Published in J Pharmacol Exp Ther on October 04, 2005
Hydrogen sulfide mediates cardioprotection through Nrf2 signaling. Circ Res (2009) 2.83
Hydrogen sulfide attenuates hepatic ischemia-reperfusion injury: role of antioxidant and antiapoptotic signaling. Am J Physiol Heart Circ Physiol (2008) 2.19
Novel insights into hydrogen sulfide--mediated cytoprotection. Antioxid Redox Signal (2010) 1.79
Genetic and pharmacologic hydrogen sulfide therapy attenuates ischemia-induced heart failure in mice. Circulation (2010) 1.71
Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2007) 1.61
A new gaseous signaling molecule emerges: cardioprotective role of hydrogen sulfide. Proc Natl Acad Sci U S A (2007) 1.60
Hydrogen sulfide chemical biology: pathophysiological roles and detection. Nitric Oxide (2013) 1.56
Cardioprotective signaling to mitochondria. J Mol Cell Cardiol (2008) 1.49
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways. Pflugers Arch (2007) 1.48
Hydrogen sulfide and ischemia-reperfusion injury. Pharmacol Res (2010) 1.31
Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide. Biochim Biophys Acta (2009) 1.20
The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability. Am J Physiol Heart Circ Physiol (2012) 1.17
Hydrogen sulfide inhibits plasma renin activity. J Am Soc Nephrol (2010) 1.15
Mitochondrial approaches to protect against cardiac ischemia and reperfusion injury. Front Physiol (2011) 1.14
Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells. J Biol Chem (2011) 1.12
Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury. ACS Chem Biol (2013) 1.07
Hydrogen sulfide increases hypoxia-inducible factor-1 activity independently of von Hippel-Lindau tumor suppressor-1 in C. elegans. Mol Biol Cell (2009) 1.06
Cardioprotective effects of hydrogen sulfide. Nitric Oxide (2010) 1.06
Hydrogen sulfide protects against chemical hypoxia-induced cytotoxicity and inflammation in HaCaT cells through inhibition of ROS/NF-κB/COX-2 pathway. PLoS One (2011) 1.05
Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr (2014) 1.04
Hydrogen sulfide lowers proliferation and induces protective autophagy in colon epithelial cells. PLoS One (2012) 1.01
The role of gasotransmitters NO, H2S and CO in myocardial ischaemia/reperfusion injury and cardioprotection by preconditioning, postconditioning and remote conditioning. Br J Pharmacol (2014) 1.01
The hydrogen sulphide-releasing derivative of diclofenac protects against ischaemia-reperfusion injury in the isolated rabbit heart. Br J Pharmacol (2007) 1.00
Hydrogen sulfide triggers late-phase preconditioning in postischemic small intestine by an NO- and p38 MAPK-dependent mechanism. Am J Physiol Heart Circ Physiol (2009) 1.00
Nitrative thioredoxin inactivation as a cause of enhanced myocardial ischemia/reperfusion injury in the aging heart. Free Radic Biol Med (2007) 0.98
Differing effects of exogenous and endogenous hydrogen sulphide in carrageenan-induced knee joint synovitis in the rat. Br J Pharmacol (2010) 0.96
Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells. Kidney Int (2011) 0.96
Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection. J Am Coll Cardiol (2012) 0.95
Cinaciguat, a novel activator of soluble guanylate cyclase, protects against ischemia/reperfusion injury: role of hydrogen sulfide. Am J Physiol Heart Circ Physiol (2012) 0.95
Hydrogen sulfide attenuates cardiac hypertrophy and fibrosis induced by abdominal aortic coarctation in rats. Mol Med Rep (2012) 0.93
Cyclooxygenase-2 mediates the delayed cardioprotection induced by hydrogen sulfide preconditioning in isolated rat cardiomyocytes. Pflugers Arch (2007) 0.92
H(2)S-releasing aspirin protects against aspirin-induced gastric injury via reducing oxidative stress. PLoS One (2012) 0.90
Emergent role of gasotransmitters in ischemia-reperfusion injury. Med Gas Res (2011) 0.89
H(2)S and HS(-) donor NaHS releases nitric oxide from nitrosothiols, metal nitrosyl complex, brain homogenate and murine L1210 leukaemia cells. Pflugers Arch (2008) 0.89
Protective effect of hydrogen sulphide against 6-OHDA-induced cell injury in SH-SY5Y cells involves PKC/PI3K/Akt pathway. Br J Pharmacol (2010) 0.89
Hydrogen sulfide alleviates myocardial collagen remodeling in association with inhibition of TGF-β/Smad signaling pathway in spontaneously hypertensive rats. Mol Med (2015) 0.88
