hypomethylation and is associated with poor prognosis in esophageal squamous cell carcinoma. Oncotarget (2016) 0.75
miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer. Cell Death Dis (2016) 0.75
Epigenetics in Cancer: A Hematological Perspective. PLoS Genet (2016) 0.75
Rb-dependent cellular senescence, multinucleation and susceptibility to oncogenic transformation through PKC scaffolding by SSeCKS/AKAP12. Cell Cycle (2010) 1.63
Molecular characterization of the t(3;9) associated with immortalization in the MCF10A cell line. Cancer Genet Cytogenet (2005) 1.20
Cytogenetic and cDNA microarray expression analysis of MCF10 human breast cancer progression cell lines. Cancer Res (2009) 1.05
Genomic heterogeneity and instability in colorectal cancer: spectral karyotyping, glutathione transferase-Ml and ras. Mutat Res (2004) 0.84
Ladder-like amplification of the type I interferon gene cluster in the human osteosarcoma cell line MG63. Chromosome Res (2008) 0.79
Comparative genomic instabilities of thyroid and colon cancers. Arch Otolaryngol Head Neck Surg (2007) 0.75