Human antimicrobial peptides: defensins, cathelicidins and histatins.

PubWeight™: 1.78‹?› | Rank: Top 3%

🔗 View Article (PMID 16215847)

Published in Biotechnol Lett on September 01, 2005

Authors

Kris De Smet1, Roland Contreras

Author Affiliations

1: Unit of Fundamental and Applied Molecular Biology, Department for Molecular Biomedical Research, Ghent University and VIB, Technologiepark 927, B-9052, Ghent, Belgium.

Associated clinical trials:

Vitamin D in Ventilated ICU Patients (R21 HL-110044) | NCT01372995

Effect of Vitamin D3 on Lung Function and Exercise Tolerance in COPD Patients | NCT03781895

Articles citing this

Medical biofilms. Biotechnol Bioeng (2008) 1.70

The Bifidobacterium dentium Bd1 genome sequence reflects its genetic adaptation to the human oral cavity. PLoS Genet (2009) 1.64

Contribution of bacterial outer membrane vesicles to innate bacterial defense. BMC Microbiol (2011) 1.48

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature (2014) 1.40

Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39

How nature morphs peptide scaffolds into antibiotics. Chembiochem (2009) 1.14

Vitamin D and chronic lung disease: a review of molecular mechanisms and clinical studies. Adv Nutr (2011) 1.12

Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins. Biochem J (2007) 1.10

Host-microbial interactions and regulation of intestinal epithelial barrier function: From physiology to pathology. World J Gastrointest Pathophysiol (2012) 1.09

Human antimicrobial peptide LL-37 inhibits adhesion of Candida albicans by interacting with yeast cell-wall carbohydrates. PLoS One (2011) 1.08

NADPH oxidase-driven phagocyte recruitment controls Candida albicans filamentous growth and prevents mortality. PLoS Pathog (2013) 1.06

RNase 7 contributes to the cutaneous defense against Enterococcus faecium. PLoS One (2009) 1.06

The dietary histone deacetylase inhibitor sulforaphane induces human beta-defensin-2 in intestinal epithelial cells. Immunology (2008) 1.02

Role of the Vibrio cholerae matrix protein Bap1 in cross-resistance to antimicrobial peptides. PLoS Pathog (2013) 0.99

Saliva--a diagnostic window to the body, both in health and in disease. J Med Life (2010) 0.99

Antibody complementarity-determining regions (CDRs): a bridge between adaptive and innate immunity. PLoS One (2009) 0.99

Composition effect on peptide interaction with lipids and bacteria: variants of C3a peptide CNY21. Biophys J (2006) 0.94

Salivary antimicrobial peptides (LL-37 and alpha-defensins HNP1-3), antimicrobial and IgA responses to prolonged exercise. Eur J Appl Physiol (2009) 0.93

Effects of Vitamin D Intake on FEV1 and COPD Exacerbation: A Randomized Clinical Trial Study. Glob J Health Sci (2015) 0.92

Intestinal epithelial cells and their role in innate mucosal immunity. Cell Tissue Res (2010) 0.92

Host Defense and the Airway Epithelium: Frontline Responses That Protect against Bacterial Invasion and Pneumonia. J Pathog (2011) 0.92

Aspergillus-associated airway disease, inflammation, and the innate immune response. Biomed Res Int (2013) 0.91

Antimicrobial functionalized genetically engineered spider silk. Biomaterials (2011) 0.91

Bacteroides fragilis enterotoxin induces human beta-defensin-2 expression in intestinal epithelial cells via a mitogen-activated protein kinase/I kappaB kinase/NF-kappaB-dependent pathway. Infect Immun (2010) 0.91

Non-hematopoietic cells contribute to protective tolerance to Aspergillus fumigatus via a TRIF pathway converging on IDO. Cell Mol Immunol (2010) 0.91

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain. J Neuroinflammation (2013) 0.90

Deletion of mtrC in Haemophilus ducreyi increases sensitivity to human antimicrobial peptides and activates the CpxRA regulon. Infect Immun (2011) 0.90

Biofilms: an advancement in our understanding of Francisella species. Virulence (2013) 0.90