Hydrogen sulfide-mediated myocardial pre- and post-conditioning. Expert Rev Clin Pharmacol (2011) 0.87
H2S during circulatory shock: some unresolved questions. Nitric Oxide (2014) 0.86
Hydrogen sulfide prevents hydrogen peroxide-induced activation of epithelial sodium channel through a PTEN/PI(3,4,5)P3 dependent pathway. PLoS One (2013) 0.86
Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. Oxid Med Cell Longev (2015) 0.84
The Cardioprotective Effects of Hydrogen Sulfide in Heart Diseases: From Molecular Mechanisms to Therapeutic Potential. Oxid Med Cell Longev (2015) 0.84
Cardioprotection by H2S engages a cGMP-dependent protein kinase G/phospholamban pathway. Cardiovasc Res (2015) 0.83
An exogenous hydrogen sulphide donor, NaHS, inhibits the apoptosis signaling pathway to exert cardio-protective effects in a rat hemorrhagic shock model. Int J Clin Exp Pathol (2015) 0.82
Up Regulation of cystathione γ lyase and Hydrogen Sulphide in the Myocardium Inhibits the Progression of Isoproterenol-Caffeine Induced Left Ventricular Hypertrophy in Wistar Kyoto Rats. PLoS One (2016) 0.81
GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats. J Biomed Res (2014) 0.81
Retracted Freshly crushed garlic is a superior cardioprotective agent than processed garlic. J Agric Food Chem (2009) 0.81
Hydrogen sulfide targets EGFR Cys797/Cys798 residues to induce Na(+)/K(+)-ATPase endocytosis and inhibition in renal tubular epithelial cells and increase sodium excretion in chronic salt-loaded rats. Antioxid Redox Signal (2014) 0.80
Endogenous hydrogen sulfide mediates the cardioprotection induced by ischemic postconditioning in the early reperfusion phase. Exp Ther Med (2012) 0.79
Hydrogen Sulfide in the RVLM and PVN has No Effect on Cardiovascular Regulation. Front Physiol (2011) 0.79
Analysis of cardiovascular responses to the H2S donors Na2S and NaHS in the rat. Am J Physiol Heart Circ Physiol (2015) 0.78
Role of Hydrogen Sulfide in Ischemia-Reperfusion Injury. Oxid Med Cell Longev (2015) 0.78
Ginkgolide B increases hydrogen sulfide and protects against endothelial dysfunction in diabetic rats. Croat Med J (2015) 0.78
mTORC2 phosphorylation of Akt1: a possible mechanism for hydrogen sulfide-induced cardioprotection. PLoS One (2014) 0.78
Lost in translation: miRNAs and mRNAs in ischemic preconditioning and ischemia/reperfusion injury. J Mol Cell Cardiol (2015) 0.78
Effects of hydrogen sulphide on the isolated perfused rat heart. Sultan Qaboos Univ Med J (2011) 0.77
The summer of hydrogen sulfide: highlights from two international conferences. Med Gas Res (2013) 0.77
Cystathionine γ-lyase is expressed in human atherosclerotic plaque microvessels and is involved in micro-angiogenesis. Sci Rep (2016) 0.77
Hydrogen sulfide improves cardiomyocytes electrical remodeling post ischemia/reperfusion injury in rats. Int J Clin Exp Pathol (2015) 0.77
Hydrogen sulfide ameliorates the kidney dysfunction and damage in cisplatin-induced nephrotoxicity in rat. Vet Res Forum (2014) 0.77
Contribution of hydrogen sulfide to the control of coronary blood flow. Microcirculation (2014) 0.77
Hydrogen Sulfide Prevents Advanced Glycation End-Products Induced Activation of the Epithelial Sodium Channel. Oxid Med Cell Longev (2015) 0.77
Heart failure management: the present and the future. Antioxid Redox Signal (2009) 0.77
Sulfur compounds block MCP-1 production by Mycoplasma fermentans-infected macrophages through NF-κB inhibition. J Transl Med (2014) 0.77
Hydrogen sulfide donor protects porcine oocytes against aging and improves the developmental potential of aged porcine oocytes. PLoS One (2015) 0.76
Interaction of H2S with Calcium Permeable Channels and Transporters. Oxid Med Cell Longev (2015) 0.76
Subcellular Energetics and Metabolism: Potential Therapeutic Applications. Anesth Analg (2017) 0.75
Hydrogen sulfide and PKG in ischemia-reperfusion injury: sources, signaling, accelerators and brakes. Basic Res Cardiol (2015) 0.75
Regulatory effects of hydrogen sulfide on alveolar epithelial cell endoplasmic reticulum stress in rats with acute lung injury. World J Emerg Med (2015) 0.75
H2S-releasing nanoemulsions: a new formulation to inhibit tumor cells proliferation and improve tissue repair. Oncotarget (2016) 0.75
