Published in Proc Natl Acad Sci U S A on October 10, 2005
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Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap. PLoS One (2008) 1.16
Loop C and the mechanism of acetylcholine receptor-channel gating. J Gen Physiol (2013) 1.12
Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site. Mol Pharmacol (2010) 1.11
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Conformational dynamics of the alphaM3 transmembrane helix during acetylcholine receptor channel gating. Biophys J (2007) 1.00
Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model. PLoS Comput Biol (2011) 0.94
Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor. J Biol Chem (2013) 0.94
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Structural answers and persistent questions about how nicotinic receptors work. Front Biosci (2008) 0.93
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Probing protein packing surrounding the residues in and flanking the nicotinic acetylcholine receptor M2M3 loop. J Neurosci (2009) 0.86
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Energy for wild-type acetylcholine receptor channel gating from different choline derivatives. Biophys J (2013) 0.84
The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels. J Physiol (2011) 0.84
What have we learned from single ion channels? J Physiol (2007) 0.81
Energetic contributions to channel gating of residues in the muscle nicotinic receptor β1 subunit. PLoS One (2013) 0.78
Novel mouse model reveals distinct activity-dependent and -independent contributions to synapse development. PLoS One (2011) 0.77
Refined structure of the nicotinic acetylcholine receptor at 4A resolution. J Mol Biol (2005) 12.16
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Mapping the conformational wave of acetylcholine receptor channel gating. Nature (2000) 4.00
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Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry (2002) 1.86
Asymmetric and independent contribution of the second transmembrane segment 12' residues to diliganded gating of acetylcholine receptor channels: a single-channel study with choline as the agonist. J Gen Physiol (2000) 1.83
The role of loop 5 in acetylcholine receptor channel gating. J Gen Physiol (2003) 1.82
Structural dynamics of the M4 transmembrane segment during acetylcholine receptor gating. Structure (2004) 1.76
The extracellular linker of muscle acetylcholine receptor channels is a gating control element. J Gen Physiol (2000) 1.74
A speed limit for conformational change of an allosteric membrane protein. Proc Natl Acad Sci U S A (2004) 1.74
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Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channels. Biochemistry (2003) 1.29
Evidence for a centrally located gate in the pore of a serotonin-gated ion channel. J Neurosci (2002) 1.26
Determinants of nicotinic receptor gating in natural and unnatural side chain structures at the M2 9' position. Neuron (1996) 1.19
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Gating dynamics of the acetylcholine receptor extracellular domain. J Gen Physiol (2004) 2.57
Modal gating of NMDA receptors and the shape of their synaptic response. Nat Neurosci (2003) 2.26
A stepwise mechanism for acetylcholine receptor channel gating. Nature (2007) 2.08
Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker. J Gen Physiol (2007) 1.98
Reaction mechanism determines NMDA receptor response to repetitive stimulation. Nature (2004) 1.87
Structure of the transition state of gating in the acetylcholine receptor channel pore: a phi-value analysis. Biochemistry (2002) 1.86
The role of loop 5 in acetylcholine receptor channel gating. J Gen Physiol (2003) 1.82
Unliganded gating of acetylcholine receptor channels. Proc Natl Acad Sci U S A (2008) 1.80
Phi-value analysis of a linear, sequential reaction mechanism: theory and application to ion channel gating. Biophys J (2005) 1.80
A speed limit for conformational change of an allosteric membrane protein. Proc Natl Acad Sci U S A (2004) 1.74
Desensitization of diliganded mouse muscle nicotinic acetylcholine receptor channels. J Physiol (2002) 1.53
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Acetylcholine receptor gating: movement in the alpha-subunit extracellular domain. J Gen Physiol (2007) 1.38
Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker. J Gen Physiol (2007) 1.33
Acetylcholine receptor channels activated by a single agonist molecule. Biophys J (2010) 1.30
Energy and structure of the M2 helix in acetylcholine receptor-channel gating. Biophys J (2009) 1.29
The intrinsic energy of the gating isomerization of a neuromuscular acetylcholine receptor channel. J Gen Physiol (2012) 1.25
Modes and models of GABA(A) receptor gating. J Physiol (2006) 1.23
Energetics of gating at the apo-acetylcholine receptor transmitter binding site. J Gen Physiol (2010) 1.22
Gating at the mouth of the acetylcholine receptor channel: energetic consequences of mutations in the alphaM2-cap. PLoS One (2008) 1.16
Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels. J Biol Chem (2009) 1.13
Temperature dependence of acetylcholine receptor channels activated by different agonists. Biophys J (2011) 1.13
Loop C and the mechanism of acetylcholine receptor-channel gating. J Gen Physiol (2013) 1.12
An integrated catch-and-hold mechanism activates nicotinic acetylcholine receptors. J Gen Physiol (2012) 1.11
Glycine hinges with opposing actions at the acetylcholine receptor-channel transmitter binding site. Mol Pharmacol (2010) 1.11
The NMDA receptor gating machine: lessons from single channels. Neuroscientist (2004) 1.07
Plasticity of acetylcholine receptor gating motions via rate-energy relationships. Biophys J (2005) 1.06
Sources of energy for gating by neurotransmitters in acetylcholine receptor channels. Proc Natl Acad Sci U S A (2012) 1.06
Conformational dynamics of the alphaM3 transmembrane helix during acetylcholine receptor channel gating. Biophys J (2007) 1.00
Linking the acetylcholine receptor-channel agonist-binding sites with the gate. Biophys J (2010) 1.00
Desensitization contributes to the synaptic response of gain-of-function mutants of the muscle nicotinic receptor. J Gen Physiol (2006) 0.96
Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model. PLoS Comput Biol (2011) 0.94
Function of interfacial prolines at the transmitter-binding sites of the neuromuscular acetylcholine receptor. J Biol Chem (2013) 0.94
Mapping heat exchange in an allosteric protein. Biophys J (2011) 0.92
Decremental response to high-frequency trains of acetylcholine pulses but unaltered fractional Ca2+ currents in a panel of "slow-channel syndrome" nicotinic receptor mutants. J Gen Physiol (2009) 0.91
Asymmetric transmitter binding sites of fetal muscle acetylcholine receptors shape their synaptic response. Proc Natl Acad Sci U S A (2013) 0.89
Action of nicotine and analogs on acetylcholine receptors having mutations of transmitter-binding site residue αG153. J Gen Physiol (2013) 0.87
Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating. J Biol Chem (2010) 0.85
Observations on rate theory for rugged energy landscapes. Biophys J (2008) 0.84
Energy for wild-type acetylcholine receptor channel gating from different choline derivatives. Biophys J (2013) 0.84
The energetic consequences of loop 9 gating motions in acetylcholine receptor-channels. J Physiol (2011) 0.84