Fusobacterium nucleatum-associated beta-defensin inducer (FAD-I): identification, isolation, and functional evaluation. J Biol Chem (2010) 0.88

Histatin peptides: Pharmacological functions and their applications in dentistry. Saudi Pharm J (2016) 0.87

Antimicrobial activities of chemokines: not just a side-effect? Front Immunol (2012) 0.86

The possible role of the novel cytokines il-35 and il-37 in inflammatory bowel disease. Mediators Inflamm (2014) 0.86

Eurocin, a new fungal defensin: structure, lipid binding, and its mode of action. J Biol Chem (2012) 0.86

Enhanced resistance to bacterial and fungal pathogens by overexpression of a human cathelicidin antimicrobial peptide (hCAP18/LL-37) in Chinese cabbage. Plant Biotechnol Rep (2011) 0.86

Peptides of the constant region of antibodies display fungicidal activity. PLoS One (2012) 0.85

Structural and antimicrobial properties of human pre-elafin/trappin-2 and derived peptides against Pseudomonas aeruginosa. BMC Microbiol (2010) 0.85

Fitness level impacts salivary antimicrobial protein responses to a single bout of cycling exercise. Eur J Appl Physiol (2015) 0.84

The short form of TSLP is constitutively translated in human keratinocytes and has characteristics of an antimicrobial peptide. Mucosal Immunol (2014) 0.84

Antimicrobial Peptides in Innate Immunity against Mycobacteria. Immune Netw (2011) 0.82

Relevance of α-defensins (HNP1-3) and defensin β-1 in diabetes. World J Gastroenterol (2014) 0.81

Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins. PLoS One (2012) 0.80

In vitro potential of equine DEFA1 and eCATH1 as alternative antimicrobial drugs in rhodococcosis treatment. Antimicrob Agents Chemother (2012) 0.80

Topical antimicrobials for burn infections - an update. Recent Pat Antiinfect Drug Discov (2013) 0.80

Borrelia burgdorferi resistance to a major skin antimicrobial peptide is independent of outer surface lipoprotein content. Antimicrob Agents Chemother (2009) 0.80

Structure of chemokine-derived antimicrobial Peptide interleukin-8alpha and interaction with detergent micelles and oriented lipid bilayers. Biochemistry (2009) 0.79

Surface thermodynamic homeostasis of salivary conditioning films through polar-apolar layering. Clin Oral Investig (2011) 0.79

Characterizing the role of cell-wall β-1,3-exoglucanase Xog1p in Candida albicans adhesion by the human antimicrobial peptide LL-37. PLoS One (2011) 0.79

High Dose Vitamin D Administration in Ventilated Intensive Care Unit Patients: A Pilot Double Blind Randomized Controlled Trial. J Clin Transl Endocrinol (2016) 0.78

Tissue-specific human beta-defensins (HBD)-1, HBD-2 and HBD-3 secretion profile from human amniochorionic membranes stimulated with Candida albicans in a two-compartment tissue culture system. Reprod Biol Endocrinol (2012) 0.78

Antimicrobial peptides and their analogs: searching for new potential therapeutics. Perspect Medicin Chem (2014) 0.78

Buffering capacity and size of siRNA polyplexes influence cytokine levels. Mol Ther (2012) 0.78

Effects of whole cigarette smoke on human beta defensins expression and secretion by oral mucosal epithelial cells. Tob Induc Dis (2015) 0.78

Expression and function of psoriasin (S100A7) and koebnerisin (S100A15) in the brain. Infect Immun (2013) 0.77

A Deep Insight into the Sialome of Male and Female Aedes aegypti Mosquitoes. PLoS One (2016) 0.77

Salivary enzymes and flow rate: Markers of peptic ulcer. J Oral Biol Craniofac Res (2014) 0.77

Expression pattern of arenicins-the antimicrobial peptides of polychaete Arenicola marina. Front Physiol (2014) 0.77

Snake Cathelicidin NA-CATH and Smaller Helical Antimicrobial Peptides Are Effective against Burkholderia thailandensis. PLoS Negl Trop Dis (2015) 0.77