GYY4137 stimulates osteoblastic cell proliferation and differentiation via an ERK1/2-dependent anti-oxidant mechanism. Am J Transl Res (2017) 0.75
Key proteins of activating cell death can be predicted through a kainic acid-induced excitotoxic stress. Biomed Res Int (2015) 0.75
The effects of hydrogen sulfide under sevoflurane administration against ischemia and reperfusion injury in isolated rat heart. Korean J Anesthesiol (2012) 0.75
Beyond a gasotransmitter: hydrogen sulfide and polysulfide in cardiovascular health and immune response. Antioxid Redox Signal (2017) 0.75
The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res (2007) 3.15
Herb-drug interactions: a literature review. Drugs (2005) 2.59
Anti-inflammatory and gastrointestinal effects of a novel diclofenac derivative. Free Radic Biol Med (2006) 1.81
Endogenous hydrogen sulfide contributes to the cardioprotection by metabolic inhibition preconditioning in the rat ventricular myocytes. J Mol Cell Cardiol (2005) 1.71
Rapid determination of common mutations in glutathione S-transferase gene by PCR-based methods in healthy Chinese. Clin Chim Acta (2005) 1.50
Cardioprotection induced by hydrogen sulfide preconditioning involves activation of ERK and PI3K/Akt pathways. Pflugers Arch (2007) 1.48
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One (2011) 1.37
Cholesterol involvement in the pathogenesis of neurodegenerative diseases. Mol Cell Neurosci (2009) 1.35
Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells. FASEB J (2006) 1.30
Metabolism and transport of oxazaphosphorines and the clinical implications. Drug Metab Rev (2005) 1.25
Chronic sodium hydrosulfide treatment decreases medial thickening of intramyocardial coronary arterioles, interstitial fibrosis, and ROS production in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol (2007) 1.24
H2S preconditioning-induced PKC activation regulates intracellular calcium handling in rat cardiomyocytes. Am J Physiol Cell Physiol (2007) 1.22
Contractile and vasorelaxant effects of hydrogen sulfide and its biosynthesis in the human internal mammary artery. J Pharmacol Exp Ther (2007) 1.20
Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis. J Leukoc Biol (2007) 1.17
Effects of ganopoly (a Ganoderma lucidum polysaccharide extract) on the immune functions in advanced-stage cancer patients. Immunol Invest (2003) 1.09
Bioactivation and hepatotoxicity of nitroaromatic drugs. Curr Drug Metab (2006) 1.07
Intracardiac intracellular angiotensin system in diabetes. Am J Physiol Regul Integr Comp Physiol (2011) 1.03
Prediction of drug-target interactions for drug repositioning only based on genomic expression similarity. PLoS Comput Biol (2013) 1.02
Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. Int J Cancer (2005) 1.02
Human multidrug resistance associated protein 4 confers resistance to camptothecins. Pharm Res (2005) 1.01
The intracrine renin-angiotensin system. Clin Sci (Lond) (2012) 1.01
An interethnic comparison of polymorphisms of the genes encoding drug-metabolizing enzymes and drug transporters: experience in Singapore. Drug Metab Rev (2005) 0.99
Negative regulation of beta-adrenergic function by hydrogen sulphide in the rat hearts. J Mol Cell Cardiol (2008) 0.96
Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat. Life Sci (2002) 0.94
Development and characterization of simple sequence repeat markers providing genome-wide coverage and high resolution in maize. DNA Res (2013) 0.94
Effect of S-diclofenac, a novel hydrogen sulfide releasing derivative inhibit rat vascular smooth muscle cell proliferation. Eur J Pharmacol (2008) 0.93
Cyclooxygenase-2 mediates the delayed cardioprotection induced by hydrogen sulfide preconditioning in isolated rat cardiomyocytes. Pflugers Arch (2007) 0.92
Targeted delivery of a combination therapy consisting of combretastatin A4 and low-dose doxorubicin against tumor neovasculature. Nanomedicine (2011) 0.91
Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice. Immunol Invest (2005) 0.90
The role of urotensin II in cardiovascular and renal physiology and diseases. Br J Pharmacol (2006) 0.89
One-step purification of functional human and rat pancreatic alpha cells. Integr Biol (Camb) (2012) 0.89
Concurrent nephrotic syndrome and acute renal failure caused by chronic lymphocytic leukemia (CLL): a case report and literature review. Diagn Pathol (2011) 0.88
Overexpression of phytoene synthase gene from Salicornia europaea alters response to reactive oxygen species under salt stress in transgenic Arabidopsis. Biotechnol Lett (2008) 0.87
Clinical outcomes and management of mechanism-based inhibition of cytochrome P450 3A4. Ther Clin Risk Manag (2005) 0.87
A mechanistic study of the intestinal absorption of cryptotanshinone, the major active constituent of Salvia miltiorrhiza. J Pharmacol Exp Ther (2006) 0.85
Effect of enteral nutrition and ecoimmunonutrition on bacterial translocation and cytokine production in patients with severe acute pancreatitis. J Surg Res (2013) 0.85
Hydrogen sulfide: regulatory role on blood pressure in hyperhomocysteinemia. Vascul Pharmacol (2010) 0.84
Effects of water-soluble Ganoderma lucidum polysaccharides on the immune functions of patients with advanced lung cancer. J Med Food (2005) 0.84
The PKCalpha-D294G mutant found in pituitary and thyroid tumors fails to transduce extracellular signals. Cancer Res (2005) 0.84
Insights into oxazaphosphorine resistance and possible approaches to its circumvention. Drug Resist Updat (2005) 0.83
St. John's Wort modulates the toxicities and pharmacokinetics of CPT-11 (irinotecan) in rats. Pharm Res (2005) 0.83
Difference between Pb and Cd accumulation in 19 elite maize inbred lines and application prospects. J Biomed Biotechnol (2012) 0.83
Simultaneous determination of the lactone and carboxylate forms of irinotecan (CPT-11) and its active metabolite SN-38 by high-performance liquid chromatography: application to plasma pharmacokinetic studies in the rat. J Chromatogr B Analyt Technol Biomed Life Sci (2005) 0.83
Ganoderma lucidum polysaccharide fractions accelerate healing of acetic acid-induced ulcers in rats. J Med Food (2004) 0.83
Approximate entropy of fetal heart rate variability as a predictor of fetal distress in women at term pregnancy. Acta Obstet Gynecol Scand (2005) 0.83
Simultaneous determination of metformin and gliclazide in human plasma by liquid chromatography-tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers. J Mass Spectrom (2005) 0.83
The very C-terminus of protein kinase Cepsilon is critical for the full catalytic competence but its hydrophobic motif is dispensable for the interaction with 3-phosphoinositide-dependent kinase-1. Cell Signal (2005) 0.83
Increased susceptibility of db/db mice to rosiglitazone-induced plasma volume expansion: role of dysregulation of renal water transporters. Am J Physiol Renal Physiol (2013) 0.82
Angiotensin type 1a receptor-deficient mice develop diabetes-induced cardiac dysfunction, which is prevented by renin-angiotensin system inhibitors. Cardiovasc Diabetol (2013) 0.82
GSK3beta modulates PACAP-induced neuritogenesis in PC12 cells by acting downstream of Rap1 in a caveolae-dependent manner. Cell Signal (2008) 0.81
Direct renin inhibition prevents cardiac dysfunction in a diabetic mouse model: comparison with an angiotensin receptor antagonist and angiotensin-converting enzyme inhibitor. Clin Sci (Lond) (2013) 0.81
Phenotyping and genotyping study of thiopurine S-methyltransferase in healthy Chinese children: a comparison of Han and Yao ethnic groups. Br J Clin Pharmacol (2004) 0.81
Induction of propranolol metabolism by Ginkgo biloba extract EGb 761 in rats. Curr Drug Metab (2006) 0.81
Design of new oxazaphosphorine anticancer drugs. Curr Pharm Des (2007) 0.80
Hydrogen sulfide regulates Na+/H+ exchanger activity via stimulation of phosphoinositide 3-kinase/Akt and protein kinase G pathways. J Pharmacol Exp Ther (2011) 0.80
The very C-terminus of PRK1/PKN is essential for its activation by RhoA and downstream signaling. Cell Signal (2006) 0.80
Do multiple nuclear factor kappa B activation mechanisms explain its varied effects in the heart? Ochsner J (2013) 0.80
Cloning and characterization of miRNAs from maize seedling roots under low phosphorus stress. Mol Biol Rep (2012) 0.80
Cultivar variations of Australian-grown Danshen (Salvia miltiorrhiza): bioactive markers and root yields. Chem Biodivers (2009) 0.80
Determination of adefovir in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study. Rapid Commun Mass Spectrom (2005) 0.80
Novel agents that potentially inhibit irinotecan-induced diarrhea. Curr Med Chem (2005) 0.79