Functions of Cationic Host Defense Peptides in Immunity. Pharmaceuticals (Basel) (2016) 0.77

Oral innate immunity in HIV infection in HAART era. J Oral Pathol Med (2015) 0.77

Cloning and expression of a clamworm antimicrobial peptide perinerin in Pichia pastoris. Curr Microbiol (2009) 0.77

Side chain hydrophobicity modulates therapeutic activity and membrane selectivity of antimicrobial peptide mastoparan-X. PLoS One (2014) 0.76

OmpA Binding Mediates the Effect of Antimicrobial Peptide LL-37 on Acinetobacter baumannii. PLoS One (2015) 0.76

Exploring the mechanisms of action of human secretory RNase 3 and RNase 7 against Candida albicans. Microbiologyopen (2016) 0.76

Antimicrobial Peptide CMA3 Derived from the CA-MA Hybrid Peptide: Antibacterial and Anti-inflammatory Activities with Low Cytotoxicity and Mechanism of Action in Escherichia coli. Antimicrob Agents Chemother (2015) 0.76

Dehydroandrographolide enhances innate immunity of intestinal tract through up-regulation the expression of hBD-2. Daru (2015) 0.76

Salivary Antimicrobial Peptides in Early Detection of Periodontitis. Front Cell Infect Microbiol (2015) 0.76

Implications of salivary protein binding to commensal and pathogenic bacteria. J Oral Biosci (2013) 0.76

Short, Synthetic Cationic Peptides Have Antibacterial Activity against Mycobacterium smegmatis by Forming Pores in Membrane and Synergizing with Antibiotics. Antibiotics (Basel) (2015) 0.76

Optical and dielectric sensors based on antimicrobial peptides for microorganism diagnosis. Front Microbiol (2014) 0.76

CXCL10 Acts as a Bifunctional Antimicrobial Molecule against Bacillus anthracis. MBio (2016) 0.76

Virucidal activity of Haemaphysalis longicornis longicin P4 peptide against tick-borne encephalitis virus surrogate Langat virus. Parasit Vectors (2016) 0.75

Human β-defensin-2 production from S. cerevisiae using the repressible MET17 promoter. Microb Cell Fact (2017) 0.75

Natural antimicrobial peptides as promising anti-HIV candidates. Curr Top Pept Protein Res (2016) 0.75

An insight into the sialome of the horse fly, Tabanus bromius. Insect Biochem Mol Biol (2015) 0.75

Scaffold-based anti-infection strategies in bone repair. Ann Biomed Eng (2014) 0.75

In vitro studies on the antimicrobial peptide human beta-defensin 9 (HBD9): signalling pathways and pathogen-related response (an American Ophthalmological Society thesis). Trans Am Ophthalmol Soc (2014) 0.75

Articles by these authors

Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88. Nat Biotechnol (2007) 6.21

Structure and function in rhodopsin: high-level expression of rhodopsin with restricted and homogeneous N-glycosylation by a tetracycline-inducible N-acetylglucosaminyltransferase I-negative HEK293S stable mammalian cell line. Proc Natl Acad Sci U S A (2002) 5.91

Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics. Nat Med (2004) 2.29

Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus. Eukaryot Cell (2008) 1.47

N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus. Hepatology (2007) 1.37

Non-pathogenic trypanosomatid protozoa as a platform for protein research and production. Protein Expr Purif (2002) 1.33

In vivo synthesis of mammalian-like, hybrid-type N-glycans in Pichia pastoris. Appl Environ Microbiol (2004) 1.33

Glycome mapping on DNA sequencing equipment. Nat Protoc (2006) 1.32

Engineering complex-type N-glycosylation in Pichia pastoris using GlycoSwitch technology. Nat Protoc (2009) 1.21

Cloning and characterization of the glucosidase II alpha subunit gene of Trichoderma reesei: a frameshift mutation results in the aberrant glycosylation profile of the hypercellulolytic strain Rut-C30. Appl Environ Microbiol (2005) 1.19

Factors influencing glycosylation of Trichoderma reesei cellulases. I: Postsecretorial changes of the O- and N-glycosylation pattern of Cel7A. Glycobiology (2004) 1.19