Redistribution of power spectrum of heart rate variability during acute umbilical artery embolism and hypoxemia in late-gestation fetal sheep. Eur J Obstet Gynecol Reprod Biol (2004) 0.79
A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia. J Med Food (2005) 0.79
The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner. Arch Biochem Biophys (2008) 0.79
Determination of thalidomide by high performance liquid chromatography: plasma pharmacokinetic studies in the rat. J Pharm Biomed Anal (2005) 0.79
Changes of plasma and placental tissue factor pathway inhibitor-2 in women with preeclampsia and normal pregnancy. Thromb Res (2010) 0.78
H2S Synthesizing Enzymes: Biochemistry and Molecular Aspects. Handb Exp Pharmacol (2015) 0.78
Effects of magnesium sulfate on heart rate, blood pressure variability and baroreflex sensitivity in preeclamptic rats treated with L-NAME. Hypertens Pregnancy (2013) 0.78
Association of ion-channel genotype and macrocyclic lactone sensitivity traits in Haemonchus contortus. Mol Biochem Parasitol (2010) 0.78
Significant intestinal excretion, one source of variability in pharmacokinetics of COL-3, a chemically modified tetracycline. Pharm Res (2005) 0.77
Inhibition of human CYP1A2 oxidation of 5,6-dimethyl-xanthenone-4-acetic acid by acridines: a molecular modelling study. Clin Exp Pharmacol Physiol (2005) 0.77
Phenotyping and genotyping studies of thiopurine S-methyltransferase in Kazaks. Pharm Res (2005) 0.77
A proteomic analysis of placental trophoblastic cells in preeclampsia-eclampsia. Cell Biochem Biophys (2014) 0.77
Pharmacokinetics of recombinant human endostatin in rats. Curr Drug Metab (2006) 0.77
Octyl gallate markedly promotes anti-amyloidogenic processing of APP through estrogen receptor-mediated ADAM10 activation. PLoS One (2013) 0.77
A comparison of glutathione S-transferase mutant frequencies in healthy Han and Uygur Chinese. Eur J Drug Metab Pharmacokinet (2005) 0.77
The changes of visfatin in serum and its expression in fat and placental tissue in pregnant women with gestational diabetes. Diabetes Res Clin Pract (2010) 0.77
Mechanism-based enterohepatic circulation model of mycophenolic acid and its glucuronide metabolite: assessment of impact of cyclosporine dose in Asian renal transplant patients. J Clin Pharmacol (2009) 0.76
Roles of apolipoprotein E (ApoE) and inducible nitric oxide synthase (iNOS) in inflammation and apoptosis in preeclampsia pathogenesis and progression. PLoS One (2013) 0.76
Transcriptional responses of maize seedling root to phosphorus starvation. Mol Biol Rep (2013) 0.76
Altered Bcl-2 and Bax expression is associated with cultured first trimester human cytotrophoblasts apoptosis induced by hypoxia. Life Sci (2006) 0.76
Effect of coenzyme Q10 on warfarin hydroxylation in rat and human liver microsomes. Curr Drug Metab (2005) 0.75
Correspondence re: J. Lu et al., thalidomide metabolites in mice and patients with multiple myeloma. Clin. Cancer Res., 9: 1680-1688, 2003. Clin Cancer Res (2003) 0.75
Cyp1A1-mediated activation of thalidomide and suppression of embryo fibroblast proliferation. Drug Metab Dispos (2003) 0.75
Shell-cross-linked micelles from PNIPAM-b-(PLL)2 Y-shaped miktoarm star copolymer as drug carriers. Biomacromolecules (2010) 0.75
Nuclear accumulation and up-regulation of p53 and its associated proteins after H2S treatment in human lung fibroblasts. J Cell Mol Med (2008) 0.75
[Cloning and functional validation of promoter of mo-molybdopterin cofactor sulfurase gene in maize]. Yi Chuan (2014) 0.75
Oncogenic role of microRNA-423-5p in hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int (2015) 0.75
High-throughput determination of carbocysteine in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study of two formulations in healthy volunteers. Rapid Commun Mass Spectrom (2006) 0.75
Activin inhibits telomerase activity in cancer. Biochem Biophys Res Commun (2009) 0.75
Alteration of the pharmacokinetics of COL-3, a matrix metalloproteinase inhibitor, due to acute gastrointestinal toxicity of doxorubicin. Pharm Res (2005) 0.75
Effect of omeprazole on the hydroxylation of warfarin enantiomers in human: in-vitro studies with liver microsomes and cDNA-expressed cytochrome P450 isozymes. Curr Drug Metab (2005) 0.75