N-glycomic changes in serum proteins during human aging. Rejuvenation Res (2007) 1.13

Dependence of neurotrophic factor activation of Trk tyrosine kinase receptors on cellular sialidase. Glycobiology (2006) 1.09

Fed-batch fermentation of GM-CSF-producing glycoengineered Pichia pastoris under controlled specific growth rate. Microb Cell Fact (2010) 1.04

Serum protein N-glycans profiling for the discovery of potential biomarkers for nonalcoholic steatohepatitis. J Proteome Res (2009) 1.00

Total serum protein N-glycome profiling on a capillary electrophoresis-microfluidics platform. Electrophoresis (2004) 0.99

N-glycan profiles as tools in diagnosis of hepatocellular carcinoma and prediction of healthy human ageing. Mech Ageing Dev (2008) 0.91

Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells. Glycobiology (2007) 0.90

A high-throughput screening system for genes extending life-span. Exp Gerontol (2003) 0.88

Immunization with an engineered mutant trans-sialidase highly protects mice from experimental Trypanosoma cruzi infection: a vaccine candidate. Vaccine (2008) 0.87

Increased fucosylation and reduced branching of serum glycoprotein N-glycans in all known subtypes of congenital disorder of glycosylation I. Glycobiology (2003) 0.86

Clearance mechanism of a mannosylated antibody-enzyme fusion protein used in experimental cancer therapy. Glycobiology (2006) 0.86

Secretion of functional human enzymes by Tetrahymena thermophila. BMC Biotechnol (2006) 0.86

Pichia surface display: display of proteins on the surface of glycoengineered Pichia pastoris strains. Biotechnol Lett (2008) 0.86

Altered serum N-glycomics in chronic hepatitis B patients. Liver Int (2009) 0.85

Expression of the human ferritin light chain in a frataxin mutant yeast affects ageing and cell death. Exp Gerontol (2004) 0.85

Modification of the N-glycosylation pathway to produce homogeneous, human-like glycans using GlycoSwitch plasmids. Methods Mol Biol (2007) 0.83

Alteration of N-glycome in diethylnitrosamine-induced hepatocellular carcinoma mice: a non-invasive monitoring tool for liver cancer. Liver Int (2010) 0.81

Over-expression of heat shock protein 70 in mice is associated with growth retardation, tumor formation, and early death. Rejuvenation Res (2008) 0.81

Identifying genes that extend life span using a high-throughput screening system. Methods Mol Biol (2007) 0.80

The bud scar-based screening system for hunting human genes extending life span. Ann N Y Acad Sci (2004) 0.80

Nonclassical export pathway: overexpression of NCE102 reduces protein and DNA damage and prolongs lifespan in an SGS1 deficient Saccharomyces cerevisiae. Biogerontology (2007) 0.79

Role of oxidative phosphorylation in histatin 5-induced cell death in Saccharomyces cerevisiae. Biotechnol Lett (2004) 0.79

Fishing for lectins from diverse sequence libraries by yeast surface display - an exploratory study. Glycobiology (2007) 0.78

Development of a S. cerevisiae whole cell biocatalyst for in vitro sialylation of oligosaccharides. J Biotechnol (2005) 0.77

Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation. Glycobiology (2004) 0.77

Rating of CCl(4)-induced rat liver fibrosis by blood serum glycomics. J Gastroenterol Hepatol (2007) 0.76

Bax-induced cell death in Candida albicans. Yeast (2004) 0.76

Old yellow enzyme interferes with Bax-induced NADPH loss and lipid peroxidation in yeast. FEMS Yeast Res (2005) 0.76

[N-glycomic changes in hepatocellular carcinoma patients with liver cirrhosis induced by hepatitis B virus]. Zhonghua Gan Zang Bing Za Zhi (2008) 0.75

Use of a meltable polyacrylamide matrix for sodium dodecyl sulfate-polyacrylamide gel electrophoresis in a procedure for N-glycan analysis on picomole amounts of glycoproteins. Anal Biochem (2002) 0.75